5 results about "Plaque rupture" patented technology

The application discloses application of CCL3-AS1 in regulating stability of carotid artery plaque, overexpression of CCL3-AS1 induces inflammatory activity of macrophages and secretion of MMP9, promotes plaque rupture and thrombosis; on the contrary, knockdown of CCL3-AS1 inhibits inflammatory activity of macrophages and secretion of MMP9, reduces plaque rupture and thrombosis; in addition, the application also discloses that CCL3-AS1 enhances MMP9 mRNA stability by combining with hnRNP-K, thereby increasing MMP9 expression and secretion and degrading fibrous cap collagen. The application discloses important role of CCL3-AS1 in stability of carotid artery plaque and a molecular mechanism, provides a new diagnostic marker and a treatment target, not only provides a new direction for research on atherosclerosis related diseases, but also provides a new tool and a means for clinical diagnosis and treatment.

The application provides a CEUS image analysis method based on key frame segmentation and time sequence tracking fusion, a CEUS video risk grading overall framework based on key frame screening, segmentation and time sequence fusion, integrates video preprocessing, key frame extraction, plaque segmentation, time sequence feature fusion and multi-frame risk decision and the like links, forms a complete risk grading process, and can be used for automatic grading of carotid plaque rupture risk. The application has the advantages of significantly improving efficiency, enhancing time sequence sensitivity, stabilizing grading results, being strong in clinical interpretability and being good in universality, and can be popularized to CEUS image analysis of organs such as liver and kidney.

The application discloses a kind of numerical simulation systems of stent intervention smooth particle dynamics based on intravascular image;Including: vascular attribute collection module, stent establishment module, particle and assembly module, stent release setting module and release stent mechanics simulation module, particle and assembly module reads the three-dimensional vascular model of vascular attribute collection module, the three-dimensional stent model of stent establishment module and the specified lesion position of input, and constitutes the complete model to be particle;Particle is generated after particle by the particleization of stent model through the pre-processing of smooth particle method, and the complete model after particle;Stent release setting module sets given geometric constraint to stent;Release stent mechanics simulation module simulates using smooth particle method according to the boundary condition of force.The present application combines patient image data, realizes the stress distribution when stent expansion is predicted before operation, improves compliance and support force balance;Evaluate the risk of plaque rupture, avoid vascular injury.