33 results about "Artery Endothelium" patented technology

A device and method for treatment of intracranial vasospasm is provided. The device is a microcatheter having a steeply tapered end and is thicker walled, and in a preferred embodiment is braided to provide greater pushability. In order to achieve a thicker walled catheter, in one embodiment, the inner lumen diameter can be reduced, leaving the outer diameter the same while in another embodiment the catheter is larger in outer diameter. In one embodiment, the microcatheter is coated with performance enhancing lubricant, such as a hydrophilic coating. Further, the microcatheter can also be coated with drugs and serve as a drug delivery device, drugs being embedded into vessel intima. In the use of the method of treatment, the device is fed into the smaller arterial vessels in the brain simultaneously dilating arteries of various caliber along the path of the catheter to relieve vasospasm; pharmacological agents can then be delivered by the microcatheter to further effect treatment.

The invention relates to a third generation PCI therapeutic saccule support system, a preparation method and application, and belongs to the field of biomedical engineering. The therapeutic saccule support treatment system comprises a catheter and a saccule, and is characterized in that the support is a naked support, and a therapeutic medicament and / or a cell coat are attached to the surface of the saccule. After the saccule expansion support is placed into a coronary artery through the catheter, the saccule is expanded through transient pressure so that the medicament or the cell coat on the saccule can tightly cling to the inner wall of a blood vessel so as to repair the blood vessel intima injured by saccule expansion. The system well combines the advantages of the first generation support system and the second generation support system so that the saccule carries the medicament to enter the blood vessel once, and the support is the naked support and only plays a role in supporting the blood vessel so as to well solve the problem of long-term non healing of the injured blood vessel caused by the sustainable medicament of the second generation support system, effectively prevent the formation of thrombus and restrain the occurrence of restenosis.

The invention relates to a preparation method of a composite small-caliber artificial blood vessel, and a product thereof. The preparation method comprises the following steps of decellularizing a coronary artery to obtain a decellularized blood vessel; then heparinizing the decellularized blood vessel, using a mixed electrospinning solution of gelatin and poly L-lactide-caprolactone (PLCL) for spinning, and removing an organic solvent, thus obtaining the small-caliber artificial blood vessel. The prepared artificial blood vessel is a double-layer tissue engineering blood vessel, adopts decellularized porcine coronary artery as an artificial blood vessel inner layer, has good compliance and cytocompatibility, and can promote cell adhesion, proliferation and differentiation, and spreading so as to accomplish reendothelialization of the blood vessel; an outer layer is a blending layer of the PLCL and the gelatin, so that the mechanical property of the blood vessel is improved, cells of smooth muscle and the like are favorably intruded, and a middle layer of the blood vessel is formed; the inner surface of the inner layer can be modified by different drugs such as heparin, so that theantithrombus of the artificial blood vessel is improved, the blood vessel intima formation is promoted, and the blood vessel is favorably rebuilt.

The invention discloses a micro-fluidic chip-level extracorporeal circulation system for vascular endothelial cell mechanics biological research, and belongs to the technical field of cell mechanics biological experiment devices. The system comprises three parts: 1) the micro-fluidic chip is composed of a sandwich structure cell culture cavity and a multi-element fluid mechanics loop for simulating hemodynamic characteristics; 2, the fluid loading device is combined with a feedback control system, and hemodynamic signals such as blood pressure, wall shear stress and circumferential stretchingstrain borne by different target artery endothelium can be generated in the cell culture cavity; 3) the signal acquisition and processing system can be used for observing cell mechanics biological response in real time and feeding back detection data to the control system so as to further adjust the fluid loading device. The system accurately simulates a real target artery vascular endothelial extracellular hemodynamic microenvironment, and provides a miniaturized, objective, standardized and quantified experimental platform for researching a quantitative relationship between hemodynamic signals and a vascular endothelial cell mechanics biological mechanism.

The invention discloses an electrical impedance detector for artery endothelial functions of arteries and a method, which belong to the technical field of medical instruments. The electrical impedance detector comprises a front arm upper electrode, a front arm lower electrode, a high-frequency low-amplitude constant-current-source generator, an alternating-current voltage detecting circuit, a signal amplifier, a filter circuit, an A / D (analog / digital) conversion circuit and a computer. The alternating-current voltage detecting circuit detects voltage change, analog voltage signals of alternating-current voltage are converted into digital signals by the amplifier, the filter circuit and the A / D conversion circuit, and the digital signals are inputted to the computer. An electrical impedance changing curve along with time and brachial artery blood flow-mediated dilation are calculated, and the curve and a brachial artery dilation analysis result are displayed on a display finally. Compared with the prior art, the method has the advantages that instruments are simple, cost is low, miniaturization is realized, popularization is easy, and market prospect is wide.

The invention provides an application of astragaloside IV (AS-IV) in inhibiting local inflammatory response and treating arterial restenosis, and relates to the technical field of novel applications of traditional Chinese medicines. According to the invention, a rat carotid artery balloon injury model is established to simulate vascular intimal injury after percutaneous coronary intervention (PCI)surgery, and the inhibitory effect of the AS-IV on proliferation of VSMCs and inflammation in vivo is clarified, so that a novel safe and effective solution is provided for prevention and treatment of restenosis after the PCI surgery.

The invention discloses a multi-angle vascular anastomosis fixation device. The multi-angle vascular anastomosis fixation device comprises a device body; the device body is provided with a track; a first connecting rod and a second connecting rod are installed on the track in sequence; both the first connecting rod and the second connecting rod can slide on the track back and forth; the far end ofthe first connecting rod is hinged with a third connecting rod; the far end of the second connecting rod is hinged with a fourth connecting rod; the far end of the third connecting rod is connected to a first vascular clamp through a universal joint; and the far end of the fourth connecting rod is connected to a second vascular clamp through a universal joint. The multi-angle vascular anastomosisfixation device provided by the invention has the vascular clamps, which can slide on the linear track back and forth; a vascular wall can be pulled and fixed continuously and stably; the anterior and posterior walls of broken ends of blood vessels can be shown clearly; the proper vascular clamp can be selected and used according to a free blood vessel condition and its travelling angle; a support frame is arranged on the vascular clamp; the support frame has the function of opening a vessel cavity; endangium is not injured; multi-angle fixation also can be carried out; and in particular, thedevice can be used for pulling and fixing blood vessels travelling in different angles.

The invention provides a semen plantaginis polysaccharide oral pharmaceutical preparation, preparation method and application. The oral pharmaceutical preparation is prepared through the following steps, that is, microwave extraction, concentration, precipitation separation and pharmaceutical preparation. The oral pharmaceutical preparation can be made into granules, tablets, pillers or oral liquids according to a weight percentage of 5 to 80 percent of semen plantaginis polysaccharide and the rest of other pharmaceutical adjuvants. A preliminary research proves that semen plantaginis can play an obvious role in resisting oxidation and clearing freeradicals, block the generation of oxLDL and relax blood vessels and protect the artery endothelium by releasing nitric oxide (NO). The semen plantaginis polysaccharide oral pharmaceutical preparation is expected to be developed to be a new pharmaceutical preparation product capable of resisting oxidation, clearing freeradicals and preventing and curing atherosclerosis.

The invention provides an intelligent measurement method and system for carotid artery intima-media thickness. The method comprises the following steps: acquiring an ultrasonic image of a carotid artery; identifying carotid artery blood vessels in the ultrasonic image by adopting a blood vessel identification model; adopting a contour recognition model to recognize the initial contour of the intima-media membrane of the carotid artery blood vessel; processing the initial contour to obtain a target contour of the intima-media membrane, wherein the target contour comprises a first edge curve formed by connecting lines of first boundary points between the intima and the lumen of the blood vessel, and a second edge curve formed by connecting lines of second boundary points between the intima-media and the adventitia of the blood vessel; obtaining the maximum distance between the first edge curve and the second edge curve, taking a first boundary point corresponding to the maximum distance as a first target point, and taking a second boundary point corresponding to the maximum distance as a second target point; taking a connecting line between the first target point and the second target point as a reference line, and intercepting a contour section containing the first target point and the second target point in the target contour; and calculating the average distance between the first edge curve and the second edge curve in the contour section as the thickness of the intima-media membrane. The measurement efficiency is improved, and the measurement effect is stable.

The invention provides a stent for blocking arterial aneurysm of an initial part of an arterial branch and application thereof. The stent comprises a stent body, a film-covered part, a proximal big opening and a distal small opening. The stent body is of a net structure; when the surface of the stent is wholly covered with covering film, a film-covered stent is formed; when the surface of a longer side of the stent is covered with a layer of covering film and the other side is not covered with covering film, a semi-film-covered stent is formed; the proximal end of the stent is a big open port and the distal end is a small open port, so that the stent is shaped as a funnel. The stent can be used for curing arterial aneurysm of an initial part of an arterial branch; the film-covered part can favorably block arterial aneurysm; the stimulation of the stent to the intimae of blood vessels is reduced; the stent can simplify operation, improve the curative effect and improve the safety of intravascular operation.

The invention relates to uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in smooth muscle cell proliferation inhibition and coronary artery restenosis control, and concretely relates to Salvia miltiorrhiza Bunge and Panax Notoginseng extraction technologies, and uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in vascular smooth muscle cell proliferation inhibition and coronary artery expanding formation restenosis control. Experiments prove that 50%, 95%, a 50%+95% combination and a 50%+80%+95% combination in extract products of Salvia miltiorrhiza Bunge and Panax Notoginseng can effectively inhibit the proliferation of vascular smooth muscles and control the incrassation of balloon injury postoperative endangium; and the vascular smooth muscle proliferation inhibition and balloon injury postoperative endangium incrassation control effects of the 50%+95% combination and the 50%+80%+95% combination are better than that of the individual dosing of each of the positions.

The invention discloses a degradable blood vessel stapler with a drug film layer and a preparation process thereof, comprising a sleeve made of degradable metal materials; Pore ​​structure; the inner wall and / or outer wall of the casing is provided with a drug film layer, and the drug film layer is a polymer film containing a drug component or a biofilm containing a drug component. The vascular stapler of the present invention can quickly and effectively connect end-to-end vascular intima without suturing, is convenient for anastomosis, is well positioned, and is not easy to move; moreover, the surface of the thin tube wall of the vascular stapler is not only beneficial to the intima tissue of the host vessel Crawling, growing, covering, fast healing, and effective treatment of vascular diseases; at the same time, the sleeve can play a supporting role and improve the patency of blood vessels, especially after the vascular intima heals, the degradable sleeve can quickly degrade and remove from the body The clinical events such as restenosis and complications in the late stage of non-degradable drug-eluting stents were solved.

The invention discloses a Chinese medicament kudzu-vine root for preventing and treating vascular restenosis, or a medicament composite comprising a kudzu-vine root which serves as a raw material, or the application of extractive which takes the kudzu-vine root as the raw material and serves as an active ingredient in the preparation of a medicament which is used for preventing and treating the vascular restenosis. The invention also discloses a method for preparing the medicament for preventing and treating the vascular restenosis. The Chinese medicament kudzu-vine root for preventing and treating the vascular restenosis is novel medicament application besides the original published medicament effect of the kudzu-vine root. The Chinese medicament kudzu-vine root for preventing and treating the vascular restenosis can obviously improve coronary heart diseases, apoplexy and sequel caused by atherosclerosis, and lumen restenosis caused by newly born endangium after angioplasty and artery scaffold treatment, regulate structural disorder caused by vascular remodeling, and effectively control thrombosis on an injured part and followed thrombus organization. The Chinese medicament kudzu-vine root for preventing and treating the vascular restenosis has the advantages of positive clinical effects, obvious curative effect and quick response, and compared with a scaffold operation and a bypass operation, the Chinese medicament kudzu-vine root also has the advantages of higher safety, lower cost, and more stable and more reliable late result.

The invention relates to a stent for a blood vessel. The stent comprises a coating film and an anchoring piece which are connected with each other, the anchoring piece is used for fixing the coating film in the blood vessel; the coating film is used for covering the diseased region of the blood vessel. The anchoring piece of the stent is used for better attaching the coating film to the vascular intima and fixing the coating film at an expected implantation position when the stent is scoured by blood, the coating film can hold unstable plaques on the vascular intima and prevent the unstable plaques from being broken; meanwhile, the coating film can trigger foreign body reaction in a living body, so that vascular endothelial growth is stimulated. Unstable plaques grow into stable plaques, and the occurrence rate of acute thrombus is reduced. The stent can also be used for treating vascular tearing in the interventional process, and thrombus events caused by falling of the torn vascular wall are avoided.

The invention discloses an integrated puncture and perfusion catheter for abdominal organ transplantation donor perfusion, one end of the integrated puncture and perfusion catheter is provided with a puncture part, and the puncture part comprises a puncture piece, an accommodating channel and a retraction assembly capable of controlling the puncture piece to retract into the accommodating channel; the puncture part is arranged in the containing channel and can stretch out and draw back to enter the containing channel, and the retraction assembly is connected with the puncture part. The catheter has the advantages of being convenient to operate, good in puncture effect, capable of avoiding blood splashing, capable of preventing damage to endangium, capable of effectively improving the perfusion efficiency, capable of guaranteeing the quality of donor organs and the like.

The invention discloses a novel scatheless anesthesia catheter, comprising an inner tube, wherein a scale mark and an X-ray developing line are arranged at the outer wall of the inner tube; an outer tube is sleeved outside the inner tube; a soft head is arranged at the end part of the outer tube; and the soft head is fixedly connected with the outer tube. The novel scatheless anesthesia catheter is simpler in manufacturing process because the scale mark and the X-ray developing line are processed at the outer wall of the inner tube; the production cost is reduced; meanwhile, the outer pipe is sleeved outside the inner tube; and the scale mark or the X-ray developing line can be prevented from affecting a patient. The novel scatheless anesthesia catheter can rapidly and smoothly enter a human body. Therefore, the piercing risk is greatly reduced; the damage to an inner membrane of a blood vessel is reduced, and the novel scatheless anesthesia catheter is safe, reliable and convenient to use.

The invention relates to the field of medical image analysis, in particular to a carotid artery ultrasound image blood vessel and intima positioning method based on a deep learning network. The method comprises the following steps: S1, acquiring an ultrasonic original image containing the common carotid artery in real time; S2, performing optimization processing on the ultrasonic original image to obtain an ultrasonic post-processing image; S3, weighting the ultrasonic original image and the ultrasonic post-processing image to obtain a weighted image; S4, cutting the weighted image into cut images with the same width and depth; and S5, inputting the cut image into a pre-trained full-automatic segmentation network, outputting an intima segmentation result and a blood vessel segmentation result, and applying the intima segmentation result and the blood vessel segmentation result to IMT measurement and user guidance. Accurate positioning and segmentation of blood vessels and intima of blood vessels are achieved. Compared with a traditional algorithm, the method does not need manual intervention at all, and compared with a secondary structure, real-time calculation is easier to achieve, and the real-time requirement is met.

The invention provides a head and neck artery acute occlusion thrombus extraction device, and belongs to the technical field of medical instrument structures. The device comprises a saccule guide catheter, a micro catheter, a micro guide wire and a thrombus taking bag; the saccule guide catheter is an inflating ball which is capable of being inflated and deflated and installed on the outer wall of the guide catheter, the micro catheter is arranged in the guide catheter and serves as a conveying channel of the thrombus taking bag, an opening of the thrombus taking bag is fixed by two micro metal wires, after being unfolded, the opening of the bag is opened into a round shape and tightly attached to the vessel wall, the thrombus taking bag is cylindrical, the caliber is gradually reduced, friction on the vessel wall is reduced, vascular intimal injury is reduced, holes of 100-150 um are densely distributed in the bag, and blood flow is smooth. When the thrombus extraction device is used, thrombi are smashed with the micro guide wire to be collected after the bag is unfolded, or the bag can be directly pulled down to collect the thrombi. The head and neck artery acute occlusion thrombus extraction device is reasonable in structural design, easy to operate and capable of completely capturing the thrombi and preventing the thrombi from escaping.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent and a preparation method thereof. The thermal induction type shape memory high-molecular polymer is adopted as an intravascular stent material, and deformation can be generated under the influence of the body temperature of a human body, so that the two ends of a broken blood vessel are supported, and blood flow is unblocked; meanwhile, vascular endothelial growth factors are added into the vascular stent material, so that endothelial cells in blood can be collected, the endothelialization rate is increased, cells on the most superficial layer of the endovascular intima of a human body grow towards the lumen surface of an artificial blood vessel, and a layer of membranous tissue of the endothelial cells is formed; thus, the number of platelets can be reduced by loading heparin on the inner wall of the intravascular stent, so that the thrombus symptom is relieved.

The invention discloses an intracavity intima peeling device, which comprises a first pipe, a second pipe, an outlet, a passage, a thorn and a driving element, wherein the first end of the first pipeis a peeling head capable of being used for peeling the intima from the inner wall of the cavity; the first end of the second pipe extends in from the second end of the first pipe and can extend out from the first end of the first pipe, is movably matched with the first pipe and can rotate to and fro; the outlet is formed in the outer wall of the first end of the second pipe; one end of the passage communicates with the outlet; the other end of the passage extends in the direction towards the inner wall of the second pipe and penetrates through the inner wall of the second pipe; the thorn is movably arranged in the passage, and comprises a main thorn end; the driving element is movably arranged in the second pipe in a sleeving way, and can drive the main thorn end of the thorn to extend out of the outlet. When the intracavity intima peeling device is used for operation, the blood vessel incision is not needed; the operation wound is small (minimally invasive); the artificial stenosis due to incision and suture can be avoided; the hyperplasia endangium can be integrally peeled away; the occurrence rate of restenosis is reduced.

The invention relates to an interventional medical device and the application of aphidicolin. An interventional medical device includes a device body and drugs loaded on the device body. The active drug in the medicine is selected from at least one of aphidicolin, a pharmaceutically acceptable salt of aphidicolin, a solvate of aphidicolin, and aphidicolin derivatives. The inventors discovered unexpectedly that when aphidicolin is loaded on the surface of the interventional device, it can effectively inhibit the growth of smooth muscle cells, there is no obvious hyperplasia of the vascular intima, and the toxicity to the surrounding cells is small, so as to prevent or treat Restenosis after transluminal vascular angioplasty provides a new option.

The invention discloses an integrated puncture perfusion catheter for perfusion of abdominal organ transplant donors. One end of the integrated puncture perfusion catheter is provided with a puncture part, and the puncture part includes a puncture part, an accommodating channel and a controllable The puncturing member is retracted into the retreating assembly in the accommodating channel, the puncturing member is arranged in the accommodating channel and can stretch in and out of the accommodating channel, and the retracting assembly is connected with the puncturing member. The invention has the advantages of convenient operation, good puncture effect, avoiding blood spatter, preventing damage to the intima of blood vessels, effectively improving perfusion efficiency, ensuring the quality of donor organs, and the like.

The invention discloses an adjustable endovascular exfoliator which comprises a fixing mechanism, a driving mechanism is fixedly arranged on the right side of the fixing mechanism, a moving mechanism is slidably arranged outside the driving mechanism in a sleeving mode, and a plurality of spokes capable of exfoliating angiosclerosis plaques are fixedly arranged on the right side of the fixing mechanism in a surrounding mode. The right side of the spoke is fixedly connected with the moving mechanism, the driving mechanism is sleeved with a pushing mechanism capable of driving the moving mechanism to move leftwards or rightwards in a threaded mode, the pushing mechanism is rotationally connected with the moving mechanism, and scales allowing the moving distance of the pushing mechanism to be observed are integrally arranged outside the driving mechanism. According to the adjustable endovascular exfoliator, a surgeon can tighten up the spokes, and exfoliating treatment is carried out on plaques in a blood vessel through the tightened spokes, so that by using the adjustable endangium exfoliating device, angiosclerosis plaques can be exfoliated and eliminated, and the surgical treatment effect is improved.

The invention relates to the technical field of medical treatment, in particular to a blood vessel supporting ring and a blood vessel supporting ring assembly. The blood vessel supporting ring comprises a separation part, and the separation part is arranged to prevent the inner membranes of blood vessels from being adhered together, that is, the separation part is arranged to separate the mutually adhered inner membranes of the blood vessels from the interiors of blood vessel lumens, so that the inner membranes of the blood vessels are kept in gaps. The technical problem that when people carry out blood vessel anastomosis, a blood vessel wall on the opposite side is easy to penetrate through is solved, so that the success rate of blood vessel anastomosis is improved. In addition, according to the blood vessel supporting ring and the blood vessel supporting ring assembly, the structure is simple, the operation is convenient, the sizes of two anastomosis ends can be adjusted, so that the diameters of the anastomosis ends are consistent, the broken ends of a blood vessel and tissues around an adventitia are conveniently and quickly trimmed, the difficulty of anastomosis of the blood vessel is reduced, the support ring can be trimmed after the blood vessel is sutured, and in addition, the eversion of the inner membrane of the blood vessel is uniform.

The invention provides use of a PI3K / mTOR dual inhibitor, a medicine carrying stent and a preparation method of the medicine carrying stent. The PI3K / mTOR dual inhibitor is used for preparing a medicine for inhibiting vascular intimal hyperplasia and is loaded to a stent body to form the medicine carrying stent for inhibiting the vascular intimal hyperplasia; the PI3K / mTOR dual inhibitor is capable of simultaneously inhibiting PI3K and mTOR and can play duel-target role of the single medicine; and compared with a pure mTOR inhibitor, the PI3K / mTOR dual inhibitor has the advantages that the effect of inhibiting vascular smooth muscles is relatively strong, the vascular intimal hyperplasia is effectively inhibited, and the restenosis rate of blood vessels is further decreased.

The invention relates to the technical field of medical treatment, in particular to a transbronchial pulmonary artery denervation device which comprises an ultrasonic probe, a bronchoscope, an operation tube, a puncture needle and an ablation catheter. The ultrasonic probe is fixed at one end of the operation tube, the bronchoscope is fixed on the operation tube, and an exchange channel with two open ends is arranged in the operation tube; the puncture needle and the ablation catheter are alternately arranged in the exchange channel in a penetrating manner. The sympathetic nerve of the pulmonary artery adventitia can be directly injured under the guidance of the bronchoscope and the ultrasonic endoscope, meanwhile, the risk of injury of the vascular intima is avoided, the operation difficulty of pulmonary artery denervation is reduced, the operation safety is improved, and a new treatment choice is provided for increasing pulmonary hypertension patients.

The invention discloses a small-caliber tissue-improved composite artificial blood vessel, comprising outer-layer tissue, inner-layer tissue and cross-linked tissue, wherein the outer-layer tissue iscomposed of a blending layer, microparticle holes and an aorta elastic layer; the inner-layer tissue is composed of a decellularized endocardium, an endocardium hyperplasia layer and an antithromboticdrug layer; the cross-linked tissue is composed of N-hydroxysuccinimide and carbodiimide, the effect of facilitating vascular endothelial cell proliferation is achieved through a micropore structureat first, and then through a natural decellularization matrix material, good compliance and cell compatibility are achieved, adhesion, proliferation, differentiation and spreading of cells can be promoted, and re-endothelialization of a blood vessel is completed; an outer layer is a blending layer of silk fibroin, carboxylated bacterial cellulose and gelatin, so the mechanical properties of the blood vessel are improved, and invasion of cells such as smooth muscles is facilitated; and the inner side of an inner layer can be modified by different medicines such as heparin, so the antithrombosisof the artificial blood vessel is improved, the formation of endangium is promoted, and the reconstruction of the blood vessel is finally facilitated.

The invention provides a retractable drug coating stent, and belongs to the technical field of medical apparatus and instruments. The stent comprises an inner tube, a middle tube, an outer tube and a self-expanding stent, and the near ends of the inner tube, the middle tube and the outer tube are connected with a pushing device; the far end of the inner tube is provided with a tip; the surface of the self-expanding stent is provided with spines, the surface of the self-expanding stent is provided with a drug coating, and the self-expanding stent is connected to the far end of the middle tube; and the self-expanding stent has a folded state and an expanded state. According to the retractable drug coating stent, the surface of the self-expanding stent is provided with the spines, the spines can penetrate through calcified lesions and tunica intima and enter tunica media vasorum and tunica adventitia vasorum for deep administration, and the drug utilization rate is increased; and the drug coating stent cannot be retained in the body of a patient, meanwhile, blood flow cannot be blocked in the mode, the drug delivery time can further be controlled, the whole operation process is simple and convenient, and the stent is easy to operate.