41results about How to "Damage relief" patented technology

This invention discloses a landing buffer device for unmanned aerial vehicles (UAVs), relating to the field of aviation equipment technology. By integrating the roller body and the sliding plate as two grounding structures onto the landing gear, the device can quickly switch operating modes according to ground conditions through the linkage of the piston cylinder and piston rod. On flat ground, the roller is used first to reduce gliding resistance, while on muddy or slippery ground, the sliding plate is used for grounding, effectively preventing roller jamming and enhancing all-terrain adaptability and landing safety. Simultaneously, the mechanical buffer composed of a second and third spring, combined with the hydraulic damping buffer composed of buffer components, forms a highly efficient double-layer energy-absorbing buffer structure, which to a certain extent alleviates the damage to the aircraft and equipment caused by landing impact, thus improving the landing safety of the UAV.

The invention belongs to the field of biological medicine, and discloses a chicoric acid (CA)-loaded tetrahedral framework nucleic acid (tFNA) nano preparation for treating acute gouty arthritis. According to the preparation, tFNA formed by self-assembly is taken as a carrier, and a natural active ingredient CA is loaded to form a CA-tFNA compound. The compound overcomes the defects that CA is poor in water solubility and low in bioavailability, and existing drugs are weak in targeting and large in side effect. Through the targeted delivery and synergistic effect of tFNA, the preparation can be effectively enriched in inflammatory joints, significantly inhibit NF-kappa B signal pathways, and down-regulate the expression of key proinflammatory factors such as TNF-alpha and IL-1beta, so that joint swelling and synovial tissue damage are relieved, and repair is promoted. Experiments show that the traditional Chinese medicine composition is remarkable in curative effect and good in safety, and a novel efficient treatment strategy is provided for acute gouty arthritis.

The invention discloses staphylococcus warneri CCSM005 separated from human skin and capable of improving skin health and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The staphylococcus warneri CCSM005 provided by the invention can be fermented to produce the L-glycine-valine dipeptide, and a fermentation supernatant of the staphylococcus warneri CCSM005 has a good effect of repairing a skin barrier function, which is specifically shown in that the activity of damaged HaCaT cells is improved in vitro, and the gene level expression of FLG, ZO-1, CLDN and Occludin can be improved at the same time after the damage. Therefore, the staphylococcus warneri CCSM005 has a huge application prospect in preparation of external daily chemical products or medicines for repairing the skin barrier.

The utility model discloses municipal road and bridge pavement rapid repairing equipment which comprises a bottom plate and a road pressing roller, a base is installed in the center of the top of the bottom plate, a driving motor is fixedly installed on one side of the base in a penetrating mode, a plurality of heating plates are installed in the pressure roller, and buffering devices are arranged on the surfaces and the two ends of the heating plates. According to the device, the driving motor is arranged to drive the swing device to rotate, the swing device drives the connecting plate to rotate, and the connecting plate drives the hydraulic cylinder in the U-shaped seat to generate angular deviation, so that the pressure roller is driven to be in contact with the ground, and the inflatable sealing skirt edge can be inflated through the inflation hole in the pavement repairing process; and the hydraulic cylinder and the repairing assembly can be quickly disassembled and maintained by arranging the quick disassembling mechanism, it can be guaranteed that damage to internal parts caused by road bumping can be effectively relieved through the buffering device when the heating plate conducts heating, and the service life is prolonged.

The invention relates to the field of wind power blade front edge protection, in particular to a polyurethane / foamed nickel composite material for a wind power blade front edge and a preparation method of the polyurethane / foamed nickel composite material. The composite material comprises a component A, a component B and a foamed nickel metal framework, the component A comprises the following components in parts by weight: polyether polyol, pigment filler, an organic solvent, an ultraviolet light absorber, a wetting dispersant, a defoaming agent, a flatting agent and an anti-settling aid; the component B is diisocyanate; the foamed nickel metal framework, the component A and the polyurethane coating prepared from the component B form a bicontinuous phase structure. The'shadow protection effect 'and'carpet protection effect' of the foamed nickel metal framework in the polyurethane / foamed nickel composite material are utilized, and the prepared polyurethane / foamed nickel composite material can effectively change the flowing direction of liquid drops, relieve concentrated stress, delay propagation of cracks on the surface and inside of a polyurethane coating, prevent the coating from falling off and the like. And the rain erosion resistance of the polyurethane coating is greatly improved.

The invention provides an extract with high saikoside B2 content, a preparation method and application of the extract, and a combined medicine containing the extract, and belongs to the technical field of natural medicine preparation. The method comprises the following steps: efficiently extracting saikoside A and saikoside D in a radix bupleuri raw material by using an alkaline ethanol solution, further realizing efficient resolution of saikoside A and saikoside D by using macroporous adsorption resin, and quantitatively converting saikoside D into saikoside B2 by using a chemical method, thereby obtaining the high-content effective part of saikoside B2. The high-content effective part of saikoside B2 only contains a small amount of saikoside A except the main component saikoside B2, so that the toxicity is greatly reduced while the biological activity of the saikoside B2 is ensured. The high-content effective part of saikosaponin B2 can be used for preparing medicines for treating and preventing gout, rheumatoid arthritis, acute enteritis, skin light injury, skin inflammation and other diseases, can be independently used, and can also be combined with other medicines for use.

The present application relates to a kind of cylindrical electrode paste and its preparation method.A kind of cylindrical electrode paste, by mass parts, including 15-20 parts of anthracite main material, 25-40 parts of residual anode, 3-10 parts of graphite fragment, 25-35 parts of coke, 15-30 parts of organic binder, 6-18 parts of bio-based binder. Among them, organic binder includes medium temperature pitch, anthracene oil, beta resin. Among them, bio-based binder includes carbonized hydrophobic composite modified wood bamboo powder, sodium carboxymethyl cellulose. The carbonized hydrophobic composite modified wood bamboo powder of the present application and sodium carboxymethyl cellulose are compounded to form a bio-based binder, which cooperates with the organic binder to ensure the bonding strength, high temperature resistance and electrical conductivity of the cylindrical electrode paste, while realizing the green and low-carbon utilization of biomass, solving the problems of high temperature failure, moisture absorption and easy caking, and many pores of traditional bio-based binder, reducing the resistivity and production cost, and improving the structural density and use stability.

This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.

The invention discloses a skin-derived staphylococcus warneri CCSM004 prepared metagen with a skin barrier repairing effect, and belongs to the technical field of microorganisms and the technical field of medicines. The staphylococcus warneri CCSM004 provided by the invention can generate L-glycine-valine dipeptide and oleamide, and a fermentation supernatant prepared from the staphylococcus warneri CCSM004 has a good effect of repairing a barrier function, which is specifically shown in that the activity of damaged HaCaT cells is improved in vitro, and the gene level expression of FLG, IVL, AQP3, ZO-1, CLDN and Occludin can be improved at the same time after the damage. Therefore, the staphylococcus warneri has a huge application prospect in preparation of external cosmetics or medicines for repairing the skin barrier.

The invention discloses a preparation method and application of bionic nano immunomodulatory bait, and the preparation method comprises the following steps: firstly, obtaining neutrophils, treating the neutrophils with a cell lysis buffer solution containing a calcium ion chelating agent and a protease inhibitor, collecting supernate, and then centrifuging and purifying to obtain neutrophils membranes; then mixing an organic phase containing a polymer polylactic acid-glycolic acid copolymer and a therapeutic drug with a polyvinyl alcohol solution, and emulsifying to obtain a PLGA-therapeutic drug nano core; and finally, co-extruding the material and the neutrophile granulocyte membrane. The neutrophile granulocyte membrane is used as a camouflage shell, the nano bait capable of efficiently targeting an inflammatory site and neutralizing multiple inflammatory mediators is constructed, the nano bait is applied to brain injury after cardio-pulmonary resuscitation, efficient and active targeting on an inflammatory brain area can be achieved, the death rate of neurons can be reduced, and the nano bait has an extremely good application prospect.

This invention provides a functional fascia gun head, belonging to the field of massage devices and physical therapy technology. This functional fascia gun head consists of a power-generating layer and a regular fascia gun head; the power-generating layer can be placed outside or inside the regular fascia gun head. Another design of the functional fascia gun head is entirely composed of a power-generating layer. When the fascia gun is in operation, the power-generating layer generates a Maxwell pulse electric field and a pulse displacement field current under force, forming a pulse wave. This pulse wave can effectively penetrate multiple layers of skin structure, promoting blood circulation and cell activation, achieving various health benefits such as warming the meridians and activating collaterals, relaxing muscles, relieving pain, preventing injury, dispelling cold and dampness, harmonizing yin and yang, promoting homeostasis, and delaying aging. The power-generating layer is made of various materials and has various structural forms; the manufacturing process is simple, significantly improving the product's multifunctionality and ease of use, providing more diversified and efficient options for the medical and beauty fields.

The utility model relates to the technical field of electromagnetic heater, concretely is a shockproof detection integration electromagnetic heater, the utility model discloses shockproof detection integration electromagnetic heater, the below of shockproof detection integration electromagnetic heater is placed with base, the top of base is placed with the damping telescopic link even, the outer ring of damping telescopic link is placed with damping spring, the outer ring of damping spring is placed with the locating pipe, the locating pipe is evenly set up at the top of base, the outer ring of locating pipe is slidably connected with the buffer lining, the outer ring of buffer lining is provided with the connecting sleeve, the utility model discloses, through the shock absorber that damping spring and damping telescopic link cooperate each other can alleviate the damage that the inside component of shockproof detection integration electromagnetic heater caused by vibration, and still improve shockproof detection integration electromagnetic heater to the detection accuracy of vibration that influences device work.

The utility model relates to the technical field of wind turbine mechanical engineering provides high -strength bolt fastening frock of wind turbine, including frock body, positioning structure, and elastic coupling structure, frock body is provided with at least two positioning holes, and the adjacent positioning hole forms a limit position on frock body between, two positioning structures are oppositely established, two positioning structures are movably established on frock body, wherein a positioning hole is formed on the elastic coupling structure, a plurality of installation cavities and elastomer are axially provided in the elastic coupling structure, a plurality of installation cavities are arranged along the circumferential direction of the elastic coupling structure, and the elastomer is arranged in the installation cavity. The utility model can adapt to the blade bolt with flat protrusion, so as to solve the problem that the existing electric wrench cannot directly apply pre-tightening force to the blade bolt, the fastening frock can be used with electric or pneumatic tool, thereby realizing mechanization, automatic fastening operation.

The application discloses a rhynoxanthine type diterpene and a preparation method and application thereof; the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia, and has at least one of structural formulae as shown in formula (I), formula (II) and formula (III); the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia in the Lauraceae Cinnamomum plant; the application uses an alcohol, palmitic acid and other induced liver cell damage models to evaluate hepatoprotective activity, finds that the rhynoxanthine type diterpene can effectively relieve alcohol, palmitic acid and other induced liver cell damage, and indicates that the rhynoxanthine type diterpene has hepatoprotective activity, can be used for preparing hepatoprotective drugs, and has a good research and development prospect.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

The application discloses application of a pilose antler polysaccharide in preparation of a radioactive liver injury protection product and belongs to the technical field of biological pharmacy. The application of the pilose antler polysaccharide in preparation of the radioactive liver injury protection product shows that the polysaccharide can not only effectively reduce oxidative stress and inflammatory injury, but also specifically intervene in the core pathological mechanism of the radioactive liver injury, that is, the pilose antler polysaccharide can inhibit progressive liver fibrosis by down-regulating the expression of a TGF-beta signal path and regulate the expression balance of BAX / Bcl-2 genes to block liver cell apoptosis mediated by a mitochondrion path, thereby effectively relieving liver injury caused by ionizing radiation, and the pilose antler polysaccharide has no toxic side effects and has a wide application prospect.

The present application relates to a kind of fusion protein comprising selenomethionine and its application in the treatment of acute pancreatitis, belong to the field of biological medicine.The fusion protein is prepared by in vivo biological chelation method from TAT-14-PTD-p65 fusion protein and organic selenium (selected from selenomethionine), the fusion protein is designed by "Nrf2 activation-NF-κB inhibition-selenium donor" trinity, comprising Nrf2 activation element (TAT-14 peptide), NF-κB inhibition element (PTD-p65-P1) and selenium donor element (selenomethionine), is connected by (Gly4Ser) 2 connecting peptide to avoid spatial interference.Experiments show that the fusion protein and its selenium chelate can inhibit the activation of pancreatic tissue NF-κB inflammatory pathway, up-regulate pancreatic Nrf2 / HO-1 antioxidant pathway, significantly reduce the serum lipase and amylase levels of C57 mice with acute pancreatitis, inhibit inflammatory response and oxidative stress, relieve pancreatic tissue damage, and selenium chelate is better.

The invention belongs to the technical field of medicines, and particularly discloses application of targeted mesenchymal stem cell NAT10 and RNA acetylation in inflammatory diseases. The invention reveals for the first time that NAT10 mediated ac4C modification is a key positive regulatory factor for regulating the immune function of mesenchymal stem cells (MSC), and an inflammatory environment can inhibit the pathway so as to cause weakening of the MSC function. Based on the discovery, NAT10 expression in the MSC is up-regulated through a genetic means, and the MSC with the enhanced function is prepared. The cell shows a higher ac4C acetylation level, and the expression of key immunosuppressive factors iNOS and COX2 and the secretion of products NO and PGE2 are remarkably improved, so that a stronger T cell inhibition capability is obtained. Animal experiments show that the MSC with the enhanced function shows a remarkably superior treatment effect compared with common MSC in disease models of inflammatory liver injury, periodontitis and the like.

The invention relates to the technical field of medicines, and discloses application of gastrodin in preparation of a medicine for preventing and treating radioactive liver injury, and the radioactive liver injury is liver injury caused by ionizing radiation exposure. The gastrodin is found to be capable of effectively intervening a specific mechanism of the radiation-induced liver injury, so that the death rate of mice with the radiation-induced liver injury is remarkably reduced, meanwhile, the core pathological characteristics of hepatic vein occlusion and hepatic fibrosis of the radiation-induced liver injury are reversed, and the radiation-induced liver injury is treated in a more targeted manner. On the other hand, gastrodin is used before radiation exposure, so that serious radioactive liver injury after radiation exposure can be prevented.

This invention discloses a pharmaceutical composition for alleviating sotorasidib-induced intestinal injury and its uses, belonging to the field of pharmaceutical technology. This invention proposes an intervention strategy to prevent and / or alleviate sotorasidib-induced intestinal injury by activating the cAMP signaling pathway. The cAMP signaling pathway activator can restore PKA activity and / or CREB phosphorylation levels, reduce sotorasidib-induced intestinal epithelial cell apoptosis, improve cell proliferation, and alleviate intestinal barrier damage. This invention also provides a combination of the cAMP signaling pathway activator and sotorasidib for the preparation of antitumor drugs. Cell model verification showed that the combined strategy did not significantly weaken the antitumor effect of sotorasidib, suggesting that this combined strategy has the potential for application as an adjuvant protective measure.

This application relates to a biocompatible repair gel ointment and its preparation method, belonging to the pharmaceutical field. The raw materials for preparation include the following components in weight percentage: 32-36% emollient occlusive agent, 7.8-9.4% emulsion stabilizing system, 18.7-25.5% polyol moisturizer, 0.59-0.8% skin repair active ingredient, 1-1.2% preservative synergist, 0.48-0.52% thickening rheology modifier, and water. The preparation method includes the following steps: mixing the emollient occlusive agent and the emulsion stabilizing system, heating and stirring to obtain an oil phase; mixing the polyol moisturizer, the preservative synergist, and water, heating and stirring to obtain an aqueous phase; adding the aqueous phase to the oil phase, homogenizing and emulsifying to obtain an emulsion system; adding the skin repair active ingredient and the thickening rheology modifier; stirring, cooling, and discharging to obtain the repair gel ointment. This application has the effects of improving transdermal water loss control, anti-inflammatory properties, and barrier repair performance.

The invention belongs to the field of biomedical materials and periodontal tissue engineering, and relates to an injectable anti-oxidation mechanical buffer porous hydrogel microsphere delivery odontogenic stem cell system as well as a preparation method and application of the injectable anti-oxidation mechanical buffer porous hydrogel microsphere delivery odontogenic stem cell system. The microsphere is constructed by adopting a dynamic bond-covalent bond dual-network structure, has injectability, stress relaxation and mechanical support properties, and introduces a polyphenol functional group to remove active oxygen and regulate and control an inflammatory microenvironment. The communicated porous microspheres with controllable particle sizes are obtained through emulsification balling and freezing pore-forming processes and are used for loading the odontogenic stem cells to form a regeneration delivery system. The system can improve the dryness and osteogenic differentiation capacity of the odontogenic stem cells, reduce oxidative stress and inflammatory response, promote alveolar bone defect repair and bone mass recovery under the conditions of inflammation and orthodontic pressure stress, and has good biocompatibility and application prospects.

The application discloses Luzhou-flavor liquor dreg water-soluble glucose oligosaccharide and a preparation method and application thereof, and belongs to the technical field of medicines.The application extracts water-soluble glucose oligosaccharide from Luzhou-flavor liquor dreg as raw material.The main chain of the Luzhou-flavor liquor dreg water-soluble glucose oligosaccharide is composed of glucose, and the side chain comprises arabinose and glucose; the Luzhou-flavor liquor dreg water-soluble glucose oligosaccharide is composed of arabinose, galactose, glucose and xylose, and the molar ratio is 8.81:2.54:76.82:6.90.The water-soluble glucose oligosaccharide prepared by the application can obviously improve the symptoms of alcoholic liver, and has the effects of inhibiting liver damage and improving the activity of liver antioxidant enzymes.In addition, the Luzhou-flavor dreg in the application is a by-product of liquor fermentation, has high raw material yield and low cost, and the application can improve the resource utilization value of the dreg.

The application discloses a kind of bionic automatic air-supplying anti-cavitation surfaces.The surface includes a substrate, an electrode sheet, and a layer of hydrophobic material disposed on the electrode sheet for anti-cavitation.The electrode sheet is connected to a direct current power source, and when the electrode sheet is in contact with liquid water, an electrolysis reaction occurs, generating gas.The hydrophobic material is gas-philic under water, and the gas generated by the electrode is maintained in the pores of the hydrophobic material without escaping.When surrounding cavitation bubbles collapse, the gas in the pores changes the direction of the jet, protecting important components from the impact of high-speed jets.When the gas in the pores is depleted, an electrolysis reaction replenishes the gas, and the electrolysis reaction automatically ends when the gas replenishment is complete.The application can avoid material suffering from cavitation, and automatically replenish gas through electrolysis, while avoiding energy waste from constant electrolysis in a calm state.It is an intelligent anti-cavitation structure surface.

The present application relates to the technical field of traditional Chinese medicine extraction, and discloses a water chestnut peel extract and application thereof in preparation of a medicine for treating chloasma; during preparation of the extract, low-temperature extraction is carried out by using an acid-alcohol mixed solvent, and enrichment is carried out by using macroporous resin purification, so that the water chestnut peel extract with high purity of active ingredients and complete retention can be prepared, the utilization rate of active ingredients in the water chestnut peel is effectively improved, and resource waste is reduced. The water chestnut peel extract provided by the present application can effectively inhibit tyrosinase activity, and shows excellent treatment potential for chloasma, a pigment deposition disease, thereby providing a solution to the current situation that chloasma is difficult to treat.

The invention discloses staphylococcus warneri CCSM003 separated from human skin and capable of repairing a skin barrier and a metagen of the staphylococcus warneri CCSM003, and belongs to the field of microbial technologies and medicines. The staphylococcus warneri CCSM003 provided by the invention can be fermented to generate the L-glycine-valine dipeptide, and the staphylococcus warneri CCSM003 has a good effect of repairing a barrier function in the aspect of external use and an application prospect, specifically, the activity of damaged HaCaT cells is improved in vitro; the gene level expression of FLG, IVL, AQP3, ZO-1, CLDN and Occludin can be improved at the same time in the aspect of improving functional protein and structural protein after damage. Therefore, the staphylococcus warneri has a huge application prospect in preparation of external cosmetics or medicines for repairing the skin barrier.

The invention discloses a medicine for treating hepatotoxicity of bosutinib by taking a CAMK2G gene or protein as a target spot, and belongs to the technical field of medicines. According to the medicine, the hepatotoxicity of bosutinib is relieved by down-regulating the expression of the CAMK2G gene or restoring the phosphorylation of the CAMK2G protein. The invention reveals that the CAMK2G gene is a key gene of liver injury and abnormal glucose metabolism caused by bosutinib, and provides a new prevention and treatment target for intervening hepatotoxicity caused by bosutinib. According to the invention, the CAMK2G phosphorylation activator is utilized to recover CAMK2G phosphorylation to relieve liver injury and abnormal glucose metabolism, a new direction is provided for finding an intervention strategy for causing hepatotoxicity by drugs, and the current situation that few intervention drugs can be used clinically and the mechanism is single is solved to a certain extent.

This invention relates to the use of peptides as therapeutic agents for degenerative brain diseases. Specifically, it confirms that the peptides of this invention, by targeting microglia, induce microglia in an inflammatory state to an anti-inflammatory state in a disease environment, thereby reducing neuroinflammation and enhancing phagocytic function to clear amyloid-β. Furthermore, in animal models of degenerative brain diseases, the effects of reducing amyloid-β, restoring synaptic plasticity, and improving cognitive impairments related to anxiety, learning, and memory have been confirmed. Therefore, the peptides of this invention can be effectively used as active ingredients in compositions for the prevention or treatment of degenerative brain diseases and the resulting cognitive, learning, or memory impairments.

The invention relates to the technical field of biology, and discloses an effect of Collagen in relieving vomitoxin injury bovine rumen epithelial cells by vitamin E. The Collagen is a COL1A1 protein, a COL2A1 protein and a COL5A1 protein. Research finds that in a DON damage model, the content of COL1A1 protein, the content of COL2A1 protein and the content of COL5A1 protein are obviously reduced, after vitamin E is added, the content of COL1A1 protein, the content of COL2A1 protein and the content of COL5A1 protein are increased again, meanwhile, damage of vomitoxin to bovine rumen epithelial cells is reduced, and it is prompted that the expression quantity of COL1A1 protein, the expression quantity of COL2A1 protein and the expression quantity of COL5A1 protein are related to vomitoxin damage; according to the present invention, the bovine rumen epithelial cells are subjected to the overexpression of the COL1A1 protein, the COL2A1 protein and the COL5A1 protein in the bovine rumen epithelial cells, such that the damage of the vomitoxin to the bovine rumen epithelial cells is reduced, such that the damage of the vomitoxin to the bovine rumen epithelial cells can be alleviated through the up-regulation of the expression of the COL1A1 protein, the COL2A1 protein and the COL5A1 protein so as to provide the new target spot for the preparation of the drug for alleviating the vomitoxin damage.