104results about How to "Damage relief" patented technology

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention provides a positive pole piece, a preparation method thereof and a battery, and aims to solve the technical problem of poor cycle performance of the battery caused by gas production of a lithium supplement agent. The positive pole piece comprises a current collector and a first active material layer arranged on the current collector, the first active material layer comprises a first positive active material, a lithium supplement agent and a first conductive agent, and the first conductive agent comprises porous carbon. The lithium supplement agent and the porous carbon are added into the first active material layer of the positive pole piece, and the porous carbon can promote the lithium supplement agent to be dispersed in the first active material layer and improve the porosity of the positive pole piece, so that a large number of lithium ions released by the lithium supplement agent can be conducted through pore channels in the porous carbon; moreover, gas generated by the lithium supplement agent can be led out and released through the pore channels in the porous carbon, so that the damage of the gas generated by the lithium supplement agent to the interface of the positive pole piece is relieved, the transmission efficiency of lithium ions in the positive pole piece is improved, and the cycle performance of the battery is improved.

The invention provides an application of an active peptide in preparation of a medicine for preventing and treating ALD (Atomic Lymphosis Disease). The amino acid sequence of the active peptide is shown as SEQ ID NO: 1, the active peptide can effectively relieve damage of ethyl alcohol to liver cells, increase of glutamic-pyruvic transaminase activity, lactic dehydrogenase activity and malondialdehyde content and decrease of glutathione content caused by ethyl alcohol can be remarkably inhibited, then the preventing and treating effect on ALD is achieved, and the active peptide is suitable for preparing drugs for preventing and treating ALD and has a good application prospect. Meanwhile, an active peptide resource library with ALD prevention and treatment effects is also enriched.

The invention discloses pediococcus pentosaceus CCFM1402 capable of effectively repairing a skin barrier and a self-fermentation metabolite of the pediococcus pentosaceus CCFM1402, and belongs to the technical field of microorganisms and medicines. The pediococcus pentosaceus CCFM1402 provided by the invention has the effect of improving the skin barrier function in both external use and oral administration; the cell activity of damaged HaCaT cells and the expression of the gene level of skin barrier function protein and tight junction protein can be improved by virtue of a thallus lysate and a fermented supernatant (metagen) of the external pediococcus pentosaceus CCFM1402; and the DNFB-induced mouse skin barrier injury can be relieved in the aspects of appearance, skin barrier protein expression and the like by orally taking viable bacteria and postbiotics of the pediococcus pentosaceus CCFM1402. Therefore, the pediococcus pentosaceus CCFM1402 has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The utility model belongs to the technical field of textile machinery, and particularly discloses a cashmere carding device which comprises a conveying table, a cotton feeding plate, a feeding roller and a driving unit, a machine body is arranged on one side of the conveying table, a wool feeding hopper and a conveying curtain are connected to the machine body, an outlet of the wool feeding hopper is located above the conveying curtain, and the conveying table is detachably connected with the cotton feeding plate. A feeding roller is arranged on the feeding plate, an opening cylinder is arranged on one side of the feeding plate, two ends of the feeding roller and two ends of the opening cylinder are connected with bearing seats, the feeding roller is connected onto the feeding plate through the bearing seats, the opening cylinder is connected onto the conveying table through the bearing seats, and the feeding roller and the opening cylinder rotate through a driving unit. Cashmere is fed from the wool feeding hopper and conveyed to the conveying curtain through the wool feeding hopper, the conveying curtain conveys the cashmere to the cotton feeding plate, fluff on the cotton feeding plate moves towards the feeding roller, the fluff is conveyed to the opening cylinder by the feeding roller to be opened and carded, the damage degree of cashmere fibers can be reduced through the cotton feeding plate, and then the opening quality in the cashmere production process is improved.

The invention belongs to the technical field of biology, and particularly relates to a genetically modified mesenchymal stem cell as well as a preparation method and application thereof. The invention relates to a gene modified mesenchymal stem cell, the gene modified mesenchymal stem cell is a mesenchymal stem cell of an over-expression SIRT6 gene, and the acquisition number of the SIRT6 on NCBI (National Center of Biotechnology Information) is NM001193285. The invention finds that SIRT6 is helpful for delaying the cell senescence process and obviously improving the anti-senescence capability of cells by regulating senescence-related genes and proteins.

The invention relates to the field of osteoarthritis drug treatment, in particular to application of RuO2 nano-enzyme in preparation of a drug for treating osteoarthritis, and particularly relates to knee osteoarthritis. The RuO2 nano-enzyme disclosed by the invention is prepared according to the following method: carrying out incubation deposition on Cu2O sphere nano-particles and RuCl3 to obtain Cu2O and RuO2, and etching Cu2O and RuO2 spheres to obtain the RuO2 nano-enzyme. The RuO2 nano-enzyme provided by the invention is a hollow RuO2 nano-enzyme sphere, and after the RuO2 nano-enzyme is horizontally used in an animal body for intervention, the hollow RuO2 nano-enzyme sphere can be used as a hollow RuO2 nano-enzyme sphere; the RuO2 nano-enzyme can effectively delay the development of knee osteoarthritis of a mouse knee osteoarthritis model caused by medial meniscus instability (DMM), improve the pain condition and movement function of a DMM modeling mouse, reduce the gonarthromeningitis degree and relieve knee joint cartilage degeneration and injury, and the effectiveness of the RuO2 nano-enzyme in delaying the knee osteoarthritis disease is further proved. The invention provides a novel method for treating knee osteoarthritis, and has strong practicability and application prospect.

The invention relates to the field of hair dyeing products, in particular to a low-irritation essential oil hair dye and a preparation method thereof. The invention relates to a low-irritation essential oil hair dye, which comprises a No.1 agent and a No.2 agent, the No.1 agent comprises a humectant, a hair coloring agent, an antioxidant, a chelating agent and a solvent A; a thickening agent A, an emulsifier A and a hair conditioner; a pH regulator A, and polydimethylsiloxane; the disinfectant is prepared from an aromatic A, polyquaternium-7, polyquaternium-10, argania spinosa kernel oil, a camellia extract, a ginger root extract and a preservative; the agent 2 comprises a solvent B, cetearyl trimethyl ammonium chloride, sodium stannate and a pH regulator B; a thickener B, an emulsifier B and mineral oil; a chelating agent C; and an oxidant. The hair dye provided by the invention can reduce irritation under the condition of ensuring the hair dyeing effect and relieve the frizz degree of dyed hair, and has a plurality of advantages.

The invention discloses a method for effectively relieving soybean antigen protein Glycinin in fish feed and application of the method. The invention discloses application of N-acetylcysteine as a functional feed additive capable of relieving carp enteritis induced by soybean antigen protein Glycinin. The feed disclosed by the invention comprises a soybean antigen protein Glycinin and N-acetylcysteine (NAC). According to the present invention, 1.5-6.0 g / kg of NAC is added to a feed containing 80 g / kg of Glycinin, such that the fish growth, the feed utilization rate, the digestion function, the protein metabolism function, the immune function, the oxidation resistance and the intestinal morphology can be significantly improved, and the soybean antigen protein Glycinin-induced growth inhibition and the intestinal injury can be effectively relieved; the functional fish feed additive provided by the invention is relatively low in cost and easy to popularize, and is beneficial to development of novel green antibiotic-replacing additives, improvement of the utilization rate of soybean protein sources, reduction of feed cost and promotion of healthy culture of fishes.

The invention relates to combined lactobacillus salivarius LS100 for inhibiting vaginitis pathogenic bacteria and preventing and treating vaginitis and application of the combined lactobacillus salivarius LS100. The combined lactobacillus salivarius LS100 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32135. The combined lactobacillus salivarius LS100 has good hydrogen peroxide production capacity and adhesion capacity, and can be used for preparing medicines for preventing and treating vaginitis. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent generation of drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection and / or preventing and treating vaginitis.

The invention relates to an application of chrysin in preparation of drugs for treating mammalian NFAT2 related diseases. It is confirmed for the first time that chrysin shows significant anti-inflammatory activity in a KD mouse model and a cell injury model. This effect may be achieved by modulating NFAT2. The discovery has important significance for understanding and potentially treating the vascular endothelial injury of the Kawasaki disease, and a new insight is provided for treating the Kawasaki disease by using traditional Chinese medicines.

The invention relates to the technical field of laser, in particular to a macro-energy optical fiber coupling laser for shock peening, which comprises a Cassegrain unstable resonant cavity and a Cassegrain unstable resonant cavity endoscope, the Cassegrain unstable resonant cavity endoscope comprises a plano-convex total reflection mirror and a Gaussian output mirror, and the plano-convex total reflection mirror is connected with the Gaussian output mirror. A laser pulse modulation assembly, a first laser gain assembly and a polarization assembly are arranged between the plano-convex total reflection mirror and the Gaussian output mirror; the frequency doubling assembly comprises a beam shrinking system and a frequency doubling crystal, and a second laser gain assembly is arranged between the frequency doubling assembly and the Cassegrain unstable resonant cavity; the optical fiber coupling assembly with the homogenizer comprises an attenuator and a beam expanding system, a honeycomb mirror is arranged behind the beam expanding system, and a focus lens is further arranged behind the honeycomb mirror; and the optical fiber is arranged behind the focus lens. The problem that high-strength laser pulses damage the inlet surface of the optical fiber and the interior of a core material can be solved.

The invention discloses lactobacillus reuteri CCFM1403 with a skin repairing effect and a metagen of the lactobacillus reuteri CCFM1403, and belongs to the technical field of microorganisms and medicines. The lactobacillus reuteri CCFM1403 provided by the invention has the effect of improving the barrier function of the skin in two aspects of external use and oral administration, and is specifically shown in that when the thallus lysate of the lactobacillus reuteri CCFM1403 is externally used, the cell viability and the related barrier function of keratinocytes after injury and the expression of a structural protein gene level can be improved; and the DNFB-induced mouse skin barrier injury can be relieved in the aspects of TEWL in apparent aspect, water content of cuticle, skin barrier protein expression and the like by orally taking viable bacteria and postbiotics of the lactobacillus reuteri CCFM1403. Therefore, the lactobacillus reuteri has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention discloses a metagen which is prepared from bifidobacterium adolescentis CCFM1404 and has the effect of improving skin health, and belongs to the technical field of microorganisms and medicines. The metagen (especially the thallus lysate) of the bifidobacterium adolescentis CCFM1404, provided by the invention, has a good skin barrier repairing effect, which is specifically shown in that the cell viability of keratinocytes after injury and the expression of FLG, IVL and LOR gene levels can be improved by externally applying the thallus lysate of the bifidobacterium adolescentis CCFM1404; the DNFB-induced mouse skin barrier injury can be relieved in the aspects of apparent TEWL and epidermis thickness, up-regulation of epidermis and basal layer protein and the like by oral administration of metabiotics (including thallus lysate and fermentation supernatant) of bifidobacterium adolescentis. Therefore, the bifidobacterium adolescentis has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention belongs to the technical field of application of traditional Chinese medicines, and specifically relates to an application of an Amomum villosum extract in preparing a UA-lowering and anti-gouty arthritis drug. The Amomum villosum extract is extracted to obtain the Amomum villosum extract. A hyperuricemia mouse model and a gouty arthritis mouse model are established, and the results show that the Amomum villosum ethanol extract reduces the UA level by synergistically reducing excessive UA generation and promoting UA excretion, and comprehensively exerts an anti-gout effect by inhibiting the release of inflammatory factors such as IL-6, TNF-α and IL-1β, and has the characteristics of better drug efficacy and better drug safety. Therefore, the Amomum villosum ethanol extract can be applied to drugs and health foods for gout patients, and has better development and utilization value as well as huge social and economic benefits.

This invention discloses a landing buffer device for unmanned aerial vehicles (UAVs), relating to the field of aviation equipment technology. By integrating the roller body and the sliding plate as two grounding structures onto the landing gear, the device can quickly switch operating modes according to ground conditions through the linkage of the piston cylinder and piston rod. On flat ground, the roller is used first to reduce gliding resistance, while on muddy or slippery ground, the sliding plate is used for grounding, effectively preventing roller jamming and enhancing all-terrain adaptability and landing safety. Simultaneously, the mechanical buffer composed of a second and third spring, combined with the hydraulic damping buffer composed of buffer components, forms a highly efficient double-layer energy-absorbing buffer structure, which to a certain extent alleviates the damage to the aircraft and equipment caused by landing impact, thus improving the landing safety of the UAV.

The invention belongs to the field of biological medicine, and discloses a chicoric acid (CA)-loaded tetrahedral framework nucleic acid (tFNA) nano preparation for treating acute gouty arthritis. According to the preparation, tFNA formed by self-assembly is taken as a carrier, and a natural active ingredient CA is loaded to form a CA-tFNA compound. The compound overcomes the defects that CA is poor in water solubility and low in bioavailability, and existing drugs are weak in targeting and large in side effect. Through the targeted delivery and synergistic effect of tFNA, the preparation can be effectively enriched in inflammatory joints, significantly inhibit NF-kappa B signal pathways, and down-regulate the expression of key proinflammatory factors such as TNF-alpha and IL-1beta, so that joint swelling and synovial tissue damage are relieved, and repair is promoted. Experiments show that the traditional Chinese medicine composition is remarkable in curative effect and good in safety, and a novel efficient treatment strategy is provided for acute gouty arthritis.

The invention provides a preparation method of a mesenchymal stem cell exosome incubated by a GLP-1 medicine. The preparation method comprises the following steps: S1, preparing materials; s2, separating the human adipose tissue-derived stromal cells; s3, cell surface marker protein detection; s4, carrying out GLP-1 incubation; and S5, extracting the exosome. According to the preparation method of the mesenchymal stem cell exosome incubated with the GLP-1 medicine, the human adipose tissue-derived stromal cell exosome is collected in a specific mode, the whole process is simple and convenient, the obtained human adipose tissue-derived stromal cell exosome is stable in effect, damage of myocardial cells after myocardial infarction can be effectively relieved, the heart function can be enhanced, and the human adipose tissue-derived stromal cell exosome can be used for treating myocardial infarction. The compensatory cardiac machine load is reduced, and the heart failure is relieved.

The invention discloses a Dai medicine composition as well as a preparation method and application thereof, and belongs to the technical field of medicines. The Dai medicine composition comprises the following raw materials in parts by weight: 10-20 parts of a turmeric extract and 10-20 parts of amomum tsao-ko essential oil, the turmeric extract is an alcohol extract of turmeric, and the content of sweet myrrh curcumol in the turmeric extract is 5-10 wt.%. The invention discloses application of the Dai medicine composition in preparation of a medicine for preventing or / and treating acute myocardial infarction. The acute myocardial infarction comprises acute myocardial infarction under the condition of non-alcoholic fatty liver. Based on the Yaojiao theory of Dai medicine, the turmeric extract and the amomum tsao-ko essential oil are creatively matched, and the turmeric extract and the amomum tsao-ko essential oil are combined to supplement soil to achieve the effects of leveling four towers, clearing away fire and toxic materials and promoting blood circulation and ventilating. Tests show that the composition disclosed by the invention can relieve liver injury caused by non-alcoholic fatty liver disease, effectively inhibit left ventricular remodeling, improve cardiac functions and reduce acute myocardial infarction of mice under the condition of NAFLD (non-alcoholic fatty liver disease).

The invention provides a preparation method and application of amino acid derived carbon dot nano-enzyme, and belongs to the technical field of new biomedical materials. The amino acid comprises one of histidine, proline, cysteine, tryptophan, aspartic acid, arginine, lysine, methionine and phenylalanine; the mass ratio of the amino acid to the citric acid monohydrate is (1: 1)-(1: 5). The amino acid derived carbon dots provided by the invention have free radical scavenging activity and superoxide dismutase-like properties, and show low toxicity and good biological safety at the levels of cells, nematodes and animals. Meanwhile, the amino acid derived carbon dot nano-enzyme also shows excellent anti-inflammatory activity, can down-regulate the inflammatory level of cells, reduce the damage of oxidative stress to nematodes, improve the intestinal flora structure, increase the richness and diversity of intestinal flora, relieve and treat DSS-induced mouse ulcerative colitis, and has a good application prospect. The compound can be further applied to preparation of drugs for treating inflammatory bowel diseases.

The invention discloses staphylococcus warneri CCSM005 separated from human skin and capable of improving skin health and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The staphylococcus warneri CCSM005 provided by the invention can be fermented to produce the L-glycine-valine dipeptide, and a fermentation supernatant of the staphylococcus warneri CCSM005 has a good effect of repairing a skin barrier function, which is specifically shown in that the activity of damaged HaCaT cells is improved in vitro, and the gene level expression of FLG, ZO-1, CLDN and Occludin can be improved at the same time after the damage. Therefore, the staphylococcus warneri CCSM005 has a huge application prospect in preparation of external daily chemical products or medicines for repairing the skin barrier.

The utility model discloses municipal road and bridge pavement rapid repairing equipment which comprises a bottom plate and a road pressing roller, a base is installed in the center of the top of the bottom plate, a driving motor is fixedly installed on one side of the base in a penetrating mode, a plurality of heating plates are installed in the pressure roller, and buffering devices are arranged on the surfaces and the two ends of the heating plates. According to the device, the driving motor is arranged to drive the swing device to rotate, the swing device drives the connecting plate to rotate, and the connecting plate drives the hydraulic cylinder in the U-shaped seat to generate angular deviation, so that the pressure roller is driven to be in contact with the ground, and the inflatable sealing skirt edge can be inflated through the inflation hole in the pavement repairing process; and the hydraulic cylinder and the repairing assembly can be quickly disassembled and maintained by arranging the quick disassembling mechanism, it can be guaranteed that damage to internal parts caused by road bumping can be effectively relieved through the buffering device when the heating plate conducts heating, and the service life is prolonged.

The invention provides a lactobacillus plantarum YDJ-03 and an application of the lactobacillus plantarum YDJ-03. According to the invention, the plant lactobacillus YDJ-03 is found for the first time, and the plant lactobacillus YDJ-03 can effectively reduce the malondialdehyde level of the body liver, improve the SOD (superoxide dismutase) activity of the body liver, reduce lipid peroxidation of the body, reduce the serum uric acid level of the body, reduce the serum creatinine level of the body and relieve kidney injury; the compound can be used for preparing food or medicines for preventing and treating kidney injury, protecting liver, regulating fat, protecting intestinal tracts, resisting oxidation and resisting inflammation, and has a relatively great application prospect.

The invention relates to the field of wind power blade front edge protection, in particular to a polyurethane / foamed nickel composite material for a wind power blade front edge and a preparation method of the polyurethane / foamed nickel composite material. The composite material comprises a component A, a component B and a foamed nickel metal framework, the component A comprises the following components in parts by weight: polyether polyol, pigment filler, an organic solvent, an ultraviolet light absorber, a wetting dispersant, a defoaming agent, a flatting agent and an anti-settling aid; the component B is diisocyanate; the foamed nickel metal framework, the component A and the polyurethane coating prepared from the component B form a bicontinuous phase structure. The'shadow protection effect 'and'carpet protection effect' of the foamed nickel metal framework in the polyurethane / foamed nickel composite material are utilized, and the prepared polyurethane / foamed nickel composite material can effectively change the flowing direction of liquid drops, relieve concentrated stress, delay propagation of cracks on the surface and inside of a polyurethane coating, prevent the coating from falling off and the like. And the rain erosion resistance of the polyurethane coating is greatly improved.

The invention relates to an extraction method of Cinnamomum camphora polysaccharide, which comprises the following steps: crushing Cinnamomum camphora fruits, heating and extracting with water at 65-90 DEG C, concentrating a water extracting solution under reduced pressure, carrying out alcohol precipitation on a concentrated solution, deproteinizing, carrying out alcohol precipitation again, and freeze-drying to obtain the Cinnamomum camphora polysaccharide A; or crushing Cinnamomum camphora fruits, respectively extracting the crushed Cinnamomum camphora fruits with petroleum ether and ethyl acetate at room temperature, carrying out solid-liquid separation, carrying out heating extraction on residues with water at 65-90 DEG C, carrying out vacuum concentration on a water extract, carrying out alcohol precipitation on a concentrated solution, deproteinizing, carrying out alcohol precipitation again, and freeze-drying to obtain Cinnamomum camphora polysaccharide B; the Cinnamomum camphora polysaccharide A and / or the Cinnamomum camphora polysaccharide B are / is the Cinnamomum camphora polysaccharide. The invention also discovers a new application of the camellia oleifera tree polysaccharide, and the extracted camellia oleifera tree polysaccharide has a remarkable treatment effect and no toxic or side effect, and can be used for development and utilization of anti-oxidative stress drugs, especially liver protection drugs.

The invention relates to a graphene heating pad and a preparation method and application thereof, and belongs to the technical field of graphene automobile heating seat pads. The graphene heating pad comprises a graphene heating film layer, the graphene heating film layer comprises a graphene heating body with two free ends, a plurality of ventilation holes are formed in the periphery of the graphene heating body, the graphene heating body is arranged in a snake shape to form a snake-shaped heating wire, and the snake-shaped heating wire is arranged to avoid the ventilation holes. Porous rivets are arranged at the two free ends of the graphene heating body, the wiring harness is electrically connected with the graphene heating body, and the wiring harness is led out through the porous rivets and is communicated with a power supply. The heating area of the graphene heating body is large and uniform, the graphene heating body is coated with the upper protective film layer and the lower protective film layer, dust prevention, water prevention, friction prevention, external force prevention and the like can be achieved, and the service life is prolonged.

The application belongs to the technical field of biological medicine, and particularly relates to application of calcium chelator BAPTA and a pharmaceutical composition. The calcium chelator BAPTA delays aging of lung fibroblasts and lung tissues by eliminating calcium accumulation in lung fibroblasts, reducing accumulation of reactive oxygen species ROS (ROS) in lung fibroblasts, DNA damage, and release of inflammatory factors. The calcium chelator BAPTA ultimately realizes the function of treating pulmonary fibrosis by inhibiting weight loss, lung tissue inflammatory cell infiltration, lung collagen deposition, and expression of fibrosis markers. The application provides a new drug source for delaying aging of lung fibroblasts and lung tissues and studying occurrence and development of pulmonary fibrosis. The drug is safe and reliable, has strong pharmacological action, small side effects, and definite curative effect.

The invention provides an extract with high saikoside B2 content, a preparation method and application of the extract, and a combined medicine containing the extract, and belongs to the technical field of natural medicine preparation. The method comprises the following steps: efficiently extracting saikoside A and saikoside D in a radix bupleuri raw material by using an alkaline ethanol solution, further realizing efficient resolution of saikoside A and saikoside D by using macroporous adsorption resin, and quantitatively converting saikoside D into saikoside B2 by using a chemical method, thereby obtaining the high-content effective part of saikoside B2. The high-content effective part of saikoside B2 only contains a small amount of saikoside A except the main component saikoside B2, so that the toxicity is greatly reduced while the biological activity of the saikoside B2 is ensured. The high-content effective part of saikosaponin B2 can be used for preparing medicines for treating and preventing gout, rheumatoid arthritis, acute enteritis, skin light injury, skin inflammation and other diseases, can be independently used, and can also be combined with other medicines for use.

The invention discloses a fermented lactobacillus and its application. The fermented lactobacillus of the invention is classified and named as fermented mucus lactobacillus Limosilactobacillus fermentum , strain number FL16, and the deposit number is CGMCC No. 27414. The fermented Lactobacillus can be used to prepare probiotic preparations for preventing or treating porcine intestinal diseases, and can also be used to construct an in vitro probiotic-polarity-reversed porcine intestinal organoid co-culture model, which can be used to explore the interaction between bacteria and intestinal epithelium.

The invention belongs to the technical field of medicines, and particularly relates to saccharum alhagi acidic polysaccharide as well as an extraction and separation method and application thereof. The method for separating the polysaccharide in the saccharum alhagi comprises the following steps: degreasing the saccharum alhagi, removing impurities, then carrying out water extraction and alcohol precipitation to obtain crude saccharum alhagi polysaccharide, deproteinizing and decoloring the crude saccharum alhagi polysaccharide, and separating the decolored crude polysaccharide by a dialysis method to obtain high-molecular-weight polysaccharide and low-molecular-weight oligosaccharide, performing activity screening on the high-molecular-weight polysaccharide and the low-molecular-weight oligosaccharide through a mouse suffering from ulcerative colitis; or carrying out DEAE cellulose column chromatography separation on the decolored crude polysaccharide to obtain various gradient polysaccharides, and respectively carrying out sephadex column chromatography to obtain the homogeneous acidic polysaccharide. The obtained acidic polysaccharide is subjected to activity verification through an adult zebra fish model and a young zebra fish model suffering from ulcerative colitis, and results prove that the obtained acidic polysaccharide has the effects of relieving zebra fish intestinal injury, recovering mucus secretion, inflammatory cell aggregation and other symptoms.