35 results about "Psoriasis treatment" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to application of an inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein. The application provides application of the inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein in preparation of a medicine for preventing and / or treating psoriasis, and an amino acid sequence of the HSP60 protein (heat shock protein 60) is shown as SEQ ID NO. 1. The application provides a brand-new, mechanism-driven psoriasis treatment target, lactic acid modification of lysine at the 249th position of HSP60 protein. By inhibiting the specific modification, the purpose of precise intervention and treatment from an upstream of the disease is achieved by stabilizing mitochondrial function and blocking intrinsic immune activation triggered by metabolic stress.

The invention belongs to the technical field of polypeptide drugs, and particularly relates to a small molecule polypeptide and application thereof in psoriasis treatment. Specifically, the invention successfully designs and synthesizes a small molecule polypeptide OGP6 with the effect of intervening psoriasis. Experiments prove that the compound can effectively inhibit a cGAS-STING signal channel in a targeted manner, intervene psoriasis inflammation starting from the source, avoid the problems of anti-drug antibody generation, curative effect failure and the like caused by long-term antagonism of an existing biological agent to a single cell factor, is better in curative effect durability, and also has the characteristics of small molecular weight, simple synthesis process, low cost, low cost and the like. Therefore, the method has a good practical application value.

The present application belongs to the technical field of polypeptide drugs, and particularly relates to a kind of small molecule polypeptide and its application in psoriasis treatment.The present application successfully designs and synthesizes a kind of small molecule polypeptide OGP6 with the effect of intervening psoriasis.By test verification, it can effectively target inhibition cGAS-STING signal pathway, intervene psoriasis inflammation start from source, avoid the existing biological preparation long-term antagonism single cytokine to cause the problem such as drug resistance antibody production, curative effect invalidation, and its still has the advantages such as small molecular weight, simple synthesis process, low cost, easy to scale production, therefore has good practical application value.

The invention belongs to the technical field of biology, and relates to application of isovaleric acid in treatment of psoriasis. In order to solve the problems that existing psoriasis treatment drugs (such as biological agents) have side effects, the curative effect is reduced, and relapse occurs after drug withdrawal, the invention provides a psoriasis treatment scheme taking isovaleric acid as an active component, and the imiquimod-induced psoriasis-like skin lesion can be remarkably relieved by locally smearing the isovaleric acid with the concentration of 2mM; the epidermis excessive proliferation and the expression of inflammatory factors such as IL-17A, IL-17F and CXCL1 are reduced. The isovaleric acid disclosed by the invention is a small molecule compound, is simple to prepare, convenient to administrate and high in safety, fills the application blank of the isovaleric acid in the field of psoriasis treatment, and provides a new effective way for psoriasis treatment.

The invention belongs to the technical field of biological computer analysis, and discloses an analysis method based on network pharmacology and a molecular docking technology. The psoriasis treatment of fucoidin is analyzed on the basis of network pharmacology and a molecular docking technology, five core targets, 30 GO annotations and 66 KEGG pathways are screened through the network pharmacology and the molecular docking technology, and the affinity of active ingredients and the core targets is good.

The invention discloses a layered microneedle patch as well as a preparation method and application thereof, and belongs to the field of biological medicines. Wherein the needle body tip is composed of a therapeutic agent and L-arginine shell modified glycan gel, has excellent biocompatibility and free DNA removal ability, and can deliver deferoxamine and synergistically regulate and control inflammation signals; the upper part of the needle body and the substrate are made of low-molecular-weight hyaluronic acid which is quickly dissolved after being in contact with skin, so that the needle tip is quickly separated from the substrate, the needle tip is retained at a diseased region, and effective deposition of a medicine at the diseased region is ensured; the layered microneedle can slowly release deferoxamine through pH response so as to inhibit ferroptosis; the modified chitosan can efficiently remove free DNA so as to reduce immune inflammation and cooperatively block immune inflammation circulation. The preparation process of the layered microneedle is controllable, the material biocompatibility is excellent, and the layered microneedle has the advantages of efficient targeted delivery, long-acting release and synergistic treatment, so that a feasible strategy is provided for psoriasis treatment.

The present invention discloses a selenium-containing soluble composite microneedle and its preparation method and application, belonging to the technical fields of biomaterials and biomedicine. The microneedle forming matrix is selenium hyaluronate, loaded with drug-loaded tetrahedral framework nucleic acid, and the base part is polyvinyl alcohol. The preparation method includes: Step 1, preparation of selenium hyaluronate; Step 2, preparation and drug loading of tetrahedral framework nucleic acid; Step 3, preparation of selenium-containing and drug-loaded microneedle patches. The present invention synthesizes selenium hyaluronate by a specific chemical method, uses selenium hyaluronate as the base, loads drug-loaded tetrahedral framework nucleic acid, and utilizes the advantages of high permeability, good biocompatibility, and editability of tetrahedral framework nucleic acid to improve the sustained and controlled release ability of microneedles, realize the efficient transdermal delivery of drugs, and reduce the pain and discomfort that may be brought by traditional drug delivery methods. It provides a new and effective drug delivery system in the field of psoriasis treatment.

The invention relates to the technical field of biological medicine, and discloses a keratin related gene and application thereof in regulation and improvement of psoriasis, and the keratin related gene comprises KRT25, KRT28, KRT85 and KRTAP11-1. The invention also discloses application of the endocrine related gene in regulation and improvement of psoriasis, and the endocrine related gene is a CGA gene. By maintaining the expression level of the KRT25 gene, the KRT28 gene, the KRT85 gene, the KRTAP11-1 gene and / or the CGA gene, the psoriasis is relieved. The invention focuses on a dark green module, through GO / KEGG enrichment analysis, protein interaction network (PPI) construction and experimental verification, the molecular mechanism of OMT is further discussed, a network which takes keratin as a center and is related to endocrine (CGA gene) is clear as an effective node for psoriasis treatment, and a foundation is laid for discovery of a new target for psoriasis treatment.

The invention discloses an application of a novel peptide UPCP in preparation of a medicine for treating and / or preventing psoriasis. Belongs to the technical field of biological medicine. The application discloses the treatment effect of the novel peptide UPCP on psoriasis for the first time, and researches find that the novel peptide UPCP can effectively relieve symptoms of a psoriasis model induced by LSP, TNF alpha and M2 in an in-vitro cell experiment, significantly down-regulate the expression level of psoriasis cell markers, significantly reduce the transcriptional level of psoriasis-related inflammatory factors, and improve the psoriasis treatment effect. The condition of excessive proliferation of HaCaT cells is effectively reduced. In in-vivo experiments, psoriasis symptoms such as skin desquamation, hyperplasia, erythema, thickening and splenomegaly of an imiquimod-induced psoriasis mouse model can be effectively relieved, the effect of treating psoriasis is achieved, and a new theoretical basis and intervention means are provided for clinical treatment of psoriasis.

The invention discloses a psoriasis biological targeting antibody treatment response prediction device based on machine learning, and the psoriasis treatment response prediction device takes the expression level and clinical data of the differential expression gene of a psoriasis patient as the input, and further realizes the accurate prediction of the drug treatment response result of the psoriasis patient. When the psoriasis treatment response prediction device is used for drug treatment response prediction, the average ROC-AUC value is larger than 0.9, and it is indicated that the psoriasis treatment response prediction device can achieve accurate drug treatment response.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a local external cream composition for treating psoriasis. The topical external cream composition for treating psoriasis is prepared from deaminated tyrosine, azone and a matrix, wherein the matrix is prepared from liquid paraffin, sorbitol, an emulsifying agent, tween-80, white vaseline, beewax, glycerin monostearate, solid paraffin and the like according to a specific weight percentage. By optimizing a prescription and a process, the cream composition which is good in stability, high in transdermal absorption efficiency and capable of effectively delivering DAT to a skin focus is prepared, psoriasis-like skin lesion is effectively improved, inflammation and epidermal hyperplasia are relieved, and the cream composition is good in safety. A brand-new, effective and safe external medicine selection and application are provided for the field of psoriasis treatment by taking the deaminated tyrosine as an active component.

The invention discloses a personalized dosage adjusting device and method for psoriasis treatment medicine, and relates to the technical field of psoriasis treatment.The personalized dosage adjusting device comprises a monitoring mechanism, the monitoring mechanism comprises a shell, and a detection mechanism is arranged above the shell; the detection mechanism comprises a data collection unit, the data collection unit is arranged in the shell, and the data collection unit is used for collecting skin state image data of a psoriasis patient. The drug dosage most suitable for a patient can be calculated according to the influence of the drug on the physical condition of the patient after medication and the skin treatment effect in cooperation with the oral description of the patient and a biomarker detection result, the accuracy of the drug dosage of the psoriasis treatment drug is improved, personalized dosage adjustment is conveniently carried out according to the conditions of different patients after medication, and the curative effect of the psoriasis treatment drug is improved. The side effects caused by excessive medication are greatly reduced while the treatment effect and the treatment compliance of a patient are ensured.

The invention discloses a composite hydrogel with a redox bidirectional regulation function and a preparation method and application thereof, and belongs to the field of biomedical materials.According to the composite hydrogel, polyvinyl alcohol and carboxymethyl chitosan serve as gel matrixes, crosslinking of the two matrixes is achieved through genipin by means of the action of hydrogen bonds and amido bonds, and the composite hydrogel with the redox bidirectional regulation function is obtained. The hydrogel network is loaded with chlorella capable of removing active oxygen components and Ag (at) ZnO capable of generating the active oxygen components. According to the hydrogel, the ROS level can be indirectly regulated and controlled by regulating and controlling the illumination condition, so that potential balance between oxidative stress resistance and ROS accumulation is realized. The hydrogel is locally fed to an imiquimod-induced psoriasis mouse model, a good anti-psoriasis treatment effect is obtained, and it is proved that the hydrogel can effectively resist local skin lesion of psoriasis in a multifunctional, non-irritant and non-invasive mode.

The present invention discloses the use of Lactobacillus casei Zhang in preparing a preparation for treating skin diseases, relating to the technical field of microbial probiotic preparations. The present invention provides the use of Lactobacillus casei Zhang in preparing a preparation for treating or alleviating psoriasis. The Lactobacillus casei Zhang has a deposit number of CGMCC No. 5469. The Lactobacillus casei Zhang of the present invention has an alleviating effect on the symptoms of psoriasis, can inhibit the weight loss trend of psoriasis patients, and reduce the spleen index. It can be used to prepare a preparation for alleviating psoriasis. It can also be used as a microecological preparation in medicines, fermented foods, or health products, providing a potential option for developing new psoriasis treatment methods.

The invention relates to chlorogenic acid nanogold and a preparation method and application of a gel preparation of the chlorogenic acid nanogold, and belongs to the technical field of biological medicine. A biosynthesis method is adopted, chlorogenic acid is used as a reducing agent and a stabilizing agent at the same time, and the chlorogenic acid functionalized gold nanoparticles are synthesized in one step. Furthermore, the prepared chlorogenic acid nanogold is combined with an aqueous gel matrix for the first time, and the temperature-sensitive chlorogenic acid nanogold hydrogel suitable for skin administration is developed. The dosage form can remarkably prolong the retention time of the medicine on the skin surface and improve the transdermal absorption efficiency, so that the continuous release of the anti-inflammatory component is realized. The chlorogenic acid nanogold hydrogel provided by the invention shows higher safety based on the characteristics of natural components while ensuring the curative effect equivalent to that of betamethasone-calcipotriol, and has a remarkable clinical application prospect in the field of psoriasis treatment.

The invention belongs to the technical field of biological medicines, and relates to a dried orange peel polysaccharide, a preparation method thereof and an application of the dried orange peel polysaccharide in preparation of psoriasis treatment drugs, the monosaccharide in the dried orange peel polysaccharide comprises rhamnose, arabinose, galactose, glucose and galacturonic acid according to a molar percentage ratio of (5-6): (24-27): (10-15): (7-10): (45-50). Compared with the prior art, the pericarpium citri reticulatae polysaccharide prepared by the invention has the advantages of being good in safety, high in anti-inflammatory activity, capable of effectively improving the oxidative stress state of cells, remarkably reducing epidermis aggregates, relieving excessive proliferation of epidermis, effectively relieving desquamation and erythema symptoms of skin lesions of psoriasis and the like, and can be used for preparing psoriasis treatment medicines; the treatment scheme of psoriasis is expanded, and wide application prospects and important clinical significance are achieved.

The invention discloses a steam spray tail end device of a traditional Chinese medicine fumigation machine for psoriasis treatment, which comprises a fumigation treatment box body, a fumigation groove is formed in the upper end of the fumigation treatment box body, a cover plate is rotatably mounted on the left side of the upper end of the fumigation treatment box body, and a spray head communicated with the fumigation machine is rotatably mounted at the lower end of the cover plate; the first rod piece and the second rod piece are respectively arranged on the left side and the right side of the lower end of the cover plate through bearings; the waterproof soft cushion is mounted on the inner wall of the lower end of the fumigation tank; the two rotating rods are respectively mounted at the lower end and in the right side of the fumigation treatment box body; and the supporting rod is rotationally mounted at the upper end of the cover plate. According to the steam spraying tail end device of the traditional Chinese medicine fumigation machine for psoriasis treatment, through swinging of the spray head, the fumigation range is expanded, the balance of the fumigation temperature is guaranteed, uniform steam spraying treatment can be conducted on the whole body, meanwhile, massage operation can be conducted in the treatment period, and the discomfort caused by the fact that a patient keeps the same posture for a long time is reduced.

The invention belongs to the technical field of biology, and particularly relates to a psoriasis treatment preparation and method and application. The expression of SECTM1 in the skin of a psoriasis patient is increased, an SECTM1 antibody can inhibit immune cells and relieve inflammatory response, psoriasis mice treated by the SECTM1 antibody can cause expression reduction of inflammatory factors Il6, Tnfa, Il1b, Il22 and Il17a, psoriasis skin treated by the SECTM1 antibody can cause reduction of CD7 + cell infiltration quantity, and hacat cells knock down SECTM1 gene expression so as to inhibit proliferation of skin epithelial cells, so that the SECTM1 antibody can be used for treating psoriasis mice. Therefore, the SECTM1 antibody preparation can be used for treating psoriasis, and the recurrence rate is low.

A pharmaceutical composition for treatment of psoriasis is disclosed in the present invention. The pharmaceutical composition is a plant extract rich in bioactive constituents and applied topically for psoriasis treatment without any adverse effects. The present invention also provides a method for obtaining the extract and identifies various uses of the extract as a medicament in both human and veterinary therapy. Specifically, a 1.4% concentration of the bioactive extract has been shown to prevent the formation of psoriasis plaques when applied topically and 3.7% extract was found to clear psoriatic scales after 8 days of application topically Fig. 1A

The invention relates to the field of new application of compounds, in particular to application of 3-ylurea propionic acid and a pharmaceutical composition thereof in preparation of drugs for treating psoriasis. According to the invention, a BALB / c mouse psoriasis model is constructed through induction of imiquimod emulsifiable paste, and the therapeutic effect of a compound 3-ylurea propionic acid on the model is researched. Researches find that compared with a model group, apparent skin lesion and histopathologic lesion of back skin of a 3-ylurea propionic acid group are remarkably relieved; the spleen swelling and the spleen index are obviously reduced; and the levels of IL-6 and TNF-alpha in serum are reduced. Experimental exploration proves that the compound 3-ylurea propionic acid has an anti-inflammatory effect and has a treatment effect on a mouse psoriasis model. The invention not only provides a new application direction for 3-ylurea propionic acid, but also provides a new drug choice for psoriasis treatment.

The invention belongs to the technical field of biomedicine, and particularly relates to tacrolimus liposome subcutaneous in-situ gel as well as a preparation method and application thereof, glutathione modified low-acyl gellan gum is wrapped outside tacrolimus-loaded liposome, subcutaneous gelation can be realized after subcutaneous injection, and the tacrolimus liposome subcutaneous in-situ gel is prepared. According to the present invention, the drug sustained-release effect is good, the problem of frequent psoriasis administration is improved, the drug encapsulation stability is improved, and the good psoriasis treatment effect is provided.

The invention discloses a preparation method of a difunctional cationic mesoporous silica nano material loaded with drunkenness-quitting sulfur. The preparation method comprises the following steps: synthesizing SeSe-MSN; synthesis of the SeSe-MSNs modified by epoxy is carried out on the SeSe-MSNs; the preparation method comprises the following steps: synthesizing SeSe-MSN-Netil; and synthesizing the DSF (at) SeSeMSN-Netin. In the preparation method of the difunctional cationic mesoporous silica nano-material loaded with the drunkenness-quitting sulfur, different types of polycationic compounds are grafted on the surface of the mesoporous silica nano-material through an epoxy-opening reaction, and cations on the surface of the mesoporous silica material can be efficiently combined and remove free nucleic acid; activation of epidermis cells is inhibited, inflammatory response in psoriasis is reduced, and an efficient and safe anti-inflammatory effect is finally obtained; compared with a traditional psoriasis treatment medicine, the compound is used for anti-inflammatory treatment and is more efficient, safer and controllable, and a new thought and a new material are provided for efficient intervention of clinical psoriasis.

The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing erythema, scaling (desquamation), and thickening (infiltration) of the skin in an animal model of psoriasis. Based on these findings, pharmaceutical compositions for the prevention and / or treatment of psoriasis, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.

The present invention discloses the use of decorin or its encoding gene as a target in the preparation of a psoriasis treatment drug. Through a series of experiments, the present invention demonstrates that DCN can effectively protect against imiquimod-induced psoriatic skin inflammation in mice, improve skin scaling, erythema, thickening, and abnormal epidermal differentiation, enhance the skin's barrier function, reduce the infiltration of inflammatory cells, and exert a certain anti-inflammatory effect. The experimental studies of the present invention have confirmed that DCN has significant efficacy in psoriasis models, is safe, highly effective, and has no side effects, and has a simple production process, showing the potential for medical transformation. This will also help expand the potential application value of DCN in various other inflammatory skin diseases.

The invention discloses a preparation method of abelmoschus manihot composition external medicinal liquor for treating psoriasis, and relates to the technical field of traditional Chinese medicine external preparations. Comprising the following steps: (1) raw material compatibility and pretreatment: taking 10-30 parts by mass of abelmoschus manihot, 5-15 parts by mass of processed pinellia ternate, 5-15 parts by mass of processed paris polyphylla, 5-15 parts by mass of rheum officinale, 5-15 parts by mass of tobacco stems, 5-15 parts by mass of senecio scandens, 3-10 parts by mass of nidus vespae, 5-15 parts by mass of cortex dictamni, 5-15 parts by mass of szechwan chinaberry fruit, 5-15 parts by mass of cocklebur fruit, 5-15 parts by mass of cortex lycii radicis, 5-15 parts by mass of fructus kochiae and 5-15 parts by mass of coptis chinensis. The ministerial drug processed rhizoma paridis relieves swelling and pain, the adjuvant processed rhizoma pinelliae eliminates dampness and phlegm, and the conductant drug borneol is transdermal and guides channels; the eighteen medicinal materials have a synergistic effect and have a treatment effect on multiple links such as inflammation, hyperplasia, pruritus and infection of the psoriasis; extracting effective components with different polarities by stages by adopting a gradient soaking extraction process; the clarity and the stability of the medicinal liquor are ensured by a multi-stage precise filtering system; the low-temperature treatment protects the activity of volatile components.

The invention discloses a synthesis method of a psoriasis treatment drug apremilast, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethanone as an initial raw material, and carrying out reductive amination to obtain an intermediate 1; splitting the intermediate 1 by tartrate to obtain an intermediate 2; and finally, carrying out condensation reaction on the intermediate 2 and 3-acetamido phthalic anhydride to obtain apremilast. The invention develops a green and efficient synthesis process of apremilast, the preparation of a target product is realized through three-step reaction, the process breaks through the technical bottleneck that the traditional route depends on high-pressure hydrogenation conditions and noble metal catalysts (such as palladium on carbon), and the whole process adopts normal-pressure operation and mild temperature and avoids high-temperature reaction. The safety in industrial production is improved to a great extent, and the method is more suitable for industrial continuous production.

The invention belongs to the technical field of medicines, and particularly relates to a pomegranate peel ethanol extract for treating psoriasis as well as a preparation method and application of the pomegranate peel ethanol extract. The invention aims to discuss the treatment effect and mechanism of the pomegranate peel ethanol extract (PEE) on imiquimod (IMQ)-induced mouse psoriasis-like skin lesions. Through UPLC-MS / MS analysis, 2872 compounds, mainly including flavonoids, phenolic acids and triterpenoids, are identified in PEE (Polyether Emission). Animal pharmacodynamics shows that the IMQ-induced psoriasis-like symptoms of mice can be remarkably relieved by locally applying PEE. Histopathologic analysis shows that PEE improves skin structure abnormity induced by IMQ and inhibits proliferation of keratinocytes. The discovery has very important application value for developing functional products and medicines related to psoriasis treatment.

A method for extracting tung oil as a medicinal substance comprises the following steps: Step 1: Selecting mature tung seeds, removing the outer shell, leaving the oil-containing embryo, drying and pulverizing it into tung seed kernel powder; Step 2: Mixing and stirring the tung seed kernel powder with ethanol to obtain crude tung oil; Step 3: Allowing the crude tung oil to stand at low temperature to remove the aqueous phase, gum, and pigments, obtaining refined tung oil; Step 4: Detoxifying the refined tung oil using a mild saponification process; Step 5: Re-extracting the detoxified tung oil with ethyl acetate to obtain a tung oil extract enriched with active ingredients. This invention also proposes a psoriasis treatment drug based on natural tung oil extract, aiming to overcome the limitations of existing therapies in terms of cost, administration method, side effects, and insufficient coverage of complex pathological mechanisms. It achieves comprehensive treatment of psoriasis through multi-dimensional regulation of inflammation, cell proliferation, and metabolism using a tung oil extraction method and its application in treating psoriasis.

The invention belongs to the field of medicines, and discloses application of a carboplatin compound in preparation of medicines for preventing and treating psoriasis. According to the present invention, in the tumor treatment effect research of the carboplatin compound ZC2377, the psoriasis treatment activity of the carboplatin compound ZC2377 is accidentally found, such that the result is verified through the further experiment, and the practical application value of the carboplatin compound ZC2377 is provided.

The invention discloses a Daphne type diterpenoid compound or a pharmaceutical salt thereof. The structure of the Daphne type diterpenoid compound is shown in the specification. The monomeric compound WJ is extracted from the traditional Chinese medicine stellera chamaejasme by adopting a separation technology. The pharmacological action of the compound WJ and the relation between the compound WJ and the immune microenvironment are deeply explored, and it is found that the compound WJ can improve the immune microenvironment through a JAK2 / PI3K / AKT axis, so that the effect of treating psoriasis is achieved. The results provide a powerful scientific basis for the compound WJ as a potential psoriasis treatment drug, and also provide a new thought for further development of a novel treatment drug with an immunoregulation effect.