120 results about "Psoriasis treatment" patented technology

The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.

A composition comprising Gan Jiang, Dan Shen, Jiang Xiang, Huang Qi, Gui Zhi and Cang Zhu, is highly effective in treating psoriasis.

The invention relates to a formula for hair treatment and head psoriasis treatment, a reagent kit thereof and application. The formula comprises a component capable of being cross-linked with amino in keratin fibers, the component can be mixed with a hair dye or a blenching agent which can be commercially obtained, and the formula is used for enhancing hair quality, preventing alopecia and treating symptoms of psoriasis on the head.

The invention aims to provide an application of mesenchymal stem cells in the preparation of psoriasis treatment medicines. Skin-derived mesenchymal stem cells used in the invention have the advantages of easy obtaining, no immune repellency, high curative effect, difficult recurrence after disease heal, and small side effects.

The invention discloses a safe and effective medicine for psoriasis treatment, which is formed by the raw materials with the following weight account, garter snake 10 to 20 portions, catnip of 5 to 10 portions, windbreaking of 5 to 10 portions, cicada skin of 5 to 10 part, fructuskochiae of 5 to 10 portions, osthol of 5 to 10 portions, dittany skin of 5 to 10 portions, charles abraham of 5 to 10 portions, lightyellow sophora root of 5 to 10 portions, phellodendron of 5 to 10 portions, and astragalus of 7.5 to 15 portions. The preparation method of the invention is: grounding the raw materials into fine powder, mixing evenly, and putting into the capsule. Meanwhile, the traditional Chinese medicine has no obvious side effect.

The invention relates to the medicine technical field of psoriasis treatment, especially relates to the traditional Chinese medicine technical field of psoriasis treatment. The present invention adopts the following technical scheme that the Chinese medicine materials comprises the following raw materials by weight of indigowoad root, rhizoma paridis, buffalo horn powder, heydyotis, Poria cocos, cortex moutan, scorpion, muscardine silkworm, talcum powder, duckweed, broom cypress fruit, arctium fruit, radix paeoniae rubrathe, rehmanniae radix, Cortex dictamni, coix seed, phellodendron, Sophora flavescens and licorice. Compared with the prior art, the invention provides a traditional Chinese medicine for eliminating the diseases of the patient, and promoting physical and mental health, and has the advantages of low treatment cost, convenient medicine administration, fast curative effect and no side-effect.

The invention discloses an application of CD200 in psoriasis, and belongs to the field of biological medicines. The invention specifically relates to an application of CD200 protein or CD200 fusion protein in treatment of psoriasis. Through the research, when an effective amount of exogenous CD200 protein or CD200 fusion protein is given in vitro, NF-kappa B signal transduction can be inhibited, the activation of inflammatory macrophages is inhibited, the secretion of IL-1beta, IL-6 and TNF-alpha inflammatory factors and the excessive proliferation of keratinocytes can be reduced, so that theprotein can be applied to psoriasis treatment.

The invention provides a Chinese medicament for treating psoriasis, and belongs to the technical field of Chinese medicaments for treating psoriasis, and the Chinese medicament can treat the psoriasis in a severe phase and effectively reduce repeated attacks. The technical scheme adopted by the invention is as follows: the Chinese medicament for treating psoriasis is prepared from the following raw materials in parts by weight: 2 to 4 parts of fineleaf schizonepeta herb, 2 to 3 parts of divaricate saposhnikovia root, 2 to 3 parts of ephedra, 0.5 to 1 part of ginseng, 1 to 3 parts of cocklebur fruit, 1 to 2 parts of dried tangerine peel, 1 to 2 parts of hemlock parsley, 1 to 2 parts of poria, 0.5 to 1 part of angelica root, 1 to 3 parts of cassia twig, 1 to 3 parts of Chinese angelica, 1 to 2 parts of safflower, 0.5 to 1 part of Chinese rhubarb, and 1 to 3 parts of indigowoad root; and the raw materials are decocted or produced into capsules. The Chinese medicament is applied in the technical field of psoriasis treatment.

The invention discloses an application of zedoary turmeric oil in the preparation of psoriasis treatment medicines. Animal tests prove that the zedoary turmeric oil has a substantial curative effect on psoriasis, and can be used for preparing the psoriasis treatment medicines. The zedoary turmeric oil has no toxic side effects, has no obvious untoward effects even after long term administration, and has great clinic application values.

One embodiment of a pharmaceutical material for psoriasis treatment includes a liquid preparation by extracting herbs selected from the group consisting of Artemisia capillaris, Plumeria acutifolia, and Melaleuca alternifolia. Artemisia capillaris is about 5 to about 21 weight % of the liquid preparation, Plumeria acutifolia is about 65 to about 90 weight % of the liquid preparation, and Melaleuca alternifolia is about 4 to about 16 weight % of the liquid preparation respectively.

The invention provides a medicine used for treating psoriasis as well as an extraction method, extract and an application thereof. The medicine used for treating psoriasis is prepared from the following raw materials in parts by weight: 6-10 parts of bulgaria inquinans, 6-12 parts of Chinese angelica, 6-15 parts of cortex dictamni and 3-9 parts of liquorice. The medicine used for treating psoriasis has the effects of relieving itching, calming, activating blood, dissipating stasis, reducing blood viscosity, improving microcirculation, clearing heat, drying dampness, detoxifying and resisting to bacteria, has a certain photodynamic effect and can enhance the treatment effect, so that the medicine used for treating psoriasis has an especially obvious psoriasis treatment effect.

The present invention discloses a traditional Chinese drug mixture for treating psoriasis, and belongs to the technical field of drugs for treatment of the psoriasis. The traditional Chinese drug mixture of present invention adopts the following technical scheme that: the Chinese patent medicine for treating the psoriasis is characterized in that: the Chinese patent medicine is prepared by the following drugs, wherein the drugs comprise, by weight, lightyellow sophora root, dictamni cortex, rehmannia dride rhizome, coix seed, red peony root, indigowoad root, Chinese manyleaf paris rhizome, buffalo horn powder, spreading hedyotis herb, cortex moutan, tuckahoe, scorpion, stiff silkworm, redroot gromwell, honeysuckle, snake slough, coptis chinensis, fineleaf schizonepeta herb, gypsum, common anemarrhena, common motherwort fruit, largehead atractylodes rhizome, divaricate saposhnikovia and licorice root. Compared to the prior art, with the present invention, the traditional Chinese drug mixture with effects of elimination of diseases of patients, improvement of physical and mental health, low treatment cost, convenient taking by patients, rapid therapeutic effect, no side effect and treatment of the psoriasis is provided, and the substantive characteristics and the significant progress in the psoriasis treatment are provided.

The invention provides an application of a 3-[[2-[3-oxo-(1, 2-benzisoxazole-6-yl) methoxyl]-5-[(2-hydroxyl-4-cyclopentoxyl benzoyl)] phenyl] propionic acid (compound I) in preparation for treatment of connexin CX31 mediated skin disease. The connexin CX31 mediated skin disease comprises erythrokeratodermia variabilis or psoriasis. The pharmacological experiment proves that a low-dose group and a high-dose group of the compound I can remarkably reduce skin damage degree of a psoriasis animal sample; the content of TNF-alpha in murine serum can be restrained by the low-dose group of the compound I, then inflammatory cell infiltration is restrained, the inflammatory response is relieved, and the compound I has good psoriasis treatment effect and can be used for treating the connexin CX31 mediated skin disease.

The invention relates to the technical field of medicine, in particular to application of a PPARdelta (Peroxisome proliferator-activated receptor delta) selective antagonist in preparation of drugs for treating psoriasis. According to the invention, the PPARdelta selective antagonist is used for treating mice psoriasis-like inflammation caused by IMQ, and the result shows that the curative effect of GSK3787 is more significant. According to the invention, the application of the PPARdelta selective antagonist in the treatment of skin diseases is developed, meanwhile the mechanical application of the GSK3787 is extended to the skin field, and a new treatment measure is provided for clinical anti-psoriasis treatment.

The invention provides psoriasis treatment medicine and a preparation method and a detection method. The psoriasis treatment medicine is mainly composed of radix rehmanniae, saponin, oldenlandia diffusa, cortex dictamni, lithospermum, rhizoma smilacis glabrae, isatis root, paeonia suffruticosa, sophora flower, rhizoma anemarrhenae, red peony root, gypsum, bistort rhizome, burdock, cicada slough, indigo naturalis, honeysuckle, salviae miltiorrhizae, licorice and arisaema cum bile. The preparation method comprises the following steps: mixing radix rehmanniae, saponin, oldenlandia diffusa, cortex dictamni, lithospermum, rhizoma smilacis glabrae and isatis root, adding water for decocting twice, filtering to obtain filtrate, crushing the reset components to fine powder, sieving, uniformly mixing, and adding the mixed powder into the filtrate to process pills via water. Thin layer chromatography is used for detecting. The psoriasis treatment medicine provided by the invention abides by the principle of formulating prescription in traditional Chinese medicine of assistant and guide, the herbs are combined to ensure the functions of warm reinforcing liver and spleen, dispelling wind and eliminating dampness, regulating qi and blood, clearing and activating the channels and collaterals, promoting blood circulation to remove blood stasis, strengthening the body resistance to eliminate pathogenic factors, adjusting the immunity, and perfecting skin microcirculation, the psoriasis treatment medicine is used for preventing and treating psoriasis, is exact in curative effect and free of toxic side effects, and a variety of traditional Chinese medicine preparations are convenient to take.

The present invention relates to the technical field of psoriasis treatment, particularly to the technical field of a Chinese patent medicine for treating psoriasis. The present invention has the following technical scheme that the Chinese patent medicine comprises the following raw materials by weight part: cortex moutan, red sage root, rehmanniae radix, Poria cocos, fructus leonuri, fried herba schizonepetae, indigowoad root, honeysuckle flower, radix macrotomiae, densefruit pittany root-bark, curcuma rhizome, safflower, dark plum, calcined oyster, radix paeoniae rubrathe and licorice. Compared with the prior art, the invention provides a Chinese patent medicine for eliminating the diseases of the patient, and promoting physical and mental health, and has the advantages of low treatment cost, convenient medicine administration, fast curative effect and no side-effect.

A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of psoriasis.

The invention belongs to the field of biomedical polymer materials and discloses a microneedle patch capable of programmatically releasing a psoriasis treatment medicine and a preparation method of the microneedle patch. A microneedle on the microneedle patch comprises a biocompatible matrix capable of quickly dissolving and releasing the psoriasis treatment medicine, and polymer particles which are positioned on the surface and/or inside the biocompatible matrix and can slowly release the psoriasis treatment medicine, wherein a matrix material adopted by the biocompatible matrix is a lyotropeor a soluble substance, and the biocompatible matrix is internally provided with independently existing psoriasis medicine components so as to be rapidly dissolved and released; the polymer particlesare indissolvable polymer particles doped with psoriasis drug components, and the psoriasis drug components in the polymer particles can be slowly released under the action of insoluble polymers. According to the invention, the programmed release of the psoriasis treatment medicine can be effectively realized by improving the internal structure and composition of the microneedle in close accordance with the medication requirements of psoriasis treatment.

The invention discloses a method for enantioselective synthesis of tacalcitol and relates to the field of chemical synthesis of psoriasis treatment drug tacalcitol. The method has simple processes, purifying convenience and a high yield. The method comprises that in the presence of chiral oxazaborolidine and a borane complex system as catalysts, a prochiral ketone compound 1(S), 3(R)-bis(t-butyldimethylsilyloxy)-20(R)-(3'-isopropyl-3'-oxo)alkenyl-9, 10-semipregna-5, 7 (E), 10 (19)-triene is subjected to asymmetric catalytic reduction, the reduction product is subjected to photocatalysis double bond isomerization, a t-butyldimethylsilane-based protective group is removed and tacalcitol is obtained. The method is economic, can be operated simply, realize high optical purity and chemical purity and can be industrialized easily.

The invention relates to a preparation method of a semisolid preparation for psoriasis treatment; the preparation method comprises the specific steps of 1) adding a mixture of tacalcitol 1-5 ppm of total weight of the semisolid preparation and a therapeutically effective amount of corticosteroids into a matrix accounting for 2-40% of the prescription amount, and stirring and mixing; 2) stirring the remaining prescription amount of the matrix and other medicinal excipients under the protection of gas at the temperature of 60-90 DEG C and in a nitrogen-oxide molar ratio of not less than 3.7; 3) combining the mixtures of steps 1) and 2), and stirring and mixing under the protection of gas at the temperature of 60-90 DEG C and in a nitrogen-oxygen molar ratio of not less than 3.7 to obtain the semisolid preparation mixed well. The preparation method of the semisolid preparation for psoriasis treatment has the advantages that equipment requirements in the preparation process can be lowered, the complex preparation process is simplified, and the preparation time of the semisolid preparation is shortened at the premise of ensuring the distribution uniformity of active matters in the semisolid preparation.

The present invention discloses application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in the preparation of a psoriasis treatment drug. The 2-deoxy-D-glucose is an existing medicine, the toxicology and pharmacology of 2-deoxy-D-glucose are relatively clear, the research and development cost is low, the popularization and application value is large, and the 2-deoxy-D-glucose is suitable for the preparation of the externally applied agents and injection drugs for the treatment of psoriasis.

The invention provides a small RNA used for psoriasis treatment, and derivatives and medicinal preparations thereof. The small RNA inhibits the expression of psoriasis pathopoiesis related gene products comprising TNF alpha, IL-1a, IL6 and IL by inhibiting the expression of CREB1 and ATF1. The above small RNA medicines can substantially improve the psoriasis model mouse skin symptom formed after smearing mice with a 5% Imiquimod cream in an external use mode, can mitigate the cuticle thickening degree of pathologic skins, can improve the skin keratinization, can promote the hair growth of the pathologic skins, and has a certain treatment effect on the psoriasis.

The invention discloses a gingival mesenchymal stem cell exosome preparation and application thereof, and belongs to the technical field of biology. The invention discloses an application of an exosome derived from gingival mesenchymal stem cells in preparation of a medicine for treating treatment psoriasis. The gingival mesenchymal stem cell exosome preparation disclosed by the invention can be locally applied to a psoriasis diseased region and can relieve or inhibit inflammatory cell infiltration and inflammatory factor expression of the diseased region, so that the effects of treatment anddisease relief of diseases are achieved; the exosome preparation can also be used as a psoriasis drug additive or a combined drug preparation for psoriasis treatment.