20 results about "Psoriasis treatment" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to application of an inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein. The application provides application of the inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein in preparation of a medicine for preventing and / or treating psoriasis, and an amino acid sequence of the HSP60 protein (heat shock protein 60) is shown as SEQ ID NO. 1. The application provides a brand-new, mechanism-driven psoriasis treatment target, lactic acid modification of lysine at the 249th position of HSP60 protein. By inhibiting the specific modification, the purpose of precise intervention and treatment from an upstream of the disease is achieved by stabilizing mitochondrial function and blocking intrinsic immune activation triggered by metabolic stress.

The invention belongs to the technical field of polypeptide drugs, and particularly relates to a small molecule polypeptide and application thereof in psoriasis treatment. Specifically, the invention successfully designs and synthesizes a small molecule polypeptide OGP6 with the effect of intervening psoriasis. Experiments prove that the compound can effectively inhibit a cGAS-STING signal channel in a targeted manner, intervene psoriasis inflammation starting from the source, avoid the problems of anti-drug antibody generation, curative effect failure and the like caused by long-term antagonism of an existing biological agent to a single cell factor, is better in curative effect durability, and also has the characteristics of small molecular weight, simple synthesis process, low cost, low cost and the like. Therefore, the method has a good practical application value.

The present application belongs to the technical field of polypeptide drugs, and particularly relates to a kind of small molecule polypeptide and its application in psoriasis treatment.The present application successfully designs and synthesizes a kind of small molecule polypeptide OGP6 with the effect of intervening psoriasis.By test verification, it can effectively target inhibition cGAS-STING signal pathway, intervene psoriasis inflammation start from source, avoid the existing biological preparation long-term antagonism single cytokine to cause the problem such as drug resistance antibody production, curative effect invalidation, and its still has the advantages such as small molecular weight, simple synthesis process, low cost, easy to scale production, therefore has good practical application value.

The invention belongs to the technical field of biology, and relates to application of isovaleric acid in treatment of psoriasis. In order to solve the problems that existing psoriasis treatment drugs (such as biological agents) have side effects, the curative effect is reduced, and relapse occurs after drug withdrawal, the invention provides a psoriasis treatment scheme taking isovaleric acid as an active component, and the imiquimod-induced psoriasis-like skin lesion can be remarkably relieved by locally smearing the isovaleric acid with the concentration of 2mM; the epidermis excessive proliferation and the expression of inflammatory factors such as IL-17A, IL-17F and CXCL1 are reduced. The isovaleric acid disclosed by the invention is a small molecule compound, is simple to prepare, convenient to administrate and high in safety, fills the application blank of the isovaleric acid in the field of psoriasis treatment, and provides a new effective way for psoriasis treatment.

The invention relates to the technical field of biological medicine, and discloses a keratin related gene and application thereof in regulation and improvement of psoriasis, and the keratin related gene comprises KRT25, KRT28, KRT85 and KRTAP11-1. The invention also discloses application of the endocrine related gene in regulation and improvement of psoriasis, and the endocrine related gene is a CGA gene. By maintaining the expression level of the KRT25 gene, the KRT28 gene, the KRT85 gene, the KRTAP11-1 gene and / or the CGA gene, the psoriasis is relieved. The invention focuses on a dark green module, through GO / KEGG enrichment analysis, protein interaction network (PPI) construction and experimental verification, the molecular mechanism of OMT is further discussed, a network which takes keratin as a center and is related to endocrine (CGA gene) is clear as an effective node for psoriasis treatment, and a foundation is laid for discovery of a new target for psoriasis treatment.

The invention discloses an application of a novel peptide UPCP in preparation of a medicine for treating and / or preventing psoriasis. Belongs to the technical field of biological medicine. The application discloses the treatment effect of the novel peptide UPCP on psoriasis for the first time, and researches find that the novel peptide UPCP can effectively relieve symptoms of a psoriasis model induced by LSP, TNF alpha and M2 in an in-vitro cell experiment, significantly down-regulate the expression level of psoriasis cell markers, significantly reduce the transcriptional level of psoriasis-related inflammatory factors, and improve the psoriasis treatment effect. The condition of excessive proliferation of HaCaT cells is effectively reduced. In in-vivo experiments, psoriasis symptoms such as skin desquamation, hyperplasia, erythema, thickening and splenomegaly of an imiquimod-induced psoriasis mouse model can be effectively relieved, the effect of treating psoriasis is achieved, and a new theoretical basis and intervention means are provided for clinical treatment of psoriasis.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a local external cream composition for treating psoriasis. The topical external cream composition for treating psoriasis is prepared from deaminated tyrosine, azone and a matrix, wherein the matrix is prepared from liquid paraffin, sorbitol, an emulsifying agent, tween-80, white vaseline, beewax, glycerin monostearate, solid paraffin and the like according to a specific weight percentage. By optimizing a prescription and a process, the cream composition which is good in stability, high in transdermal absorption efficiency and capable of effectively delivering DAT to a skin focus is prepared, psoriasis-like skin lesion is effectively improved, inflammation and epidermal hyperplasia are relieved, and the cream composition is good in safety. A brand-new, effective and safe external medicine selection and application are provided for the field of psoriasis treatment by taking the deaminated tyrosine as an active component.

The invention relates to chlorogenic acid nanogold and a preparation method and application of a gel preparation of the chlorogenic acid nanogold, and belongs to the technical field of biological medicine. A biosynthesis method is adopted, chlorogenic acid is used as a reducing agent and a stabilizing agent at the same time, and the chlorogenic acid functionalized gold nanoparticles are synthesized in one step. Furthermore, the prepared chlorogenic acid nanogold is combined with an aqueous gel matrix for the first time, and the temperature-sensitive chlorogenic acid nanogold hydrogel suitable for skin administration is developed. The dosage form can remarkably prolong the retention time of the medicine on the skin surface and improve the transdermal absorption efficiency, so that the continuous release of the anti-inflammatory component is realized. The chlorogenic acid nanogold hydrogel provided by the invention shows higher safety based on the characteristics of natural components while ensuring the curative effect equivalent to that of betamethasone-calcipotriol, and has a remarkable clinical application prospect in the field of psoriasis treatment.

The invention belongs to the technical field of biological medicines, and relates to a dried orange peel polysaccharide, a preparation method thereof and an application of the dried orange peel polysaccharide in preparation of psoriasis treatment drugs, the monosaccharide in the dried orange peel polysaccharide comprises rhamnose, arabinose, galactose, glucose and galacturonic acid according to a molar percentage ratio of (5-6): (24-27): (10-15): (7-10): (45-50). Compared with the prior art, the pericarpium citri reticulatae polysaccharide prepared by the invention has the advantages of being good in safety, high in anti-inflammatory activity, capable of effectively improving the oxidative stress state of cells, remarkably reducing epidermis aggregates, relieving excessive proliferation of epidermis, effectively relieving desquamation and erythema symptoms of skin lesions of psoriasis and the like, and can be used for preparing psoriasis treatment medicines; the treatment scheme of psoriasis is expanded, and wide application prospects and important clinical significance are achieved.

The invention discloses a steam spray tail end device of a traditional Chinese medicine fumigation machine for psoriasis treatment, which comprises a fumigation treatment box body, a fumigation groove is formed in the upper end of the fumigation treatment box body, a cover plate is rotatably mounted on the left side of the upper end of the fumigation treatment box body, and a spray head communicated with the fumigation machine is rotatably mounted at the lower end of the cover plate; the first rod piece and the second rod piece are respectively arranged on the left side and the right side of the lower end of the cover plate through bearings; the waterproof soft cushion is mounted on the inner wall of the lower end of the fumigation tank; the two rotating rods are respectively mounted at the lower end and in the right side of the fumigation treatment box body; and the supporting rod is rotationally mounted at the upper end of the cover plate. According to the steam spraying tail end device of the traditional Chinese medicine fumigation machine for psoriasis treatment, through swinging of the spray head, the fumigation range is expanded, the balance of the fumigation temperature is guaranteed, uniform steam spraying treatment can be conducted on the whole body, meanwhile, massage operation can be conducted in the treatment period, and the discomfort caused by the fact that a patient keeps the same posture for a long time is reduced.

The invention belongs to the technical field of biology, and particularly relates to a psoriasis treatment preparation and method and application. The expression of SECTM1 in the skin of a psoriasis patient is increased, an SECTM1 antibody can inhibit immune cells and relieve inflammatory response, psoriasis mice treated by the SECTM1 antibody can cause expression reduction of inflammatory factors Il6, Tnfa, Il1b, Il22 and Il17a, psoriasis skin treated by the SECTM1 antibody can cause reduction of CD7 + cell infiltration quantity, and hacat cells knock down SECTM1 gene expression so as to inhibit proliferation of skin epithelial cells, so that the SECTM1 antibody can be used for treating psoriasis mice. Therefore, the SECTM1 antibody preparation can be used for treating psoriasis, and the recurrence rate is low.

A pharmaceutical composition for treatment of psoriasis is disclosed in the present invention. The pharmaceutical composition is a plant extract rich in bioactive constituents and applied topically for psoriasis treatment without any adverse effects. The present invention also provides a method for obtaining the extract and identifies various uses of the extract as a medicament in both human and veterinary therapy. Specifically, a 1.4% concentration of the bioactive extract has been shown to prevent the formation of psoriasis plaques when applied topically and 3.7% extract was found to clear psoriatic scales after 8 days of application topically Fig. 1A

The invention discloses a preparation method of abelmoschus manihot composition external medicinal liquor for treating psoriasis, and relates to the technical field of traditional Chinese medicine external preparations. Comprising the following steps: (1) raw material compatibility and pretreatment: taking 10-30 parts by mass of abelmoschus manihot, 5-15 parts by mass of processed pinellia ternate, 5-15 parts by mass of processed paris polyphylla, 5-15 parts by mass of rheum officinale, 5-15 parts by mass of tobacco stems, 5-15 parts by mass of senecio scandens, 3-10 parts by mass of nidus vespae, 5-15 parts by mass of cortex dictamni, 5-15 parts by mass of szechwan chinaberry fruit, 5-15 parts by mass of cocklebur fruit, 5-15 parts by mass of cortex lycii radicis, 5-15 parts by mass of fructus kochiae and 5-15 parts by mass of coptis chinensis. The ministerial drug processed rhizoma paridis relieves swelling and pain, the adjuvant processed rhizoma pinelliae eliminates dampness and phlegm, and the conductant drug borneol is transdermal and guides channels; the eighteen medicinal materials have a synergistic effect and have a treatment effect on multiple links such as inflammation, hyperplasia, pruritus and infection of the psoriasis; extracting effective components with different polarities by stages by adopting a gradient soaking extraction process; the clarity and the stability of the medicinal liquor are ensured by a multi-stage precise filtering system; the low-temperature treatment protects the activity of volatile components.

The invention discloses a synthesis method of a psoriasis treatment drug apremilast, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethanone as an initial raw material, and carrying out reductive amination to obtain an intermediate 1; splitting the intermediate 1 by tartrate to obtain an intermediate 2; and finally, carrying out condensation reaction on the intermediate 2 and 3-acetamido phthalic anhydride to obtain apremilast. The invention develops a green and efficient synthesis process of apremilast, the preparation of a target product is realized through three-step reaction, the process breaks through the technical bottleneck that the traditional route depends on high-pressure hydrogenation conditions and noble metal catalysts (such as palladium on carbon), and the whole process adopts normal-pressure operation and mild temperature and avoids high-temperature reaction. The safety in industrial production is improved to a great extent, and the method is more suitable for industrial continuous production.

A method for extracting tung oil as a medicinal substance comprises the following steps: Step 1: Selecting mature tung seeds, removing the outer shell, leaving the oil-containing embryo, drying and pulverizing it into tung seed kernel powder; Step 2: Mixing and stirring the tung seed kernel powder with ethanol to obtain crude tung oil; Step 3: Allowing the crude tung oil to stand at low temperature to remove the aqueous phase, gum, and pigments, obtaining refined tung oil; Step 4: Detoxifying the refined tung oil using a mild saponification process; Step 5: Re-extracting the detoxified tung oil with ethyl acetate to obtain a tung oil extract enriched with active ingredients. This invention also proposes a psoriasis treatment drug based on natural tung oil extract, aiming to overcome the limitations of existing therapies in terms of cost, administration method, side effects, and insufficient coverage of complex pathological mechanisms. It achieves comprehensive treatment of psoriasis through multi-dimensional regulation of inflammation, cell proliferation, and metabolism using a tung oil extraction method and its application in treating psoriasis.

The invention belongs to the field of medicines, and discloses application of a carboplatin compound in preparation of medicines for preventing and treating psoriasis. According to the present invention, in the tumor treatment effect research of the carboplatin compound ZC2377, the psoriasis treatment activity of the carboplatin compound ZC2377 is accidentally found, such that the result is verified through the further experiment, and the practical application value of the carboplatin compound ZC2377 is provided.

The invention discloses an application of a CK2 inhibitor CX4945 in preparation of medicines for treating skin inflammations such as psoriasis and the like. The CK2 inhibitor CX4945 ointment provided by the invention can be used for remarkably reducing the pathological injury of the skin of a psoriasis mouse and reducing the neutrophil infiltration of the dermis layer of the skin. The medicine can be prepared into external ointment, is locally applied for use, is convenient to use, has no obvious side effect, is high in patient compliance, and can be prepared into a psoriasis treatment medicine.

The invention discloses a biomass-based tea tree essential oil slow-release application patch for treating psoriasis and a preparation method of the biomass-based tea tree essential oil slow-release application patch. The method comprises the following steps: extracting collagen sponge from an animal connective tissue raw material, preparing a collagen solution, adding tea tree essential oil, and emulsifying to obtain a collagen Pickering emulsion; fungus strains are inoculated on a PDA solid culture medium to be cultured to obtain hyphae, then the hyphae are scraped and implanted into a PDB liquid culture medium to be cultured, and hypha membranes are obtained; finally, the mycelium membrane is coated with the collagen Pickering emulsion, so that the collagen Pickering emulsion naturally permeates into the mycelium membrane, and the biomass-based tea tree essential oil slow-release application patch is obtained after drying. The biomass-based tea tree essential oil sustained-release application patch which takes all components as biomass raw materials, has the advantages of drug sustained release, instant adhesion when encountering water and toughness when encountering water is prepared, and can be used for treating psoriasis. The sustained-release application patch has good mechanical strength, can be directly adhered to skin, has strong compliance to dynamic affected parts, and does not bring extra pain to patients.

The invention relates to an application of a stable silicic acid aqueous solution in preparation of a product for treating psoriasis, and the mass concentration of the stable silicic acid aqueous solution is 0.5-2%. The stable silicic acid aqueous solution serves as an active component, and psoriasis can be treated at the mass concentration of 0.5%-2%. Meanwhile, the stable silicic acid aqueous solution is low in raw material cost, environment-friendly and safe, and can be used as a safe alternative medicament for treating psoriasis with a good curative effect.

The application discloses application of anti-IGFBP7 antibodies in treating skin diseases, belongs to the technical field of psoriasis treatment, and discloses application of anti-IGFBP7 antibodies in preparation of a medicament for treating psoriasis, wherein the medicament is used for reducing and treating psoriasis-like inflammation by inhibiting expression of IGFBP7 in blood vessels of skin of a psoriasis patient. After the anti-IGFBP7 antibodies are used, psoriasis inflammation is reduced, meanwhile, epidermal thickness of a psoriasis patient is reduced, erythema formation is inhibited, and the generation of scales is reduced. In protecting vascular barrier function and treating psoriasis, the anti-IGFBP7 antibodies have a good medicinal prospect.