4 results about "Psoriasis treatment" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to application of an inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein. The application provides application of the inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein in preparation of a medicine for preventing and / or treating psoriasis, and an amino acid sequence of the HSP60 protein (heat shock protein 60) is shown as SEQ ID NO. 1. The application provides a brand-new, mechanism-driven psoriasis treatment target, lactic acid modification of lysine at the 249th position of HSP60 protein. By inhibiting the specific modification, the purpose of precise intervention and treatment from an upstream of the disease is achieved by stabilizing mitochondrial function and blocking intrinsic immune activation triggered by metabolic stress.

The present application belongs to the technical field of polypeptide drugs, and particularly relates to a kind of small molecule polypeptide and its application in psoriasis treatment.The present application successfully designs and synthesizes a kind of small molecule polypeptide OGP6 with the effect of intervening psoriasis.By test verification, it can effectively target inhibition cGAS-STING signal pathway, intervene psoriasis inflammation start from source, avoid the existing biological preparation long-term antagonism single cytokine to cause the problem such as drug resistance antibody production, curative effect invalidation, and its still has the advantages such as small molecular weight, simple synthesis process, low cost, easy to scale production, therefore has good practical application value.

A method for extracting tung oil as a medicinal substance comprises the following steps: Step 1: Selecting mature tung seeds, removing the outer shell, leaving the oil-containing embryo, drying and pulverizing it into tung seed kernel powder; Step 2: Mixing and stirring the tung seed kernel powder with ethanol to obtain crude tung oil; Step 3: Allowing the crude tung oil to stand at low temperature to remove the aqueous phase, gum, and pigments, obtaining refined tung oil; Step 4: Detoxifying the refined tung oil using a mild saponification process; Step 5: Re-extracting the detoxified tung oil with ethyl acetate to obtain a tung oil extract enriched with active ingredients. This invention also proposes a psoriasis treatment drug based on natural tung oil extract, aiming to overcome the limitations of existing therapies in terms of cost, administration method, side effects, and insufficient coverage of complex pathological mechanisms. It achieves comprehensive treatment of psoriasis through multi-dimensional regulation of inflammation, cell proliferation, and metabolism using a tung oil extraction method and its application in treating psoriasis.

The application discloses application of anti-IGFBP7 antibodies in treating skin diseases, belongs to the technical field of psoriasis treatment, and discloses application of anti-IGFBP7 antibodies in preparation of a medicament for treating psoriasis, wherein the medicament is used for reducing and treating psoriasis-like inflammation by inhibiting expression of IGFBP7 in blood vessels of skin of a psoriasis patient. After the anti-IGFBP7 antibodies are used, psoriasis inflammation is reduced, meanwhile, epidermal thickness of a psoriasis patient is reduced, erythema formation is inhibited, and the generation of scales is reduced. In protecting vascular barrier function and treating psoriasis, the anti-IGFBP7 antibodies have a good medicinal prospect.