64 results about "Psoriasis treatment" patented technology

The invention discloses methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel for treating psoriasis and a preparation method of the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel. The method comprises the following steps: firstly, loading methotrexate by using sulfonated bacterial cellulose, and then coupling with chitosan to form the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel. The synthesis method is simple, the prepared methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel can promote the transdermal release effect of methotrexate and control the release speed of methotrexate, skin inflammation caused by psoriasis is continuously and effectively relieved, and the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel has good biological safety.

The invention discloses a sesterterpenoid compound, a preparation method thereof and application of the sesterterpenoid compound in preparation of a medicine for treating psoriasis, and belongs to the technical field of biological medicine. Comprising a compound 1-4, and the structural formula of the compound 1-4 is as follows: # imgabs0. A new molecular template is provided for developing a new psoriasis treatment medicine, and a new thought is provided for further developing a novel treatment strategy with an immunomodulatory effect.

The invention discloses a selenium-containing soluble composite microneedle as well as a preparation method and application thereof, and belongs to the technical field of biological materials and biological medicines, a microneedle forming matrix is selenized hyaluronic acid and medicine-loaded tetrahedral framework nucleic acid, and a substrate part is polyvinyl alcohol; the preparation method comprises the following steps: step 1, preparation of selenized hyaluronic acid; step 2, preparation of tetrahedral framework nucleic acid and drug loading; and step 3, preparation of the selenium-containing and drug-loaded microneedle patch. The selenized hyaluronic acid is synthesized through a specific chemical method, the selenized hyaluronic acid is used as a substrate to load the medicine-carrying tetrahedral framework nucleic acid, and the advantages of high permeability, good biocompatibility, editability and the like of the tetrahedral framework nucleic acid are utilized, so that the sustained and controlled release capacity of the microneedle is improved, efficient transdermal delivery of the medicine is realized, and the application prospect is broad. And pain and discomfort possibly caused by a traditional administration mode are reduced. The invention provides a novel and effective drug delivery system in the field of psoriasis treatment.

The invention discloses a high-entropy alloy nanoparticle and application thereof. The nanoparticles are formed by specific noble metals, have multienzyme activity, and can effectively remove ROS (reactive oxygen species) at an inflammation part and remodel the free radical steady state of the inflammation part; the skin inflammation reaction can be inhibited by adjusting a JAK-STAT signal channel; skin inflammation caused by psoriasis can be relieved by down-regulating inflammatory factors IL-6, IL-17 and IL-23, and a new treatment scheme is provided for psoriasis treatment.

The invention provides a drug-loaded microneedle patch for treating psoriasis and a preparation method of the drug-loaded microneedle patch, and belongs to the technical field of medicines. The preparation method comprises the following steps: preparing a Zr-ferrocene-MOF material, modifying the surface of the Zr-ferrocene-MOF material with tannic acid, coupling the modified material with an acryloyl chloride modified glycine and a compound coupled with adalimumab and judiciumab, then initiating copolymerization, pouring a pre-polymerized solution into a PDMS micro-needle mold, and carrying out ultrasonic treatment, illumination, demolding and drying to prepare the drug-loaded micro-needle patch for treating psoriasis. The microneedle patch prepared by the invention has the advantages of high mechanical strength, fatigue resistance, certain photo-thermal antibacterial and anti-inflammatory effects, slow and controlled release of drugs adalimumab and jucuiliumab, long time and firm attachment on skin, and better facilitation of drug release, so that the microneedle patch has the advantages of excellent treatment effect, extremely small side effect, high patient compliance, and no toxic or side effect. Wide application prospects are realized.

The application belongs to the technical field of biological medicine, and particularly relates to application of an inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein. The application provides application of the inhibitor for inhibiting lactic acid modification of lysine at the 249th position of HSP60 protein in preparation of a medicine for preventing and / or treating psoriasis, and an amino acid sequence of the HSP60 protein (heat shock protein 60) is shown as SEQ ID NO. 1. The application provides a brand-new, mechanism-driven psoriasis treatment target, lactic acid modification of lysine at the 249th position of HSP60 protein. By inhibiting the specific modification, the purpose of precise intervention and treatment from an upstream of the disease is achieved by stabilizing mitochondrial function and blocking intrinsic immune activation triggered by metabolic stress.

The invention relates to the technical field of biological medicine, in particular to application of OASL in treatment of psoriasis. The disclosure finds that the OASL promotes the generation of inflammatory factors and the disorder of lipid metabolism by promoting an MAPK signal channel so as to promote cell proliferation, and the pathogenic effect of the OASL in psoriasis is proved. And by accurately positioning a treatment target, the side effects in the psoriasis treatment process can be effectively reduced.

The invention discloses application of Daurisoline in preparation of a medicine for treating psoriasis and the medicine, relates to the technical field of preparation of the medicine for treating the psoriasis, provides new application of the Daurisoline and a new medicine for treating the psoriasis, and provides a new strategy for providing a new treatment method and a new treatment medicine for clinical intervention of the psoriasis.

The invention belongs to the technical field of polypeptide drugs, and particularly relates to a small molecule polypeptide and application thereof in psoriasis treatment. Specifically, the invention successfully designs and synthesizes a small molecule polypeptide OGP6 with the effect of intervening psoriasis. Experiments prove that the compound can effectively inhibit a cGAS-STING signal channel in a targeted manner, intervene psoriasis inflammation starting from the source, avoid the problems of anti-drug antibody generation, curative effect failure and the like caused by long-term antagonism of an existing biological agent to a single cell factor, is better in curative effect durability, and also has the characteristics of small molecular weight, simple synthesis process, low cost, low cost and the like. Therefore, the method has a good practical application value.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating psoriasis as well as a preparation method and application thereof. The traditional Chinese medicine composition for treating psoriasis is characterized by being prepared from the following raw materials in parts by weight: 2 to 16 parts of radix gentianae macrophyllae, 4 to 11 parts of radix sophorae flavescentis, 14 to 31 parts of herba hedyotidis diffusae, 14 to 31 parts of caulis lonicerae, 9 to 16 parts of caulis spatholobi and 9 to 16 parts of ramulus uncariae cum uncis. The traditional Chinese medicine composition for treating psoriasis not only plays a local treatment role through mechanisms of penetrating through striae and interstices, relaxing meridians, regulating qi and blood, expelling evil and strengthening body resistance and the like, but also penetrates into viscera through skin hair orifices to play a role of internal and external combined treatment. The traditional Chinese medicine composition is simple and convenient to use, convenient to carry and easy to popularize, the medication compliance of patients is effectively improved, and a guarantee is provided for the continuity of psoriasis treatment.

The present application belongs to the technical field of polypeptide drugs, and particularly relates to a kind of small molecule polypeptide and its application in psoriasis treatment.The present application successfully designs and synthesizes a kind of small molecule polypeptide OGP6 with the effect of intervening psoriasis.By test verification, it can effectively target inhibition cGAS-STING signal pathway, intervene psoriasis inflammation start from source, avoid the existing biological preparation long-term antagonism single cytokine to cause the problem such as drug resistance antibody production, curative effect invalidation, and its still has the advantages such as small molecular weight, simple synthesis process, low cost, easy to scale production, therefore has good practical application value.

The invention belongs to the technical field of biology, and relates to application of isovaleric acid in treatment of psoriasis. In order to solve the problems that existing psoriasis treatment drugs (such as biological agents) have side effects, the curative effect is reduced, and relapse occurs after drug withdrawal, the invention provides a psoriasis treatment scheme taking isovaleric acid as an active component, and the imiquimod-induced psoriasis-like skin lesion can be remarkably relieved by locally smearing the isovaleric acid with the concentration of 2mM; the epidermis excessive proliferation and the expression of inflammatory factors such as IL-17A, IL-17F and CXCL1 are reduced. The isovaleric acid disclosed by the invention is a small molecule compound, is simple to prepare, convenient to administrate and high in safety, fills the application blank of the isovaleric acid in the field of psoriasis treatment, and provides a new effective way for psoriasis treatment.

The invention belongs to the technical field of biological computer analysis, and discloses an analysis method based on network pharmacology and a molecular docking technology. The psoriasis treatment of fucoidin is analyzed on the basis of network pharmacology and a molecular docking technology, five core targets, 30 GO annotations and 66 KEGG pathways are screened through the network pharmacology and the molecular docking technology, and the affinity of active ingredients and the core targets is good.

The invention discloses a layered microneedle patch as well as a preparation method and application thereof, and belongs to the field of biological medicines. Wherein the needle body tip is composed of a therapeutic agent and L-arginine shell modified glycan gel, has excellent biocompatibility and free DNA removal ability, and can deliver deferoxamine and synergistically regulate and control inflammation signals; the upper part of the needle body and the substrate are made of low-molecular-weight hyaluronic acid which is quickly dissolved after being in contact with skin, so that the needle tip is quickly separated from the substrate, the needle tip is retained at a diseased region, and effective deposition of a medicine at the diseased region is ensured; the layered microneedle can slowly release deferoxamine through pH response so as to inhibit ferroptosis; the modified chitosan can efficiently remove free DNA so as to reduce immune inflammation and cooperatively block immune inflammation circulation. The preparation process of the layered microneedle is controllable, the material biocompatibility is excellent, and the layered microneedle has the advantages of efficient targeted delivery, long-acting release and synergistic treatment, so that a feasible strategy is provided for psoriasis treatment.

The present invention discloses a selenium-containing soluble composite microneedle and its preparation method and application, belonging to the technical fields of biomaterials and biomedicine. The microneedle forming matrix is selenium hyaluronate, loaded with drug-loaded tetrahedral framework nucleic acid, and the base part is polyvinyl alcohol. The preparation method includes: Step 1, preparation of selenium hyaluronate; Step 2, preparation and drug loading of tetrahedral framework nucleic acid; Step 3, preparation of selenium-containing and drug-loaded microneedle patches. The present invention synthesizes selenium hyaluronate by a specific chemical method, uses selenium hyaluronate as the base, loads drug-loaded tetrahedral framework nucleic acid, and utilizes the advantages of high permeability, good biocompatibility, and editability of tetrahedral framework nucleic acid to improve the sustained and controlled release ability of microneedles, realize the efficient transdermal delivery of drugs, and reduce the pain and discomfort that may be brought by traditional drug delivery methods. It provides a new and effective drug delivery system in the field of psoriasis treatment.

The utility model relates to the technical field of psoriasis treatment, and discloses a head Chinese medicine fumigation device with a self-heating function, comprising a fumigation cap; a fixing component is provided at the bottom of the fumigation cap; a fumigation treatment component is provided inside the fumigation cap, and the fumigation treatment component comprises: a heat insulation layer, which is arranged on the inner side wall of the fumigation cap; a heating layer, which is arranged on the inner side of the heat insulation layer; a vacuum layer, which is arranged between the heat insulation layer and the heating layer; a water-proof layer, which is fixedly connected to the inner side wall of the heating layer; the fumigation treatment component can heat and keep the internal absorbent cotton warm, and ensure the temperature of hot compress fumigation during treatment, thereby improving the hot compress fumigation treatment effect; the fixing component fixes the head by means of elastic straps and buckles, and can be quickly and firmly fixed on the head, and the internal absorbent cotton can be stably fixed in the cap, further improving the stability of the fixation, so that the patient will not shake or fall off when moving the head.

The present invention relates generally to a dosage regimen for psoriasis treatment with antibodies that bind to the p19 subunit of human IL-23, in particular for treatment of this disease.

The invention relates to the technical field of biological medicine, and discloses a keratin related gene and application thereof in regulation and improvement of psoriasis, and the keratin related gene comprises KRT25, KRT28, KRT85 and KRTAP11-1. The invention also discloses application of the endocrine related gene in regulation and improvement of psoriasis, and the endocrine related gene is a CGA gene. By maintaining the expression level of the KRT25 gene, the KRT28 gene, the KRT85 gene, the KRTAP11-1 gene and / or the CGA gene, the psoriasis is relieved. The invention focuses on a dark green module, through GO / KEGG enrichment analysis, protein interaction network (PPI) construction and experimental verification, the molecular mechanism of OMT is further discussed, a network which takes keratin as a center and is related to endocrine (CGA gene) is clear as an effective node for psoriasis treatment, and a foundation is laid for discovery of a new target for psoriasis treatment.

The invention relates to a peptide for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention also relates to a pharmaceutical composition for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the pharmaceutical composition comprises a peptide, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention further relates to a composition for skin improvement, a cosmetic composition, a topical skin cream composition and a nutritional compositions, wherein said compositions comprise a peptide comprising amino acids joined by peptide bonds, wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro).

The invention discloses a Fab-scFv novel fusion protein and application thereof, and belongs to the field of biological medicine. The Fab-scFv fusion protein is obtained by fusing three amino acid sequences, and through mammalian cell expression, purification identification and animal experiments, it is shown that the Fab-scFv fusion protein has potential application value in psoriasis treatment. The Fab-scFv fusion protein exceeds the ability of infliximab to combine with FcRn on keratinocytes, further inhibits proliferation of the keratinocytes, reduces skin tissue neutrophil infiltration, pathogenicity Th1, Th2 and Th22, increases Treg cells and the like, and has the treatment titer exceeding the psoriasis treatment effect of infliximab with the same molar concentration. In addition, the traditional Chinese medicine composition can efficiently interact with keratinocytes which play a key role in psoriasis, so that the effect of more efficiently treating psoriasis is realized.

The invention discloses an application of a novel peptide UPCP in preparation of a medicine for treating and / or preventing psoriasis. Belongs to the technical field of biological medicine. The application discloses the treatment effect of the novel peptide UPCP on psoriasis for the first time, and researches find that the novel peptide UPCP can effectively relieve symptoms of a psoriasis model induced by LSP, TNF alpha and M2 in an in-vitro cell experiment, significantly down-regulate the expression level of psoriasis cell markers, significantly reduce the transcriptional level of psoriasis-related inflammatory factors, and improve the psoriasis treatment effect. The condition of excessive proliferation of HaCaT cells is effectively reduced. In in-vivo experiments, psoriasis symptoms such as skin desquamation, hyperplasia, erythema, thickening and splenomegaly of an imiquimod-induced psoriasis mouse model can be effectively relieved, the effect of treating psoriasis is achieved, and a new theoretical basis and intervention means are provided for clinical treatment of psoriasis.

The invention discloses a psoriasis biological targeting antibody treatment response prediction device based on machine learning, and the psoriasis treatment response prediction device takes the expression level and clinical data of the differential expression gene of a psoriasis patient as the input, and further realizes the accurate prediction of the drug treatment response result of the psoriasis patient. When the psoriasis treatment response prediction device is used for drug treatment response prediction, the average ROC-AUC value is larger than 0.9, and it is indicated that the psoriasis treatment response prediction device can achieve accurate drug treatment response.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a local external cream composition for treating psoriasis. The topical external cream composition for treating psoriasis is prepared from deaminated tyrosine, azone and a matrix, wherein the matrix is prepared from liquid paraffin, sorbitol, an emulsifying agent, tween-80, white vaseline, beewax, glycerin monostearate, solid paraffin and the like according to a specific weight percentage. By optimizing a prescription and a process, the cream composition which is good in stability, high in transdermal absorption efficiency and capable of effectively delivering DAT to a skin focus is prepared, psoriasis-like skin lesion is effectively improved, inflammation and epidermal hyperplasia are relieved, and the cream composition is good in safety. A brand-new, effective and safe external medicine selection and application are provided for the field of psoriasis treatment by taking the deaminated tyrosine as an active component.

The present invention discloses a method for constructing an animal inflammatory model of psoriasis with different severities of skin lesions, comprising the following steps: raising 30 Balb / C mice according to a standard feeding method; weighing and calculating the body surface area of ​​each mouse at baseline D0, and removing the hair of the mice; randomly dividing the 30 Balb / C mice into three groups according to the lesion area, namely a mild group, a moderate group and a severe group; using 5 mg / cm 2 Imiquimod was evenly applied to the lesion area of ​​each mouse; the mice were killed after 7 days of intervention, and the skin tissue and spleen of the mice were taken for subsequent examination. The changes in the skin lesions of the mice were recorded by taking photos with a camera. After 7 days of treatment with imiquimod cream, typical psoriasis-like lesions appeared. The constructed psoriasis animal model has very similar clinical symptoms to psoriasis patients, can show psoriasis-related histological changes and immune system changes, and can be used to screen psoriasis treatment drugs.

The invention discloses a personalized dosage adjusting device and method for psoriasis treatment medicine, and relates to the technical field of psoriasis treatment.The personalized dosage adjusting device comprises a monitoring mechanism, the monitoring mechanism comprises a shell, and a detection mechanism is arranged above the shell; the detection mechanism comprises a data collection unit, the data collection unit is arranged in the shell, and the data collection unit is used for collecting skin state image data of a psoriasis patient. The drug dosage most suitable for a patient can be calculated according to the influence of the drug on the physical condition of the patient after medication and the skin treatment effect in cooperation with the oral description of the patient and a biomarker detection result, the accuracy of the drug dosage of the psoriasis treatment drug is improved, personalized dosage adjustment is conveniently carried out according to the conditions of different patients after medication, and the curative effect of the psoriasis treatment drug is improved. The side effects caused by excessive medication are greatly reduced while the treatment effect and the treatment compliance of a patient are ensured.

The invention discloses a composite hydrogel with a redox bidirectional regulation function and a preparation method and application thereof, and belongs to the field of biomedical materials.According to the composite hydrogel, polyvinyl alcohol and carboxymethyl chitosan serve as gel matrixes, crosslinking of the two matrixes is achieved through genipin by means of the action of hydrogen bonds and amido bonds, and the composite hydrogel with the redox bidirectional regulation function is obtained. The hydrogel network is loaded with chlorella capable of removing active oxygen components and Ag (at) ZnO capable of generating the active oxygen components. According to the hydrogel, the ROS level can be indirectly regulated and controlled by regulating and controlling the illumination condition, so that potential balance between oxidative stress resistance and ROS accumulation is realized. The hydrogel is locally fed to an imiquimod-induced psoriasis mouse model, a good anti-psoriasis treatment effect is obtained, and it is proved that the hydrogel can effectively resist local skin lesion of psoriasis in a multifunctional, non-irritant and non-invasive mode.

Provided is a novel therapeutic or prophylactic agent for psoriasis. A psoriasis therapeutic or prophylactic agent which contains a serotonin 4 receptor agonist.

The present invention discloses the use of Lactobacillus casei Zhang in preparing a preparation for treating skin diseases, relating to the technical field of microbial probiotic preparations. The present invention provides the use of Lactobacillus casei Zhang in preparing a preparation for treating or alleviating psoriasis. The Lactobacillus casei Zhang has a deposit number of CGMCC No. 5469. The Lactobacillus casei Zhang of the present invention has an alleviating effect on the symptoms of psoriasis, can inhibit the weight loss trend of psoriasis patients, and reduce the spleen index. It can be used to prepare a preparation for alleviating psoriasis. It can also be used as a microecological preparation in medicines, fermented foods, or health products, providing a potential option for developing new psoriasis treatment methods.

The invention relates to chlorogenic acid nanogold and a preparation method and application of a gel preparation of the chlorogenic acid nanogold, and belongs to the technical field of biological medicine. A biosynthesis method is adopted, chlorogenic acid is used as a reducing agent and a stabilizing agent at the same time, and the chlorogenic acid functionalized gold nanoparticles are synthesized in one step. Furthermore, the prepared chlorogenic acid nanogold is combined with an aqueous gel matrix for the first time, and the temperature-sensitive chlorogenic acid nanogold hydrogel suitable for skin administration is developed. The dosage form can remarkably prolong the retention time of the medicine on the skin surface and improve the transdermal absorption efficiency, so that the continuous release of the anti-inflammatory component is realized. The chlorogenic acid nanogold hydrogel provided by the invention shows higher safety based on the characteristics of natural components while ensuring the curative effect equivalent to that of betamethasone-calcipotriol, and has a remarkable clinical application prospect in the field of psoriasis treatment.

The invention belongs to the technical field of biological medicines, and relates to a dried orange peel polysaccharide, a preparation method thereof and an application of the dried orange peel polysaccharide in preparation of psoriasis treatment drugs, the monosaccharide in the dried orange peel polysaccharide comprises rhamnose, arabinose, galactose, glucose and galacturonic acid according to a molar percentage ratio of (5-6): (24-27): (10-15): (7-10): (45-50). Compared with the prior art, the pericarpium citri reticulatae polysaccharide prepared by the invention has the advantages of being good in safety, high in anti-inflammatory activity, capable of effectively improving the oxidative stress state of cells, remarkably reducing epidermis aggregates, relieving excessive proliferation of epidermis, effectively relieving desquamation and erythema symptoms of skin lesions of psoriasis and the like, and can be used for preparing psoriasis treatment medicines; the treatment scheme of psoriasis is expanded, and wide application prospects and important clinical significance are achieved.