81 results about "Psoriasis patient" patented technology

The present invention relates to methods of treating psoriasis by inhibiting one or more matrix metalloproteinase enzymes ("MMPs"). It is based, at least in part, on the discovery that the expression patterns of certain MMPs and related molecules are altered in patients suffering from psoriasis, relative to normal subjects. Certain expression patterns are altered even in unaffected skin of psoriasis-afflicted patients, although aberrancies are more pronounced in psoriatic lesions. In various non-limiting embodiments, the present invention provides for methods of treating psoriasis, including preventing the development of new psoriatic lesions, comprising administering, to subjects in need of such treatment, effective concentrations of compounds which inhibit the enzymatic activity of one or more MMP. Suitable inhibitors include tetracycline and its derivatives and various hydroxymate, carboxylic acid, and phosphonic acid derivatives. Therapy may comprise systemic and / or local administration of inhibitor. In additional embodiments, the present invention provides for methods of diagnosing MMP inhibitor responsive skin lesions, for evaluating the level of disease activity in a subject, and for transgenic animal and tissue culture models of psoriasis.

A Chinese medicine for treating psorinsis, ichthyosis, tinea, neurodermatitis, urticaria, eczema, flat wart, etc is composed of the orally taken capsules prepared from 19 Chinese-medicinal materials including dahurian angelica root, etc. the exterior-applied component A prepared from 6 Chinese-medicinal materials including cloves, etc. and the exterior-applied component B prepared from said component A and 14 Chinese-medicinal materials including dahurian angelica root, etc.

The invention discloses a traditional Chinese medicine composition for treating psoriasis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of radix paeoniae rubra, 3-9 parts of rhizoma curcumae, 10-20 parts of glabrous sarcandra herb, 10-20 parts of rhizoma smilacis glabrae and 5-15 parts of dark plum. The traditional Chinese medicine composition has the following benefits: the treating effect can be achieved by virtue of a relatively small dose, the toxicity is remarkably reduced, the traditional Chinese medicine composition takes effect relatively fast, and recurrence can be delayed; the traditional Chinese medicine has a more outstanding effect on common psoriasis (PASI 50 can reach 60%); especially for an early-onset psoriasis patient, such complications as cardiovascular events, psoriasis arfhropathica and diabetes can be reduced (for a patient who takes the traditional Chinese medicine composition, the complication rate can be lowered by 20%); therefore, the traditional Chinese medicine composition can remarkably improve the life quality of the psoriasis patients, and has a better effect.

The invention relates to external medicinal liquor for curing psoriasis, belonging to the traditional Chinese medicine field. The external medicinal liquor is characterized in that: the raw material medicine making active ingredients of the medicinal liquor by weight is: 10 grams of coralbean bark, 100 grams of chaulmoogra, 100 grams of fructus cnidii selinum, 90 grams of radix sophorae flavescentis and 30 grams of camphor. The raw material medicine is porphyrized, placed into a container and then added with 500 milliliters of distilled spirit to be immersed for 10 days, and then the process is completed after filtration and deslagging. The external medicinal liquor plays a part in itch removal, antipyresis and toxin expelling. The external medicinal liquor begins from the pathogenic causes of psoriasis patients and recovers the immunity function of the psoriasis patients. The external medicinal liquor is particularly suitable for various stubborn diseases which can not be cured for a long time and patients who suffer from repeated attack after stopping taking medicine, and is characterized by short treatment period, quickness in taking effect, recurrence resistance, no toxic side effect and so on. As shown by clinical verification, the itch is removed after taking the external medicinal liquor for 7 days and the cortex is softened after taking the external medicinal liquor for 15 days; and general patients only need two to four treatment periods. The effectiveness ratio of the external medicinal liquor is 100 percent and the cure rate of the external medicinal liquor is 97.6 percent.

The invention provides an external application traditional Chinese drug for treating psoriasis vulgaris. The external application traditional Chinese drug is a agent prepared from the following raw materials, by weight, 5-9 parts of densefruit pittany root bark, 5-9 parts of japanese ampelopsis root tuber, 5-9 parts of lightyellow sophora root, 9-15 parts of fructus kochiae, 5-9 parts of pinellia, 2-5 parts of amur corktree bark, 3-9 parts of common cnidium fruit, 1-5 parts of alum, 6-9 parts of stiff silkworm, 2-4 parts of chaulmoogratree seed, 9-15 parts of dried alum, 6-12 parts of mirabilite, 10-30 parts of wild buckwheat rhizome, 1-4 parts of glaber herba sarcandrae inj, 3-9 parts of japanese pogodatree flower, 2-6 parts of kansu euphorbia root, 9-15 parts of sulphur, 6-9 parts of kaempferia galanga, 3-9 parts of pomegranata rind, 6-15 parts of common bletilla tuber, 3-9 parts of podophyllum, 3-9 parts of siberian cocklebur fruit, 6-12 parts of smoked plum, 9-15 parts of flatspine pricklyash, 6-9 parts of psoralea corylifolia, 3-9 parts of common camptotheca fruit, 9-15 parts of Chinese soapberry fruit, and 1-30 parts of Chinese azalea flower. According to the traditional Chinese drug preparation of the present invention, the traditional Chinese drug five element theory is adopted, the medicine is applied aiming at the symptoms according to the psoriasis vulgaris etiopathogenisis, and the external application traditional Chinese drug has effects of heat clearing, detoxification, blood activating, and collateral dredging, and is suitable for more than 99% psoriasis vulgaris patients.

The invention relates to an externally-applied liniment for treating psoriasis, which belongs to the field of traditional Chinese medicines. The externally-applied liniment is characterized by comprising the following components in parts by weight: 10g of cortex pseudolaricis, 6g of Chinese honeylocust fruit, 5g of sulfur, 3g of realgar, 5g of mercurous chloride, 5g of borneol, 5g of camphor, 10g of crude white alum, 5g of cantharis and 20g of kuhseng. The externally-applied liniment is prepared by pulverizing the medicines, comminuting, putting into a container, adding into 500ml of white spirit, soaking for 15 days, filtering and deslagging. The invention acts as the functions of destroying parasites, relieving itching, eliminating dampness, allaying fever, expelling toxin, removing scurfs, moistening the skin and nourishing the muscle. The medicine starts with the pathogenic root of a patient with the psoriasis, restores the immunological function of the patient, especially a patient who is not recovered after long-time treatment and is easy to relapse, and has the characteristics of good curative effect, short treatment course, quick acting and little possibility of relapse. By clinical verification, the pruritus is lightened after the medicine is taken for 5 days, the cortex is softened after 13 days, and a common illness can be recovered by 2-3 treatment courses. The effective rate is 98%, and the cure rate is 86%.

A Chinese medicine in the form of particles for treating psoriasis is prepared from 13 Chinese-medicinal materials including gypsum, rehmannia root, red peony root, scutellaria root, etc. Its preparing process is also disclosed.

The invention discloses a traditional Chinese medicine lotion for treating psoriasis. The traditional Chinese medicine lotion belongs to the pharmaceutical field. The traditional Chinese medicine lotion is prepared by a stewing process with honeycomb, folium artemisiae argyi, acorus calamus, cortex phellodendri, herba schizonepetae, radix sophorae flavescentis, saposhnicovia divaricata, radix angelicae, realgar, broussonetia papeyrifera, christina loosestrife herb, galla chinensis, rhizoma smilacis glabrae, wild chrysanthemum flower, fructus kochiae, liquidambar formosana hance, fructus cnidii, fructus xanthii and tribulus terrestris as raw materials. The traditional Chinese medicine lotion is used for medicated bath of psoriasis; medicine can be absorbed through skin surface during the medicated bath. High concentration medicine active ingredients permeate the outside of cuticular cell membranes, folliculus pili, glandula sebacea, sweat duct orifices and the like gently and uniformly, and enter the body rapidly through systemic capillaries from the outside to the inside. The traditional Chinese medicine lotion has good effects for regulating of qi and blood, balancing yin and yang, dredging channels and collaterals, warming channels and expelling cold, dispelling wind and eliminating dampness, clearing heat and removing toxicity, reducing swelling and removing stasis, dredging collaterals and relieving itching, nourishing and promoting tissue regeneration, and detoxifying to remove spots.

The invention relates to the technical field of traditional Chinese medicine, in particular to sucrose-free psoriasis relieving granules and a quality detection method thereof. Due to the fact that in psoriasis relieving granules on the market at present, a large amount of sucrose is adopted as an auxiliary material, medicine selection of people suffering from hyperglycemia, hyperlipidemia and the like is limited, and application and popularization of the product are limited. The sucrose-free psoriasis relieving granules are prepared from, by weight, 182 parts of rhizoma rehmanniae, 92 parts of moutan bark, 92 parts of red peony roots, 92 parts of radix angelica sinensis, 92 parts of radix sophorae flavescentis, 92 parts of honeysuckle flowers, 92 parts of radix scrophulariae, 92 parts of fructus arctii, 46 parts of periostracum cicada, 92 parts of cortex dictamni, 46 parts of radix saposhnikoviae, 92 parts of folium isatidis, 46 parts of safflower, 450-600 parts of sucrose-free auxiliary materials and a non-sucrose flavoring agent; the sucrose-free granules are prepared according to the following method (please see the method in the description). The sucrose-free psoriasis relieving granules are a sucrose-free preparation and are good in dispersity and moisture resistance and suitable for being taken by psoriasis patients suffering from the hyperglycemia, the hyperlipidemia and the like, and convenience is provided for the psoriasis patients suffering from the hyperglycemia, the hyperlipidemia and the like. The invention further provides the quality detection method of the sucrose-free psoriasis relieving granules.

The present disclosure relates to methods for treating new-onset plaque-type psoriasis patients and inhibiting the progression of structural damage in these patients, using IL-17 antagonists, e.g., secukinumab. Also disclosed herein are uses of IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab, for treating new-onset plaque-type psoriasis patients, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

The invention discloses a natural skin repairing emulsion for psoriasis. The emulsion is composed of the following raw materials: caprylic / capric triglyceride, cetostearyl alcohol, silicone oil, synthetic squalane, glyceryl stearate, glycerol, coix seed oil and the balance of deionize water. The emulsion is composed of the following raw materials: 3-5% of caprylic / capric triglyceride, 3-5% of cetostearyl alcohol, 0.5-3% of silicone oil, 3-5% of synthetic squalane, 1-3.5% of glyceryl stearate, 4-8% of glycerol, 1.5-4.5% of coix seed oil and the balance of deionize water. The emulsion has a scientific and reasonable structure, is safe and convenient to use, can effectively relieve the rash severity of psoriasis patients, reduce PASI score, relieve pruritus, improve clinical manifestations such as dermatauxe and desquamation, and provides a new method for clinical psoriasis skin repair.

The invention relates to an externally applied medicine for the treatment of psoriasis, the psoriasis is a common chronic inflammatory skin disease and is characterized in that the epithelial cells are proliferated rapidly, thereby thickening the skin, the proliferation is similar to cancers, so the disease is also called the immortally cancer and the disease has no better treatment method at home and abroad till now. The invention provides a Chinese herbal medicine for the treatment of psoriasis, which is composed of munronia sinica, ruellia drymophila, wild red rice, stalagmite, ailanthus-like pricklyash bark, root of delavay dobinea, gaultheria yunnanensis, pseudostreblus indica bur., fruit of kwangsi dutchmanspipe and so on; the invention completely uses the Chinese herbal medicine components, and has no toxicity or side effects; furthermore, the invention has better efficacy for patients with different types of psoriasis, and the effective rate can achieve more than 98 percent.

The invention belongs to the technical field of biology, and relates to a gene marker and a detection kit for predicting the clinical efficacy of methotrexate in the treatment of psoriasis. A LCE3D SNP site rs4112788AG genotype is used as a gene marker for predicting that clinical efficacy of methotrexate in treating psoriasis. The relationship between the LCE3D SNP site rs4112788AG genotype and clinical efficacy of MTX in the treatment of psoriasis is studied. The results showed that rs4112788 genotype is related to clinical efficacy of MTX. The kit is provided to investigate the efficacy ofMTX therapy and the risk of hepatotoxicity in psoriasis patients with or without the rs4112788AG genotype at the LCE3D SNP locus, predict and evaluate the clinical efficacy of MTX in the treatment ofpsoriasis, thus guiding clinicians to formulate appropriate MTX treatment intervention program and providing a basis for improving the clinical efficacy of MTX.

The invention relates to application of arsenic trioxide in the preparation of psoriasis therapeutics. The invention is characterized in that the application refers to the use of arsenic trioxide as a main effective ingredient in the preparation of psoriasis therapeutics, including arsenic trioxide 0.01-2% by weight. The invention has the advantages that the composition is unique, the therapeutic effect is clear, good economy and safety are achieved, no significant toxic and side effect occurs, and the composition has the effects of activating blood to dredge collaterals, removing wind and evil, harmonizing ying and wei, and balancing yin and yang and is suitable for psoriasis patients to administer; clinical researches show that it is possible to significantly improve symptoms of the psoriasis patients, with 85.71% of total effective rate.

The invention discloses a traditional Chinese medicinal treatment liquid for treating erosive psoriasis, and belongs to the field of pharmacy. The traditional Chinese medicinal treatment liquid for treating erosive psoriasis is prepared through boiling 8-10% of fructus cnidii, 8-10% of Nux Vomica, 8% of radix paeoniae rubra, 7% of Amur Corktree Bark, 9% of Lithospermum erythrorhizon, 8% of Herba Schizonepetae, 7% of sophora flavescens, 6% of Divaricate Saposhnikovia Root, 9% of honeysuckle flower, 8% of unprocessed licorice root, 7% of radix bupleuri, 6% of Dictamnus dasycarpus and 7% of Atractylodes lancea in a proper amount of water. The treatment liquid has good efficacy of qi and blood regulating, yin and yang balancing, channel dredging, channel warming and cold dispelling, wind and dampness dispelling, heat clearing and detoxifying, swelling eliminating and blood stasis removing, vein relaxing and itch relieving, nutrition enhancing and tissue regeneration promoting, and toxin dispelling and speckle fading, and is specially used for externally washing erosive psoriasis patients.

The invention discloses a traditional Chinese medicinal oral liquid for treating erythra type psoriasis, and belongs to the field of pharmacy. The traditional Chinese medicinal oral liquid for treating erythra type psoriasis is prepared through boiling 9-11% of Radix Scutellariae, 8-10% of radix paeoniae rubra, 7% of Amur Corktree Bark, 5% of unprocessed rehmannia root, 6% of sophora flower, 6% of cortex moutan, 8% of Lithospermum erythrorhizon, 6% of Herba Schizonepetae, 7% of Radix Scrophulariae, 7% of Divaricate Saposhnikovia Root, 7% of honeysuckle flower, 7% of Chinese gall, 7% of Siberian Cocklour Fruit and 8% of Chinese angelica root in a proper amount of water. The oral liquid has good efficacy of qi and blood regulating, yin and yang balancing, channel dredging, channel warming and cold dispelling, wind and dampness dispelling, heat clearing and detoxifying, swelling eliminating and blood stasis removing, vein relaxing and itch relieving, nutrition enhancing and tissue regeneration promoting, and toxin dispelling and speckle fading, and is specially used for orally treating erythra type psoriasis patients.

The invention discloses a preparation method of a traditional Chinese medicine formula for treating psoriasis. The preparation method comprises the following steps: (1) weighing the medicine by weight; (2) cleaning and soaking the weighed medicine; (3) decocting the soaked medicine in a decocting pot; (4) decocting with strong fire to boiling and decocting with slow fire; (5) adding water for decocting twice after the completion of the decoction; (6) filtering out the medicine. The preparation method of the traditional Chinese medicine composition of the invention has specific steps and scientific rigorousness in the course of the operation, and after many years of experience, the prepared medicine has obvious effect on the treatment of psoriasis, and the selected raw materials are not toxic and free of side effects. The traditional Chinese medicine formula can be used for mild and severe psoriasis patients, and is wide in application range, scientific, simple in steps, and easy to operate.

Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis. The use of certain cell markers and mRNA levels as biomarkers to predict whether a psoriasis treatment is likely to be successful is also provided. Further, the expression of these genes or cell markers can be used to monitor progress of treatment effectiveness and patient compliance in psoriasis patients who are receiving treatment.

The invention relates to a psoriasis animal model and a construction method and application thereof. The construction method includes the step of carrying out imiquimod administration on the surface of animal skin to obtain the psoriasis animal model. The psoriasis animal model and the construction method and application thereof are used for animal skin for the first time to construct the psoriasis animal model; the psoriasis animal model is similar to a human psoriasis patient, and skin lesion symptoms of an administration part of the psoriasis animal model also comprise red inflammatory plaques with clear local boundaries of the skin, papules, squamous scurf or a layer of light red shiny semitransparent film and the like; after being scratched, small punctiform bleeding occurs; and the performance is highly similar to the performance of the patient, so that good clinical symptom simulation is achieved.

The invention provides a combined drug for treating psoriasis. The combined drug includes an anticholinergic drug and a sedative drug used in combination. According to the combined drug provided by the invention, the anticholinergic drug and the sedative drug are used according to a specific ratio, so that the treatment effect can be effectively enhanced, onset of psoriasis patients can be delayed, and the degree of skin damage to scalps, nails, hands and feet can be improved; the combined drug provided by the invention has little or no side effects and high safety; and at the same time, the combined drug provided by the invention can effectively treat the psoriasis, the effect is better than that of an anticholinergic drug scopolamine alone, so that results indicate that the drug providedby the invention has a synergistic effect when used in combination according to the specific ratio, and has a good clinical application prospect.

The invention belongs to the technical field of biology, and relates to a gene marker and a detection kit for the curative effect of a psoriasis drug. The invention provides an application of a site rs2292199 in preparation of a medicine for treating psoriasis, wherein the genotype of the rs2292199 is AG or AA. The invention also relates to a detection kit for predicting the clinical curative effect of methotrexate (MTX) on psoriasis, and the kit predicts the clinical curative effect of MTX by detecting the SNP site of the TMF1 of a psoriasis patient. Clinical doctors can be assisted in classifying psoriasis patients and selecting MTX treatment intervention schemes, and a basis is provided for improving the clinical curative effect of MTX.

The invention discloses a traditional Chinese medicine liniment for treating psoriasis. The traditional Chinese medicine liniment is characterized by consisting of the following raw materials by weight: 10-20g of divaricate saposhnikovia root, 10-20g of cortex dictamni, 10-20g of radish skin, 10-20g of pear peel, 5-15g of Chinese blister beetle, 5-15g of sulfur, 5-15g of borneol, 5-15g of resina draconis and 5-15g safflower. The traditional Chinese medicine liniment has the effects of clearing heat, cooling blood, nourishing blood and moistening skin and promoting blood circulation to remove meridian obstruction, and after being used by patients suffering from psoriasis, the traditional Chinese medicine liniment can rapidly repair skin disease damage and activate cell tissue regeneration capacity, is exact in curative effect and fast in effectiveness and does not have toxic or side effect.

A method for predicting maintenance of response to IL-23 antibody therapy and treating a patient having psoriasis with extended dosing intervals after measuring at least one indicator from psoriasis patients before and during treatment with an IL-23 antibody is useful in the treatment of psoriasis.

The invention provides a method and a detection kit for identifying a psoriasis biomarker. The biomarker is a ratio of free glucose to free mannose, wherein the free glucose and the free mannose are obtained by subjecting serum to pre-column 3-methyl-1-phenyl-2-pyrazolin-5-one (PMP) derivatization high-performance liquid chromatography. A detection method is a pre-column PMP derivatization high-performance liquid chromatography. According to the technical scheme, the method and the detection kit for identifying the psoriasis biomarker have the advantages that the pre-treatment is simple, the analysis time is short, the instrument price is reasonable, the conventional use is met, the operation steps are simple and easy to learn, the detection result is high in accuracy, a normal person anda psoriasis patient can be distinguished by just blood sampling, moreover, the required serum amount is very few, the amount of sampled blood is less than 1 mL, and the like. An obtained result showsthat by means of the analysis method, the free mannose and the free glucose in the serum of the psoriasis patient can be fast quantified, so that the method and the detection kit for identifying the psoriasis biomarker have significant meaning in studying a relation between free glucose and the free mannose in the serum and psoriasis and finding a novel psoriasis clinical detection marker.

The invention discloses a traditional Chinese medicine composition for treating psoriasis. The traditional Chinese medicine composition is prepared from the following materials in parts by weight: 15-20 parts of radix scutellariae, 15-20 parts of poria cocos, 10-15 parts of rhizoma bletillae, 10-15 parts of cortex dictamni, 8-12 parts of Chinese lobelia, 8-12 parts of cortex lycii radicis, 6-10 parts of geranium wilfordii, 6-10 parts of caulis sinomenii, 5-10 parts of Chinese violet and 5-10 parts of notopterygium root. The traditional Chinese medicine composition disclosed by the invention can effectively relieve the illness state of a psoriasis patient, is short in course of treatment, can radically treat psoriasis, is high in cure rate, free of relapse, safe and free of toxic and side effects.

The invention relates to the technical field of medical auxiliary tools, and discloses an ointment wiping device for psoriasis treatment. The ointment wiping device comprises a supporting frame, a horizontal supporting plate, an ointment outlet pipe, balls, a controller and an intelligent mobile terminal, wherein the horizontal supporting plate can move in the longitudinal direction of a moving device; a first ointment extruding device is arranged in the ointment outlet pipe and used for extruding the ointment outlet pipe, and the first ointment extruding device comprises a limiting sleeve and an extruding sleeve; the ointment outlet pipe is provided with a groove seam in the height direction; one end of a first connecting rod extends into the groove seam to be fixedly connected with the extruding sleeve, the other end of the first connecting rod is detachably connected with a lifting device camera, and the first connecting rod is arranged at the bottom of the horizontal supporting plate; the controller is arranged on the horizontal supporting plate, and the supporting frame, the lifting device and the camera are in signal connection with the controller; and the intelligent mobile terminal is in wireless communication with the controller. By means of the ointment wiping device for psoriasis treatment, a psoriasis patient can wipe ointment by himself / herself, time and labor are saved, and the disease pain of the psoriasis patient is relieved.

The invention relates to an external Chinese medicinal composition for treating psoriasis, which consists of the following raw materials in part by weight: 25 to 30 parts of bitter almond kernel, 25 to 30 parts of chaulmoogratree, 8 to 10 parts of croton seed, 0.3 to 0.5 part of blister beetle, and 0.3 to 0.5 part of hydrargyri oxydum rubrum. The raw materials are ground into fine powder together by weight and uniformly mixed with sesame oil for external use. The composition has the advantages of simple treatment method, convenient medication, obvious medicinal effect, no side effects, short treatment course, and complete eradication; and clinical observation of 2,000 psoriasis patients proves that the composition has a cure rate of 92 percent, and prevents relapse.

The invention discloses a traditional Chinese medicine compound for treating psoriasis. The traditional Chinese medicine compound comprises 5-15 parts of ossa draconis, 5-20 parts of oyster, 5-10 parts of flos sophorae, 3-18 parts of lithospermum, 2-16 parts of radix rehmanniae, 5-18 parts of rhizoma smilacis glabrae, 4-16 parts of honeysuckle flowers, 10-30 parts of liquorice, salivia chinensis, periostracum cicada and ligusticum wallichii, wherein the honeysuckle flowers are selected from tree-type four-season honeysuckle flowers. The traditional Chinese medicine compound provided by the invention is free from adverse reaction in a use process and is effective in treating psoriasis; the selected medicine raw materials are not toxic to each other; both mild and serious psoriasis patients can take the traditional Chinese medicine compound; the application scope is wide; erythema and scale on the skin can be eliminated; internal heat of body can be eliminated; the psychosis can be improved.