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3 results about "ADAMTS" patented technology
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ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13.
Prodrugs of adamts inhibitors, methods of making and medical uses thereof
Disclosed are compounds of Formula (I) useful as inhibitors of ADAMTS-5 and / or ADAMTS-4, pharmaceutical compositions thereof, and their use as therapeutic agents for the treatment of diseases involving cartilage degradation or destruction of cartilage homeostasis, in particular osteoarthritis and / or rheumatoid arthritis.
Owner:JIANGSU HENGRUI MEDICINE CO LTD
Immunogenic peptide fragments of metalloprotease ADAMTS-7 and uses thereof in anti-atherosclerosis and related diseases
ActiveUS12599654B2Peptide/protein ingredientsVertebrate antigen ingredientsDiseaseImmunogenic peptide
Immunogenic peptide fragments of metalloprotease ADAMTS-7 including a first short peptide, which is any one of the followings: a short peptide having the amino acid sequence shown in SEQ ID NO: 1 in the sequence listing; a short peptide having the amino acid sequence shown in SEQ ID NO: 2 in the sequence listing; a short peptide having the amino acid sequence shown in SEQ ID NO: 3 in the sequence listing; a short peptide having the amino acid sequence shown in SEQ ID NO: 4 in the sequence listing. The description includes uses of conjugates containing the above short peptides and vaccines containing the conjugates. The vaccines containing the short peptides can remarkably inhibit the intimal neogenesis in the vascular restenosis mouse models and the occurrence of atherosclerosis in high-fat-fed mice, and can be used for the prevention or treatment of atherosclerosis and / or vascular restenosis.
Owner:BEIJING KIMWAY BIOTECH CO LTD
Method and kit for detecting ADAMTS13 activity and inhibitor
PendingCN122042973AMicrobiological testing/measurementColor/spectral properties measurementsAdamts13 activityPre-dialysis
The invention discloses a method for detecting the activity of ADAMTS13, a method for detecting an ADAMTS13 inhibitor and a kit. The method comprises the following steps: exposing a VWF restriction enzyme cutting site through urea by adopting an ELISA (Enzyme-Linked Immunosorbent Assay) combined dialysis technology, cutting VWF by utilizing ADAMTS13, separating large and small molecule VWF through dialysis, finally detecting the absorbance ratio of the VWF before and after dialysis through the ELISA, and calculating the activity or inhibitor state of ADAMTS13. The method provided by the invention has the advantages of strong specificity, high sensitivity and good repeatability, and is suitable for large-scale sample detection.
Owner:HANGZHOU ADICON CLINICAL LAB INC