44 results about "Imidazolidine" patented technology

The invention belongs to the technical field of preparation of compounds, and discloses high-purity 2-imidazolidinone and a preparation method thereof. The preparation method of the high-purity 2-imidazolidinone comprises the following steps: reacting ethylenediamine, dimethyl carbonate and an ionic liquid catalyst to obtain primary 2-imidazolidinone; mixing the obtained primary 2-imidazolidinone with dimethyl carbonate, and filtering to obtain high-purity 2-imidazolidinone; the ionic liquid catalyst is chloridized 1-butyl-3-methylimidazole, brominated 1-butyl-3-methylimidazole, chloridized 1-ethyl-3-methylimidazole, brominated 1-ethyl-3-methylimidazole, 1-butyl-3-methylimidazole tetrafluoroborate or 1-ethyl-3-methylimidazole tetrafluoroborate, and the ionic liquid catalyst is an ionic liquid catalyst which is chloridized 1-butyl-3-methylimidazole, brominated 1-ethyl-3-methylimidazole, brominated 1-ethyl-3-methylimidazole tetrafluoroborate or 1-ethyl-3-methylimidazole tetrafluoroborate. According to the preparation method of the high-purity 2-imidazolidinone, a small amount of high-boiling-point byproducts such as MI and NMI and a dimethyl carbonate solution are further treated, and the target product MI with high purity is obtained.

The present application relates to fine chemicals, and in particular to a method for preparing 2-imidazolidinone by using carbon dioxide. The method comprises reacting CO2 and ethylenediamine in the presence of inorganic sulfide to obtain 2-imidazolidinone. The method uses cheap and readily available sulfur-containing compounds as catalysts for activating CO2 for the first time, and converts ethylenediamine and CO2 into 2-imidazolidinone under relatively low temperature and supercritical conditions. Compared with the prior art, the reaction conditions of the present application are more simple and controllable, and do not require expensive and complex catalysts for post-processing, have the advantages of low energy consumption and low cost, and have extremely high popularization and application value.

The present invention relates to 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, a method for producing the same, and a composition for prevention, improvement or treatment of neurodegenerative disease containing the same. Specifically, 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, which are novel compounds of the present invention, can be used as an excellent composition for prevention, improvement or treatment of neurodegenerative disease.

The invention belongs to the technical field of organic matter preparation, and discloses 1, 3-dimethyl-2-imidazolinone and a green synthesis method thereof. The synthesis method comprises the following steps: in a carbon dioxide atmosphere, mixing methanol with a catalyst, reacting to obtain dimethyl carbonate, mixing cesium carbonate, ethylenediamine and methanol, introducing carbon dioxide, reacting to obtain 2-imidazolidinone, and reacting dimethyl carbonate, 2-imidazolidinone and the catalyst to obtain 1, 3-dimethyl-2-imidazolidinone. The raw materials in the whole technological process are in closed circulation, circular economy is achieved to the maximum extent, and the method is a green and environment-friendly synthesis process.

To provide a composite gas adsorbent, a method for producing the composite gas adsorbent, a deodorizing filter, and an air purifier, which are capable of removing, in a well-balanced manner and rapidly, a composite gas containing more than one of aldehyde odor substances, basic odor substances, acidic odor substances and volatile organic compounds existing in the environment.SOLUTION: A composite gas adsorbent comprises activated carbon, where 3-30 mass% of 2-imidazolidinone and 3-30 mass% of phosphoric acid are supported on the activated carbon, and potassium is contained in an amount of 0.1 mass fraction% or more. The adsorbent has an acetone equilibrium adsorption performance of 12.0 mass fraction% or more, measured using acetone at a concentration of 37.5 g / m3 in conformity with JIS K 1474 (2014). The adsorbent has adsorption performance with respect to a composite gas containing more than one aldehyde odor substances, basic odor substances, acidic odor substances and volatile organic compounds.SELECTED DRAWING: None

The invention discloses an application of a tetrahydropyridopyrimidinone compound with a structural characteristic shown in a formula (I) or pharmaceutically acceptable salt, hydrate or crystal form thereof in treatment of human casein lyase (HsClpP) mediated diseases, and belongs to the field of chemical medicines. The technical problem to be solved by the invention is to provide the tetrahydropyridinopyrimidinone compound. The imidazolidine derivative is characterized by having a tetrahydropyridinopyrimidinone skeleton structure, and nitrogen atoms on an imidazolidine ring are connected with other substituent groups. The compounds have obvious activity of regulating and controlling HsClpP, and can be used for treating HsClpP-mediated related diseases.

The application discloses a kind of MVR coupling multi-effect rectification imidacloprid wastewater resource recovery method and device, including light tower, heavy tower, rectification tower, MVR compressor, MVR falling film reboiler and MVR distilled water tank, after heating, the pesticide wastewater raw material liquid from production workshop enters light tower, after decompression separation in light tower, light component material dichloroethane and methanol obtained at the top of light tower are pumped to plant area recovery system;After light removal by light tower, the liquid is pumped to heavy tower heating and is separated by flash evaporation;Heavy tower produces water vapor, after compression, the enthalpy is increased, and then it is used as heat source to return to the reboiler of heavy tower to heat the circulating liquid, after distillation and concentration, the heavy component liquid is pumped into the rectification tower and is distilled under reduced pressure, after rectification, DMF and a small part of water vapor are pumped to plant area recovery system production line for reuse, and the remaining mother liquor enriched imidazolidine is recovered after cooling.The device can reduce the heat transfer end difference, reduce energy consumption, and realize multi-effect rectification pesticide production wastewater resource recovery.

The present application relates to compositions and methods for the preparation of a spray dried amorphous solid dispersion comprising 5-{3-[4-(3-methyl-benzyloxy) thiophenyl] furan-2-yl} imidazolidine-2, 4-dione and hydroxypropyl beta-cyclodextrin. In particular, the present application relates to an improved spray drying process for producing amorphous solid dispersions with enhanced performance by using a co-solvent system and / or an antioxidant.

The present disclosure relates to a 2-substituted imidazolidine derivative containing an aryl bipyridyloxy structure, and a preparation method and use thereof, which is obtained by the reaction of 2-substituted imidazolidine and aryl bipyridyloxy compound. The 2-substituted imidazolidine derivative containing an aryl bipyridyloxy structure has a good insecticidal effect on harmful insects, and the compound can be used to prepare insecticides in the fields of agriculture, horticulture, etc.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-imidazolidinone and a catalyst used in the preparation method. The invention discloses a preparation method of a sulfonic acid functionalized ionic liquid catalyst. The preparation method comprises the following steps: (1) synthesis of a PMO carrier; (2) sulfonic acid functionalization: preparing a sulfonic acid functionalized material SMO-SO3H by using a PMO carrier; and (3) immobilizing and activating the ionic liquid to obtain the sulfonic acid functionalized ionic liquid catalyst (SMO-IL). The invention also discloses a method for efficiently and greenly preparing 2-imidazolidinone by taking ethylene carbonate and urea as raw materials under the action of the self-made catalyst.

The application discloses a thioimidazolidinone compound based on a microwave-assisted method and a preparation method and application thereof, and belongs to the technical field of compound preparation. The application solves the problems of the traditional synthesis method of the thioimidazolidinone compound, such as the use of toxic solvents, low yield, long time, and many by-products. The application uses alpha-amino acid as raw material, uses water as solvent, uses the thermal effect induced by the microwave field to shorten the reaction time from several hours to minutes, successfully synthesizes the thioimidazolidinone compound, and uses phase transfer catalyst to improve the reaction rate and yield. The application avoids the use of toxic solvents such as DMF, reduces the reaction time, and the product yield is more than 95%. In addition, the thioimidazolidinone compound can be used as a corrosion inhibitor alone, and can be used in combination with a surfactant and / or a synergist, and has excellent corrosion inhibition effect; the thioimidazolidinone compound can also be used in the fields of medicine, pesticide, material synthesis and fine chemical industry, and has wide application scenarios.

To provide a water-discoloring composition which develops a color by contact with water, has a high color density in color development, does not form a deposit even in a room temperature environment, has a low viscosity, and is practically easy to handle, and to provide an applicator housing the same.SOLUTION: The water-discoloring composition contains at least an electron-donating color-developing organic compound, an electron-accepting compound, and a specific amide compound and / or a specific imidazolidinone compound, and the applicator contains the composition.SELECTED DRAWING: None

The invention discloses a salt-resistant emulsion type fracturing fluid densifier and a preparation process thereof, and relates to the technical field of densifiers, the salt-resistant emulsion type fracturing fluid densifier is prepared from the following components: 2-methyl-N-[2-(2-oxo-1-imidazolidinyl) ethyl]-2-acrylamide, 3-[N, N-dimethyl formamide, 2-(2-oxo-1-imidazolidinyl) ethyl]-2-acrylamide, 2-(2-oxo-1-imidazolidinyl) ethyl The invention relates to a water-based paint which is prepared from N, N-dimethyl-[2-(2-methylpropyl-2-enoyloxy) ethyl] ammonium] propane-1-sulfonic acid inner salt, N-vinyl caprolactam, perfluorooctyl ethyl acrylate, a cross-linking monomer, an oil phase system, a compound emulsifier, an initiating system, a nano reinforced phase, a chelating agent and deionized water. The salt-resistant emulsion type fracturing fluid thickening agent can still keep stable viscosity under high-temperature and high-salt conditions, and the preparation process is simple.

The invention relates to the field of lithium ion batteries, and discloses a non-aqueous electrolyte, a lithium battery and electric equipment. Three additives including the N-sulfonyl substituted 2-imidazolidinone derivative, the sulfur-containing compound and the trimethyl phosphite are added into the non-aqueous electrolyte, the three additives generate a synergistic effect, volume expansion of a silicon-based negative electrode is inhibited, excessive decomposition of the electrolyte is avoided, consumption of active lithium and excessive generation of an SEI film are slowed down, and the service life of the non-aqueous electrolyte is prolonged. Therefore, the comprehensive performance of the silicon-based negative electrode lithium ion battery is improved. From the non-aqueous electrolyte formula optimization direction, a series of problems of interface damage and the like caused by volume expansion of the silicon-based negative electrode are improved by a simple, economical and effective method, and the application range of the silicon-based negative electrode lithium battery is widened.

The invention relates to the technical field of modified polyurethane composite materials, and particularly discloses a flame-retardant polyurethane ionic gel material and a preparation method thereof.The flame-retardant polyurethane ionic gel material is prepared from, by mass, tetrafluoroboric acid ionic liquid, diethyl aluminum hypophosphite, piperazine pyrophosphate, polycaprolactone, polypropylene glycol, isophorone diisocyanate and imidazolidinyl urea. The mass percentage of the polycaprolactone is 20%, the mass percentage of the polypropylene glycol is 18.5%, the mass percentage of the isophorone diisocyanate is 2.0-3.0%, the mass percentage of the imidazolidinyl urea is 3.0-4.0%, the mass percentage of the aluminum diethylhypophosphite is 7.0%, the mass percentage of the piperazine pyrophosphate is 7.0%, and the mass percentage of the tetrafluoroboric acid ionic liquid is 40.0%. The ionic gel based on flame retardant polyurethane disclosed by the invention has excellent flame retardant property.

The application relates to a synthesis method for constructing 2,4-imidazolidinedione compounds in a DNA coding compound library. The method takes 2-amino-N-acetamide compounds of On-DNA and p-nitrophenyl chloroformate as raw materials, reacts under the action of alkali, and obtains 2,4-imidazolidinedione compounds. The method has the advantages of mild reaction condition, simple operation, good substrate universality, good product yield and suitability for DNA coding compound synthesis in a multi-well plate.

The invention provides a preparation method of a chiral imidazolidine compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixing an (S)-N-tert-butylimine compound # imgabs0 #, a dipole precursor # imgabs1 # and a photocatalyst such as tris (2-phenylpyridine) iridium in an organic solvent under the protection of inert gas, and carrying out asymmetric [3 + 2] cycloaddition reaction under illumination to obtain the chiral imidazolidine compound. The method for synthesizing the chiral imidazolidine compound through iridium / blue light concerted catalysis is constructed by taking a cheap photocatalyst as a catalyst, and has the advantages of mild conditions, wide substrate applicability, high economic benefits and the like.

An imidazolidinylide compound for use as a shut-down additive for a lithium-ion battery. The imidazolidinylide compound has a formula (I),wherein, R1 to R4, each independently the other, is a linear C1- to C16-alkyl group, a branched C1- to C16-alkyl group, a C2- to C16-alkenyl group, a C3- to C8-cycloalkyl group, or a C3- to C16-arene group, wherein at least one of R2 and R3 may also be H, R1 to R4, each independently of the other, is completely, partially or not fluorinated, and R1 to R3 may each also contain O as a heteroatom.

Method for obtaining 3-(n-tolyl)-5,6-dihydroimidase[2,1-b][1,3]thiazole involves the reaction of imidazolidine-2-thione with α-bromoacetophenone. Starting imidazolidine-2-thione is dissolved in ethanol, and α-bromoacetophenone is added. Then reaction mixture is boiled for 4 hours without catalyst. After the reaction is complete, solvent is removed, solid residue is dissolved in 30 mL of acetone, neutralized with aqueous solution of NaHCO₃ , and extracted with chloroform three times in 10-mL portions. The combined organic phases are dried over Na₂ SO₄ and evaporated to obtain the target product, which is identified as 3-(n-tolyl)-5,6-dihydroimidase[2,1-b][1,3]thiazole.

The present application relates to compositions and methods in preparation of spray dried amorphous solid dispersion comprising 5-{3-[4-(3-methyl-benzyloxy) phenylthio]fur-2-yl}imidazolidine-2, 4-dione and hydroxypropyl beta-cyclodextrin. In particular, the present application relates to an improved spray drying method for producing amorphous solid dispersions with enhanced properties by the use of a co-solvent system and / or an antioxidant.

This invention provides a water-color-changing material, a water-color-changing indicator, and a colorant that develop color upon contact with water, exhibiting a deep color when colored, showing good color development even with a small amount of water, and maintaining its color over time. [Solution] A water-color-changing material, a water-color-changing indicator, and a colorant comprising a porous material containing a water-color-changing composition comprising an electron-donating chromogenic organic compound, an electron-accepting compound, and an amide compound and / or an imidazolidinone compound. Furthermore, the amide compound may be an amide compound of a specific structure, and the imidazolidinone compound may be an imidazolidinone compound of a specific structure.

A compound 5-(3-bromophenyl)-3-((diethylamino)methyl)-5-methylimidazolidine-2,4-dione, its synthesis, use as an antibacterial agent and an inhibitor of Chronic Obstructive Pulmonary Disease (COPD).

The present invention relates to process for preparation of Form I polymorph of 1-[(6-chloro-3-pyridyl) methyl]-N-nitroimidazolidin-2-ylideneamine (imidacloprid). In particular the present invention relates to process for preparation of Form I of imidacloprid containing dimer impurity≤0.5%.

The invention discloses a polyurethane coating as well as a preparation method and application thereof. The invention relates to a polyurethane coating, which is prepared from the following raw materials according to the following solid-to-liquid ratio: a solvent, polyethylene glycol 2000, polycaprolactone glycol 2000, isophorone diisocyanate, a catalyst, a trans-4, 5-dihydroxy-1, 2-disulfane solution, an imidazolidinyl urea solution and a chain extender according to the solid-to-liquid ratio of (10 to 40): (1 to 2) g: (4 to 5) g: (1 to 5): (0.01 to 1): (5.20 to 7): (20 to 40): (2 to 10). The oil-water separation membrane prepared by adopting the polyurethane coating disclosed by the invention is a super-hydrophilic oil-water separation membrane, integrates strong adhesive force to a substrate, high mechanical property of a coating and dual protection and oil stain resistance, and can be used for large-scale long-term use of an oil-water separation material under severe conditions.

The invention relates to the technical field of olefin polymerization catalysts, and provides a compound system loaded with a 2-imidazolidinone compound as well as a preparation method and application of the compound system. The catalyst component contains an inorganic oxide and an active component, the active component is a reaction product of titanium halide, magnesium halide, a 2-imidazolidinone compound and an electron donor compound, based on the total weight of the catalyst component, the content of the inorganic oxide is 5-50 wt%, and the content of the active component is 50-95 wt%. The catalyst component is loaded on an inorganic oxide, a high-dispersity catalyst component can be obtained, the catalyst component can be used for olefin polymerization reaction, and the prepared polymer has high melt index and low hexane extract.

The present invention relates to pyrrolidine and imidazolidine derivatives and their use in the treatment and prevention of cancer, as well as compositions containing said derivatives and their preparation.

The invention discloses a thioimidazolidinone compound based on a microwave-assisted method as well as a preparation method and application of the thioimidazolidinone compound, and belongs to the technical field of compound preparation. The invention solves the problems of toxic solvent use, low yield, long time, more byproducts and the like in the traditional synthesis method of the thioimidazolidinone compound. According to the method, alpha-amino acid is taken as a raw material, water is taken as a solvent, the reaction time is shortened from several hours to minute level by utilizing the microwave field induced heat effect, the thioimidazolidinone compound is successfully synthesized, and the reaction rate and the yield are improved by adopting the phase transfer catalyst. The use of toxic solvents such as DMF (Dimethyl Formamide) is avoided, the reaction time is shortened, and the product yield exceeds 95%. Besides, the thioimidazolidinone compound can be independently used as a corrosion inhibitor and can also be compounded with a surfactant and / or a synergistic agent for use, and the corrosion inhibition effect is excellent; the thioimidazolidinone compound can also be used in the fields of medicines, pesticides, material synthesis and fine chemical engineering, and has wide application scenarios.

An improved process for the preparation of Ipatasertib is described, which is achieved by efficient preparation of its intermediate 1-(4-chlorophenyl)imidazolidine-2,4-dione followed by condensation reaction with morpholine in the presence of ammonium chloride. In particular, the present invention relates to a process for the preparation of Ipatasertib by using a continuous process for distillation, drying and recycling of the dried morpholine back to the reactor to remove water produced in the reaction, thus providing Ipatasertib in high yield. More particularly, the present invention relates to a process for providing Ipatasertib in very high purity by simple washing with toluene and water. More particularly, the present invention relates to a process for industrial application scale, economically efficient.

A composition having a pH in a range of 1 to 6, containing hydrogen peroxide, and one or more compounds selected from orthodiphenols, imidazolidin-2,4-diones, and salts thereof. The orthodiphenols have the following general structure:where R1, R2, and R3 are independently selected from H, OH, halogen, C1-C12 linear or branched alkyl or alkenyl, O—X, NO2, COOH, SO3H, aryl, and heteroaryl, and X is a C1-C12 linear or branched alkyl. The imidazolidin-2,4-diones have the following general structure:where R4, R5, and R6 are independently selected from H, OH, halogen, C1-C12 linear or branched alkyl or alkenyl, O—X, COOH, phenyl, diphenyl, ureyl, and X is a C1-C12 linear or branched alkyl.

The invention discloses a dioxoimidazolidine locally acting androgen receptor antagonist. The androgen receptor antagonist is a compound as shown in a formula I, or a stereoisomer of the compound, or a pharmaceutically acceptable salt of the compound. The compound provided by the invention is relatively good in skin stability and slow in metabolism, plays a role in resisting androgen alopecia, but is extremely poor in stability in plasma, so that systemic androgen antagonism side effects caused by systemic distribution are avoided. Meanwhile, the compound provided by the invention has relatively high skin retention volume in a rat in-vitro skin transdermal test. # imgabs0 #