35results about How to "Achieve healing" patented technology

The invention provides a lipidosome, a preparation method thereof and application of the lipidosome in preparation of a medicine for treating PARP inhibitor-resistant breast cancer, and relates to the technical field of biology. The preparation method of the liposome provided by the invention comprises the following steps: under a stirring condition, injecting an ethanol solution dissolved with soybean phospholipid and cholesterol into a histidine aqueous solution for hydration, volatilizing an ethanol component after the hydration is finished, and carrying out ultrasonic treatment to prepare the liposome. The preparation method is simple and convenient, and the prepared liposome loaded with histidine is high in encapsulation efficiency. The research of the inventor finds that histidine metabolism reprogramming occurs in the PARPi resistance process of breast cancer cells, so that DNA synthesis repair is maintained. And after the PARPi-resistant breast cancer cells are treated by adopting the liposome disclosed by the invention, the histidine content in the breast cancer cells can be increased, so that the PARPi-resistant cells are sensitive to PARPi, and further the treatment on the PARPi-resistant breast cancer is realized.

The invention belongs to the technical field of biomedicine, and particularly relates to an iridium and chromium co-doped long afterglow nano material as well as a preparation method and application thereof. The iridium and chromium co-doped zinc gallium germanate long-afterglow nano-material is a iridium and chromium co-doped zinc gallium germanate long-afterglow nano-material, the molecular formula of the iridium and chromium co-doped zinc gallium germanate long-afterglow nano-material is Zn1. 3Ga1. 6Ge0. 1O4: Cr 0.0075, and Ir 0.05, and the invention provides a preparation method of the iridium and chromium co-doped zinc gallium germanate long-afterglow nano-material. The iridium and chromium co-doped long afterglow nano material has afterglow imaging capability, peroxidase-like activity and photothermal conversion potential, can realize cell imaging and photothermal imaging of tumors after being used, and has the potential of realizing tumor treatment. In addition, in the electro-catalytic reaction, the iridium and chromium co-doped long afterglow nano material improves the oxygen evolution reaction of the electrode under the light irradiation condition.

The invention belongs to the technical field of biological medicine, and particularly relates to application of SAAL1 as a prognosis evaluation marker and a drug target of neuroblastoma. The invention provides a series of applications of SAAL1 as a neuroblastoma drug target, including prognosis, treatment and other aspects of neuroblastoma. The invention proves that the NB tumor staging and risk level grading of the high-expression SAAL1 gene are high, the survival time of a child patient is short, and the SAAL1 gene can be used as a neuroblastoma prognosis molecule. In a human neuroblastoma cell line, cell proliferation can be inhibited by knocking down the SAAL1, which indicates that the SAAL1 can be used as a therapeutic target of the neuroblastoma. According to the invention, NB risk level grading can be realized from a molecular level, NB treatment can be realized by targeting the SAAL1 gene, and clinical doctors can be assisted in prognosis judgment and targeted treatment of NB.

The invention discloses a microneedle patch loaded with a sorafenib and copper-doped Prussian blue nano material and application of the microneedle patch in in-situ triple-negative breast cancer treatment. The sorafenib and the copper-doped Prussian blue nano material are loaded in a needle body of the microneedle patch. The microneedle patch can accurately deliver nanoparticles and sorafenib to tumor tissues, the chemical kinetics effect is enhanced through an efficient and mild photothermal therapy, the ferroptosis of triple negative breast cancer cells is enhanced through ferroptosis induced by the nanoparticles and sorafenib in cooperation with drugs, then cell death is induced, and the curative effect is improved. And a brand-new and promising treatment method is provided for in-situ triple-negative breast cancer treatment.

According to the chitosan-coated gamma-cyclodextrin metal organic framework delivery system and the preparation method and application thereof, hippophae rhamnoides polyphenol serving as an active component is efficiently loaded through a hydrophobic cavity of the chitosan-coated gamma-cyclodextrin metal organic framework delivery system, and encapsulation and release of the hippophae rhamnoides polyphenol can be achieved through the hydrophilic surface of the chitosan-coated gamma-cyclodextrin metal organic framework delivery system; chitosan is adopted as a protective layer to coat the cyclodextrin metal organic framework and the sea-buckthorn polyphenol, so that the carrier and the active components are prevented from being damaged by gastric acid and small intestine digestive enzymes, and the sea-buckthorn polyphenol can be accurately positioned to the colon part through the targeted positioning effect of the chitosan, so that the treatment on the colitis is realized, and the treatment effect is good. The invention provides a more effective and safer inflammation treatment means.

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

The invention discloses a preparation method and application of gold-modified cerium oxide drug-loaded nanoparticles, and the preparation method comprises the following steps: dispersing soluble cerium salt in an ethylene glycol solution of a template agent, adjusting the pH value to 5-7, then carrying out a hydrothermal reaction to obtain cerium oxide nanoparticles, then dispersing the cerium oxide nanoparticles in ultrapure water, and carrying out ultrasonic treatment to obtain the gold-modified cerium oxide drug-loaded nanoparticles. And adding gold tetrachlorate into the dispersion system, adjusting the pH value to 7-11 to obtain gold-modified cerium oxide nano-microspheres, and loading chemotherapeutic drugs to obtain the gold-modified cerium oxide drug-loaded nano-microspheres. The obtained gold-modified cerium oxide drug-loaded nano-microspheres have the advantages of multiple enzyme activities, good biocompatibility, excellent antibacterial performance and excellent photo-thermal performance, can relieve an anoxic environment in tumor treatment, consume GSH, overcome tumor drug resistance and the like, and have good application prospects in the field of tumor treatment.

The present invention discloses a wearable electrical stimulation treatment device for promoting periodontal tissue remodeling, comprising a brace, wherein an electrode portion is provided at the gum contact portion of the brace, and a piezoelectric portion is provided at the tooth surface contact portion of the brace, wherein the electrode portion and the piezoelectric portion are connected via a metal wire embedded inside the brace. The invention provides a wearable electrical stimulation treatment device for promoting periodontal tissue remodeling, which can not only achieve maintenance treatment for periodontitis patients, but also accelerate orthodontic tooth movement. The present invention has high sensitivity during use, good stability and stretchability, and is low in price, simple to operate, safe and non-toxic. Patients can treat themselves at home, and it is easy to achieve large-scale industrial production, and is suitable for the field of scalable biomedical electronics.

The invention relates to a Nile red-based photosensitizer as well as preparation and application thereof, and develops a series of Nile red-based photosensitizers, the structural formula of which is as follows: # imgabs0. By changing the electron donating ability of a donor, the Nile red-based photosensitizers not only have profound influence on the structure of the photosensitizers, but also have important significance on active oxygen generation of the photosensitizers. The NTPA disclosed by the invention has ultrahigh active oxygen generation capacity, has huge potential of resisting multiple drug-resistant bacteria and promoting healing of subcutaneous abscess wounds, and shows the most excellent photodynamic therapy performance. The yield of active oxygen can exceed 470 times within 5 minutes under the irradiation of white light, the NTPA nanoparticles (NPs) show extremely high killing capacity on various drug-resistant bacteria in vitro, the in-vitro bacteriostasis rate can reach 99.9%, and the NTPA nanoparticles also show excellent sterilization and wound healing promoting capacity on the living body level and have huge application prospects.

The invention discloses a hydrogen sulfide responsive carbon monoxide donor molecule as well as a preparation method and application thereof. The hydrogen sulfide responsive carbon monoxide donor molecule has the following structure: # imgabs 0 #, R1, R2, R3 and R4 are respectively and independently selected from groups with electron withdrawing property, groups with electron donating property or hydrogen atoms, and X is selected from O or # imgabs 1 #. Acyloxydiene-Fe (CO) 3 is selected as an element for releasing carbon monoxide and an azido group is selected as a hydrogen sulfide response element, so that the formed donor molecule has hydrogen sulfide responsiveness and can release carbon monoxide in the presence of hydrogen sulfide, and the hydrogen sulfide response rate and the release rate of carbon monoxide of the donor material can be adjusted; therefore, the treatment on the colitis and the inhibition on the colorectal cancer can be realized.

The invention discloses a gallium-indium alloy nano dispersion system, preparation thereof and application of the gallium-indium alloy nano dispersion system in radio frequency sensibilization, and belongs to the cross technical field of chemistry, medicine and other subjects. Raw materials of the gallium-indium alloy nanometer dispersion system comprise gold nanoparticles prepared by a glutathione reduction method and nanometer liquid drops obtained after ultrasonic treatment of liquid metal gallium-indium alloy, and electrochemical replacement occurs in the process that the gold nanoparticles prepared by the glutathione reduction method make contact with the liquid metal nanometer liquid drops. And adsorbing on the surface of the nano liquid drop of the liquid metal gallium-indium alloy after ultrasonic treatment. The gallium-indium alloy nano dispersion system can generate various reactive oxygen free radicals under the action of radio-frequency electromagnetic waves, enables the temperature of an irradiated part to rise quickly, cooperatively kills tumor cells, activates whole-body anti-tumor immune response, and effectively inhibits tumor recurrence and metastasis. The gold nanoparticles not only can significantly improve the stability of the nano-dispersion, but also endow the nano-dispersion with catalase activity, and further enhance the antitumor activity of the nano-dispersion.

The present invention provides a biological preparation for accelerating the repair of bone damage, and belongs to the field of medical technology. The core active ingredient of the biological preparation is the natural polypeptide Ocellatin-1. The key to the present invention is to find that Ocellatin-1 can effectively reduce the inhibitory effect of glucocorticoids on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, so that it can be prepared into a biological preparation for inhibiting osteoporosis and accelerating the repair of bone damage in patients. Experimental results show that within the concentration range of 1-500μg / ml, Ocellatin-1 has no obvious toxicity to cells, and at 10μg / ml, it can restore the cell proliferation and osteogenic differentiation functions inhibited by dexamethasone to the best extent. Therefore, the present invention provides a new, efficient and safe treatment approach for patients with osteoporosis, and has broad application prospects.

The invention provides a corona discharge shock wave balloon catheter which comprises an inner tube, a balloon is arranged outside the inner tube, and conductive liquid is arranged between the inner tube and the balloon. The positive electrode cable is arranged along the outer wall of the inner pipe, and at least one positive electrode is arranged on the positive electrode cable; the negative electrode cable is arranged along the outer wall of the inner tube, and the negative electrode cable is provided with at least one negative electrode; one negative electrode and at least one positive electrode form a group of electrode pair, the gap between the positive electrode and the negative electrode of the electrode pair is 3-10mm, and the voltage range of the electrode pair is 300-1000V. The positive electrode and the negative electrode of the electrode pair in the balloon catheter are arranged at intervals, and the voltage range of the electrode pair is set, so that the phenomenon of pulse corona discharge instead of pulse arc discharge is generated when the electrode pair works, the working voltage is lower and safer, the service life of the electrodes is longer, the electrodes are easier to process, and the sound pressure is more stable and controllable; the invention further provides stone crushing equipment.

The present invention belongs to the field of gene therapy or biological gene technology, and particularly relates to a gene combination and its expression vector and use. The gene combination is used to exist and express in nasal cells; including: U6 promoter and downstream sgRNA gene and tandem tumor suppressor gene, wherein the sgRNA gene targets tumor suppressor gene; super hTERT promoter and downstream dCas9 gene and / or miniSaCas9 gene, and tandem VP64 gene; SPLUNC1 promoter and downstream artificial miRNA gene; wherein, U6 promoter, super hTERT promoter, dCas9 gene, miniSaCas9 gene, VP64 gene, SPLUNC1 promoter and artificial miRNA gene are shown in SEQ ID NO.1-7 in sequence. The sgRNA initiated by U6 promoter and the dCas9-VP64 initiated by super hTERT are tandemly activated to activate downstream tumor suppressor genes, such as P53, etc., and finally cause apoptosis of nasopharyngeal carcinoma cells, thereby achieving treatment of nasopharyngeal carcinoma.

The invention discloses polysaccharide-based gastrointestinal tract tissue marking hydrogel as well as a preparation method and application thereof. The invention provides a preparation method of gastrointestinal tract tissue labeling hydrogel by utilizing the property that polysaccharide is subjected to Schiff base reaction with oxidized dextran after being grafted with polyaniline. Compared with the existing commercial marking liquid, the marking hydrogel disclosed by the invention has a better marking effect, and overcomes the defects that the conventional marking liquid is easy to coagulate and easy to leak during injection and the like. The polysaccharide-based gastrointestinal tract tissue marking hydrogel prepared by the invention has good biocompatibility, injectability, controllable degradability and excellent stability, and can be used for accurate positioning of gastrointestinal tract pathological tissues or specific parts under an endoscope and treatment of cancerous tissues.

The present invention discloses a serine hydrolase inhibitor and a preparation method and application thereof, belonging to the field of biomedical technology. The technical solution of the present invention provides a serine hydrolase inhibitor, wherein the inhibitor has one or more of the structural formulas proposed in the present invention. In addition, the present invention also proposes a preparation method of the above-mentioned serine hydrolase inhibitor, comprising the following steps: mixing warhead (1), a benzaldehyde sulfonyl compound (2) and sodium sulfate to obtain an imine intermediate; adding the imine intermediate to palladium carbon under the action of a reducing agent to obtain the serine hydrolase inhibitor. In addition, the present invention also proposes an application of the above-mentioned serine hydrolase inhibitor in the preparation of a drug for inhibiting the expression of PNPLA6 protein. The inhibitor proposed in the present invention can specifically inhibit PNPLA6 protein.

The invention belongs to the technical field of biomedicine, and particularly relates to a preparation method and application of a double-targeting bionic nano diagnosis and treatment agent, the preparation method of the double-targeting bionic nano diagnosis and treatment agent comprises the following steps: step 1, synthesis of MnFe2O4 nanoparticles; step 2, loading DHA (docosahexaenoic acid) on the MnFe2O4 nano particles, so as to prepare a MnFe2O4-DHA nano drug; 3, the outer side of the MnFe2O4-DHA nano drug is wrapped with a GL261 cell membrane, and MnFe2O4-DHA (at) CM is prepared. The nano-drug can effectively penetrate through BBB and is actively targeted to a tumor site, so that the MnFe2O4-DHA nano-drug is accurately released in cells, tumor marker targeted therapy is realized, H2O2 is efficiently catalyzed by the synthesized bionic nano-drug into toxic dual ROS-hydroxyl free radicals and singlet oxygen, tumor cells are killed, and the tumor marker targeted therapy is realized. An in-vivo anti-oxidation system is jointly inhibited inside and outside, a cascade amplification ferroptosis treatment effect is generated, and a relatively good killing effect on tumors can be achieved.

The invention relates to a novel automatic microneedle stimulation drug spraying and hair increasing device and a control method, and the method comprises the following steps: S1, carrying out DH calibration on a mechanical arm mechanism for controlling the automatic microneedle stimulation drug spraying and hair increasing device, the automatic microneedle stimulation medicine spraying and hair increasing device comprises a microneedle stimulation unit and a structured light sensor module which are installed on the mechanical arm mechanism. S2, calculating the pose gTp of the microneedle coordinate system of the microneedle stimulation unit relative to the tail end coordinate system of the mechanical arm mechanism; s3, carrying out hand-eye calibration on the coordinate system of the tail end of the mechanical arm and the coordinate system of the structured light sensor; s4, reconstructing a 3D point cloud of a head scalp area of the patient by using a structured light sensor, and converting the 3D point cloud into a grid table by using a Marching Cubes algorithm; S5, extracting a scalp area needing to be treated; S6, planning a needle insertion position; and S7, performing needle insertion operation.

The utility model discloses pelvic floor muscle treatment equipment with lifting and positioning functions, which comprises a bottom frame assembly, a sofa assembly fixedly mounted at the top of the bottom frame assembly, a display screen assembly fixedly mounted on the sofa assembly, a lifting support mechanism fixedly mounted on the sofa assembly, and a pulse magnetic assembly fixedly mounted on the lifting support mechanism. The back surface of the sofa assembly is fixedly provided with a rear cover assembly and a drawer assembly; the lifting support mechanism is composed of a lifting support silicon rubber case, a lifting support mounting plate, a lifting support assembly, a damping column, an upper sensor fixing support, a sensor, a lower sensor fixing support, a sliding table module, a microswitch, a microswitch fixing bent plate, a sliding table back plate and a wire pressing sheet; the pelvic floor muscle treatment equipment with the lifting and positioning functions relates to the technical field of pelvic floor muscle treatment equipment, and solves the problems that an existing pelvic floor muscle treatment device is single in function, poor in use effect and incapable of meeting rehabilitation requirements of patients.

The invention discloses a synthesis method of monoatomic manganese-doped amino-rich PEG (polyethylene glycol) carbon quantum dots, and belongs to the technical field of biomedical materials.The synthesis method comprises the following steps: 1) adding manganese chloride into PEG400, and uniformly mixing to form a uniform mixed solution A; 2) adding ethylenediamine hydrochloride into the mixed solution A obtained in the step 1), and uniformly mixing to form a uniform mixed solution B; and (3) carrying out hydrothermal reaction on the mixed solution B obtained in the step (2), after the reaction is finished, cooling to room temperature, washing, purifying and drying to obtain the monoatomic manganese-doped amino-enriched PEG carbon quantum dots. The synthesized Mn (at) NH2-CDs can efficiently inhibit ferroptosis by removing active oxygen and ferrous ions, and the inhibition effect of the Mn (at) NH2-CDs on the cellular level is obviously higher than that of existing common active oxygen removing drugs and iron ion chelating agents; and the surface of the material is rich in amino groups, so that the material carries a large number of positive charges, and can penetrate through a blood brain barrier to enter brain tissues to inhibit ferroptosis through adsorption-mediated transendocytosis, thereby realizing treatment of shock wave brain injury.

The invention provides a beta-carboline alkaloid coumaroyl glucoside compound, an extraction method and application thereof, and a monoamine oxidase inhibitor. The beta-carboline alkaloid coumaroyl glucoside compound provided by the invention has a structure as shown in a formula 1 or a formula 2, is novel in structure, has good monoamine oxidase inhibitory activity, can slow down monoamine neurotransmitter consumption in the brain, slow down oxidative damage and realize treatment of neurodegenerative diseases, and has good application prospects. Further, the compound can be used for preparing a monoamine oxidase inhibitor or preparing a medicine for resisting neurodegenerative diseases, can also be used for developing health-care food, and is wide in application prospect. # imgabs0 #

The invention belongs to the technical field of medical equipment, and particularly relates to a plateau hyperbaric oxygen cabin vehicle based on automatic pressure control, which comprises a square cabin, a control system, a fire extinguishing system, an oxygen supply system, a chassis and a stretcher lifting device, the interior of the square cabin is divided into an equipment room, an operation room and an oxygen cabin room; the control system comprises a PLC module, an environment monitoring unit, an environment adjusting unit, a pressure supply unit and a pressure adjusting unit. The device has high altitude environment adaptability, namely excellent cross-country ability, maneuverability and low-temperature adaptability, meanwhile, burden and requirements on operators can be relieved in a scientific pressure control mode, the probability of middle ear barotrauma of the rescued personnel in the treatment process is reduced, and the treatment effect of the rescued personnel is improved. The treatment efficiency of diseases such as plateau pulmonary edema or encephaledema is improved; the air quality in the oxygen cabin can be regulated and controlled in an automatic or manual mode according to real-time data; and the burden of workers in the plateau environment for carrying the wounded to get on and off the vehicle by using a stretcher is reduced.

The utility model discloses a multidimensional polymerization microwave therapy system, relates to medical equipment technical field, including electromagnetic wave therapeutic machine and treatment couch, treatment couch includes bed body, transfer element and mattress, transfer element installs on the bed body, and the mattress installs on transfer element, the mattress can be driven by transfer element to move relative to bed body, and the transfer element is equipped on the bed body. The electromagnetic wave therapeutic machine is arranged close to the therapeutic bed, the therapeutic end of the electromagnetic wave therapeutic machine is provided with a non-contact application device, the non-contact application device is used for carrying out electromagnetic wave irradiation on the focus in the body of the patient, the non-contact application device comprises a cover body and a coil, and the cover body is arranged on the periphery of the coil in a sleeving mode; a radiation opening is formed in the bottom end of the cover body and used for facing a focus in a patient, the top end of the cover body is used for being connected with an electromagnetic wave generator of an electromagnetic wave therapeutic machine, and the coil is arranged in a three-dimensional spiral shape. The temperature control device can ensure that the lesion in the body of a patient reaches the effective treatment temperature, improves the treatment effect, and is convenient to use.

The invention belongs to the technical field of biological medicines, and particularly relates to engineered platelets, a preparation method thereof and application of the engineered platelets in type 1 diabetes mellitus. According to the engineering blood platelet, PD-L1 protein, PD-L2 protein, BTLA protein and Galectin-9 protein are overexpressed, and the engineering blood platelet is prepared by adopting a cell factor IFN-gamma to stimulate megakaryocyte. Experiments find that engineered platelets over-expressing PD-L1, PD-L2, BTLA and Galectin-9 molecules can accumulate in inflamed pancreatic tissues and inhibit the activity of pancreatic autoreactive T cells, so that beta-cells producing insulin are protected from being attacked, the beta-cells can be rescued by intervening an immune system, insulin secretion is recovered, and the effect of preventing and treating insulin is achieved. Therefore, the blood sugar of the NOD mouse is kept at a normal level, the treatment of newborn type 1 diabetes is realized, and the medicine has a very good treatment effect when being applied to the treatment of diabetes.

The application discloses a traditional Chinese medicine hot air pressure therapeutic instrument, relates to the technical field of medical equipment, and solves the problems that the air pressure therapeutic instrument in the prior art cannot be inflated in sequence and is single in function. The device comprises a binding belt, an air pressure assembly installed on the binding belt, a medicine storage bag and a heater, a gas conveying pipe connected to the air pressure assembly, and the heater is located behind the medicine storage bag. The air pressure assembly comprises a plurality of air bags installed at equal intervals on the binding belt, a gas conveying channel communicated with the bottoms of the air bags, an exhaust channel arranged at the right side of the air bag, a piston arranged between the air bag and the gas conveying channel, and a spring sleeved on the piston, and the lowermost gas conveying channel is communicated with the gas conveying pipe. The device has diversity, the heat generated by the heater can assist the Chinese herbal medicine components in the medicine storage bag to better penetrate into the deep layer of the skin of a patient, the air pressure assembly, the heater and the medicine storage bag are used in cooperation, blood circulation can be promoted through mechanical pressure, the drug penetration and the heat therapy can be used in cooperation, and comprehensive treatment is achieved.

The invention belongs to the technical field of biological medicine, and provides an immunotherapy response prediction marker RBM28 and application thereof in combined treatment sensitization, the application is characterized in that the expression level of RBM28 is used as an evaluation index, a TG003 and PD-1 or ATO and PD-1 combined inhibitor is used for in-vitro treatment of esophageal squamous carcinoma tumor cells and mouse models, and the immunotherapy response prediction marker RBM28 can be used for immunotherapy sensitization. The immunotherapy prediction effect of the RBM28 expression level as an evaluation index on the esophageal squamous cell carcinoma and the treatment effect of the TG003 and PD-1 or ATO and PD-1 combined inhibitor on the esophageal squamous cell carcinoma are evaluated; results show that high expression of RBM28 is related to development of various tumors, and RBM28 can be used as an immunotherapy response prediction marker; the inhibitor can be used for jointly treating esophageal squamous cell carcinoma, inhibiting RBM28 phosphorylation, inducing immune activation, enhancing the curative effect of immunotherapy and remarkably reducing the tumor volume so as to achieve the purpose of treating esophageal squamous cell carcinoma.

The present application discloses a port-wine stain treatment device and an operation method thereof, and relates to the technical field of cosmetic medical devices, a light source emitting unit, a treatment head and a host computer, wherein the light source emitting unit is used to selectively emit a first laser source of a first wavelength band and a second laser source of a second wavelength band, wherein the first laser source is used for photothermal therapy, and the second laser source is used for photodynamic therapy and distance measurement; the treatment head comprises a housing and a plastic lens disposed in the housing, wherein the plastic lens can move along the central axis of the plastic lens, and the plastic lens is used to receive the first laser source and project therapeutic light to the lesion tissue, or receive the second laser source and project therapeutic light spot or distance measurement light spot to the lesion tissue; the host computer comprises an image acquisition unit, a data processing unit and a controller, wherein the image acquisition unit receives the distance measurement light spot reflected by the lesion tissue and determines the area size of the distance measurement light spot, and when the area of ​​the distance measurement light spot is the smallest, the image acquisition unit feeds back the position of the plastic lens to the data processing unit; the data processing unit acquires the distance H between the light output end of the treatment head and the affected part according to the position of the plastic lens, and the controller can control the output optical power of the therapeutic light according to the distance H. The present application has the effect of improving the convenience of physicians in adjusting and operating the photodynamic therapy device.

The present application relates to the use of FAM69B inhibitors in the preparation of a medicament for treating ALS or FTD. The present application first demonstrates that FAM69B protein can regulate the function and pathological behavior of TDP-43, and serves as a new target for treating ALS or FTD. Inhibition of the expression of FAM69B protein can significantly reduce the protein level of pathological TDP-43, thereby achieving treatment of TDP-43 related diseases.

The invention provides a preparation method of rubber modified asphalt with self-healing performance, which comprises the following steps of: preparing dynamic covalent cross-linked rubber by using desulfurized rubber, natural rubber, liquid polysulfide rubber and 1, 8-diazabicyclo [5.4. 0] undec-7-ene as raw materials through a kneading machine and a plate vulkameter; and modifying the 70 # matrix asphalt by adopting dynamic covalent cross-linked rubber to obtain the rubber modified asphalt. The method is obvious in improvement effect, and the purpose of improving the self-healing performance of the rubber modified asphalt can be achieved.

The invention relates to the technical field of powder coatings, in particular to a low-temperature curing powder coating and a preparation method thereof.The preparation method comprises the steps that a low-temperature curing polyurethane oligomer, a curing agent, nanometer titania, a flatting agent and polyethylene wax are evenly mixed, and a premix is obtained; and carrying out melt extrusion, grinding and sieving on the premix, and uniformly mixing the premix with the modified microcapsules to prepare the low-temperature curing powder coating. The low-temperature curing polyurethane oligomer and the modified microcapsule are matched for use, so that the prepared coating film has relatively low curing temperature and also has good antibacterial property and self-healing property, and the overall quality of the coating film is improved; moreover, the obtained powder coating can be cured at a relatively low temperature, energy conservation is better realized in actual use, meanwhile, the mass loss of the modified microcapsule at the temperature is very small, and the quality of a formed coating film is ensured.