8results about How to "Achieve healing" patented technology

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

The invention discloses a synthesis method of monoatomic manganese-doped amino-rich PEG (polyethylene glycol) carbon quantum dots, and belongs to the technical field of biomedical materials.The synthesis method comprises the following steps: 1) adding manganese chloride into PEG400, and uniformly mixing to form a uniform mixed solution A; 2) adding ethylenediamine hydrochloride into the mixed solution A obtained in the step 1), and uniformly mixing to form a uniform mixed solution B; and (3) carrying out hydrothermal reaction on the mixed solution B obtained in the step (2), after the reaction is finished, cooling to room temperature, washing, purifying and drying to obtain the monoatomic manganese-doped amino-enriched PEG carbon quantum dots. The synthesized Mn (at) NH2-CDs can efficiently inhibit ferroptosis by removing active oxygen and ferrous ions, and the inhibition effect of the Mn (at) NH2-CDs on the cellular level is obviously higher than that of existing common active oxygen removing drugs and iron ion chelating agents; and the surface of the material is rich in amino groups, so that the material carries a large number of positive charges, and can penetrate through a blood brain barrier to enter brain tissues to inhibit ferroptosis through adsorption-mediated transendocytosis, thereby realizing treatment of shock wave brain injury.

The utility model discloses a multidimensional polymerization microwave therapy system, relates to medical equipment technical field, including electromagnetic wave therapeutic machine and treatment couch, treatment couch includes bed body, transfer element and mattress, transfer element installs on the bed body, and the mattress installs on transfer element, the mattress can be driven by transfer element to move relative to bed body, and the transfer element is equipped on the bed body. The electromagnetic wave therapeutic machine is arranged close to the therapeutic bed, the therapeutic end of the electromagnetic wave therapeutic machine is provided with a non-contact application device, the non-contact application device is used for carrying out electromagnetic wave irradiation on the focus in the body of the patient, the non-contact application device comprises a cover body and a coil, and the cover body is arranged on the periphery of the coil in a sleeving mode; a radiation opening is formed in the bottom end of the cover body and used for facing a focus in a patient, the top end of the cover body is used for being connected with an electromagnetic wave generator of an electromagnetic wave therapeutic machine, and the coil is arranged in a three-dimensional spiral shape. The temperature control device can ensure that the lesion in the body of a patient reaches the effective treatment temperature, improves the treatment effect, and is convenient to use.

The application discloses a traditional Chinese medicine hot air pressure therapeutic instrument, relates to the technical field of medical equipment, and solves the problems that the air pressure therapeutic instrument in the prior art cannot be inflated in sequence and is single in function. The device comprises a binding belt, an air pressure assembly installed on the binding belt, a medicine storage bag and a heater, a gas conveying pipe connected to the air pressure assembly, and the heater is located behind the medicine storage bag. The air pressure assembly comprises a plurality of air bags installed at equal intervals on the binding belt, a gas conveying channel communicated with the bottoms of the air bags, an exhaust channel arranged at the right side of the air bag, a piston arranged between the air bag and the gas conveying channel, and a spring sleeved on the piston, and the lowermost gas conveying channel is communicated with the gas conveying pipe. The device has diversity, the heat generated by the heater can assist the Chinese herbal medicine components in the medicine storage bag to better penetrate into the deep layer of the skin of a patient, the air pressure assembly, the heater and the medicine storage bag are used in cooperation, blood circulation can be promoted through mechanical pressure, the drug penetration and the heat therapy can be used in cooperation, and comprehensive treatment is achieved.

The invention belongs to the technical field of biological medicine, and provides an immunotherapy response prediction marker RBM28 and application thereof in combined treatment sensitization, the application is characterized in that the expression level of RBM28 is used as an evaluation index, a TG003 and PD-1 or ATO and PD-1 combined inhibitor is used for in-vitro treatment of esophageal squamous carcinoma tumor cells and mouse models, and the immunotherapy response prediction marker RBM28 can be used for immunotherapy sensitization. The immunotherapy prediction effect of the RBM28 expression level as an evaluation index on the esophageal squamous cell carcinoma and the treatment effect of the TG003 and PD-1 or ATO and PD-1 combined inhibitor on the esophageal squamous cell carcinoma are evaluated; results show that high expression of RBM28 is related to development of various tumors, and RBM28 can be used as an immunotherapy response prediction marker; the inhibitor can be used for jointly treating esophageal squamous cell carcinoma, inhibiting RBM28 phosphorylation, inducing immune activation, enhancing the curative effect of immunotherapy and remarkably reducing the tumor volume so as to achieve the purpose of treating esophageal squamous cell carcinoma.

The invention provides a preparation method of rubber modified asphalt with self-healing performance, which comprises the following steps of: preparing dynamic covalent cross-linked rubber by using desulfurized rubber, natural rubber, liquid polysulfide rubber and 1, 8-diazabicyclo [5.4. 0] undec-7-ene as raw materials through a kneading machine and a plate vulkameter; and modifying the 70 # matrix asphalt by adopting dynamic covalent cross-linked rubber to obtain the rubber modified asphalt. The method is obvious in improvement effect, and the purpose of improving the self-healing performance of the rubber modified asphalt can be achieved.

The application discloses a phased focusing ultrasonic treatment method and system, through relative time delay of radio frequency signals in different channels, the sound velocity at different positions in the target region can be accurately estimated, and then the relative time delay of radio frequency signals emitted by different array elements is determined based on the focal point position, and finally the radio frequency signals emitted by each array element are superimposed in phase at the focal point based on the time delay matrix, a high-energy focusing area is formed, the focal point is treated, compared with the treatment mode using a fixed sound velocity, the influence of different sound velocities of different positions of tissues on treatment is considered, so that the position of the treatment focal point can be accurately determined without increasing additional equipment, damage to non-target tissues is avoided, and the treatment effect is effectively improved.

The application provides application of ipomoea nil exocyst in preparation of a medicine for preventing, alleviating or treating osteomyelitis. The application creatively finds that the ipomoea nil exocyst can significantly inhibit the expression of macrophage pyroptosis markers GSDMD-NT and Caspase-1, promote the expression of osteogenesis markers RUNX2 and OPN, and mediate immune regulation to achieve the treatment of osteomyelitis. The ipomoea nil exocyst is loaded in a three-dimensional cross-linked skeleton formed by oxidized dextran, aminopolysaccharide and gelatin, has better mass transfer delivery effect, and significantly improves the treatment effect on osteomyelitis.