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Neuroblastoma is a form of cancer that is made up of cells that are found in nerve tissues of the body. These cells are called neuroblasts and they are early nerve cells of the sympathetic nervous system, so they can be found anywhere along this system.
An immunoliposome targeting ganglioside GD2 and mitochondria, and a preparation method and application thereof
ActiveCN117281775BHydroxy compound active ingredientsMacromolecular non-active ingredientsCholesterolCytotoxicity
The application belongs to the technical field of biological medicine, and particularly relates to an immune liposome targeting ganglioside GD2 and mitochondria as well as a preparation method and application thereof. The application couples LX3 and thiolated daratumumab to DSPE-PEG2000 respectively to obtain DSPE-PEG2000-LX3 and DSPE-PEG2000-aGD2, and then is compounded with DSPC and cholesterol to obtain the immune liposome, which has good dispersity, excellent stability and cannot induce cytotoxicity. Cell combination and uptake analysis shows that the immune liposome can specifically target ganglioside GD2 positive tumor cells and then further reach mitochondria thereof. Compared with existing liposomes, the immune liposome provided by the application has double targeting functions of ganglioside GD2 and mitochondria, and can selectively deliver an anti-tumor drug into mitochondria of neuroblastoma cells.
Owner:GUILIN MEDICAL UNIVERSITY