The invention discloses a traditional Chinese medicinal external lotion for treating infective wounds caused by multi-drug resistant bacteria. According to traditional Chinese medicine, treatment based on syndrome differentiation is conducted in accordance with different symptoms of deficiency and excess, cold and heat, blood stasis and edema for the pathogenesis causing the infective wounds due to multi-drug resistant bacteria. The external lotion disclosed by the invention is prepared from the following traditional Chinese medicines: indian stringbush root, yellow bedstraw herb, Chinese crinum leaves, breeders gladiolus corm, wedelia chinensis, pyrolusite, circaeashape loosestrife herb, gelsmium elegans, kerr treebine keaf, euphorbia antiquorum, beautiful galangal seeds and herba eupatorii. Upon clinical tests, the total effective rate reaches 95%; and the external lotion is free from cases of cross infection and is relatively good in curative effect.