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Organic/inorganic combined antibacterial composition and preparation method and application thereof

The technology of an antibacterial composition and an inorganic antibacterial agent is applied in the field of organic/inorganic combined antibacterial composition and its preparation, which can solve the problems of not reaching effective blood drug concentration, degrading residues in vivo, poor sustained release effect, etc. The effect of multi-drug resistant bacteria

Active Publication Date: 2019-06-21
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional systemic injection of antibiotics often fails to reach the effective blood concentration in the local area of ​​infection, and the therapeutic effect is not ideal. Moreover, due to the abuse of antibiotics, many infectious pathogens have multiple cross-drug resistance. The combination of antibiotics can only be used in Reduce the occurrence of drug resistance to a certain extent
In addition, organic drug stents have the problems of poor slow-release effect and residual degradation in vivo, which are difficult to meet clinical needs

Method used

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  • Organic/inorganic combined antibacterial composition and preparation method and application thereof
  • Organic/inorganic combined antibacterial composition and preparation method and application thereof
  • Organic/inorganic combined antibacterial composition and preparation method and application thereof

Examples

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Embodiment 1

[0035] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0036] In the organic / inorganic combined antibacterial composition, the mass ratio of nanometer copper, tigecycline and polydopamine is 4:1:4.

[0037] The preparation method comprises the following steps:

[0038] (1) Dissolve 0.1g of chitosan, 1ml of acetic acid and 0.5g of citric acid in 130ml of distilled water, stir magnetically for 10min, transfer to a 50ml Teflon-lined autoclave, and react at 180°C for 6h. After the reaction is completed, The autoclave was cooled to room temperature, and the resulting reaction solution was carbon dots of citric acid.

[0039] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon dots, 40g of sodium hydroxide and 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70°C for 12h, and dissolve the resulting precipitate After washing with distilled water and absolu...

Embodiment 2

[0042] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0043] In the organic / inorganic combined antibacterial composition, the mass ratio of nanometer copper, tigecycline and polydopamine is 2:1:4.

[0044] The preparation method comprises the following steps:

[0045] (1) Dissolve 0.2g chitosan, 1.5ml acetic acid and 0.5g citric acid in 130ml distilled water, stir magnetically for 10min, transfer to a 50ml Teflon-lined autoclave, react at 180°C for 6h, and the reaction is complete Afterwards, the autoclave was cooled to room temperature, and the resulting reaction solution was carbon dots of citric acid.

[0046] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon dots, 80g of sodium hydroxide, and 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70°C for 18h, and dissolve the resulting precipitate After washing with distilled water and absolute et...

Embodiment 3

[0049] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0050] In the organic / inorganic combined antibacterial composition, the mass ratio of nanometer copper, tigecycline and polydopamine is 4:3:8.

[0051] The preparation method comprises the following steps:

[0052] (1) Dissolve 0.4g chitosan, 2ml acetic acid and 2g citric acid in 130ml distilled water, stir magnetically for 10min, transfer to a 50ml polytetrafluoroethylene-lined autoclave, and react at 180°C for 6h. The autoclave was cooled to room temperature, and the resulting reaction solution was carbon dots of citric acid.

[0053] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon dots, 160g of sodium hydroxide, and 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70°C for 24h, and dissolve the resulting precipitate After washing with distilled water and absolute ethanol, freeze-dry at -80°...

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Abstract

The invention belongs to the technical field of medical materials and particularly relates to an organic / inorganic combined antibacterial composition and a preparation method and application thereof.The organic / inorganic combined antibacterial composition comprises nano-copper, tigecycline and polydopamine; the compound of inorganic antibacterial agent nanometer copper and organic antibiotic tigecycline is wrapped by polydopamine to produce the produce. The results show that the product has good resistance to multi-drug resistant bacteria and is attached to the surface of a catheter after air drying and filming, slow release of the antibacterial agent is achieved, and technical shortcomings that single antibactic has poor antibacterial effect, low antibacterial duration and easy sheddingof spraying composite films.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an organic / inorganic combined antibacterial composition and its preparation method and application. Background technique [0002] In clinical operations, the complications caused by catheter-related infection are a very difficult problem, and the original material of the catheter itself is not antibacterial, and pathogenic microorganisms are easy to adhere to the surface of the material and grow, often causing local or Systemic infection. At present, a large number of antibiotics are mainly used clinically to reduce the occurrence of catheter-related infections. However, the traditional systemic injection of antibiotics often fails to reach the effective blood concentration in the infected area, and the therapeutic effect is not ideal. Moreover, due to the abuse of antibiotics, many infectious pathogens have multiple cross-drug resistance. The combined use ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/34A61K47/34A61P31/04A61L29/16A61L29/08A61L29/10A61K31/65
Inventor 蒋刚彪吴夏晓张宇周初松刘永林胡甜李曾林陈文照
Owner SOUTH CHINA AGRI UNIV
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