230 results about "Piperazidine" patented technology

The invention relates to the technical field of flame-retardant polypropylene composite materials, in particular to a flame-retardant reinforced polypropylene composite material containing flame-retardant modified glass fibers and a preparation method of the flame-retardant reinforced polypropylene composite material. The flame-retardant modified glass fiber-containing flame-retardant reinforced polypropylene composite material is prepared from the following raw materials: 30 to 60 parts of polypropylene, 5 to 60 parts of flame-retardant modified glass fiber, 5 to 20 parts of piperazine pyrophosphate, 5 to 20 parts of melamine polyphosphate, 0.5 to 5 parts of flame-retardant synergist, 1 to 6 parts of maleic anhydride ester-grafted polypropylene, 0.5 to 3 parts of coupling agent, 0.3 to 3 parts of lubricant and 0.2 to 0.5 part of antioxidant. The flame-retardant modified glass fibers are glass fibers subjected to surface modification by using a focused piperazine phosphate-melamine polyphosphate random copolymer. According to the technical scheme, the problem that the mechanical property and flame retardant property of glass fiber reinforced polypropylene in the prior art are difficult to optimize at the same time can be solved, and the glass fiber reinforced polypropylene has ideal popularization and application prospects.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The present invention relates to the technical field of nanofiltration membranes, and particularly relates to a preparation method for a positively charged nanofiltration membrane for improving a "trade-off" effect. The preparation method comprises the following process: sequentially adding a water phase and an oil phase to the surface of a support layer to perform a reaction, so as to prepare a polyamide layer; pouring in a functionalized graphene dispersion; and sequentially placing same into an N,N-dimethyl propane diamine solution, a sodium borohydride solution and an iodomethane solution to perform a reaction, so as to obtain a nanofiltration membrane, wherein the functionalized graphene is pyrrolidone-based graphene. According to the present invention, a mixture of piperazine and polyethyleneimine is used as a water phase and is subjected to interfacial polymerization with an oil phase 1,3,5-trimesoyl chloride on the surface of the support membrane; and by means of the compounding of micromolecular piperazine and macromolecular polyethyleneimine, the rapid formation of a polyamide layer is promoted, the distance of a system cross-linked network is increased, a positively charged polyamide layer having a large pore diameter and good hydrophilicity is formed, and a good water flux and a good rejection rate are achieved, thereby improving the "trade-off" effect.

Methods for treating children, adolescents and adults with persistent or chronic immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

A ceramic membrane includes an alumina (Al2O3) layer; and a polyamide nanocomposite layer at least partially covering a surface of the alumina layer. The polyamide nanocomposite layer contains polyamide-functionalized silicon carbide (SiC) nanoparticles having an average particle size of 0.1 to 1 micrometer (μm), an amine-functionalized SiC moiety, an acyl aryl moiety, and a piperazine moiety. The amine-functionalized SiC moiety contains a SiC core and an amine functionalized silicon dioxide (SiO2) shell covering the SiC core. The amine-functionalized SiC moiety is covalently bonded to the piperazine moiety via the acyl aryl moiety; and the amine functionalized SiO2 shell contains at least one amino group containing structural unit that is covalently bonded to the SiO2 shell.

The invention provides a piperazinyl steric hindrance type liquid-solid phase change carbon trapping agent and a preparation method thereof, and relates to the field of liquid-solid phase change trapping of CO2. Alkylamine and the like are used as raw materials, piperazinyl steric hindrance type organic amine with secondary amino and tertiary amino structures is designed, and the piperazinyl steric hindrance type organic amine is prepared through ring-opening addition, nucleophilic substitution, cyclization, hydrogenation and other reactions. The piperazinyl steric hindrance type organic amine is compounded with a solvent and a functional additive to prepare the piperazinyl steric hindrance type liquid-solid phase change carbon trapping agent. According to the steric hindrance type phase change carbon trapping agent, on the basis of the electron donating effect of alkyl, the absorption rate of trapping CO2 is increased by 2.2 times compared with that of traditional steric hindrance amine (AMP); on the basis of the steric hindrance effect of the tertiary amine site, the hydrogen-bond interaction between carbamate and the solvent is weakened, liquid-solid phase splitting after the aqueous solution carbon capture system absorbs CO2 is promoted, the problem of poor cycling stability of a non-aqueous solvent system is solved, and the capture efficiency and enrichment degree of CO2 are improved.

The invention discloses a preserving fluid for stably preserving sample DNA at normal temperature and a preparation method thereof, and belongs to the technical field of biological sample preservation. The preserving fluid comprises a lysis system, a nucleic acid protection system and a buffering and stabilizing system, the cracking system comprises a composite surfactant and an enzymolysis auxiliary agent; the composite surface active agent is prepared from polyether polyol fatty acid ester and cocamidopropyl hydroxy sulfobetaine; the enzymolysis auxiliary agent comprises lysozyme Lyso-V and protease K; the nucleic acid protection system comprises a nitrogen heterocyclic polyamine-carboxylic acid derivative and dextran sulfate; the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N' ', N ''tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N''-triacetic acid, disodium ethylene diamine tetraacetate-nitrogen heterocyclic derivative, and diethylenetriamine pentaacetic acid-piperazine derivative, and the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N '', N'' tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N ''-triacetic acid. The buffering and stabilizing system comprises an amphoteric buffering agent and a polymer stabilizer; the amphoteric buffering agent comprises 2-(N-morpholino) ethanesulfonic acid and N-tri (hydroxymethyl) methylglycine.

The invention discloses a high-flame-retardant anti-cracking insulated cable and a preparation method thereof, and relates to the technical field of cross-linked polyethylene insulated cables, the high-flame-retardant anti-cracking insulated cable sequentially comprises the following structures from outside to inside: a sheath layer, a wrapping layer, an insulating layer and a conductor group; and a filling layer is arranged between the insulating layer and the conductor group. According to the invention, phosphate, acryloyl chloride, 2, 4, 6-tri (piperazinyl)-1, 3, 5-triazine and amino siloxane react to prepare a modifier, the modifier is grafted to a polyethylene molecular chain to serve as a cable material system, crosslinked polyethylene is prepared, and the modifier structure is introduced into a crosslinked network, so that the mechanical property and flame retardant property of the cable material can be effectively improved, the addition of filler is reduced, and the cost is reduced. And the plastic damage caused by the material is relieved, and the cracking phenomenon is prevented.

The invention discloses a gastric retention double-layer sustained-release tablet and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations, the active ingredient of the gastric retention double-layer sustained-release tablet is 3-[4-[4-(lH-benzotriazole-1-yl) butyl] piperazine-1-yl] benzisothiazole hydrochloride, and the gastric retention double-layer sustained-release tablet is composed of a quick-release drug release layer and a sustained-release drug release layer, the quick release layer contains an active component, a filler I and a disintegrating agent; and the sustained-release layer contains an active component, a filler II, an expansion material, a release retardant, an expansion accelerator and a stabilizer. According to the gastro-retention double-layer sustained-release tablet, the quick-release layer can quickly release the medicine to reach the effective blood concentration, and the retention time of the tablet in the stomach is prolonged after the sustained-release layer expands, so that the in-vivo absorption window of the medicine is prolonged, the maintenance of the blood concentration is realized, the in-vivo half-life period of active ingredients is remarkably prolonged, the administration frequency can be reduced, and the compliance of a patient is improved. The product is simple in preparation process, suitable for industrial production and wide in development prospect.

A method is provided for treating or preventing alcohol dependence and / or an alcohol associated disease or condition. Such a method includes administrating a pharmaceutical composition comprising an effective amount of a compound having formula (I):or a hydrates, a solvate, a pharmaceutically acceptable salt, a prodrug, or a complex thereof to a subject in need thereof. For example, (3S, 4R)-3-((R)-(1-hydroxy-ethyl)-4-((R)-[1-methyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-azetidin-2-one (MC-100093) is an exemplary compound. The composition can be used to prevent or treat alcohol dependence, attenuate alteration in glutamate transporters, reduce alcohol associated neuroinflammation, and treat or prevent alcohol associated fatty liver diseases.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The present invention provides a thermo-oxidative aging resistant polyester material and a preparation method thereof, and relates to the technical field of polyester materials, the thermo-oxidative aging resistant polyester material is prepared from the following raw materials by weight: 100 parts of a functional polycondensate, 0.5-1 part of phosphorus pentoxide, 0.3-0.5 part of polyphosphoric acid, 0.8-1.5 parts of an antioxidant, 0.5-0.8 part of a lubricant, 1-3 parts of a coupling agent, 20-30 parts of reinforcing fibers, 1-3 parts of 1, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate, and 1-3 parts of an antioxidant. 1 to 3 parts of 1, 3, 5-triglycidyl-S-triazinetrione, and 3 to 5 parts of 1-amino-8-naphthol-3, 6-disulfonic acid; the functional polycondensate is prepared from 5-hydroxyisophthalic acid, 2, 3, 5, 6-tetrafluoroterephthalyl alcohol and N, N '-bis (2-hydroxyethyl) piperazine through a condensation polymerization reaction. The material has the advantages of favorable thermo-oxidative aging resistance, favorable mechanical properties, favorable flame retardancy and long service life.

The present invention provides a blonanserin oral soluble film composition, which comprises an active drug, a film forming material and a plasticizer, and the active drug is one or more of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5, 6, 7, 8, 9, 10-hexahydrocyclooctane pyridine represented by a formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate of the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5, 6, 7, 8, 9, 10-hexahydrocyclooctane pyridine. The blonanserin oral soluble film composition has the advantages of being thin in thickness, good in taste, stable in property, good in dissolution rate, capable of being instantly dissolved in the oral cavity without drinking water, especially suitable for patients with dysphagia, free of grit feeling after being dissolved in the oral cavity, high in oral absorption speed, uniform in appearance, good in flexibility, simple in process, low in cost and suitable for industrial production. And sedimentation cannot occur in the membrane liquid preparation process, the content uniformity meets the requirement, the drug loading capacity is high, and the marketization prospect is good. # imgabs0 #

The invention relates to responsive hydrogel loaded with bionic nano-vesicles as well as a preparation method and application of the responsive hydrogel, and belongs to the technical field of medical hydrogel. The method comprises the steps that odontogenic mesenchymal stem cells are stimulated by a chemical vesicle stimulant and then mixed with melatonin mother liquor for extrusion, the bionic nano vesicles are obtained, the chemical vesicle stimulant contains a buffer solution, a dithiothreitol solution and a paraformaldehyde solution, and the buffer solution contains 8.5-9 g / L of sodium chloride, 0.2-0.24 g / L of calcium dichloride and 2.3-2.4 g / L of 4-hydroxyethyl piperazine ethanesulfonic acid; 6-arm-PEG-pp-NH2 coupled with polypeptide capable of being cut by matrix metalloproteinase, six-arm polyethylene glycol succinimide glutarate and the bionic nano-vesicle are prepared into a first precursor solution and a second precursor solution respectively, the first precursor solution and the second precursor solution are mixed and subjected to standing to form gel, and the responsive hydrogel is prepared. According to the invention, the responsive hydrogel capable of obviously enhancing bone regeneration capacity is obtained.

Provided herein are compounds of Formula (I):or a pharmaceutically acceptable salt thereof. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. Additional utilities and advantages are described herein.

The invention provides a flame-retardant PP material with high strength and high modulus and a preparation method thereof. The flame-retardant PP material comprises the following raw materials in percentage by weight: 30-60% of polypropylene resin; 20 to 30% of a flame retardant; 20 to 30% of short glass fiber; 5-10% of a filling material; 5-10% of a compatilizer; and 2-3 wt% of other auxiliary agents. By compounding the piperazine halogen-free flame retardant, the glass fiber and the inorganic mineral powder, the tensile strength of the obtained polypropylene composite material reaches 69-75 MPa, the bending modulus reaches 5000-5400 MPa, and the tensile strength and the bending modulus are higher than general requirements of new energy battery materials; the flame retardant grade can reach 1.5 V0 of UL94, and the flame retardant grade requirements of most new energy batteries are met.

The invention relates to the field of separation and purification, in particular to an anti-pollution nanofiltration membrane for magnesium-lithium separation, the anti-pollution nanofiltration membrane comprises a base membrane and a functional layer, and the functional layer is prepared from the following raw materials in parts by weight: a water phase: 1.5-2.5 parts of piperazine, 0.1-1 part of lauryl sodium sulfate, 0.5-2 parts of glycerol, 1-2 parts of triethylamine, 0.6-2 parts of ionic polymer, and the balance of water for supplementing the total amount of the water phase to 100 parts; the ionic polymer comprises at least one of sulfobetaine metacrylic acid ester, sulfobetaine and carboxyl betaine metacrylic acid ester; and an oil phase: 0.1-1 part of trimesoyl chloride, and the total amount of the oil phase is supplemented to 100 parts by normal hexane or isoparaffin. The ionic polymer is added, and a compact hydration layer is formed on the surface of the membrane by using a betaine group of the ionic polymer, so that the membrane pollution probability is reduced, and common inorganic scaling and organic pollution in the high-salt brine are remarkably inhibited; in addition, the ionic polymer enables the membrane surface to have strong negative electricity, and the magnesium ion rejection rate is improved; and the ionic polymer can also reduce the lithium ion transmission energy barrier and reduce the rejection rate.

The invention belongs to the technical field of anion exchange membranes, and discloses a trifluoroacetyl piperazine modified polyaryl piperidine membrane as well as a preparation method and application thereof in a neutral organic flow battery. The preparation method comprises the following steps: preparing a trifluoroacetyl piperazine monomer by adopting an amine ester exchange reaction, carrying out tri-monomer copolymerization on trifluoroacetyl piperazine, N-methyl-4-piperidone and p-terphenyl to obtain a polyaryl piperidine polymer main chain containing a trifluoroacetyl piperazine structure, then carrying out quaternization reaction to obtain a quaternized polymer, casting a membrane, and carrying out freeze drying to obtain the trifluoroacetyl piperazine-containing polyaryl piperidine membrane. The trifluoroacetyl piperazine modified polyaryl piperidine membrane prepared by the method shows very excellent battery performance when being applied to a neutral organic flow battery, the battery performance is greatly improved compared with that of a dimonomer ion exchange membrane without trifluoroacetyl piperazine modification, and the trifluoroacetyl piperazine modified polyaryl piperidine membrane has relatively high capacity retention rate; and the energy efficiency of the membrane is far superior to that of common commercial membranes such as AMVN.

The invention relates to the technical field of textiles, and provides an antibacterial yarn and a preparation process thereof. The antibacterial yarn comprises cotton fibers and Juncao fibers, the cotton fibers are treated through an antibacterial finishing agent, and the antibacterial finishing agent is prepared from, by mass, 1-8 parts of a compound modified antibacterial agent containing piperazinyl and phenolic hydroxyl, 0.5-1.5 parts of an antistatic agent, 1-5 parts of a thickening agent and 100 parts of water. An antibacterial agent in the compound modified antibacterial agent containing piperazinyl and phenolic hydroxyl is nanoscale tourmaline coated micron-sized tetrapod-like zinc oxide. By means of the technical scheme, the problem that in the prior art, tetrapod-like zinc oxide is adopted as an antibacterial agent to conduct antibacterial after-treatment on fabric, and the prepared antibacterial yarn is poor in durability is solved.

The application discloses a preparation of low-yellowing polyether modified amino silicone oil and a fabric finishing agent containing the same, and relates to amino silicone oil and application thereof. The application uses octamethylcyclotetrasiloxane and 3-piperazinylpropylmethyldimethoxysilane as key raw materials, converts original primary amino groups into secondary amino groups on the basis of traditional amino silicone oil, simultaneously pays attention to control of the molecular mass of the modified amino silicone oil, significantly improves the chemical stability and oxidation resistance of the silicone oil, and secondarily modifies the silicone oil by using allyl epoxy polyether, so that the originally non-hydrophilic amino silicone oil obtains certain hydrophilicity, and the self-emulsifying ability of the silicone oil and the stability of the emulsion are significantly improved. Through the modification, the final silicone oil molecular chain segment can be repeatedly and directionally arranged on the fiber surface in the form of alternating polyether and polysiloxane structure, so that the finishing agent has good hydrophilicity, softness and washability for finishing fabrics.

The present invention relates to a compound of formula (I) as PARC inhibitors for the treatment of proliferative disorders, such as e.g. cancer. Preferred compounds are e.g. N,N-dimethyl-4-(7-(N-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl) piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives, such as e.g. the present example 1, N,N-dimethyl-4-(7-(N-(1-methyl-cyclopropyl)sulfamoyl)-1-(6-methylpyridin-3-yl)imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide (II). Experimental data of PARC inhibition assays of exemplary compounds is provided.

The application provides a boron nitride nanosheet-doped polyamide composite nanofiltration membrane and a preparation method. The method uniformly disperses boron nitride nanosheets in deionized water, and then uniformly mixes the boron nitride nanosheets with a piperazine aqueous solution. The mass ratio of the boron nitride nanosheets to the piperazine is (5.01-20.04):(60-200), and a mixed solution is obtained. The mixed solution is vacuum filtered on a polyether sulfone ultrafiltration membrane, and the polyether sulfone ultrafiltration membrane is left with a mixture of uniformly dispersed boron nitride nanosheets and piperazine. A triformylchloride solution is poured on the mixture of the boron nitride nanosheets and the piperazine. The mass ratio of the boron nitride nanosheets to the triformylchloride is (5.01-20.04):100. The triformylchloride and the piperazine are interfacially polymerized on the surface of the polyether sulfone ultrafiltration membrane. The solvent of the triformylchloride solution is then poured off. After drying, a boron nitride nanosheet-doped polyamide composite nanofiltration membrane is obtained, and the permeation flux and the antifouling property of the polyamide nanofiltration membrane are improved.

The invention belongs to the technical field of medicine synthesis processes, and particularly relates to a preparation method of high-yield and high-purity tandospirone citrate. According to the method, pyrimido piperazine quaternary ammonium salt and isoindoledione are used as raw materials, a toluene and n-butanol and / or n-amyl alcohol mixed solvent is used as a solvent, tandospirone can be generated under the alkaline condition without adding a phase transfer catalyst, after acid adjustment extraction and specific organic solvent reverse phase impurity removal, a water phase is adjusted to be alkaline, and the tandospirone is obtained. And extracting with toluene, and adding a citric acid ethanol solution to directly separate out a citric acid tandospirone solid. The preparation process disclosed by the invention has a very good impurity removal effect, and the obtained tandospirone citrate is high in purity, high in process yield, good in atom economy and low in output of three wastes.

The invention discloses a synthesis method of a Vinetoram key intermediate and Vinetoram, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that 1-((4 '-chloro-5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazine hydrochloride and 2-((1H-pyrrolo [2, 3-b] pyridine-5-yl) oxy)-4-bromobenzoic acid methyl ester are used as reaction raw materials, a reaction is carried out, and the Vinetoram key intermediate and the synthesis method of the Vinetoram key intermediate are synthesized; the method comprises the following steps: carrying out a substitution reaction and a hydrolysis reaction to obtain a key intermediate of the Venotocork, and carrying out a condensation reaction on the intermediate and 3-nitro-4-((tetrahydro-2H-pyran-4-yl) methylamino) benzenesulfonamide to obtain the Venotocork. The synthesis method has the advantages of short process route, easily available raw materials, mild reaction conditions, high yield and purity of the intermediate and the Vinetoram, facilitation of the improvement of the yield and quality of the Vinetoram, and reduction of the production cost of the Vinetoram.

The invention relates to the field of yarns, in particular to an anti-pilling yarn for a wear-resistant fabric and a preparation method of the anti-pilling yarn. The problems that an existing yarn is prone to being damaged when being stressed and rubbed, and the phenomena of fuzzing and pilling occur are solved. Piperazinyl is introduced into polylactic acid to synthesize piperazinyl modified polylactic acid finishing agent emulsion, the piperazinyl endows a finishing agent with excellent lubricity and reduces the friction coefficient, polylactic acid can form a continuous film on the fiber surface to wrap the yarn and form a physical barrier, and the finishing agent emulsion improves the fuzzing and pilling resistance of the yarn through the synergistic effect. The divinyl benzene is introduced into the acrylic fiber, so that the molecular chain of the acrylic fiber is not easy to break and slip, the generation of surface hairiness is reduced, and the anti-fuzzing and anti-pilling grade of the yarn is improved; the yarn has the characteristics of good wear resistance and pilling resistance, and the woven fabric is durable and soft in touch, so that the requirements of the market on high-quality and high-performance fabrics are met.

A method for preventing, ameliorating or treating one or more disease or disorders selected from the group consisting of a skin disease, skin aging or steroid-induced skin atrophy, erectile dysfunction, and hair loss, comprises transdermally administering a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.WhereinR1 is C1-C3alkyl;R2 is H, CHO or CH═N—OH;R3 is C1-C4alkyl;R4 is C1-C6alkyl;R5 is SO2NR6R7;wherein R6 and R7 are together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein said heterocyclic ring is selected from piperidine and piperazine, wherein said heterocyclic ring is substituted with at least one R8, and wherein said R8 is independently selected from C1-C6alkyl optionally substituted with OH, ONO2, wherein at least one of said at least one R8 comprises at least one ONO2 moiety.

The invention provides a loose nanofiltration membrane and a preparation method and application thereof.The loose nanofiltration membrane comprises a PAN fiber base membrane and a functional layer attached to the PAN fiber base membrane, and raw materials of the functional layer comprise a first water-phase raw material, a second water-phase raw material and an organic-phase raw material; the first water phase raw material is selected from any one or two of polyethyleneimine and ethylenediamine, the second water phase raw material is selected from any one or more of piperazine-2-carboxylic acid, 2, 3-piperazine dicarboxylic acid, 1-methylsulfonyl piperazine, 2-cyano piperazine and N-acetyl piperazine, and the third water phase raw material is selected from any one or more of piperazine-2-carboxylic acid, 2, 3-piperazinedicarboxylic acid, 1-methylsulfonyl piperazine, 2-cyano piperazine and N-acetyl piperazine. The organic phase raw material is selected from any one or more of trimesoyl chloride, terephthaloyl chloride and isophthaloyl chloride. The loose nanofiltration membrane disclosed by the invention has relatively high permeation flux and excellent dye interception capability on various dyes, has excellent structural stability, and shows huge application potential in an actual dye wastewater separation process.

This invention discloses a piperazine substituted phenol derivative and its applications in pharmaceutical chemistry. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum anesthetic effective dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.