87 results about "Piperazidine" patented technology

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

The invention discloses a preserving fluid for stably preserving sample DNA at normal temperature and a preparation method thereof, and belongs to the technical field of biological sample preservation. The preserving fluid comprises a lysis system, a nucleic acid protection system and a buffering and stabilizing system, the cracking system comprises a composite surfactant and an enzymolysis auxiliary agent; the composite surface active agent is prepared from polyether polyol fatty acid ester and cocamidopropyl hydroxy sulfobetaine; the enzymolysis auxiliary agent comprises lysozyme Lyso-V and protease K; the nucleic acid protection system comprises a nitrogen heterocyclic polyamine-carboxylic acid derivative and dextran sulfate; the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N' ', N ''tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N''-triacetic acid, disodium ethylene diamine tetraacetate-nitrogen heterocyclic derivative, and diethylenetriamine pentaacetic acid-piperazine derivative, and the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N '', N'' tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N ''-triacetic acid. The buffering and stabilizing system comprises an amphoteric buffering agent and a polymer stabilizer; the amphoteric buffering agent comprises 2-(N-morpholino) ethanesulfonic acid and N-tri (hydroxymethyl) methylglycine.

The invention relates to the field of separation and purification, in particular to an anti-pollution nanofiltration membrane for magnesium-lithium separation, the anti-pollution nanofiltration membrane comprises a base membrane and a functional layer, and the functional layer is prepared from the following raw materials in parts by weight: a water phase: 1.5-2.5 parts of piperazine, 0.1-1 part of lauryl sodium sulfate, 0.5-2 parts of glycerol, 1-2 parts of triethylamine, 0.6-2 parts of ionic polymer, and the balance of water for supplementing the total amount of the water phase to 100 parts; the ionic polymer comprises at least one of sulfobetaine metacrylic acid ester, sulfobetaine and carboxyl betaine metacrylic acid ester; and an oil phase: 0.1-1 part of trimesoyl chloride, and the total amount of the oil phase is supplemented to 100 parts by normal hexane or isoparaffin. The ionic polymer is added, and a compact hydration layer is formed on the surface of the membrane by using a betaine group of the ionic polymer, so that the membrane pollution probability is reduced, and common inorganic scaling and organic pollution in the high-salt brine are remarkably inhibited; in addition, the ionic polymer enables the membrane surface to have strong negative electricity, and the magnesium ion rejection rate is improved; and the ionic polymer can also reduce the lithium ion transmission energy barrier and reduce the rejection rate.

The application discloses a preparation of low-yellowing polyether modified amino silicone oil and a fabric finishing agent containing the same, and relates to amino silicone oil and application thereof. The application uses octamethylcyclotetrasiloxane and 3-piperazinylpropylmethyldimethoxysilane as key raw materials, converts original primary amino groups into secondary amino groups on the basis of traditional amino silicone oil, simultaneously pays attention to control of the molecular mass of the modified amino silicone oil, significantly improves the chemical stability and oxidation resistance of the silicone oil, and secondarily modifies the silicone oil by using allyl epoxy polyether, so that the originally non-hydrophilic amino silicone oil obtains certain hydrophilicity, and the self-emulsifying ability of the silicone oil and the stability of the emulsion are significantly improved. Through the modification, the final silicone oil molecular chain segment can be repeatedly and directionally arranged on the fiber surface in the form of alternating polyether and polysiloxane structure, so that the finishing agent has good hydrophilicity, softness and washability for finishing fabrics.

The application provides a boron nitride nanosheet-doped polyamide composite nanofiltration membrane and a preparation method. The method uniformly disperses boron nitride nanosheets in deionized water, and then uniformly mixes the boron nitride nanosheets with a piperazine aqueous solution. The mass ratio of the boron nitride nanosheets to the piperazine is (5.01-20.04):(60-200), and a mixed solution is obtained. The mixed solution is vacuum filtered on a polyether sulfone ultrafiltration membrane, and the polyether sulfone ultrafiltration membrane is left with a mixture of uniformly dispersed boron nitride nanosheets and piperazine. A triformylchloride solution is poured on the mixture of the boron nitride nanosheets and the piperazine. The mass ratio of the boron nitride nanosheets to the triformylchloride is (5.01-20.04):100. The triformylchloride and the piperazine are interfacially polymerized on the surface of the polyether sulfone ultrafiltration membrane. The solvent of the triformylchloride solution is then poured off. After drying, a boron nitride nanosheet-doped polyamide composite nanofiltration membrane is obtained, and the permeation flux and the antifouling property of the polyamide nanofiltration membrane are improved.

The invention belongs to the technical field of medicine synthesis processes, and particularly relates to a preparation method of high-yield and high-purity tandospirone citrate. According to the method, pyrimido piperazine quaternary ammonium salt and isoindoledione are used as raw materials, a toluene and n-butanol and / or n-amyl alcohol mixed solvent is used as a solvent, tandospirone can be generated under the alkaline condition without adding a phase transfer catalyst, after acid adjustment extraction and specific organic solvent reverse phase impurity removal, a water phase is adjusted to be alkaline, and the tandospirone is obtained. And extracting with toluene, and adding a citric acid ethanol solution to directly separate out a citric acid tandospirone solid. The preparation process disclosed by the invention has a very good impurity removal effect, and the obtained tandospirone citrate is high in purity, high in process yield, good in atom economy and low in output of three wastes.

The invention discloses a synthesis method of a Vinetoram key intermediate and Vinetoram, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that 1-((4 '-chloro-5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazine hydrochloride and 2-((1H-pyrrolo [2, 3-b] pyridine-5-yl) oxy)-4-bromobenzoic acid methyl ester are used as reaction raw materials, a reaction is carried out, and the Vinetoram key intermediate and the synthesis method of the Vinetoram key intermediate are synthesized; the method comprises the following steps: carrying out a substitution reaction and a hydrolysis reaction to obtain a key intermediate of the Venotocork, and carrying out a condensation reaction on the intermediate and 3-nitro-4-((tetrahydro-2H-pyran-4-yl) methylamino) benzenesulfonamide to obtain the Venotocork. The synthesis method has the advantages of short process route, easily available raw materials, mild reaction conditions, high yield and purity of the intermediate and the Vinetoram, facilitation of the improvement of the yield and quality of the Vinetoram, and reduction of the production cost of the Vinetoram.

The invention relates to the field of yarns, in particular to an anti-pilling yarn for a wear-resistant fabric and a preparation method of the anti-pilling yarn. The problems that an existing yarn is prone to being damaged when being stressed and rubbed, and the phenomena of fuzzing and pilling occur are solved. Piperazinyl is introduced into polylactic acid to synthesize piperazinyl modified polylactic acid finishing agent emulsion, the piperazinyl endows a finishing agent with excellent lubricity and reduces the friction coefficient, polylactic acid can form a continuous film on the fiber surface to wrap the yarn and form a physical barrier, and the finishing agent emulsion improves the fuzzing and pilling resistance of the yarn through the synergistic effect. The divinyl benzene is introduced into the acrylic fiber, so that the molecular chain of the acrylic fiber is not easy to break and slip, the generation of surface hairiness is reduced, and the anti-fuzzing and anti-pilling grade of the yarn is improved; the yarn has the characteristics of good wear resistance and pilling resistance, and the woven fabric is durable and soft in touch, so that the requirements of the market on high-quality and high-performance fabrics are met.

The invention provides a loose nanofiltration membrane and a preparation method and application thereof.The loose nanofiltration membrane comprises a PAN fiber base membrane and a functional layer attached to the PAN fiber base membrane, and raw materials of the functional layer comprise a first water-phase raw material, a second water-phase raw material and an organic-phase raw material; the first water phase raw material is selected from any one or two of polyethyleneimine and ethylenediamine, the second water phase raw material is selected from any one or more of piperazine-2-carboxylic acid, 2, 3-piperazine dicarboxylic acid, 1-methylsulfonyl piperazine, 2-cyano piperazine and N-acetyl piperazine, and the third water phase raw material is selected from any one or more of piperazine-2-carboxylic acid, 2, 3-piperazinedicarboxylic acid, 1-methylsulfonyl piperazine, 2-cyano piperazine and N-acetyl piperazine. The organic phase raw material is selected from any one or more of trimesoyl chloride, terephthaloyl chloride and isophthaloyl chloride. The loose nanofiltration membrane disclosed by the invention has relatively high permeation flux and excellent dye interception capability on various dyes, has excellent structural stability, and shows huge application potential in an actual dye wastewater separation process.

This invention discloses a piperazine substituted phenol derivative and its applications in pharmaceutical chemistry. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum anesthetic effective dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The invention discloses an efficient synthesis method of brexpiprazole, which comprises the following steps: taking 4-bromo-benzothiophene and N-Boc-piperazine as initial raw materials, under the protection of nitrogen, carrying out reaction by using a supported catalyst to prepare 4-Boc piperazine benzothiophene, and then carrying out acidolysis to obtain 4-piperazine benzothiophene hydrochloride; the method comprises the following steps: reacting 3, 4-dihydro-7-hydroxy-2 (1H) quinolinone with 1-bromo-4-chloro-butane to generate 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone, and then converting the 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone into 7-(4-chlorobutoxy)-2 (1H)-quinolinone; then condensing with 4-piperazine benzothiophene hydrochloride to obtain a crude product of brexpiprazole; and finally, crystallizing and purifying for multiple times to obtain high-purity brexpiprazole. According to the preparation method disclosed by the invention, 4-bromo-benzothiophene and N-Boc-piperazine are taken as starting raw materials, and high-purity brexpiprazole is prepared by optimizing selection of a catalyst and conditions of each step and through an excellent purification process.

A method for treating pruritus in patients with atopic dermatitis (AD) and / or nodular prurigo (PN) is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxecyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rezabrutinib) and pharmaceutically acceptable salts thereof.

Provided are novel piperazic acid containing peptide compound stereoisomer, solvate, or pharmaceutically acceptable salt thereof, method of preparing the same, and use thereof. The peptide compound, stereoisomer, solvate, or pharmaceutically acceptable salt thereof has activities of anticancer, anti-metastasis, and growth inhibition of resistant tumors, and thus may be used to prevent or treat various cancers or metastases of cancer.

A preparation method for a CDK4 / 6 inhibitor for a compound of formula (I):5-fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)-N-(5-(piperazin-1-yl) pyrazol-2-yl)pyrimidine-2-amine. The preparation method has cheap and readily available starting materials and reagents, greatly simplified total reaction steps, shortened reaction time, improved total yield and a high purity of the key intermediate and final product, being suitable for industrial production.

The present invention relates to combination therapies for the treatment of cancer, the therapies comprising a piperazine derivative and a chemotherapeutic agent and / or a targeted therapy agent; methods of making such compounds; pharmaceutical compositions comprising such compounds; and methods of using these compounds, particularly methods for targeted therapy of hyperproliferative disorders, including benign hyperproliferative disorders, cancer, and precancerous conditions.

The invention belongs to the technical field of medicine synthesis, and particularly relates to an efficient synthesis method of brexpiprazole. The invention provides a novel preparation method of bupreprazole, which comprises the following steps: by taking 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine as a starting material, carrying out substitution reaction on the 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine and 7-hydroxy-2H-benzopyran-2-ketone to prepare an intermediate 7-(4-(4-(benzo [b] thiophene-4-yl) piperazin-1-yl) butoxy)-2H-benzopyran-2-ketone; according to the present invention, with the process, the use of the noble metal catalyst and the generation of the related dimer and the heterotopic substitution impurity can be effectively avoided, and the product obtained through the process has characteristics of high yield and high purity, and is suitable for industrial production.

The application discloses a kind of high flame-retardant anti-cracking insulated cable and preparation method thereof, it is related to crosslinked polyethylene insulated cable technical field, from outside to inside sequentially include the following structure: including sheath layer, wrapping layer, insulating layer and conductor group;Insulating layer and conductor group between being provided with filling layer.The modifier is prepared by phosphate, acryloyl chloride, 2,4,6-tri (piperazinyl) -1,3,5-triazine, aminosiloxane reaction in the application, graft on polyethylene molecular chain, as cable material system, preparation crosslinked polyethylene, the structure of modifier is introduced into its crosslinking network, can effectively improve the mechanical properties and flame-retardant property of cable material, reduce the addition of filler, alleviate the plastic damage caused by it, prevent the occurrence of cracking phenomenon.

The present application relates to novel compounds of formula (I) which are prodrugs of brexpiprazole. The novel compounds of the invention, upon administration to a subject, undergo chemical conversion by one or more metabolic processes to release an active pharmacological agent in vivo. Brexpiprazole, sold under the Rexulti (registered trademark), is an atypical antipsychotic indicated for use as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults and the treatment of schizophrenia in adults and pediatric patients ages 13 years and older.

A perfusion stock composition, for preserving a donor organ for transplantation, comprising: a source of 60 to 100 mM Na+; a source of 10 to 20 mM K+; a source of 5 to 10 mM Mg2+; a source of 0.25 to 0.75 mM Ca2+; 10 to 40 mM Tris(hydroxymethyl)aminomethane hydrochloride (Tris or THAM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 3-(N-morpholino)propanesulfonic acid (MOPS), 2-(N-morpholino)ethanesulfonic acid (IviES), N,N-bis-(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), or N / -tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES); a source of 10 to 30 mM HCO3; 1 to 30 mM glucose; 1 to 20 U / L insulin; 1 to 10 mM fructose diphosphate or a salt thereof, 1 to 40 mM aspartate or glutamate; 1 to 10 mM adenosine, cAMP or cGMP; 1 to 10 mM reduced glutathione; and 30 to 100 mM lactobionate or mannitol; and, optionally, a diluent. The present disclosure also provides a perfusion composition, a kit, a method, and a perfusion apparatus, each related to the perfusion stock composition.

The application provides a method for degrading chlorohydrocarbon in water by using illite reinforced ball-milling sulfidation micro zero-valent iron, which comprises the following steps: first, a buffer solution with pH=7 is prepared by using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, and an oxygen-free aeration treatment is performed; then, illite and S-mZVI bm are mixed to prepare a particle mixture, and the particle mixture is sealed and stored in the buffer solution with pH=7; finally, chlorohydrocarbon pollutants are added into the particle mixture of illite and S-mZVI bm , and a sealed oscillation reaction is performed, so that the concentration of the chlorohydrocarbon in the reaction system is determined. The application directly reinforces the activity of S-mZVI bm material by using illite, which is a clay mineral widely distributed in nature, so that the defects of S-mZVI bm , such as large particle size, slow degradation rate and decreased activity in the later reaction stage, are effectively solved, and the long-term reaction activity of the particles is ensured. The raw materials are green and environmentally friendly, the process is simple, and the materials are easy to obtain.

The invention relates to a preparation method of ultra-pure electronic-grade pentamethyldiethylenetriamine, and belongs to the technical field of purification of electronic chemicals. The invention aims to solve the technical problem that a by-product N, N-dimethyl piperazine in industrial-grade PMDETA is difficult to efficiently remove. According to the method, industrial-grade PMDETA is used as a raw material, and the method sequentially comprises the steps of microfiltration, ion exchange, vacuum distillation and nanofiltration. Wherein the step of vacuum rectification is carried out under the conditions that the absolute pressure is 1.0-8.0 kPa, the temperature of a tower kettle is 125-160 DEG C and the reflux ratio is 2: 1-6: 1, and efficient separation of N, N-dimethyl piperazine and PMDETA is realized by accurately controlling process parameters. The purity of the finally prepared PMDETA product is larger than 99.99%, the content of N, N-dimethyl piperazine is lower than 16 ppm, meanwhile, the content of metal ions is lower than 10 ppt, the number of particles meets the electronic grade standard, and the method is suitable for the fields of semiconductor and integrated circuit manufacturing and the like.

The application discloses a kind of piperazine derivatives and purposes thereof, and belongs to the field of pharmacy.The piperazine derivatives in the application can improve microglial cell activity, and the compounds have wide application prospects in the preparation of drugs for preventing and treating Alzheimer's disease.

Provided herein are methods of treating sickle cell disease, methods of increasing hemoglobin levels in a subject diagnosed with sickle cell disease, and methods of reducing hemolysis-associated complications in a subject diagnosed with sickle cell disease, together with kits for such treatments, in a subject in need thereof, comprising administering a Gardos channel inhibitor such as 2,2-bis(4-fluorophenyl)-2-phenylacetamide and a pyruvate kinase activator such as N-(4-((4-(Cyclopropylmethyl)-1-piperazinyl)carbonyl)phenyl)-8- quinolinesulfonamide to the subject. Subjects eligible for treatment include subjects as having hemolysis dominant (HD) sickle cell disease on the basis of laboratory markers, clinical history, and / or sequelae.

A ceramic membrane includes an alumina (Al2O3) layer; and a polyamide nanocomposite layer at least partially covering a surface of the alumina layer. The polyamide nanocomposite layer contains polyamide-functionalized silicon carbide (SiC) nanoparticles having an average particle size of 0.1 to 1 micrometer (μm), an amine-functionalized SiC moiety, an acyl aryl moiety, and a piperazine moiety. The amine-functionalized SiC moiety contains a SiC core and an amine functionalized silicon dioxide (SiO2) shell covering the SiC core. The amine-functionalized SiC moiety is covalently bonded to the piperazine moiety via the acyl aryl moiety; and the amine functionalized SiO2 shell contains at least one amino group containing structural unit that is covalently bonded to the SiO2 shell.

The invention relates to the technical field of high-performance polypropylene, in particular to a waste plastic-based regenerated PP flame-retardant material. The material is prepared from the following raw materials: regenerated polypropylene, maleic anhydride grafted polypropylene, microencapsulated ammonium polyphosphate, compound flame-retardant powder consisting of piperazine pyrophosphate and melamine polyphosphate, an auxiliary A and an auxiliary B. The auxiliary agent A is a compound of a zeolite imidazole skeleton coated with dopamine and a phosphorus-containing addition body, and the auxiliary agent B is a graft of the zeolite imidazole skeleton coated with dopamine and aminopropyl-terminated polydimethylsiloxane. A microcapsule shell layer is constructed by adopting two-section shell closing, and double-screw sectional feeding extrusion is performed, so that gradient dispersion and reaction anchoring of a flame retardant, an interface modifier and regenerated polypropylene are realized. The material shows excellent flame-retardant and anti-dripping properties, mechanical toughness and processing stability under a thin-wall injection molding condition, and is suitable for the fields of household appliance shells and automotive upholstery.