9results about How to "High antagonistic activity" patented technology

This invention belongs to the field of microbial technology, specifically relating to a strain of Acetobacter peroxide 672 and its applications. The Acetobacter peroxide 672 strain of this invention can enhance the antagonistic activity of Pichia pastoris against Rhizoctonia solani and also antagonizes Colloidal anthracnose, providing a multi-faceted solution for the biological control of crop diseases. Furthermore, the strain possesses the ability to produce indoleacetic acid, which can significantly promote the growth and development of grain crops such as wheat and corn, promote root expansion, enhance nutrient and water absorption, and thus effectively increase biomass. In addition, the strain can tolerate and degrade chemical pesticide components such as imidacloprid and carbendazim, alleviating soil pesticide residue pollution, and can effectively alleviate the inhibitory effects of low pH stress on crops, enhancing their stress resistance. Therefore, the Acetobacter peroxide 672 strain of this invention has significant application value in the biological control of crop diseases, crop growth promotion, soil pesticide residue remediation, and enhancing crop stress resistance.

The invention belongs to the technical field of strawberry biocontrol, and relates to application of chaetomium aureum JSNL-B47 in prevention and treatment of strawberry gray mold. The preservation number of the chaetomium aureum JSNL-B47 is CGMCC (China General Microbiological Culture Collection Center) NO. 40437. According to the present invention, the flat plate confrontation inhibition rate of the bacterial strain on Botrytis cinerea can achieve 67.94%, the extracellular metabolite inhibition rate can achieve 69.58%, strawberry resistance can be induced, and the scab inhibition rate can achieve 82.26%; the invention also provides a biocontrol inoculant containing hyphae, spores or secondary metabolites of the strain and a preparation method of the biocontrol inoculant. The biocontrol bacterium and the preparation thereof provided by the invention can significantly reduce the occurrence of strawberry gray mold, reduce the use of chemical pesticides, and are suitable for green agriculture.

The invention provides bacillus stutzeri HMB39561 and application thereof, and belongs to the technical field of agricultural microorganisms. The bacillus stutzeri HMB39561 disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the bacillus stutzeri HMB39561 is CGMCC No.37015. The strain not only has a good prevention and treatment effect on cotton damping-off and verticillium wilt, but also can increase the cotton yield and improve the cotton quality. The bacillus stutzeri HMB39561 disclosed by the invention can be used for green prevention and control of cotton damping-off and verticillium wilt, and has a relatively good application prospect in the field of cotton planting.

This invention provides a strain of *Pseudomonas aeruginosa* RL76, its bacterial suspension, its preparation method, and its applications, belonging to the field of agricultural microbiology technology. The *Pseudomonas aeruginosa* RL76 was deposited at the China General Microbiological Culture Collection Center (CGMCC) on January 26, 2026, with accession number CGMCC No. 37531. This invention utilizes a mixture of filter mud and soil for sugar beet cultivation. It was found that, under the same pathogen inoculation conditions, the filter mud treatment significantly alleviated the occurrence of damping-off disease in sugar beets compared to the non-filter mud treatment, suggesting that the filter mud plays a role in increasing the relative abundance of beneficial microorganisms in the soil. Therefore, this invention isolated a strain of *Pseudomonas aeruginosa* RL76 with highly efficient antagonistic activity against *Rhizoctonia solani* from the rhizosphere soil of sugar beets cultivated using a mixture of filter mud and soil, and for the first time discovered its effective control of sugar beet damping-off disease while also promoting sugar beet growth, representing a groundbreaking achievement.

The invention relates to the technical field of microorganisms, in particular to a compound fungicide containing bacillus velezensis TA-5 strains and application of the compound fungicide. The microbial agent disclosed by the invention comprises the following components: (1) a viable bacterium, a freeze-dried bacterium, an inactivated bacterium body or a strain culture of a bacillus velezensis TA-5 strain; (2) bacillus subtilis and / or chitosan oligosaccharide, and / or pharmaceutically acceptable pharmaceutic adjuvants; wherein the preservation number of the bacillus velezensis TA-5 strain in the China General Microbiological Culture Collection Center is CGMCC (China General Microbiological Culture Collection Center) NO. 33034. The bactericidal composition has an excellent prevention and treatment effect on fruits and vegetables with diseases, and especially has an excellent effect on field tests; meanwhile, the dosage of chemical agents is reduced, safety and environmental protection are achieved, and a brand new thought is provided for agricultural control.

This invention belongs to the field of agricultural microbiology technology, specifically relating to a microbacterium strain and its application in plant disease control. This invention discloses a microbacterium strain screened from wolfberry roots, named... Microbacterium sp. R5-1, deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 34797, has the 16S rDNA sequence shown in SEQ ID NO:1. It secretes siderophores, cellulase, and protease. Experimental results demonstrate that this strain exhibits inhibitory activity against the growth of *Fusarium oxysporum*, *Rhizoctonia solani*, and *Verticillium dahliae*, and shows significant control efficacy against soil-borne fungal diseases of plants caused by these fungi. This invention provides an important microbial resource for the green control of soil-borne fungal diseases of plants.

This invention belongs to the field of microbial technology, specifically disclosing a Bacillus C1-74 strain and its applications. More particularly, it relates to a Bacillus C1-74 strain that promotes growth and significantly inhibits garlic root rot. This Bacillus C1-74 strain was deposited on April 3, 2025, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, Hubei Province, with accession number CCTCC M 2025700. This invention discloses a Bacillus C1-74 strain and its applications. This Bacillus C1-74 strain significantly inhibits garlic root rot, effectively alleviating the harmful symptoms of root rot such as browning and decay of garlic roots. Simultaneously, this strain has a significant growth-promoting effect on seedlings of vegetables such as garlic, scallions, cucumbers, and tomatoes.

The invention discloses a mangrove endophytic fungus, a fermentation product of the mangrove endophytic fungus, a preparation method of a solid-state fermentation preparation and application of the mangrove endophytic fungus, the mangrove endophytic fungus, the solid-state fermentation preparation of the mangrove endophytic fungus, the mangrove endophytic fungus, the solid-state fermentation preparation of the mangrove endophytic fungus and the solid-state fermentation preparation of the mangrove endophytic fungus, the mangrove endophytic fungus, the mangrove endophytic fungus and the solid-state fermentation preparation of the mangrove endophytic fungus, the mangrove endophytic fungus, the mangrove endophytic fungus and the solid-state fermentation preparation of the mangrove endophytic fungus, a metabolite of the strain has unique structural characteristics and biological activity, and a fermentation product prepared from the mangrove endophytic fungi has good antagonistic activity on gram-positive bacteria and can be widely applied to prevention and treatment of bacterial infection.

The present application relates to compounds of formula (I) which act as antagonists of STING, useful in the treatment of autoimmune diseases, inflammatory diseases, nervous system disorders, metabolic diseases, cardiovascular diseases, ocular diseases or selective cancer types in which overexpression or activation of STING is associated.