52 results about "Levofloxacin" patented technology

The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative. The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative thereof, for use in a method for the treatment of conjunctivitis and for the prevention or treatment of inflammation or prevention of infection after cataract surgery in a subject, according to a dosage regimen that improves patient compliance and tolerability and enables the prevention and treatment of intermediate / antibiotic-resistant infections.

According to the method, melamine and urea are used as carbon and nitrogen sources, hollow tubular phosphorus-doped carbon nitride is constructed by adopting a sodium polyphosphate-assisted hydrothermal-thermal polymerization method, molybdenum disulfide is loaded on the surface of P-TCN in a hydrothermal in-situ growth mode, and the hollow tubular phosphorus-doped heterojunction photocatalyst is obtained. The hollow tubular phosphorus-doped heterojunction photocatalyst P-TCN / MoS2 is prepared; the catalyst disclosed by the invention shows excellent degradation performance on ciprofloxacin, levofloxacin, rhodamine B and methylene blue under an illumination condition. The catalyst disclosed by the invention is simple in preparation method, low in cost and easily available in raw materials, and has a wide application prospect in the field of photocatalytic treatment of antibiotic and dye wastewater.

The invention discloses a Co3O4-Cu2-xS composite photo-thermal catalyst as well as a preparation method and application thereof. The composite photo-thermal catalyst is prepared by taking a surfactant as a bridge and compounding Co3O4 and Cu2-xS. The composite photo-thermal catalyst has a reduced band gap width, can effectively promote migration and separation of photon-generated carriers, enhances the absorption efficiency of visible light-near infrared light, and shows excellent photo-thermal conversion performance. The composite photo-thermal catalyst can be used for constructing a Co3O4-Cu2-xS + PMS + NIR catalytic system, and peroxymonosulfate is activated under the irradiation of near-infrared light so as to degrade antibiotics in water. Experiments prove that the Co3O4-Cu2-xS + PMS + NIR system disclosed by the invention can achieve the degradation rate of 99% on levofloxacin within 20 minutes, and the generation efficiency of active species is remarkably improved through the synergistic effect of a photothermal effect and interface activation. The catalyst has broad-spectrum degradation activity on various antibiotics, keeps efficient and stable catalytic performance in a wide pH range, and shows excellent ion interference resistance and adaptability to various water bodies.

The utility model discloses a levofloxacin hydrochloride tablet preparation raw material quick mixing device, including frame, the frame top is provided with removal subassembly, the frame inside is provided with mixing box through removal subassembly, the both sides of mixing box are provided with guide component, and guide component is connected with the frame, the mixing box top is provided with drive assembly, the mixing box is provided with the pivot through drive assembly in the inside, the pivot is rotatably connected with mixing box, the pivot surface fixed mounting has the stirring rod. This kind of stirring and shaking combined mode can make raw materials flow and mix in multiple dimensions, can effectively avoid the situation that raw materials are not mixed sufficiently in local area, significantly improve the uniformity and effect of mixing, apply force to raw materials from different directions, speed up the mutual blending and diffusion between raw materials, can reach the ideal mixing state in shorter time, thereby improve the overall mixing efficiency, save production time.

The invention belongs to the technical field of environmental functional materials, and relates to a heterojunction photocatalyst as well as a preparation method and application thereof. The heterojunction photocatalyst is of a Z-type energy band structure and comprises beam-shaped h-BN and Ag3PO4 nano-particles loaded on the beam-shaped h-BN, and the particle size of the Ag3PO4 nano-particles ranges from 1 nm to 20 nm. According to the heterojunction photocatalyst, the initial degradation rate of levofloxacin hydrochloride in visible light within 60 min is larger than or equal to 88%, and the degradation rate is kept to be 80% or above after four times of circulation.

The application belongs to the technical field of electroluminescence, and particularly relates to a preparation method of a high-entropy oxide material and application of the high-entropy oxide material in electrochemiluminescence detection of levofloxacin. The high-entropy oxide material is a kind of five-element high-entropy oxide HEO-800 material with simple raw materials, convenient synthesis, excellent electrochemiluminescence performance, which is synthesized by taking metal nitrate of Fe, Co, Cu, Zn and Ni as raw materials, and taking Na2CO3 and NaOH as raw materials. The HEO-800 material has excellent conductivity and chemical stability, and a multi-electron reaction potential accelerates the conversion of dissolved oxygen into reactive oxygen species (ROS), enhances the electroluminescence intensity, and based on the quenching effect of LVX, a method for detecting LVX by using a luminol / HEO-800 system is established. By fitting the change of ECL intensity with the concentration of LVX, a linear calibration curve is obtained, the correlation coefficient is 0.993, and the detection limit is 1.02*10 ‑5 μM (S / N=3). The material has good sensitivity, stability and reproducibility for electrochemiluminescence detection of LVX, and provides a new scheme for designing a new electrocatalyst for testing LVX.

The application discloses a flagellum inhibiting peptide of pseudomonas aeruginosa and a preparation method and application thereof, and the sequence of the flagellum inhibiting peptide is Lys-Ile-Gly-Leu-Phe-Arg-Trp-Arg. The synthetic inhibiting peptide has a time-dependent self-assembly ability, can gradually evolve from scattered granular into filamentous structure, and finally forms a stable net-like morphology. The synthetic inhibiting peptide can significantly inhibit the flagellum motility of PAO1 and other strains of pseudomonas aeruginosa, and has synergistic antibacterial activity when combined with allicin, ciprofloxacin, meropenem, levofloxacin, polymyxin B and the like. Moreover, the synthetic inhibiting peptide has obvious bacteriostatic and healing-promoting effects on burn wound infection.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

The invention provides a method for improving the purity of a levofloxacin product, which comprises the following steps: carrying out condensation reaction on levofloxacin carboxylic acid, dimethyl sulfoxide and N-methyl piperazine, adding water into the obtained concentrate, adding a specific acidic reagent to adjust the pH value of the system to 1.0-4.5, heating to dissolve, cooling to separate out impurities, filtering, adding trichloromethane into the filtrate, extracting under the condition that the pH value is 7.0-7.5, and filtering to obtain the levofloxacin product. And collecting an organic phase, concentrating, adding ethanol, and crystallizing to obtain a high-purity levofloxacin product. According to the method, by limiting the raw material ratio, the process conditions and the specific acid reagent, generation of an isomeride impurity I is reduced from the reaction source, efficient separation of the impurity I and the levofloxacin is achieved, the content of the isomeride impurity I in the levofloxacin product is remarkably reduced, and the purity of the levofloxacin product is improved. Meanwhile, other insoluble impurities under the acidic condition are removed through filtration, so that a high-purity product with the purity of 99.86% or above is obtained. The whole impurity removal process is simple, efficient, safe, environment-friendly and especially suitable for large-scale industrial production.

A method for degrading levofloxacin in wastewater based on a visible light-driven CMP (Chemical Molecular Polymer) photocatalytic system is disclosed. This invention aims to address the problems of most existing photocatalysts being only responsive to ultraviolet light, having limited solar energy utilization efficiency, being highly susceptible to the influence of wastewater turbidity and color, and exhibiting low degradation efficiency for norfloxacin. The method comprises: 1. Synthesizing a conjugated microporous polymer; 2. Performing photocatalytic degradation under visible light irradiation. This invention aims to achieve efficient solar energy utilization by utilizing the excellent photogenerated charge generation and transport efficiency of conjugated microporous polymers for the efficient degradation of levofloxacin. This provides a mild, efficient, and environmentally friendly green method for degrading the novel pollutant levofloxacin, offering a new option for treating complex industrial wastewater.

The invention relates to a pH responsive hydrogel drug delivery system for corneal neovascularization treatment, which is a composite hydrogel LEV-DG-HPMC formed by forming LEV-DG nano-micelles from drugs levofloxacin and dipotassium glycyrrhizinate by a film dispersion method, then heating and self-assembling to form LEV-DG hydrogel, and introducing hydroxypropyl methylcellulose as a tackifier. The drug delivery system disclosed by the invention has unique pH response characteristics, can accurately identify the alkali burn microenvironment and control the release of drugs, and obviously prolongs the cornea residence time. Through the synergistic effect of DG and LEV, the vicious circle of infection-inflammation-neovascularization is effectively blocked. Experiments show that the system can significantly reduce the corneal neovascularization area and accelerate epithelium repair, has good biocompatibility and treatment effect, and provides a new solution for treatment of corneal alkali burn.

This invention discloses a compound ointment for protecting the nasal mucosa and repairing skin damage, and its preparation method, belonging to the field of pharmaceutical technology. The compound ointment is formulated with Sophora japonica fruit extract, erythromycin ointment, vitamin B6, levofloxacin hydrochloride tablets, loratadine tablets, fluticasone propionate nasal spray, sesame oil, and honey in specific weight proportions. The components work synergistically, providing protection for the nasal mucosa, treatment of rhinitis, reduction of cold air and external pollutant intrusion, and prevention of colds. It can also treat hemorrhoids, scars, eczema, and other skin damage, achieving "one medicine for multiple uses." This compound ointment has a stable dosage form, is convenient to use, has high utilization rate, high safety, and no obvious side effects, making it suitable for various populations and possessing good industrialization prospects.

The invention discloses a pharmaceutical composition and a nano preparation, a preparation method and application thereof, and relates to the technical field of biomedicine.The pharmaceutical composition comprises gallium salt and levofloxacin, the molar ratio of the gallium salt to the levofloxacin is 4: 1-300: 1, and the nano preparation comprises a polyphenol compound and the pharmaceutical composition. The gallium salt and the polyphenol compound are coordinated and complexed to form a network structure, and levofloxacin is loaded; the preparation method is a fractional step method or a one-pot synthesis method. The medicine for treating pseudomonas aeruginosa infection, which is prepared from the nano preparation, is delivered to the lung in an atomization administration manner; the invention has the following beneficial effects: the synergistic antibacterial activity is significantly enhanced; the drug stability and bioavailability are improved; and a stable platform is provided for subsequent surface targeted modification.

The invention discloses catalytic sludge biochar for strengthening iron-nitrogen anchoring through spatial constraint as well as a preparation method and application of the catalytic sludge biochar, and belongs to the technical field of organic solid waste recycling. The preparation method comprises the following steps: mixing an iron source, sludge and urea according to a certain mass ratio, adjusting the water content to 7-25%, and extruding, granulating and molding into granules with compact structures in a specific manner; and then pyrolyzing in an inert atmosphere to prepare the catalytic sludge biochar. The preparation method provided by the invention can effectively inhibit the volatilization loss of nitrogen element in the pyrolysis process and promote the reaction of iron and nitrogen, so that a rich FexN active structure is efficiently and directionally generated under the extremely low level that the use amount of urea is only 1-12% of the mass of sludge. The catalytic sludge biochar disclosed by the invention is excellent in performance, and the degradation removal rate of levofloxacin is as high as 98.94%. The method is simple in process and low in cost, and a brand new technical scheme is provided for high-value resource utilization of the sludge and efficient and economic treatment of the antibiotic wastewater difficult to degrade.

The invention provides a temperature-sensitive hydrogel for resisting bacteria and promoting repair and a preparation method thereof, the temperature-sensitive hydrogel comprises PEG-NB, a matrix metalloproteinase degradable peptide cross-linking agent, gelatin, indocyanine green and levofloxacin, and the temperature-sensitive hydrogel is prepared by photo-crosslinking. According to the temperature-sensitive hydrogel provided by the invention, the structure and the performance of the hydrogel are optimized through the synergistic effect of the gelatin and the PEG-NB, and the mechanical strength, the biocompatibility, the degradability and the like of the hydrogel are remarkably improved; meanwhile, the photo-thermal antibacterial function of the photo-thermal agent indocyanine green and the chemical antibacterial function of levofloxacin are integrated, and near-infrared light irradiation is combined, so that the antibacterial and skin repair promoting effects of the hydrogel are synergistically improved.

The invention provides enterococcus faecalis bacteriophage vBEfaS-1017 and application thereof, the enterococcus faecalis bacteriophage vBEfaS-1017 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.46182, and the preservation time is September 6, 2024. The bacteriophage vBEfaS-1017 is high in specificity, short in incubation period and ultrahigh in stability, and has activity under the conditions of extreme pH, high temperature and ultraviolet radiation; by evaluating the in-vitro bactericidal efficacy of the bacteriophage vBEfaS-1017, it is determined that the bacteriophage vBEfaS-1017 can effectively remove a biological membrane formed by host bacteria Ef 10-17, the removal rate is as high as 90%, and the bacteriophage vBEfaS-1017 is expected to become a scavenger for solving the biological membrane. Further experiments prove that the bacteriophage vBEfaS-1017 has in-vivo and in-vitro safety. Through combined use of the bacteriophage and different antibiotics, it is found that combined use of the bacteriophage vBEfaS-1017 and the antibiotic levofloxacin can effectively treat bacteremia of mice, the treatment time after infection can be prolonged by using the bacteriophage in advance, and the bacteriophage has a good application prospect in the aspect of preventing and treating enterococcus faecalis.

The invention discloses a method for detecting dimethylamine in levofloxacin, which comprises the following steps: weighing levofloxacin, adding a diluent for dissolving and diluting, and taking filtrate to obtain a test solution; taking a dimethylamine hydrochloride reference substance, and adding a diluent for dissolving and diluting to obtain a reference substance solution; respectively injecting the reference solution and the test solution into an ion chromatograph, recording chromatograms, and calculating by peak areas according to an external standard method to obtain the content of dimethylamine. According to the method for detecting the dimethylamine in the levofloxacin, the content of the dimethylamine in the levofloxacin is measured through the ion chromatography, the method is simple, convenient and feasible, high in specificity, high in accuracy and good in repeatability, the method has the advantages of being high in detection sensitivity, the content of the dimethylamine in the levofloxacin raw material can be accurately and sensitively detected, and the detection cost is low. Therefore, the quality of the levofloxacin raw material is ensured.

The invention provides a preparation method and application of a near-infrared response carbon dot composite bismuth vanadate / nickel oxide heterojunction photocatalyst. According to the material, levofloxacin is taken as a precursor, nitrogen-fluorine-doped carbon dots with an up-conversion characteristic are synthesized through a hydrothermal method, and the nitrogen-fluorine-doped carbon dots are compounded with a NiO nanosheet and a BiVO4 precursor which are prepared in advance by adopting a one-step hydrothermal strategy. Due to the up-conversion characteristic of the carbon dots, near-infrared light can be converted into visible light, spectral response is widened, and light capture efficiency is improved; meanwhile, the electron transmission capability of the material is cooperated with the built-in electric field of the BiVO4 / NiO p-n heterojunction, a multi-dimensional transmission channel is constructed, and carrier recombination is inhibited, so that the generation efficiency of active oxygen is remarkably improved, and the photocatalytic material with near-infrared light response characteristics, excellent antibiotic degradation performance and high stability is finally obtained.

This application relates to the field of drug synthesis technology and provides a method for preparing levofloxacin. The method includes first mixing N,N-dimethylaminoacrylate, triethylamine, and toluene, then adding 2,3,4,5-tetrafluorobenzoyl fluoride dropwise and reacting it with L-2-aminopropanol. After post-treatment, a toluene solution of the amine is obtained. Next, using N,N-dimethylformamide or toluene as a solvent, a cyclization reaction is carried out with differentiated feeding methods and temperature control. The product is purified by hot slurrying with a non-alcoholic organic solvent or a saturated alcohol solution of the levofloxacin cyclase. Finally, the product is purified by acidic hydrolysis, piperacillin reaction, and dimethyl sulfoxide to obtain high-purity levofloxacin. This application optimizes solvent selection and process integration, shortens reaction time, improves product yield and purity, reduces waste emissions, allows for resource utilization of byproducts, and features a simple and easily industrialized process suitable for large-scale production.

The application accords with the field of water pollution control and treatment technology, and particularly relates to a wastewater treatment device for producing left phosphorus right amine salt. The device comprises an evaporation reaction kettle, a plurality of evaporation pipes are fixedly connected to the middle part of the evaporation reaction kettle, the evaporation reaction kettle is divided into a feeding cavity, a discharging cavity and a heat exchange cavity, the evaporation reaction kettle is provided with a temperature sensor for detecting the gas in the heat exchange cavity, the evaporation reaction kettle is fixedly connected with a first push rod, the evaporation reaction kettle is slidably connected with a sliding shaft, the telescopic end of the first push rod is fixedly connected with the sliding shaft, the sliding shaft is fixedly connected with a blocking frame, and the blocking frame is used for blocking the plurality of evaporation pipes. After the high-temperature steam temperature is lower than the required value, the injection of wastewater is stopped and the plurality of evaporation pipes are blocked, so that the wastewater is accumulated in the feeding cavity, the wastewater is isolated from entering the evaporation pipes, the production amount of incompletely evaporated concentrated liquid is reduced, and the concentration of the concentrated liquid is stabilized.

The present invention relates to a storage-stable pharmaceutical composition for ophthalmic administration in the form of an aqueous solution comprising a therapeutically effective amount of antibiotic levofloxacin or a pharmaceutically acceptable salt or derivative thereof, as a first active ingredient, and a therapeutically effective amount of non-steroidal anti-inflammatory and analgesic ketorolac or a pharmaceutically acceptable salt or derivative thereof, as a second active ingredient, wherein said first active ingredient is from about 0.4 to about 0.9% w / v and said second active ingredient is from about 0.4 to about 0.9% w / v, wherein the weight / volume percentages are expressed as g / 100mL units, in order to prevent the precipitation and improve the stability of the product.

1. Name of the product in this design: Packaging Box (Levofloxacin Tablets). 2. Purpose of this design: For packaging goods. 3. The key design feature of this product is its pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a chiral electrochemical sensor based on beta-cyclodextrin / cerium-doped copper-based metal organic framework / carboxylated multi-walled carbon nanotube (beta-CD / Ce-doped Cu-MOF / MWCNTs-COOH), a preparation method of the chiral electrochemical sensor, and a detection method for carrying out chiral recognition on an ofloxacin enantiomer by using the sensor. According to the chiral electrochemical sensor, a glassy carbon electrode is used as a substrate, a composite conducting layer of a carboxylated multi-walled carbon nanotube (MWCNTs-COOH) and a cerium-doped copper-based metal organic framework (Ce-doped Cu-MOF) is modified firstly, and then a beta-cyclodextrin (beta-CD) chiral recognition layer is modified on the surface through an electrochemical polymerization method. According to the design, the electro-catalytic activity of the Ce-doped Cu-MOF, the high conductivity of the MWCNTs-COOH and the chiral selectivity of the beta-CD are integrated, so that a synergistic enhancement effect is generated. By utilizing the sensor and combining a linear sweep voltammetry (LSV), high-sensitivity and high-selectivity detection of levofloxacin can be realized. The method has the advantages of being simple in instrument, easy and convenient to operate, rapid in detection, high in sensitivity, high in selectivity, good in stability and the like, is suitable for rapid analysis of levofloxacin in pharmaceutical preparations, food and environmental samples, and has wide application prospects in the fields of drug quality control and safety monitoring.

The invention relates to the field of biomedical materials, and discloses a bionic multilayer dressing for chronic diabetic wounds and a preparation method. The dressing adopts a sequential coaxial electrostatic spinning technology to construct a three-layer composite fiber structure: a long-term response layer (PLGA (85: 15) / EGF / anti-scar medicine), a medium-term response layer (PLGA (50: 50) / bFGF / VEGF) and a quick response layer (PVA / levofloxacin / GM6001), and after glutaraldehyde steam crosslinking and curing, a composite fiber membrane with a stable structure is formed. According to the invention, through the combination of three polymer materials with different degradation characteristics, precise time sequence controlled release of rapid release of antibiotics for resisting infection, promotion of angiogenesis through medium-term release of growth factors and promotion of epithelialization through long-term release of epidermal growth factors is realized, and the natural healing process of wounds is effectively simulated and guided; the technical problems that a traditional dressing is single in function, and drug release and healing stages are not matched are solved, and the healing quality and efficiency of diabetic chronic wounds are remarkably improved.

The application relates to the technical field of water treatment, in particular to application of a multiple synergistic photocatalyst in photoelectric synergistic catalytic degradation of levofloxacin and drug-resistant bacteria in water. In water containing levofloxacin and drug-resistant bacteria, the multiple synergistic photocatalyst is added and placed in an activated carbon fiber electrode, and photoelectric synergistic catalytic treatment is carried out under the conditions of natural light irradiation and an applied voltage.

The invention provides a copper molybdate composite material, a preparation method thereof and a method for photodegrading levofloxacin hydrochloride, and belongs to the technical field of environmental chemical engineering photocatalytic water treatment.The method comprises the steps that biogas residues obtained from a sewage plant are dried and roasted, and biochar is obtained; and mixing Cu (NO3) 23H2O, Na2MoO4, water, ethylene glycol, glycerol and biochar, performing ultrasonic treatment, firing, and drying to obtain the CuMoO4 / BC composite material. The roasting temperature in the step S1 is 500 to 520 DEG C; the firing temperature in the step S2 is 180 to 200 DEG C. According to the copper molybdate-biochar composite material provided by the invention, the high specific surface area and rich functional groups of the biochar can effectively disperse copper molybdate particles, construct an efficient electron transport channel and remarkably inhibit carrier recombination, and meanwhile, the practical application potential of the material is improved due to the characteristics of low cost and easiness in preparation of the biochar, so that the bottleneck of a traditional material is comprehensively broken through; the method is an LVFX degradation technology with environmental friendliness and practical application potential.

The invention discloses a multi-drug resistant pseudomonas aeruginosa PAS57 strain and an application of the multi-drug resistant pseudomonas aeruginosa PAS57 strain. The preservation number of the pseudomonas aeruginosa PAS57 is GDMCC No: 67235. The pseudomonas aeruginosa PAS57 can be used for preparing a bacterial strain. According to the application disclosed by the invention, a KirbyBauer (KB) drug sensitivity experiment shows that the PAS57 is resistant to the levofloxacin, the ciprofloxacin, the meropenem, the imipenem and the tobramycin. The strain disclosed by the invention can be used for screening a novel antibacterial drug which is effective to the multi-drug-resistant pseudomonas aeruginosa, and a new way is provided for development of drugs for treating diseases caused by the pseudomonas aeruginosa.

The application relates to the technical field of medicine preparation, in particular to a method for preparing ofloxacin and levofloxacin, which comprises the following steps: S1, material preparation and feeding; S2, dissolving and decoloring; S3, pressure filtration and crystallization; and S4, elution and drying. The preset heating temperature, the preset temperature adjusting temperature, the standard solution turbidity and the standard solution gray scale are arranged in a central control unit; the central control unit compares real-time parameters with preset parameters, judges and adjusts the real-time operation state of the preparation equipment, ensures the working efficiency and precision of the preparation equipment, the central control unit can adjust the temperature of the solution, the feeding amount of the activated carbon and the stirring speed of the cooling stirring device according to the change of the working condition, accurately judges whether the crude product raw material is completely dissolved and whether the solution is decolorized, accurately controls the working time and the raw material feeding amount of each step, saves the raw material, avoids unnecessary waste, and improves the precision and efficiency of the preparation equipment.

The invention discloses a levofloxacin hapten, antigen and antibody as well as a preparation method and application thereof, and belongs to the technical field of small molecule immunodetection.A flexible spacer-(CH2) n-NH2 containing a terminal amino group is introduced to a nitrogen atom (namely a methyl connection site of methyl piperazine) at the tail end of a piperazine ring of a levofloxacin molecule, n is an integer of 2-8, and the flexible spacer-(CH2) n-NH2 is introduced into the nitrogen atom at the tail end of the piperazine ring of the levofloxacin molecule; therefore, a complete antigen with high immunogenicity and high specificity is constructed on the premise that a complete pharmacological structure of a quinolone mother nucleus is reserved, and a high-affinity antibody aiming at levofloxacin is obtained through induction.