24results about How to "Easy to purify" patented technology

The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-earth metal arylamine group compound is (2,6-R12PhNH)5LnLi2(THF)2, wherein Ln is a rear-earth metal selected from one of neodymium, samarium, ytterbium or yttrium; R1 is selected from one of hydrogen, methyl or isopropyl. The rare-earth metal arylamine group compound has the advantages that the rare-earth metal arylamine group compound has a definite structure; raw materials used in the preparation method are simple, easily obtained and cheap; the reaction process is simple and easily operated; the rare-earth metal arylamine group compound product is conveniently purified and the yield of the product is high; the rare-earth metal arylamine group compound has a high activity when acting as a single component catalyst to catalyze a hydrogen phosphine reaction of aldehyde or ketone and phosphite ester; the use amount of the catalyst is less; the yield is high; a substrate has wide universality; a new and simple method is provided for synthesis of a-hydroxyphosphonate.

The application discloses a kind of tetraphenyl ethylene-chalcone derivative preparation and its application preparation and its application.The structure is as follows: the method includes: 4-(1,2,2-triphenyl ethenyl) acetophenone, aldehyde derivative, sodium hydroxide (provides alkaline condition, pH=8.3~8.5), is placed in anhydrous ethanol, under the condition that heating temperature is 80 DEG C, reflux reaction 12h, after reaction is ended, the functional organic material is separated and purified.The functional organic material synthesized according to the above method has larger conjugated system, and has significant pressure-induced color change characteristics.The functional organic material disclosed in the application has low preparation cost, simple operation, simple method, and the material shows significant pressure-induced color change characteristics, can be applied to pressure-induced color change, luminescent material, printing and dyeing, color printing and anti-counterfeiting technical field.

The invention belongs to the field of medicinal chemistry, and particularly relates to a colopivir synthesis process which is simple in process route, cheap and safe in reagent, free of heating and cooling operation, low in energy consumption, good in product quality, high in yield and wide in commercial development prospect, the synthesis efficiency and operation convenience are greatly improved, and the time cost is reduced.

The present application relates to the field of chemistry, and provide a kind of preparation method of glycyrrhizin dipotassium salt based on chelating resin deep removal heavy metal, comprising the following steps: glycyrrhizin monoammonium salt is added to alkaline pure water solution, stirring, adjust pH to 7.5~8.5, obtain solution;The obtained solution is passed through mixed resin column, flush mixed resin column, combine effluent, concentrate and dry, obtain glycyrrhizin dipotassium salt;Wherein, the mixed resin in the mixed resin is the composition of cation exchange resin and new chelating resin.The preparation method of the present application is simple and reasonable, green and environmental protection, in the preparation process, using cation exchange resin and new chelating resin promote glycyrrhizin dipotassium salt purification, so that the residual alcohol content in the obtained glycyrrhizin dipotassium salt is ≤500mg / kg, residual ammonia content is ≤40mg / kg, and lead, cadmium, arsenic, mercury content is all ≤0.2mg / kg.

The application discloses a green preparation method of 4,4'-difluorobenzophenone. The method uses 4,4'-difluorobenzene as raw material, potassium bromide as catalyst, acetic acid as solvent, and oxygen as oxidant, and 4,4'-difluorobenzophenone is generated in high selectivity through one-step oxidation under mild conditions. The application surprisingly finds that in the presence of potassium bromide, a new non-metallic catalytic oxidation system of potassium bromide / acetic acid / oxygen is used to realize high-efficiency and high-selectivity conversion of the C-H bond at the benzyl position. Compared with the traditional method, the application does not need to use a transition metal catalyst, does not need to use carbon tetrachloride and other materials damaging the ozone layer, and does not need to involve a dangerous intermediate such as a diazonium salt, the process route is short, the atomic economy is high, the product yield is high, the product purity is high, the catalyst is cheap and easy to obtain, and the application has excellent industrial application prospect and green chemistry characteristics.

The application belongs to the technical field of nuclear fuel cycle and nuclear waste liquid treatment. The application reports a kind of carboxyl-substituted o-phenanthroline water-soluble ligand based on selective masking of part of trivalent actinide under high acidity conditions, and under optimal conditions, the separation coefficient of trivalent europium can reach 120 in 1.5M nitric acid; the separation coefficient of trivalent cerium can reach 4.4. The single crystal structure of the complex is a double metal dimer structure, which guarantees the high acidity tolerance and high selectivity of the ligand. The synthesis of the ligand involved in the application is simple, the extraction efficiency is high, and the extraction mode is novel; the related content will greatly promote the design and performance optimization of water-soluble lanthanum, lanthanum, actinium and actinium separation ligand.

The application relates to the technical field of medicines, and particularly provides a preparation method of lecomycin based on a biosynthesis process. The application first provides a 4''-ketone erythromycin A compound and a recombinant host cell capable of efficiently fermenting the compound. A brand-new semi-chemical synthesis route of lecomycin is designed by taking the key intermediate as a raw material, and the route comprises, in sequence, epoxidation, amination, 6-position oximation, configuration inversion, rearrangement, reduction and ring expansion. The application completely avoids the cumbersome hydroxyl and amino protection and deprotection steps in the prior art, avoids the use of noble metal catalysts, thereby significantly simplifies the process, improves the atomic economy, and the total yield can reach about 32.1%. The application provides a brand-new green synthesis route of lecomycin, which is simple in steps, high in yield, low in cost and easy to industrialize, and meanwhile protects a plurality of novel intermediates in the route.

This invention belongs to the field of optoelectronic materials technology, specifically relating to a ring-wrapped organic semiconductor material, its preparation method, and its applications. The ring-wrapped organic semiconductor material of this invention has the following general structural formula: by introducing different π-bridge conjugated connecting units, the energy levels of the material are adjusted and absorption is broadened; different alkyl chains on the π-bridges can improve the solubility and processability of the material; and it contains symmetrical, sterically hindered ring-wrapped side chains, which can improve the planarity and conformational stability of the molecular conjugated framework, thereby improving intramolecular charge transport and achieving the goal of improving the efficiency of photovoltaic devices. The ring-wrapped organic semiconductor material of this invention has good planarity and rigidity, strong visible light and near-infrared absorption characteristics, and high charge mobility, and can be used to prepare organic solar cells with high short-circuit current and energy conversion efficiency.

This invention discloses a method for the ethylene glycol hydrolysis of polyethylene terephthalate (PET) with staged control of ethylene glycol dosage. The method includes: in a first stage, adding PET and ethylene glycol to the reaction system at a molar ratio of 1:1 to 1:3, and reacting at 180–196 °C for 0.5–2 h under the action of a solid catalyst; in a second stage, adding ethylene glycol to the reaction system to achieve a molar ratio of ethylene glycol to PET of 1:5 to 1:8, and continuing the reaction for another 2–4 h. By adding ethylene glycol in stages, the conversion degree of oligomers during the reaction is improved, thereby significantly increasing the monomer yield under the same ethylene glycol dosage conditions, reducing oligomer residue, and lowering subsequent separation costs.

This invention discloses BODIPY dyes, their preparation methods, and their applications in latent fingerprint recognition. The invention prepares four BODIPY dyes with different structures and emission colors, all exhibiting high fluorescence quantum yields (over 55% absolute fluorescence quantum yield) and excellent lipophilicity. Using a spray method, latent fingerprints on different substrates can be efficiently and conveniently detected within 10 seconds. Furthermore, the detection solution demonstrates excellent stability, can be stored for up to 30 days, and achieves a color change from green to red through modulation. This modulation effectively addresses complex background colors, ensuring optimal latent fingerprint detection results under various color backgrounds.

This invention relates to a recycled raw material composition and its preparation method. The recycled raw material composition comprises recycled bis(2-hydroxyethyl) terephthalate formed by the depolymerization of waste polyester, wherein the peak area ratio of acetate compounds is 1.0% or less when analyzed by high performance liquid chromatography (HPLC). Due to the reduced impurity content, this recycled raw material composition can exhibit high purity and high quality.

The application provides a synthesis method of deoxycholic acid (DCA). The method takes phytosterol as a starting material, and synthesizes deoxycholic acid (DCA) through a series of steps such as primary alcohol oxidation reaction, witting reaction, hydrogenation reaction, selective reduction reaction, hydroxyl protection reaction, elimination reaction, allyl oxidation reaction and hydrolysis reaction. The synthesis method has high reaction yield and high product purity, the intermediates in each step are all solid, easy to purify, the post-treatment method is simple, the cost is low, suitable for quality control, convenient for industrialized production, and has a good application prospect. Moreover, the deoxycholic acid (DCA) synthesized by the method also avoids the risk of containing animal pathogens and other harmful factors.

This utility model belongs to the field of ilmenite concentrate purification, specifically an ilmenite concentrate ion purification device, including a high-pressure reactor. The reactor's inner cavity is equipped with a stirring mechanism, which includes a motor. The bottom of the motor is fixedly connected to the top of the reactor. The device uses the motor to drive a first long plate and a first bevel gear to rotate together. The first long plate drives a first stirring rod to stir the ilmenite concentrate and solvent inside the reactor clockwise. This contact reaction between the ilmenite concentrate and solvent accelerates purification. The first and third bevel gears mesh, driving a second stirring rod to rotate counterclockwise, further stirring the ilmenite concentrate and solvent inside the reactor. This clockwise rotation, synchronized with the first stirring rod, further thoroughly stirs the ilmenite concentrate and solvent inside the reactor, accelerating the contact between them and increasing the reaction speed, thereby improving purification efficiency.

This invention discloses a glycerol / polyethylene glycol-based aspartic acid monoester amphoteric-nonionic surfactant and its preparation method, belonging to the field of specialty surfactant technology. Using maleic anhydride, low-melting-point polyols with excellent melt miscibility, and fatty primary amines as raw materials, the invention prepares the target product through a three-step reaction involving selective monoesterification, Michael addition, and acid-base equivalent neutralization. The reaction atmosphere can be selected based on the characteristics of the polyol materials. This invention avoids the use of high-boiling-point solvents throughout the process, enabling directional monoester synthesis and effectively solving the technical pain points of traditional aspartic acid ester products, such as disordered composition, difficult purification, and limited industrial production. This product combines the advantages of mild and low-irritation amphoteric surfactants with the acid, alkali, and salt resistance of nonionic surfactants. The overall preparation process is green and simple, with adjustable performance, suitable for large-scale industrial production, and has broad application prospects in the fields of daily chemicals, pharmaceuticals, and industrial emulsification.

The application discloses a crystal material based on a cadmium-viologen complex, a preparation method and application of the crystal material. II (Btybipy)Cl4; wherein Btybipy is a double 1-(thienyl)-3-methyl-4,4'-bipyridyl-1-onium. II The application is connected with a cadmium-viologen complex with chlorine as a counter anion to form a zero-dimensional crystal material. (Btybipy)Cl4 is a zero-dimensional structure, and has the advantages of simple synthesis method and convenient purification; the viologen compound is used as a nitrogen-containing ligand, the viologen ligand has good water solubility, is beneficial to crystallization of the crystal material, and improves a synthesis yield; the synthesized crystal material is sensitive to light and a solvent, can occur a photochromic phenomenon, and can be applied as an ion sensing material.

This invention relates to a D-A-D structured NIR-II photothermal material, its preparation method, and its applications. Specifically, the photothermal material of this invention has a simple structure, is easy to synthesize, is easy to purify, and has a high yield. Furthermore, due to its large conjugated system, the molecular structure is stable and not easily degraded under NIR-II light irradiation. In addition, the photothermal material of this invention has excellent optical properties, good photothermal conversion efficiency, extremely low biotoxicity, and broad ultraviolet absorption in the 800-1000 nm range. Therefore, it has great application prospects in near-infrared photodynamic therapy and tumor treatment.

The present application relates to the field of radiopharmaceutical chemistry and clinical nuclear medicine technology, and particularly relates to a kind of compound targeted to FAP and its composition and application.The structure of the compound is as shown in the following formula (I).The compound can specifically respond to the enzyme highly expressed in tumor microenvironment, form active intermediate and covalently label adjacent protein, thereby prolonging the residence time of the compound of the present application at tumor target site, and improving imaging effect.After labeling with radionuclide, the obtained radioactive preparation has high uptake in tumor tissue, the tumor / non-target ratio is relatively optimal, and has good tumor uptake performance, and shows practical application prospect.(I).

The application discloses a method for synthesizing 2,5-disubstituted pyrroline by a three-enzyme co-immobilization system, and adopts a one-pot cascade biocatalysis method to synthesize 2,5-disubstituted pyrroline. The co-immobilized enzyme obtained by co-immobilizing L-amino transferase, L-lactic acid dehydrogenase and glucose dehydrogenase on an amino resin ESQ-3 is used as a catalyst for a synthesis reaction, and a deep eutectic solvent formed by betaine and glucose is added to a synthesis system. The co-immobilized enzyme is prepared by a method that L-amino transferase is first immobilized on the amino resin ESQ-3, and then L-lactic acid dehydrogenase and glucose dehydrogenase composite particles obtained by ammonium sulfate precipitation are continuously immobilized. The synthesis method can obtain a higher stable conversion rate, and a product is easier to separate and purify. Enzymes and coenzymes are efficiently recycled, regenerated and reused. In addition, a reaction medium added with the deep eutectic solvent has a significant positive effect on solubility of a substrate, stability of the enzyme and mass transfer of the system, so that an immobilized enzyme method catalytic synthesis reaction system suitable for industrial application is effectively constructed.

The application discloses a kind of formula (I) shown for dipeptidyl peptidase 4 detection bioluminescence probe and its preparation method and application.The probe has good selectivity and sensitivity to dipeptidyl peptidase 4, and can be used as dipeptidyl peptidase 4 bioluminescence probe for marking prostate cancer, gastric cancer, colorectal cancer, malignant mesothelioma, liver cancer and a variety of tumor cells.

The application discloses an indole compound, a preparation method and application thereof, and the indole compound has the structure shown in formula (I). The indole compound has anti-inflammatory activity and bioactivity of promoting angiogenesis. Meanwhile, raw materials used in a synthesis method of preparing the indole compound by using a rhodium / copper bimetal catalyst are cheap and easy to obtain, and the preparation process is simple and easy to operate.

This invention proposes a method for separating biosulfur, comprising: (1) adding an organic flocculant to a mixing tank containing a biosulfurization solution and stirring to obtain a mixed solution; wherein the organic flocculant is selected from at least one of galactosamine, N-acetylglucosamine, and mannosamine; (2) transferring the mixed solution to a settling tank and allowing it to stand to form a supernatant and a bottom precipitate; and (3) separating the supernatant and the bottom precipitate in the settling tank. The method of this invention can achieve efficient separation of biosulfur, with a biosulfur flocculation rate of 95–99 wt%. This invention also provides the application of at least one of galactosamine, N-acetylglucosamine, and mannosamine in the separation of biosulfur.

The application discloses a kind of azahemicyanine dyes and application thereof, compared with the dye similar to the function of novel azahemicyanine dye molecule provided by the application, the application can effectively prevent the non-specific combination of serum albumin and hemicyanine dye, and the stability, fluorescence quantum yield and stoke shift of the hemicyanine dye are enhanced;The dye synthesis step provided by the application is simple, easy to purify, and has high yield;By introducing six-membered heterocyclic ring into the side chain of azahemicyanine dye, the combination with protein is effectively avoided, the false positive interference of serum albumin on dye fluorescence signal is excluded, and kidney targeting is realized, and the high fidelity of imaging is improved;The probe NA-H2S2 synthesized based on the dye NA-6 provided by the application is used for rapid detection of the change of H2S2 concentration;The synthesis step of the dye molecule is simple, easy to purify, has excellent imaging performance, fluorescence signal is not interfered by serum albumin, and is suitable for high-fidelity imaging of kidney.

The application discloses a ratio type fluorescent nanometer thermometer and a preparation method and application, and is prepared as follows: a polybasic saturated fatty acid is heated and melted into a liquid state, and after cooling, a solid is formed; the solid is ground into powder; the powder is heated and melted into a liquid to obtain A liquid; ACQ fluorescent molecules and an AIE molecule with an aggregation-induced emission property are dispersed in the A liquid, and after cooling, a solid is obtained; the solid is ground into powder to obtain powder B; the powder B is dissolved in dimethyl sulfoxide to prepare a B solution; the B solution is added dropwise into an aqueous solution of a non-intercalated surfactant; after the dropwise addition is completed, stirring is continued for 20-40 min; and excess non-intercalated surfactant is removed by dialysis; the thermometer has a temperature detection range of 25-48 DEG C, effectively covering the physiological temperature of 37 DEG C; the thermometer has excellent sensitivity and accuracy, and the maximum relative thermal sensitivity thereof in a water environment is as high as 63.66% / DEG C, which is much higher than that of a previously reported ratio type fluorescent nanometer thermometer.