637 results about "Pickering emulsion" patented technology

The invention relates to a composite phase-change film based on liquid metal and PBO fiber and a preparation method thereof, and belongs to the technical field of phase-change material preparation, and the preparation method comprises the following steps: the composite phase-change film comprises a poly (p-phenylbenzobisoxazole) fiber (PBO) base material, a phase-change material and a heat-conducting filler, the phase-change material is composed of phase-change microcapsules (PM) which are prepared by taking polyurethane (PU) as a wall material and organic solid-liquid phase-change materials (OPCMs) as a core material through a Pickering emulsion polymerization method. The prepared PM has a core-shell structure, and leakage of OPCMs is effectively prevented. The PM and the PBO fiber network are combined, so that the dual packaging of the OPCMs is realized, and the leakage of the OPCMs is further prevented. Meanwhile, dispersion and interaction of the OPCMs in a PBO matrix are optimized, and formation of a network structure with a limited domain is promoted. The composite phase change film prepared by the invention has relatively high mechanical properties, remarkable heat conductivity, excellent and stable flexibility and excellent heat storage capacity.

The invention discloses a method for preparing a high-stability W / O / W type multiple Pickering emulsion based on Janus particles, and belongs to the technical field of colloid and interface chemistry. According to the preparation method, the Janus particles with different hydrophilic and hydrophobic properties are prepared by using alkylsilane modified SiO2 with different chain lengths, the multiple emulsion is stabilized together, different types of Janus particles are adsorbed on different oil-water interfaces, and the interface activity and amphipathicity of the Janus particles are fully exerted to prepare the high-stability multiple emulsion. The multi-emulsion provided by the invention has excellent stability, keeps stable under the conditions of long-term storage, strong acid, strong alkali, high-concentration electrolyte and the like, and can effectively expand the practical application of the multi-emulsion.

The invention belongs to the technical field of grease modification and lipid deep processing, and particularly relates to a method for enriching n-3 polyunsaturated fatty glyceride by an enzymic method. According to the method, alkyl-modified hollow mesoporous silica spheres are used as an immobilized enzyme carrier and an emulsifier, grease rich in n-3 polyunsaturated fatty acid is used as a raw material in a stable Pickering emulsion system, saturated fatty acid and monounsaturated fatty acid are selectively hydrolyzed by lipase, and polyunsaturated fatty glyceride is enriched. The method has the characteristics of fast reaction, high yield, wide substrate application range and reusability of the immobilized enzyme, and the content of polyunsaturated fatty acid in the polyunsaturated fatty glyceride reaches 58.05-90.53%.

The invention belongs to the field of enzymatic preparation of structural phospholipids, and particularly relates to a method for preparing phosphatidylserine through interfacial enzyme catalysis. A series of high-activity immobilized phospholipase are prepared by innovatively adopting bifunctional group modified hollow mesoporous silica microspheres as a carrier and adsorbing immobilized phospholipase D. The catalyst has the functions of a catalyst and an emulsifier, and a Pickering emulsion interfacial enzyme catalysis system can be efficiently constructed. In the system, the phosphatidylcholine and the serine are efficiently converted into the phosphatidylserine through a phosphatidyl transfer reaction, the conversion rate of the phosphatidylserine within 20 minutes can reach 85%-95%, and the catalytic efficiency reaches up to 372 mmol / (g.h). In addition, after the catalyst is recycled for 10 times, the conversion rate is still kept at 70.9%, and the catalyst shows excellent stability and reusability. The method has the remarkable advantages of being mild in reaction condition, high in catalytic efficiency, capable of being repeatedly used and the like, and a new technical approach is provided for industrial production of phosphatidylserine.

The invention belongs to the technical field of functional Pickering emulsion preparation, and particularly discloses a silk fibroin nanoparticle-stabilized biphase drug-loaded Pickering emulsion and an antibacterial application thereof. The curcumin-loaded silk fibroin nanoparticles Cur-SFNPs with uniform form and size are prepared by using an anti-solvent precipitation method. In order to improve the antibacterial effect of the Pickering emulsion, the Cur-SFNPs is utilized to stabilize the soybean oil loaded with resveratrol, and the oil-in-water type Pickering emulsion is prepared. The Pickering emulsion prepared by taking Cur-SFNPs as a stabilizer has the characteristics of small particle size, uniform distribution, storage stability, heating stability, freeze-thaw stability, food safety and environmental friendliness. And as a two-phase drug-loaded emulsion, two natural hydrophobic active drugs are loaded at the same time, so that the solubility and bioavailability of the emulsion can be enhanced, the loaded active substances play a synergistic antibacterial and antioxidant role, and the emulsion can be applied to food preservation.

The present invention discloses an amorphous curcumin nanoparticle and its preparation method and application. In the present invention, an absolute ethanol solution of curcumin and apple polyphenol is dropped into water under stirring, and then left standing for treatment to remove ethanol and adjust the pH to obtain amorphous curcumin nanoparticles. Through the bottom-up antisolvent precipitation method and the interaction between curcumin and polyphenol, and by optimizing the important conditions in the preparation process, the present invention effectively reduces the particle size of curcumin and transforms its crystal structure into an amorphous structure. At the same time, the amorphous curcumin nanoparticles can be used as an emulsifier for Pickering emulsions to prepare curcumin emulsions. Compared with curcumin nanoparticles, the curcumin emulsions have higher stability. The present invention has low energy consumption, reduced particle size, can improve solubility, enhance its bioavailability, improve its emulsifying properties, and has good application prospects.

The invention relates to a pH-responsive aromatic nanocapsule as well as a preparation method and application thereof, and the pH-responsive aromatic nanocapsule comprises the following components in percentage by mass: 0.4-10% of modified SiO2, 0.2-30% of a core material, 10.2-16% of a quaternized chitosan / polydopamine wall material and the balance of water. The preparation method comprises the following specific preparation steps: preparing a modified SiO2 suspension, adding a core material, and carrying out homogeneous emulsification under a high-speed shearing machine to prepare a Pickering emulsion; preparing a quaternized chitosan / polydopamine wall material solution; and finally, carrying out isovolumetric blending on the Pickering emulsion and the quaternized chitosan / polydopamine wall material solution (grafting the quaternized chitosan / polydopamine wall material through the modified SiO2), and stirring to obtain the aromatic nanocapsule. Compared with the prior art, the preparation method has the advantages that the lavender essential oil is taken as a core material, the quaternized chitosan / polydopamine is taken as a wall material, and the modified SiO2 stable Pickering emulsion is taken as a template, so that the catechol-based self-adhesive nanocapsule with pH responsiveness is prepared. The nanocapsule is prepared by an emulsion template method, the preparation method is mild in condition, and the prepared nanocapsule is green and safe and has excellent adhesion and antibacterial properties.

The invention discloses Pickering emulsion applied to concrete demolding and a preparation method thereof, and relates to the technical field of building materials. The Pickering emulsion is prepared from the following raw material components: 200 to 600 parts of base oil, 50 to 60 parts of a compound emulsifier, 50 to 60 parts of a co-emulsifier, 1 to 2 parts of a dispersed phase pour point depressing component, 0.5 to 1 part of an antioxidant, 8 to 10 parts of a continuous phase thixotropic stabilizing component, 10 to 15 parts of a color regulating agent and 500 to 550 parts of water. The Pickering emulsion has excellent concrete demoulding performance, also has concrete self-curing performance and anti-ultraviolet performance, and can effectively improve the structural strength of concrete, prolong the service life of concrete and ensure the appearance quality of concrete. The problems existing in a traditional release agent are solved, additional functionality and attractiveness are provided for concrete products, and the release agent is suitable for various building and infrastructure projects and has wide application prospects.

The invention relates to a paper substrate bio-based high-barrier Pickering emulsion coating and a preparation method and application thereof, and belongs to the technical field of paper coatings, the prepared coating has excellent waterproof and oil-proof performance and is suitable for surface coating of substrates such as paper, the emulsion is prepared by taking glycerol as a plasticizer and chitosan as an oil-proof agent, and the emulsion is prepared by taking the chitosan as an oil-proof agent. The cellulose nanocrystal is used as an emulsifier, and the alkyl ketene dimer AKD and palm wax are used as an oil phase. After the emulsion is coated on the surface of paper, a high-barrier coating with a core-shell structure is formed, and the core-shell structure is clear through electron microscope observation; the hydrophobic angle of the coating can reach 130 degrees to the maximum, and the coating shows remarkable hydrophobicity and oil resistance. The coating is composed of bio-based materials, has the advantages of environmental protection and sustainability, is suitable for application requirements of degradable and green packaging, is simple in preparation process and excellent in performance, and can provide efficient barrier performance for paper packaging materials.

The invention relates to the technical field of food industry, in particular to a lutein-loaded Pickering emulsion for 3D printing and a preparation method of the lutein-loaded Pickering emulsion. The preparation method comprises the following steps: extracting chlamydomonas reinhardtii protein from chlamydomonas reinhardtii powder as a raw material, preparing a chlamydomonas reinhardtii protein-xanthan gum compound from the chlamydomonas reinhardtii protein and xanthan gum with different contents, mixing the chlamydomonas reinhardtii protein-xanthan gum compound with lutein-loaded edible oil, and uniformly shearing to obtain stable lutein-loaded Pickering emulsion. And the xanthan gum is utilized to improve the stabilizing effect of the chlamydomonas reinhardtii protein on the Pickering emulsion and the protecting effect of the chlamydomonas reinhardtii protein on the xanthophyll. No chemical surfactant is added in the preparation process, so that the food safety is high; according to the present invention, the preparation operation is simple, the stability is good, the storage stability of xanthophyll can be significantly improved, and the xanthophyll nano-emulsion has characteristics of excellent viscoelasticity and excellent thixotropic recovery, can be used for 3D printing food, and has wide application prospects in the application of novel nutrient substance delivery systems and food-grade 3D printing materials.

The invention discloses a method for preparing immobilized lipase Janus particles by an emulsion template one-step method based on a zymoprotein directional adsorption strategy and application of the immobilized lipase Janus particles in a Pickering emulsion catalytic system. The natural hydrophilicity of lipase protein is utilized to drive the lipase protein to form directional adsorption on the surfaces of hydrophobic particles, and the Janus particles with hydrophilic and hydrophobic characteristics are constructed. Firstly, an organic phase containing hydrophobic particles and a water phase containing lipase are oscillated to form an emulsion, so that the lipase in the water phase is accurately adsorbed on the single side of the surface of the particles, and directional connection of zymoprotein and a hydrophobic matrix is realized. Afterwards, the Janus particles are used for constructing a Pickering emulsion system, and a microreactor is built, so that the catalytic efficiency of lipase in hydrolysis, ester synthesis and transesterification reaction is improved. The method is easy to operate, efficient and stable enzyme immobilization can be achieved, the obtained immobilized lipase Janus particles are remarkably superior to free enzyme in biological catalytic activity and cyclic utilization performance, and the application value of lipase in industrial large-scale production is remarkably improved.

The invention relates to the technical field of emulsion preparation, and discloses a metal-polyphenol network graphene oxide Janus nanosheet as well as a preparation method and application thereof, GO JNSs is taken as a solid emulsifier to encapsulate EOs, the problems that EOs are easy to volatilize and poor in water solubility at normal temperature can be solved, and the metal-polyphenol network graphene oxide Janus nanosheet and auxiliaries in a system can achieve a synergistic effect to resist bacteria. The Pickering emulsion containing GO JNSs has good emulsion stability, has excellent hydrophilicity and adhesion performance of polyphenol, can significantly enhance the wetting and spreading effects of emulsion droplets on leaf surfaces, and inhibits rebounding and splashing of the liquid droplets. The preparation process of the GO JNSs and the JNSs-EU-PE is simple, the process is environment-friendly, and the GO JNSs and the JNSs-EU-PE have industrial production prospects.

The invention provides a preparation method of a composite Pickering emulsion based on modified yeast protein. Comprising the following steps: preparing modified yeast protein through combined treatment of papain and TG enzyme; mixing the modified yeast protein solution with a chitosan solution, and heating at 90 DEG C to obtain a proteoglycan composite solution, wherein the mass ratio of yeast protein to chitosan is (5: 1)-(1: 5); after the proteoglycan composite solution is cooled to room temperature, the pH value is adjusted to 2.5-6.5; 20%-60% of vegetable oil is added into the proteoglycan composite solution, and the Pickering emulsion can be obtained through homogenization. The composite Pickering emulsion based on the modified yeast protein is suitable for complex food matrixes, good in stability and capable of efficiently embedding various functional components and remarkably delaying oxidation, photolysis or thermal degradation of the functional components, so that the product quality is improved, and the shelf life of the product is prolonged. If the monascus pigment is added, the problems of color loss and degradation of the monascus pigment in the application process can also be improved.

The invention discloses a method for preparing microcapsules from beta-cyclodextrin inclusion compound microcrystal stabilized sandalwood essential oil, and belongs to the technical field of microcapsule preparation. The method comprises the following steps: preparing sandalwood essential oil / beta-cyclodextrin inclusion compound microcrystals, emulsifying and dispersing the sandalwood essential oil by using the inclusion compound microcrystals as an emulsifier, adding resin, and carrying out a condensation reaction to prepare the microcapsule suspension. According to the preparation method, firstly, beta-cyclodextrin and essential oil are embedded to obtain clathrate microcrystals, then the clathrate microcrystals serve as an emulsifying agent, the emulsifying effect of the essential oil is improved, resin microcapsules are convenient to prepare, and the microcapsules prepared through the method are high in essential oil embedding rate and good in stability; beta-cyclodextrin inclusion compound microcrystals are selected as a Pickering emulsion stabilizer, so that the emulsifying and stabilizing effects are good, and the microcapsule emulsion is not layered.

The invention discloses a preparation method of a curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by the curcumin-loaded Pickering emulsion steady-state carrier, and belongs to the technical field of high-valued processing of food functional factors. The preparation method comprises the following steps: firstly, extracting tea protein from a tea leaf processing byproduct tea residue by adopting an alkali extraction and acid precipitation method, and secondly, constructing the tea protein-chitosan composite nanoparticles by adopting a pH induction method. And mixing the oil phase containing curcumin with the water phase, and emulsifying by using a high-speed shearing machine to prepare the Pickering emulsion. The method is simple to operate, the prepared Pickering emulsion stabilized by the tea protein-chitosan composite nanoparticles can improve the bioavailability of curcumin from 10.8% to 32.6%, meanwhile, high-value utilization of the tea protein is achieved, and the method has important significance in promoting development and application of functional food.

The invention discloses application of a particle stabilizer, an oil-in-oil Pickering emulsion as well as a preparation method and application of the oil-in-oil Pickering emulsion, and relates to the technical field of emulsion preparation. The particle stabilizer is used for preparing the oil-in-oil Pickering emulsion, and the particle stabilizer is solid insoluble nanoparticles and is selected from one or more of inorganic nanoparticles, organic nanoparticles, composite oleophobic nanoparticles and stimuli-responsive nanoparticles. The preparation method of the oil-in-oil Pickering emulsion comprises the following steps: mixing the first oil phase, the second oil phase and the particle stabilizer, and carrying out an emulsification technology to obtain the oil-in-oil Pickering emulsion. According to the emulsion system prepared by the invention, the oil phase components with different polarity differences are reasonably matched, and the oil phase type is flexibly selected according to specific requirements of target application, so that the environmental adaptability and the function application range of the emulsion can be remarkably improved, and the emulsion system has a good application prospect.

The invention belongs to the technical field of biochemical engineering, and particularly relates to a Pickering emulsion microcapsule of interface immobilized lipase as well as a preparation method and application of the Pickering emulsion microcapsule. The preparation method of the Pickering emulsion microcapsule comprises the following steps: ultrasonically dispersing silicon oxide nanoparticles which have an emulsifying function and can adsorb enzyme into an organic solvent to serve as an oil phase, dissolving lipase into a buffer solution to serve as a water phase, mixing the water phase and the oil phase, and carrying out ultrasonic dispersion to obtain the Pickering emulsion microcapsule. And then adding a silane coupling agent, organic amine and an organic solvent, and carrying out interface gel-sol treatment to obtain the Pickering emulsion microcapsule. The Pickering emulsion microcapsule disclosed by the invention has better high temperature resistance and pressure resistance, and can realize efficient preparation of epoxide in a fixed bed continuous enzyme catalysis olefin epoxidation reaction.

The invention discloses a preparation method of a double embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester, and relates to an inclusion compound based on modified cyclodextrin and a stable Pickering emulsion system thereof. According to the method, the uniformity of the cyclodextrin modification substitution degree is improved through ultrasonic assistance, the embedding rate and the embedding stability of hydrophobic active ingredients can be improved, meanwhile, the Pickering emulsion is stabilized, preparation of the double-embedded emulsion preparation is achieved, and the stability and the packaging efficiency of an emulsion preparation packaging delivery system can be effectively improved through the method. The method comprises the following steps: 1, preparing octenyl succinic acid cyclodextrin ester; 2, preparing an OSA-beta-CD / phenolic compound clathrate compound; and 3, preparing the dual-embedding emulsion preparation / emulsion. The invention provides a preparation method of a double-embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester. The double-embedding emulsion preparation / emulsion can be applied to a double-embedding food functional component delivery system.

The invention relates to Pickering emulsion, a preparation method and application thereof, and belongs to the technical field of emulsion preparation, and the preparation method comprises the following steps: S1, preparing a water phase: uniformly mixing and stirring gluten protein zymolyte obtained after gluten protein enzymolysis with polydextrose and a phosphoric acid buffer solution, heating in a water bath, and cooling to obtain the water phase; s2, preparation of an oil phase: dissolving fat-soluble active substances in edible oil to prepare the oil phase; s3, emulsion preparation: mixing the water phase and the oil phase, performing high-speed dispersion treatment, and homogenizing to obtain Pickering emulsion; the gluten protein zymolyte and the polydextrose conjugate are prepared by utilizing the Maillard reaction, and the emulsibility and the stability of the Pickering emulsion can be remarkably improved by taking the gluten protein zymolyte and the polydextrose conjugate as the emulsifier.

The invention discloses an electro-catalysis method of Pickering emulsion for nitro compound hydrogenation, and relates to the technical field of catalytic hydrogenation, the Pickering emulsion is composed of an oil phase, a water phase and a platinum-loaded hydrophilic carbon nanotube catalyst; wherein based on the weight of the carbon nanotubes in the catalyst, the platinum accounts for 5.0 wt%-10.0 wt%; in the emulsion system, the particle concentration of the platinum-loaded hydrophilic carbon nanotube catalyst is 0.05 wt%-10 wt%; in the emulsion system, the hydrophilic carbon nanotubes have certain hydrophilicity and can be well dispersed in a water phase. According to the Pickering emulsion electro-catalysis method for nitro-compound hydrogenation, in a platinum-loaded hydrophilic carbon nanotube catalyst, the hydrogenation reaction of the nitro-compound can be effectively catalyzed when platinum is in a specific proportion range of 5.0 wt%-10.0 wt%.

The invention provides a stabilizer for Pickering emulsion and application of the stabilizer, and relates to the technical field of Pickering emulsion preparation. The stabilizing agent for the Pickering emulsion is obtained by compounding 6 '-O-caffeoyl arbutin and cellulose nanocrystals. In specific application, the 6'-O-caffeoyl arbutin and the cellulose nanocrystals are prepared into a water phase, and then the water phase is mixed with an oil phase to prepare the Pickering emulsion. According to the preparation method, the defects in the prior art are overcome, the stability of the Pickering emulsion is effectively improved, meanwhile, the oxidation resistance effect of the Pickering emulsion is further enhanced, and the application value of the Pickering emulsion is improved.

The invention discloses a nanometer fiber yarn-based phytosterol Pickering emulsion as well as a preparation method and application thereof, and the nanometer fiber yarn-based phytosterol Pickering emulsion comprises the following components in parts by weight: 0.5-1 part of nanometer fiber yarn; 1 to 10 parts of phytosterol / phytosterol ester; 95 to 105 parts of a water phase component; 95 to 105 parts of an oil phase component; the nanofibers are extracted from agricultural wastes; according to the invention, the nanofiber is used as the only or main stabilizer of the phytosterol Pickering emulsion, so that the problems of solubility, emulsion stability and bioaccessibility of phytosterol can be solved at the same time; and efficient interface stability and steric hindrance stability are realized by utilizing a unique nano network structure of the nano fiber yarns, and a natural, safe and efficient phytosterol delivery system is provided.

The invention relates to a method for preparing hydrogel with strain sensing performance from xylan nanocrystal-stabilized Pickering emulsion in the field of novel functional materials, which comprises the following steps: preparing XyNC at pTMPTA composite microspheres by using XyNC-stabilized oil-water Pickering emulsion as a template and adopting a photopolymerization technology, and then preparing the hydrogel with strain sensing performance by using sodium tetraborate as a cross-linking agent. A dynamic cross-linked network between polyvinyl alcohol in a water phase and XyNC on the surface of the microsphere is constructed by utilizing a borate bond, the stability and strength of a three-dimensional skeleton of the hydrogel are remarkably enhanced, a strain-resistance effect is given to a system, and the hydrogel has excellent application in a flexible strain sensor.

The invention discloses a crisaborole Pickering emulsion as well as a preparation method and application of the crisaborole Pickering emulsion. The crisaborole Pickering emulsion prepared by the invention solves the problem of poor water solubility of crisaborole, improves the drug solubility, and has the characteristics of small particle size, high centrifugal stability, good long-term stability and the like. Compared with the traditional nanoemulsion, the Pickering emulsion disclosed by the invention shows certain advantages in the aspects of biocompatibility, cumulative transdermal amount and cutin retention, improves the curative effect of a local preparation and reduces skin toxicity, and can be used as an ideal local preparation for treating atopic dermatitis and other diseases.

The invention discloses preparation and application of a biological material for targeted therapy of osteoarthritis, and the preparation method comprises the following steps: according to a phage screening principle, after phages are combined with cartilage cells, washing off phages which are not combined with the cartilage cells, are not firmly combined with the cartilage cells and are non-specifically combined with the cartilage cells; eluting the specifically bound bacteriophage with glycine acid; after the specific binding bacteriophage is amplified by escherichia coli, screening is carried out by utilizing a bacteriophage display technology and cartilage cells; the preparation method comprises the following steps: preparing a small-size porous microgel loaded drug by adopting a multiple Pickering emulsion template method; and grafting the screened cartilage targeting peptide to the surface of the porous hydrogel microsphere to obtain the HS-SP microsphere. According to the invention, the problem of OA targeting can be effectively solved by adopting a phage display technology, and a drug is precisely targeted and delivered to an OA lesion region; the porous hydrogel microspheres with small particle size are prepared by adopting a multiple Pickering emulsion method, so that the use of a large number of surfactants is avoided, and the efficient loading and release of drugs can be realized.

The invention discloses a Pickering emulsion with stable alkylated lignin nanospheres as well as a preparation method and application of the Pickering emulsion. The preparation method of the Pickering emulsion with stable alkylated lignin nanospheres comprises the following steps: carrying out an alkylation reaction on lignin to obtain alkylated lignin; carrying out anti-solvent dialysis on the alkylated lignin to prepare nano alkylated lignin balls, so as to obtain a nano alkylated lignin ball suspension; taking the nano alkylated lignin ball suspension as a water phase, adding an unsaturated aromatic aldehyde compound as an oil phase, mixing, and carrying out ultrasonic emulsification. According to the preparation method disclosed by the invention, alkylation modified lignin is dialyzed to prepare the nano alkylated lignin balls, and the nano alkylated lignin balls have proper hydrophilic and hydrophobic properties and can be used as a stabilizer to enable an organic aldehyde oil phase and a water phase to form a stable Pickering emulsion, so that the problem that an unsaturated aromatic aldehyde compound is easy to oxidize and volatilize is solved.

The invention discloses a method for synthesizing an organic nitrile compound by using Pickering emulsion to electrocatalyze aldoxime dehydration, which comprises the following steps: ultrasonically dispersing carbon nanotubes in water, dissolving aldoxime organic matters in cyclohexane, mixing an aqueous solution with a cyclohexane solution, and forming the Pickering emulsion under the action of a homogenizer with the rotating speed of more than 1500rpm; then injecting a certain amount of nitrogen dioxide gas, continuously electrolyzing for 12 hours within the voltage range of-0.3 VRHE to-1.2 VRHE, and homogenizing for 5 seconds by the homogenizer every 5 minutes; the invention relates to the technical field of organic electro-synthesis, in particular to a method for synthesizing an organic nitrile compound by using Pickering emulsion to electrocatalyze aldoxime dehydration, which is a method for directly preparing organic nitrile from reactants aldoxime and nitrogen dioxide in a reactor under electric drive. According to the method, the traditional synthetic technical route of organic nitrile is avoided, the nitrile compound is synthesized in one step, and the method is a novel synthetic method which is brand-new, green, safe and low in harm to a human body and the environment.

The invention provides a self-healing-shape memory phase change microcapsule for cooling drilling fluid as well as a preparation method and application of the self-healing-shape memory phase change microcapsule, and belongs to the technical field of cooling of the drilling fluid and underground heat management. The preparation method of the phase change microcapsule comprises the following steps: fully dispersing a polyurethane prepolymer, a polyimide solution and hydrophobic nanocellulose in an organic solvent to obtain an oil phase; dissolving a phase change material in deionized water to obtain a water phase; under a shearing condition, dropwise adding the oil phase into the water phase, and emulsifying to form a stable oil-in-water type Pickering emulsion; and adding an aqueous solution of a chain extender, and carrying out interfacial polymerization reaction, centrifugation, washing and drying. The phase change microcapsule disclosed by the invention shows excellent cyclic service performance under the underground high-temperature and high-shear conditions, and structure repair and morphology recovery can still be realized by virtue of self-healing and shape memory effects even if a shell layer is damaged, so that the service life of the phase change microcapsule is prolonged, and the cooling persistence of the drilling fluid is improved.

The invention discloses an emulsifier for preparing a Pickering emulsion, the Pickering emulsion as well as a preparation method and application of the Pickering emulsion. The emulsifier of the Pickering emulsion is obtained by dissolving distearoyl phosphatidylcholine, cholesterol and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 in ethanol, carrying out rotary evaporation to remove ethanol, then adding an antigen aqueous solution containing an antigen, continuing rotary evaporation to obtain liposome nanoparticles, heating the liposome nanoparticles with mannose in a water bath, and carrying out freeze drying. The Pickering emulsion is obtained by dispersing an emulsifier in water as a water phase, taking squalene as an oil phase, mixing the water phase and the oil phase, and homogenizing. The Pickering emulsion disclosed by the invention is prepared by taking antigen presenting cell targeted liposome nanoparticles as a raw material; and the antigen has excellent ion concentration characteristic, pH stability, temperature stability and storage stability, and can protect the integrity of the antigen.

The invention relates to the technical field of conductive materials, and discloses a flexible conductive composite material and a preparation method and application thereof. The flexible conductive composite material comprises the following preparation raw materials: a thermoplastic elastomer, a conductive filler, cellulose nanocrystals, an inorganic salt, an organic solvent and water. According to the flexible conductive composite material provided by the invention, the Pickering emulsion is co-stabilized by the cellulose nanocrystal auxiliary conductive filler, the cellulose nanocrystal raw material is easy to obtain, biodegradable, environment-friendly and pollution-free, the Pickering emulsion is good in stability, the conductive filler is directionally enriched on an emulsion interface to form a continuous path, the bottleneck of filler dispersion is broken through, a conductive network structure is complete, and the stability of the Pickering emulsion is improved. The strain sensing response is sensitive, reversible circulation is achieved, the conductive interval is wide, the conductive seepage threshold value is about 1 wt%-2 wt%, when the addition amount of the conductive filler is 10 wt%, the conductivity is about 25 S / cm, and the conductivity is improved in a breakthrough mode.