73 results about "Ostwald ripening" patented technology

The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances such as docetaxel with reduced Ostwald ripening.

Interaction of cloquintocet mexyl in the discontinuous oil phase with water in the continuous aqueous phase of an oil-in-water emulsion, which can lead to cloquintocet mexyl hydrate formation, crystal formation and Ostwald ripening, is minimized by the use of specific surfactants and solvents which provide enhanced stability to the emulsion.

Interaction of cloquintocet mexyl in the discontinuous oil phase with water in the continuous aqueous phase of an oil-in-water emulsion, which can lead to cloquintocet mexyl hydrate formation, crystal formation and Ostwald ripening, is minimized by the use of specific surfactants and solvents which provide enhanced stability to the emulsion.

A formulation having a slightly water soluble ingredient and method for preparing the same are disclosed. The millbase formulation comprises a slightly water soluble ingredient and a dispersant comprising a water soluble or water dispersible, derivative of an alternating copolymer or a salt thereof. The alternating copolymer comprises a residue of a first comonomer and a residue of a second comonomer. In addition, the first comonomer comprises an α,β-unsaturated oxyacid, or an anhydride or other derivative thereof. Moreover, the second comonomer comprises an olefinic compound containing one or more polymerizable double bonds, or a derivative thereof. Such formulations may be used to inhibit Ostwald ripening in agricultural as well as non-agricultural applications.

The invention provides aqueous pesticidal concentrates comprising at least one colloidal solid, a dispersed emulsion phase comprising at least one substantially water-insoluble pesticidally active ingredient, which is either itself an oily liquid comprising the oil phase, is a solid but is dissolved in an oily liquid present in the oil phase, is a solid and is dispersed within the oil phase or is present as a colloidal solid adsorbed to the liquid-liquid interface between the continuous aqueous phase and the dispersed oil phase and at least one Ostwald ripening inhibitor.

The present invention provides silver oxide particles having an average diameter of less than or equal to 100 nm that are stable and can be transported in dry powder form. The surface of the silver oxide particles is coated with an extremely thin layer of a surfactant such as fatty acid. Nanosized silver oxide particles according to the invention are preferably formed via the addition of a strong base to a mixture including an aqueous silver salt solution and a surfactant dissolved in an organic solvent that is at least partially water miscible. The strong base causes silver oxide to precipitate from the mixture as nanosized particles, which are immediately encapsulated by the surfactant and thus protected from further crystal growth and Ostwald ripening. The nanosized surfactant coated particles of silver oxide can be washed and dried and then transported in dry form.

The present invention provides silver oxide particles having an average diameter of less than or equal to 100 nm that are stable and can be transported in dry powder form. The surface of the silver oxide particles is coated with an extremely thin layer of a surfactant such as fatty acid. Nanosized silver oxide particles according to the invention are preferably formed via the addition of a strong base to a mixture including an aqueous silver salt solution and a surfactant dissolved in an organic solvent that is at least partially water miscible. The strong base causes silver oxide to precipitate from the mixture as nanosized particles, which are immediately encapsulated by the surfactant and thus protected from further crystal growth and Ostwald ripening. The nanosized surfactant coated particles of silver oxide can be washed and dried and then transported in dry form.

The invention discloses a tri-metal nano particle with an asymmetric structure, a preparation method and application thereof. The preparation method comprises the steps: utilizing a golden rod as a seed and a silver nitrate solution as a metal precursor, utilizing a seed growing method to prepare rod-like template nano particles with core-shell structures and with silver coated outside the golden rod, centrifugally dispersing the particles in ultrapure water; utilizing a modified electric displacement reaction and a common reduction reaction, adding chloropalladic acid to the obtained aqueous solution containing template nano particles, utilizing ascorbic acid as a reducing agent and standing at room temperature; adjusting the molar ratio of silver nitrate and chloropalladic acid and the amount of surfactant and ascorbic acid, and obtaining dandelion-shaped nano particles under the action of Oswald ripening effect, wherein the brace is of a golden rod structure; one end of the golden rod is coated with spherical silver-palladium alloy with a branch-like structure and the other end is a pure golden rod. In the organic reaction using palladium as a catalyst, the palladium can be used as the catalyst with good activity and can be used as the tracking and detection for Raman spectrum signals.

The invention relates to a synthesis method of superfine nanorod-baculariate SnO2 nano-materials, which belongs to the technical field of materials. According to invention, technically, by taking simple water-alcohol which is a mixed solution friendly to the environment and human bodies as a solvent, a superfine nanorod-baculariate SnO2 one-dimensional nano-material is synthesized by using a hydrothermal reaction, and in the process of reaction, any toxic, harmful and volatile organic solvents such as acids, alkalis, surfactants, molding templates, catalysts and the like are not added as auxiliary solvents, therefore, the method has the characteristics of environmental friendliness, and harmlessness to the human body; and the principle of the method is implemented by that parameters such as the volume fraction of the water-alcohol, the concentration of a precursor solution, and the like are adjusted so as to form specific thermodynamic reaction conditions, and then a SnO2 nanocrystal, according to the self growth rule of the nanocrystal, and through a synergistic action process of an Ostwald ripening mechanism and directional assembling, generates a SnO2 nanorod one-dimensional nano-structured crystal. A superfine nanorod-baculariate SnO2 nano-material prepared according to the invention has good sensitivity to isopropyl alcohol, ethanol, acetone, methanol and formaldehyde gas, and according to the method, gas sensors can be manufactured.

The invention provides a method for purifying ultrafine silver nanowires. The method comprises the following steps that firstly, the unpurified ultrafine silver nanowires are prepared; and secondly, the unpurified ultrafine silver nanowires prepared in the step 1 are taken and washed with a solvent, then the unpurified ultrafine silver nanowires are dissolved through a solvent, then aqueous ammonia is dropped in, still standing is conducted, bottom precipitate is removed, and thus a purified ultrafine silver nanowire solution is obtained. The aqueous ammonia is added to the unpurified ultrafine silver nanowire solution, Ostwald ripening of silver nanoparticles in the unpurified ultrafine silver nanowire solution is assisted by the aqueous ammonia, growth of the silver nanoparticles is induced, and then the grown silver nanoparticles can be separated from the silver nanowires through a still standing process without other complicated purifying processes, and the ultrafine silver nanowires with the mass percent being 60% to 85% and the diameter being 20 nm to 30 nm are obtained.

The invention discloses a microfluid reactor based nano-particle preparation and a particle controlled preparation process. The particle controlled preparation process is characterized in that technological parameters of particles in different generation steps are regulated and controlled in a nanoliter or smaller scale by a microfluid control technology, particles quickly mix and react to form cores on line, evenly grow up and are quenched to stop growing at low temperature so as to regulate and control the size, the shape, the crystal structure and the surface performance of the particles on line, and the hierarchical structure of the particles can be regulated and controlled. The method effectively inhibits widened size distribution and crystal lattice defect caused by Ostwald ripening and directional binding during nano-particle formation. Compared with a tank stirred reactor which is unable to respectively control the technological parameters of nano-particles in different generation steps, the microfluid reactor can increase the stability of the crystal structure and the physical performance of the particles, and the structure and the performance at least can be stabilized above three months to one year according to the types of the particles. The nano-particle output of the process can reach above 300ml / hour, and the process is an environment-friendly type nano-material continuous scale production process.

The invention discloses a cobaltosic oxide- zinc oxide / grapheme ternary complex and a preparation method thereof. The cobaltosic oxide-zinc oxide / grapheme ternary complex is prepared by the following steps: Co(No3)2 6H2O and a graphene oxide water solution are mixed, then an ammonia-water solution and a surface active agent PVP are added, and during a constant temperature backflow heat treatment process, Co(OH)2 loaded on graphene is produced; then, Zn(NO3)2 6H2O is added, then ammonia water is added again, and Zn(NH3)42+ and Zn(OH)2 are generated; finally, during a constant temperature heat treatment process of a reacting kettle, Co(OH)2 and Zn(OH)2 are taken as particles and grow through ostwald ripening, so as to form nanometer cobaltosic oxide and nano-zinc oxide particles loaded on the graphene, and the cobaltosic oxide-zinc oxide / grapheme ternary complex is prepared. The cobaltosic oxide-zinc oxide / grapheme ternary complex prepared according to the preparation method provided by the invention, an excellent gas-sensitive property is shown and the cobaltosic oxide- zinc oxide / grapheme ternary complex has a relatively good application prospect in the field of gas sensors.

The invention belongs to the technical field of nanoporous materials, and concretely relates to a method for preparing a two-dimensional ordered mesoporous nanosheet by inorganic salt interface induced assembling. The method comprises the following steps: uniform diffusion and transfer of a target precursor solution in the crystal interface of an inorganic salt are achieved by vacuum suction filtration or low-speed centrifugation with the soluble inorganic salt as a substrate and an amphiphilic block copolymer as a template; a highly ordered monolayer mesoporous structure is formed by a solvent volatilization induced co-assembling technology; and gradient temperature-controlled Ostwald ripening promotes organic solvent volatilization and induces molding, and the template is removed under the protection of N2 to obtain the highly ordered monolayer two-dimensional mesoporous nanosheet material. The assembled nanosheet material has a large pore size and regular and ordered spherical porechannels; and the type of the precursor can be changed to synthesize a plurality of mesoporous metal oxides, metal simple substances and inorganic nonmetal nanosheets. The method of the invention hasthe advantages of simplicity, easily available raw material, universality to nanomaterials, and suitableness for amplified production.

Disclosed is a trekking atom nanotube growth technology capable of continuously growing long, high quality nanotubes. This patent application is a Continuation In Part of the Proximate Atom Nanotube Growth patent application Ser. No. 13 / 694,088 filed on Oct. 29, 2012. The current invention represents a departure from chemical vapor deposition technology as the atomic feedstock does not originate in the gaseous environment surrounding the nanotubes. The technology mitigates the problems that cease carbon nanotube growth in chemical vapor deposition growth techniques:1) The accumulation of material on the surface of the catalyst particles, suspected to be primarily amorphous carbon,2) The effect of Ostwald ripening that reduces the size of smaller catalyst particles and enlarges larger catalyst particles,3) The effect of some catalyst materials diffusing into the substrate used to grow carbon nanotubes and ceasing growth when the catalyst particle becomes too small.

The present disclosure provides a pharmaceutically acceptable, stable, and optically clear oil-in-water nanoemulsions (intensity-averaged diameter<100 nm) with an oil phase comprising >10% w / v of long chain triglyceride, total surfactant and cosurfactant concentration less than that of oil phase and without the use of alcohol as cosolvent in the aqueous phase. The nanoemulsions of this disclosure have extremely favorable particle size distribution, optical clarity, and product stability against Ostwald ripening with high levels of oil concentrations. Poorly water soluble, therapeutically active agents and others can be incorporated in the nanoemulsion systems to improve their solubility / stability in aqueous medium or to enhance their delivery for use in pharmaceutical, food, cosmetic, and other applications by oral, intravenous, subcutaneous, intra muscular, inhalation, nasal, topical, ocular, and transdermal routes.

The invention discloses a preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles. The method is capable of, according to an Ostwald ripening theory, and through aferroferric oxide nano-shell prepared by using a soft template method in advance, using glucose as a carbon source and performing hydrothermal coating, finally loading nanogold by using a chemical reduction method. The obtained ferroferric oxide nano-shell is a carbon-coated ferroferric oxide hollow-core nano-shell. Compared with a solid nano-shell, the carbon-coated ferroferric oxide hollow-corenano-shell is large in specific surface area, and high in drug loading ratio. On the other hand, a shell structure is capable of controlling burst release of a drug so as to achieve a purpose of slowrelease.

The invention discloses cadmium-free quantum dot nanoparticles. Quantum dot semiconductor nanoparticle compositions that incorporate ions such as zinc, aluminum, calcium, or magnesium into the quantum dot core have been found to be more stable to Ostwald ripening. A core-shell quantum dot may have a core of a semiconductor material that includes indium, magnesium, and phosphorus ions. Ions such as zinc, calcium, and / or aluminum may be included in addition to, or in place of, magnesium. The core may further include other ions, such as selenium, and / or sulfur. The core may be coated with one (or more) shells of semiconductor material. Example shell semiconductor materials include semiconductors containing zinc, sulfur, selenium, iron and / or oxygen ions.

The invention provides a preparation method for a carboxyl and polypeptide modified AIE polymer nanoparticle. The preparation method comprises the following steps: 1) preparing an emulsifier aqueous solution; 2) dissolving an AIE molecule, an Ostwald ripening effect inhibitor and an oil-soluble initiator into a mixed solution of a carboxyl functional monomer and a hydrophobic monomer so as to obtain an oil-phase solution; 3) adding the emulsifier aqueous solution into the oil-phase solution, carrying out pre-emulsification under stirring so as to obtain a crude emulsion, carrying out ultrasonic treatment so as to prepare a monomer fine emulsion, and introducing nitrogen to remove oxygen so as to prepare a carboxyl modified AIE polymer nanoparticle emulsion; 4) dissolving a carbodiimide condensing agent into an acidic pH buffer solution, adding an obtained solution into the emulsion prepared in the step 3), and carrying out an activation reaction; 5) dissolving omega-aminomaleimide intoan alkaline pH buffer solution; 6) adding an omega-aminomaleimide solution into an emulsion prepared in the step 4), and carrying out a reaction; and 7) adding a polypeptide aqueous solution with theterminal containing a cysteine sequence unit into an emulsion prepared in the step 6), and carrying out a reaction so as to prepare the carboxyl and polypeptide modified AIE polymer nanoparticle.

The present invention belongs to the fields of pharmacology, medicine and drug delivery. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles comprising microtubule inhibitor such as docetaxel, cabazitaxel and ixabepilone with reduced Ostwald ripening for oral administration.

The invention discloses a three-dimensional hollow titanium dioxide assembled from (001) surfaces, and a preparation method and application thereof. The three-dimensional hollow titanium dioxide can be applied to the field of manufacturing of positive electrode materials of lithium batteries. According to the invention, a hydro-thermal method is employed for preparation of titanium dioxide, and under the co-action of hydrofluoric acid and hydrogen peroxide, the hydrolysis process of a reaction intermediate peroxotitanic acid is effectively regulated and controlled. The formation process of a hollow structure is related to an Ostwald ripening mechanism, fluoride ions promote preferential growth of a crystal along [001] direction, and finally, the three-dimensional hollow product is formed. The method has the advantages of low cost, simple and controllable process, mild reaction, obtainment of the pure product and a high exposure rate of the (001) surfaces; and the titanium dioxide material prepared by using the method has the high-exposure (001) surfaces, is of a hollow micro-nano structure, can be applied to preparation of positive pole pieces of the lithium battery, shortens a diffusion path of lithium ions, facilitates intercalation / deintercalation behavior of lithium ions and alleviates volume expansion of the material during charging and discharging, and thus, the lithium battery has improved charging and discharging efficiency and prolonged cycle life.

The invention discloses composite particles as well as preparation and an application thereof. The composite particles comprise carboxymethylated konjac glucomannan and whey protein with the molar ratio being 4:1 through static electricity acting force, have the particle size ranging from 260 nm to 280 nm, the Zeta potential absolute value of 30 plus / minus 0.5 mv and the contact angle with water ranging from 65 degrees to 70 degrees. The composite particles can be applied to preparation of a Pickering emulsion, and the obtained Pickering emulsion has higher resistance to coalescence and Ostwald ripening of emulsion droplets and has better physical stability.

The invention relates to a vanadium nitride material. The vanadium nitride material is assembled from porous vanadium nitride nanosheets and is in a spherical structure. The spherical structure comprises hollow cavities formed by the porous vanadium nitride nanosheets through separation. A vanadate solution and a zinc salt solution are mixed according to certain proportion, Zn3(OH)2(V2O7)(H2O)2 is obtained thorough Ostwald ripening, and the vanadium nitride material is obtained after reduction and nitration. The obtained vanadium nitride material has a multi-level micro-nano structure, the pore size distribution is even and reasonable, the specific surface area is up to 18-50 m<2> / g, the vanadium nitride material is good in dispersity, and is an excellent catalyst carrier. The vanadium nitride material shows higher catalytic activity and stability when being applied to catalyzing the methanol oxidation reaction as a noble metal based catalyst carrier, and the vanadium nitride material has an excellent application prospect in the fields of low-temperature fuel cells.

The present invention provides pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances with reduced Ostwald ripening.

The invention relates to a preparation method of a polyacrylic ester emulsion modified by hollow zinc oxide microspheres with shell layers adopting sheet structures. The preparation method comprises the following steps: firstly, preparing the hollow zinc oxide microspheres with the shell layers adopting the sheet structures according to the alkaline etching mechanism and the Ostwald ripening mechanism; secondly, modifying a polyacrylic ester emulsion with the hollow zinc oxide microspheres by a physical blending method. The hollow zinc oxide microspheres with the shell layers adopting the sheet structures are formed through the prior etching of ammonia water or sodium hydroxide to the zinc hydroxide in zinc hydroxide / zinc oxide composite microspheres and the self-assembly process of oriented adsorption growth of zinc oxide nano particles, the preparation technology is simple, the reaction condition is moderate, and the operability and productivity are high, the prepared hollow zinc oxide microspheres with the shell layers adopting the sheet structures have uniform appearances. Compared with a pure polyacrylic ester coating, a polyacrylic ester emulsion coating modified by the method provided by the invention has the advantages that the moisture permeability is increased by 51%, the water tolerance is increased by 11.61%, and the tensile strength is increased by 60.26%.

The invention discloses an azoxystrobin suspension concentrate. The technical scheme is as follows: the azoxystrobin suspension concentrate is prepared from the following ingredients in percentage by weight: 15% to 40% of azoxystrobin, 1% to 6% of wetting dispersant, 0.5% to 5% of thickener, 0.1% to 0.5% of antifoamer, 3% to 10% of antifreezer, 0.1% to 0.5% of preservative, 0.1% to 0.3% of pH regulator and the balance of water, wherein the total mass percent is 100%. The invention further discloses a preparation process for the azoxystrobin suspension concentrate. The azoxystrobin suspension concentrate and the preparation method thereof have the advantages that by adopting a novel processing method and a novel assistant system, the hard water resistance and dispersion stability of the suspension concentrate can be remarkably improved, and the problems, i.e., easiness in bleeding, bottom clinging and Ostwald ripening are solved.

The invention provides a shape controllable synthesis method of cuprous oxide powder and application and relates to the technical field of preparation and application of cuprous oxide. The method comprises the following steps: directly carrying out hydrothermal reaction in an alkaline copper tartrate water system composed of copper sulfate, alkali liquid and tartaric acid; when Cu<2+> in copper tartrate is heated, reducing the Cu<2+> and slowly releasing Cu<+>; combining the Cu<+> and OH<-> in the system to form CuOH; dehydrating the CuOH to form Cu2O small crystal grains; finally, forming Cu2O cubes through the single-crystal CuOH through an Ostwald ripening manner; or introducing a proper amount of gelatin with a template effect into the alkaline copper tartrate water system; and carrying out the hydrothermal reaction to assemble a plurality of formed nanoparticles into microspheres. The maximum absorption wavelength of the prepared Cu2O powder with two shapes is about 500nm (with the band gap of about 2.2eV); and the Cu2O powder can be used for removing organic pollutants in a water body and the photocatalytic performance of spherical powder is better than that of cubic powder.

A method for preparing amino acid-and-polypeptide-modified AIE polymer nanoparticles comprises the following steps: (1) dissolving an emulsifier and an amino functional monomer in water to obtain an aqueous solution; (2) dissolving an AIE molecule, an Ostwald ripening effect inhibitor and an oil-soluble initiator in a hydrophobic monomer to obtain an oil phase solution; (3) adding the aqueous solution to the oil phase solution, stirring and pre-emulsifying the obtained mixture to obtain a crude emulsion, carrying out ultrasonic treatment to obtain a fine monomer emulsion, introducing nitrogento remove oxygen, and carrying out a reaction to produce an amino-modified AIE polymer nanoparticle emulsion; (4) dissolving omega-maleimido alkyl acid and a carbodiimide condensing agent in an acidicpH buffer solution, and performing activation to obtain an activated intermediate solution; (5) adding the activated intermediate solution to the emulsion prepared in step (3), and carrying out a reaction to obtain a maleimide-modified AIE polymer nanoparticle emulsion; and (6) adding an aqueous solution of a polypeptide containing a cysteine sequence unit at the end to the emulsion prepared in step (5), and carrying out a reaction to produce the amino acid-and-polypeptide-modified AIE polymer nanoparticles.

The invention belongs to the technical field of preparation processes and application of nano materials, and relates to a high-efficiency catalyst for growing carbon nanotubes, and a preparation method and a use method thereof. The catalyst is composed of cobalt, iron, dysprosium metal, molybdenum oxide and aluminum oxide, and all the components are evenly distributed; due to introduction of dysprosium, aggregation, growth and deactivation caused by Ostwald ripening of the catalyst can be effectively inhibited, and the efficiency of the catalyst for growing the carbon nanotubes is greatly improved. Carbon-containing gas is used as a carbon source, the catalyst is flatly laid in a quartz boat, a chemical vapor deposition reaction is carried out in a horizontal tubular furnace to prepare thecarbon nanotubes, and the yield can reach 6000% or above (the ratio of a post-growth product to a pre-growth catalyst). The dysprosium metal doped catalyst with uniform components can be prepared andused for efficiently growing the carbon nanotubes, the preparation process is simple, convenient and feasible, the cost of the raw materials is low, the purity and graphitization degree of the growncarbon nanotubes are high, and the catalyst has great significance in promoting industrial production and application of high-quality carbon nanotubes.

The invention relates to a W / O vaccine oil adjuvant formulation and a preparation method thereof. The formulation is a W / O emulsion, which comprises an aqueous phase containing a solution of antigen and an oil phase containing white oil, an emulsifier, and a stabilizing agent. The W / O emulsion has the average particle size in a range of 0.1-8.22 [mu]m and the coefficient of dispersion less than 0.1. The preparation method comprises: transferring a pre-emulsion into a storage tank for quick membrane emulsification, and allowing the obtained product to pass through a microporous membrane under the pressure in a range of 0.1-2.5 MPa to obtain the W / O vaccine oil adjuvant formulation. The W / O vaccine oil adjuvant formulation is uniform and controllable in size. The improved uniformity of the emulsion benefits enhancement of stability of emulsion droplets. Compared with an emulsion prepared through a conventional process, the emulsion in the invention is slower in the Ostwald ripening, so that when the formulation is injected into a human body, the burst release of antigen is at a low speed, and antigen can be continuously released later, thereby inducing a quick, efficient and continuous immune response level.

The invention discloses a preparation method of a rare earth hollow nanocrystal, wherein the preparation method comprises the following steps: preparing a rare earth soluble salt aqueous solution of rare earth ions La and Eu; preparing a lithium ion soluble salt aqueous solution; preparing a transparent solution from polyvinylpyrrolidone; dropwise adding the rare earth soluble salt aqueous solution and the lithium ion soluble salt aqueous solution into the obtained solution, to obtain a transparent solution; preparing an NH4F aqueous solution, slowly dropwise adding the NH4F aqueous solution to the obtained solution, to obtain a white colloidal solution; and pouring the obtained colloidal solution into a hydrothermal kettle, centrifuging, putting the obtained white product into a baking oven, and thus obtaining a rare earth hollow nanocrystalline powder. The LaF3:Eu<3+> hollow nanocrystal is formed by using self weight crystallization and localized Ostwald ripening; by doping Li<+> ions, the red luminescence intensity of the nanocrystal is greatly enhanced. The prepared rare earth hollow nanocrystal has the advantages of uniform size, good dispersion, high water solubility and fluorescence intensity and the like, and has highly important research and application significance in the aspects of biological fluorescence imaging, kinetics diagnosis and treatment, photocatalysis and the like.