792 results about "Azoxystrobin" patented technology

A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi.

The invention relates to a synthetic process of a chemical substance, and particularly relates to a synthetic method for synthesizing (E)-2-[2-(6-chloro pyrimidine-4-yloxy)phenyl]-3-methoxy methacrylate and azoxystrobin; the method comprises the following steps: mixing a raw material of 3-(alpha-methoxy)methylene benzofuran-2-(3H)-ketone and potassium carbonate in a toluene solvent, cooling to 0-10 DEG C, adding sodium methoxide, reacting for 0.4-0.6 hours; adding 4,6-dichloropyrimidine and a catalyst of DABCO, reacting for 1-2 hours, filtering to remove inorganic salts, washing the filtrate with water, performing distillation to recover toluene; adding a catalyst of potassium bisulfate into the distillation residues of the above reaction, heating to 132-145 DEG C in a reduced-pressure condition for reaction; directly adding salicylonitrile to synthesize azoxystrobin or performing toluene dissolution, water washing, solvent recovery, recrystallization and filtration to obtain an intermediate. The production and synthesis of (E)-2-[2-(6-chloro pyrimidine-4-yloxy)phenyl]-3-methoxy methacrylate by the production process of the invention has high yield, and simple operations, and the used raw materials and processes are routine reagents and methods.

The invention relates to a preparation method of a compound with general formula (I), the preparation method includes: (1) the compound with general formula (II) and the formylation reagent are carried out the formylation reaction with the presence of Lewis acid and the organic base at -20 DEG C to 100 DEG C, and then the tertiary amine is added for reaction for a period of time; (2) the product of step (1) is carried out the methylation reaction with the inorganic base and the methylation reagent at -10 DEG C to 100 DEG C, so as to get the compound with general formula (I).

A fungicidal composition containing a fungicidally effective amount of a) a compound of Formula IA and / or IB and (b) at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, chlorothalanil, isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-isobutyryloxymethoxy-4-methoxypyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester, and (5,8-difluoroquinazolin-4-yl)-{2-[2-fluoro-4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethyl}-amine provides synergistic control of selected fungi.

The invention discloses an agricultural sterilizing composite containing thifluzamide, which is a sterilizing composite containing a first active ingredient thifluzamide, second active ingredients including difenoconazole, hexaconazole, propiconazole, cyproconazole and tebuconazole, and third active ingredients including tricyclazole, isoprothiolane, fenoxanil, Kanamycinum, prochloraz and azoxystrobin, wherein the weight ratio of the first active ingredient to the second active ingredient to the third active ingredient is (1-6) : (1-6) : 6. The sterilizing composite can be applied to controlling rice sheath blight disease, rice false smut and rice blast, and has reasonable ingredients, curing and protecting function, good sterilizing effect, less times of spraying insecticide and lower cost of spraying insecticide. In addition, the activity and the sterilizing effect of the sterilizing composite are not simple addition of the activity of active ingredients, but remarkable synergism isachieved. The invention has good safety on plants, slows down the generation of resistance and meets the safety requirement on agrochemicals.

The invention discloses an ultralow volume liquid containing azoxystronbin. The ultralow volume liquid containing the azoxystronbin comprises an active component, an auxiliary and a solvent, wherein the active component is azoxystronbin or formed by compounding the azoxystronbin and an active component II; and the active component II is any one or more selected from prochloraz, prothioconazole, difenoconazole, epoxiconazole, propiconazole, hexaconazole, tebuconazole, chlorothalonil, isoprothiolane, Kitazin P, thifluzamide and fenoxanil. The weight percentage of the active component is 0.5-10% of the azoxystronbin while the weight percentage of the active component II is 1-25%; and the liquid disclosed by the invention has the advantages of high concentration, long residual activity, high safety and less water usage; and by using the liquid, the working efficiency can be also largely enhanced.

A fungicidal composition containing a fungicidally effective amount of a) a compound of Formula IA and / or IB and (b) at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, chlorothalanil, isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-isobutyryloxymethoxy-4-methoxypyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester, and (5,8-difluoroquinazolin-4-yl)-{2-[2-fluoro-4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethyl}-amine provides synergistic control of selected fungi.

The invention relates to a compound fresh-keeping agent for a Shatang orange, which comprises: one of from 0.2% to 4% of film agent of shell lac, chitosan, and wool lanline, a mixture of two or three of from 0.1% to 0.15% of antiseptic prochloraz, iprodione, pyrimethanil, fludioxonil, azoxystrobin and tecto, from 0.02% to 0.05% of the surface-active material of alkyl sodium sulfonate or a sucrose fatty acid ester, from 0.02% to 0.05% of potentiating agent of diethyl aminoethyl hexanoate or pine needle essential oil, and allowance water. The compound fresh-keeping agent has the advantages that the Shatang orange processed by the agent of the invention is not easy to rot during storage and transportation, the base and leaves of the fruit are kept, and the leaves are kept green, qualified fruit rate is over 95%, the content of vitamin C, titrable acid and dissolvable solid content is not distinctly lowered, which improves the economic value of Shatang orange.

The invention discloses a dispersible oil suspension agent containing cyproconazole. The dispersible oil suspension agent is prepared by effective active compositions including cyproconazole and azoxystrobin and a wetting agent, a dispersant, an emulsifying agent, a thickening agent, a stabilizing agent, an anti-freezing agent, a defoaming agent and non-aqua-system dispersing media, wherein the weight proportions of the compositions include that the cyproconazole ranges from 0.5% to 10%, azoxystrobin ranges from 5% to 30%, the wetting agent ranges from 0.5% to 3%, the dispersant ranges from 0.5% to 8%, the emulsifying agent ranges from 0.5% to 10%, the thickening agent ranges from 1% to 6%, the stabilizing agent ranges from 0.5% to 20%, the anti-freezing agent ranges from 1% to 5%, the defoaming agent ranges from 0.1% to 2% and the rest are the non-aqua-system dispersing media. The two active compositions can be mixed to prepare the dispersible oil suspension agent, thereby preventiveeffect of the dispersible oil suspension agent is enhanced, effective period is prolonged, and preventive effective of the dispersible oil suspension agent is obviously better than other agents prepared by the active compositions. Besides, the dispersible oil suspension agent is safe to crop and environment, application dose of agents is reduced, cost is saved, and the dispersible oil suspension agent meets the safety requirement of agrochemicals.

The invention relates to an agricultural sterilizing composite containing thifluzamide. The first active component is thifluzamide; the second active component is selected from kresoxim methyl, azoxystrobin, pyraclostrobin and phenylate kresoxim methyl; and the weight ratio of the first active component and the second active component is 16: 1 to 1: 16. The bactericide composite is used for preventing and treating the thanatephorus cucumeris and the rice false smut of the cereal crops, the thizoctonia cerealis, the rust disease, the loose kernel smut and the stinking smut, and has the advantages of reasonable components, treating and protecting functions, good sterilization effect, reduction of the usage frequency and low usage cost; and the activity and the sterilization effect of the bactericide composite are not the simple addition of the activities of the components. The invention has remarkable synergistic action and good safety to the crops, slows down the generation of the resistance and meets the safety requirements of the pesticide formulation.

The invention relates to a pesticide, in particular to a compound bactericide for mainly treating grey mold of fruits and vegetables. The compound bactericide consists of active ingredients, a filler and / or aids, wherein the active ingredients consist of fluazinam and other bactericides; the weight ratio of the fluazinam to other bactericides is 1-50:1-50; and other bactericides are one or a mixture of more of mancozeb, iprodione, fludioxonil, SYP-Z048, pyrametostrobin and azoxystrobin. Product forms of the compound bactericide for mainly treating the grey mold of fruits and vegetables are usually wettable powder, water dispersible granules and suspension agents. The compound bactericide is applicable to the prevention and control of the grey mold of various fruits and vegetables and has remarkable synergism and long effective duration, the medicaments have a novel action mechanism and a large number of action sites, and the occurrence and development of medicament resistance of grey mold bacteria can be effectively delayed; and the preparation method of the compound bactericide is simple, and the compound bactericide has high biological safety and remarkable economic benefit.

The invention relates to a preparation method of an azoxystrobin intermediate. The method comprises the following steps of: (1) synthesizing benzofuranone from o-hydroxyphenylacetic acid serving as a raw material; and (2) making benzofuranone react with trimethyl orthoformate to generate the azoxystrobin intermediate, wherein no solvent is used in the reaction in the step (1); and the reaction isperformed by the following steps of: putting o-hydroxyphenylacetic acid and 0-3 percent of catalyst into a reaction kettle; preserving heat in vacuum at the temperature 125-180 DEG C to react for 2-3hours; and evaporating water generated by the reaction in vacuum, wherein the residue in the reaction kettle is benzofuranone. The method has the advantages of simple process, high yield of the azoxystrobin intermediate and low production cost.

The invention discloses an ultra-low-capacity liquid preparation containing epoxiconazole, which uses epoxiconazole, or a compound of epoxiconazole and active component II as the active ingredient, and is prepared into an ultra-low-volume liquid preparation by adding auxiliary agents and solvents; The active ingredient II is prochloraz, propiconazole, difenoconazole, chlorothalonil, myclobutanil, ricebendazol, thifuramide, rice blastamide, isofridazine, fluazinam and enoxim Any one or both of the strobilurin. The invention is suitable for ultra-low-capacity spraying, low-capacity spraying and electrostatic spraying, and is used for preventing and controlling diseases of large-area planted crops such as rice, corn, wheat, fruit trees, cotton, vegetables, rubber trees, tea trees, forest trees and sugarcane. The invention has the advantages of high work efficiency, quick effect, long duration of effect, water saving, synergistic effect and the like.

The present invention discloses an insecticide-fertilizer particulate agent and a preparation method thereof. The insecticide-fertilizer particulate agent comprises an insecticide, a bactericide, a fertilizer and an auxiliary agent. The insecticide is composed of one or more components selected from diazinon, thiamethoxam, imidacloprid, clothianidin, chlopyrifos, phoxim, carbofuran and carbosulfan. The bactericide is composed of one or more components selected from azoxystrobin, pyraclostrobin, fludioxonil, metalaxyl, methylimidazole bacteria aniline, thifluzamide and mancozeb. The fertilizer is composed of one or more components selected from urea, ammonium sulfate, potassium sulfate, potassium chloride, monoammonium phosphate, diammonium phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, ammonium polyphosphate, potassium nitrate, zinc sulfate, manganese sulfate, magnesium sulfate, borax, boric acid, ferrous sulfate, copper sulfate, ammonium molybdate, ethylene diamine tetraacetic acid, calcium nitrate, potassium humate, organic matter, amino acid and soybean meal. The insecticide-fertilizer particulate agent is applied during the crop sowing period and can be used for preventing and controlling crop underground pests and diseases at the rootstocks of crops.

The invention discloses a bactericidal composition of azoxystrobin and mancozeb. The bactericidal composition contains azoxystrobin, mancozeb and other auxiliary agents, wherein the weight ratio of azoxystrobin to mancozeb is (1-10): (60-1). The bactericidal composition of azoxystrobin and mancozeb can be applied to prevention and control of potato late blight. The composition is wide in application range, low in cost and good in effect. The indoor test proves that the composition has obvious synergized action.

The invention relates to a compound germicidal composition and an application thereof. The germicidal composition comprises chlorantraniliprole, azoxystrobin, fludioxonil, metalaxyl, and agriculturally acceptable pesticide adjuvants, and the content ranges are that 1-30% of chlorantraniliprole, 1-30% of azoxystrobin, 1-35% of fludioxonil, 1-35% of metalaxyl, 1-5% of dispersants, 1-5% of wetting agents, 1-5% of additives, and the balance of fillers or deionized water. The germicidal composition of the invention can control various diseases which are propagated by seed and soil infection and are harmful to rice, has unexpected seed treatment effect, reduces the using cost, and increases the utilization rate of effective components.

The invention relates to an azoxystrobin synthesis method which comprises the following synthesis steps: performing coupling reaction on 2-chlorobenzonitrile and 4,6-dihydroxypyrimidine in high-boiling-point aprotic solvent in the presence of a palladium or copper catalyst under alkaline conditions to generate 4-hydroxy-6-(2-cyanophenoxy)pyrimidine; chlorinating to obtain 4-chloro-6-(2-cyanophenoxy)pyrimidine; coupling the 4-chloro-6-(2-cyanophenoxy)pyrimidine with methyl (E)-2-(2-hydroxyphenyl)-3-methoxyacrylate in high-boiling-point aprotic solvent in the presence of a copper catalyst or a tertiary amine catalyst under alkaline conditions to generate methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidine-4-yloxy]phenyl}-3-methoxyacrylate. The invention optimizes the reaction conditions, shortens the reaction time, avoids the generation of impurities, simplifies the separation and after treatment process, and is high in product yield and good in quality. Besides, the raw materials in the invention are cheap and accessible, thereby achieving low cost and being suitable for large-scale industrial production.

The invention discloses a bactericidal composite containing metconazole and methoxy acrylate compounds, which comprises A and B, wherein A is metconazole, and B is selected from any one of the following bactericides: azoxystrobin, ethofenprox, benzol ethofenprox, pyrazol ethofenprox, and olefinic trifloxystrobin, and weigh part ratio of A to B is 1-80:180. The bactericidal composite can be used for controlling various diseases, has obvious synergy, widens bactericidal spectrum and has higher activity to downy mildew, epidemic disease, anthracnose, powdery mildew, alternaria leaf spot, leaf spot, cladosporium cucumerinum, rice blast and other diseases, can reduce the dosage of pesticides and residual amount of pesticides on crops and lower environment pollution.

The invention discloses a eugenol-containing germicidal composition, and the effective ingredient of the eugenol-containing germicidal composition is one of eugenol (A) and methacrylic acid ester bactericide (B). The methacrylic acid ester bactericide comprises azoxystrobin, kresoxim-methyl, pyraclostrobin, trifloxystrobin, enestroburin, SYP-1620, ZJ0712, and the like, and the ratio of the parts by weight of the two active ingredients A to B is 1-80:1-50. The composition of the invention has an obvious synergistic effect, can prevent various diseases, has good safety to crops, and has the advantages of rain wash resistance and lasting pesticide effect, etc.

A film-spreading oil agent capable of preventing and curing rice banded sclerotial blight comprises the following components by weight percent: 10-60 percent of effective component, 3-85 percent of additive, 0-70 percent of filling material, 5-14 percent of water surface diffusant, and 0-10 percent of water, wherein the effective component is one or the combination of any one selected from difenoconazole, propiconazole, hexaconazole, epoxiconazole, tricyclazole, tebuconazole, kresoxim-methyl, azoxystrobin, trifloxystrobin, enestroburin, thifluzamide, validamycin, and prochloraz, and the weight ratio of the two effective components under two ways is (1:10)-(10:1). The oil agent has the technical effects that the effect of preventing and curing the rice banded sclerotial blight is improved, the operation is simple, labor and time are saved, no harm is caused for human body, and no pollution is caused for the ambient condition when the oil agent is applied; moreover, the utilization ratio of the effective component is improved, the labor intensity is reduced, the labor is saved, and the agricultural production cost is reduced.

The invention discloses a suspending agent formulated by difenoconazole and azoxystrobin and a preparation method of the suspending agent. The suspending agent comprises the following materials by mass: 5% to 9% of difenoconazole original drug, 21% to 28% of azoxystrobin original drug, 3% to 4% of wetting dispersant, 2% to 3% of dispersant, 2.5% to 3.5% of antifreeze, 0.15% to 0.25% of thickener, and the balance of water, and also comprises about 0.5% of adsorbent, about 0.1% of preservative, and 1% to 2% of antifoaming agent. The method comprises the following steps: (1) taking following material ingredients by weight: the difenoconazole original drug, the azoxystrobin original drug, the wetting dispersant, the dispersant, the antifreeze, and adding water to 95%, and mixing; (2) placing the above mixed materials in a sand mill, and grinding for 3h to 5h to obtain an initial product of the suspending agent; (3) mixing the thickener with water to 5%, and adding into the initial product of the suspending agent, then stirring with a stirrer at high-speed for 1.5h to 2.5h to obtain a finished product of the suspending agent. The suspending agent provided by the invention has the advantage of significant efficacy, good dispersion performance, good suspension performance, stable heat storage performance and the like, high sterilization effect in use, and good security.

The invention discloses a method for synthesizing azoxystrobin (a compound I) and a key intermediate thereof, namely 2-{2-[6-(2-cyanophenoxy)pyridine-4-yl-oxo]phenyl}-3,3-dimethoxymethyl propionate (a compound V). The method comprises two steps of: performing a coupling reaction of 2-(2-hydroxyphenyl)-3,3-dimethoxymethyl propionate (II), 2-cyanophenol (III) and 4,6-dichloropyrimidine (IV) to form the 2-{2-[6-(2-cyanophenoxy)pyridine-4-yl-oxo]phenyl}-3,3-dimethoxymethyl propionate (the compound V); and transforming the compound V into the azoxystrobin (the compound I) under the action of a catalyst B. In the method, two coupling reactions are performed in the same reactor (one-pot method), so that the using amount of alkali and a solvent is greatly reduced, the reaction time sequence is short, the total yield is high, the aftertreatment is simple and convenient, and the method is suitable for industrialized production.

The invention relates to the field of a pesticide preparation and discloses an insect-killing and disease-resistant composite and a suspension seed coating agent thereof. The insect-killing and disease-resistant composite is composed of azoxystrobin and chlorantraniliprole with the mass ratio being 1: (4-10). The suspension seed coating agent comprises 0.5-10.0% of azoxystrobin, 1.0-30.0% of chlorantraniliprole, 1.0-8.0% of wet dispersant, 0.5-10.0% of film-forming agent, 1.0-10.0% of coloring agent, 0.1-2.0% of tackifier, 0.1-1.0% of preservative, 0.1-1.0% of de-foaming agent and the balance being distilled water. The suspension seed coating agent complexes azoxystrobin and chlorantraniliprole and advantages of azoxystrobin and chlorantraniliprole are complementary; insect killing and disease prevention can be realized by using the suspension seed coating agent for one time; and meanwhile, the pesticide effect is improved, the use amount, use types and use times of pesticides are reduced, and the suspension seed coating agent can be widely applied to agricultural fields.

The invention relates to an azoxystrobin nano-water suspending agent, which comprise, by mass: 10-20% of azoxystrobin, 10-30% of hydrophobic dispersible nano-silica, 2-10% of a wetting dispersant, 0.2-3% of a thickening agent, 1-5% of an antifreezing agent, 0.01-0.2% of a preservative, and the balance water. The azoxystrobin nano-water suspending agent of the invention has the advantages of: small particle size, high fluidity, and enhanced penetration and conductivity within leaves. Due to enhanced surface energy, the nano-water suspending agent provided in the invention is easier to be adsorbed by plants. As wind blow and rain wash resistance are strengthened, pesticide residues flowing into water and soil can be reduced. With certain slow release effect, the azoxystrobin nano-water suspending agent in the invention can reach the purposes of improving drug effects and prolonging the duration period.

The invention relates to a disinfectant compound with synergy function. The compound contains more than two active ingredients and acceptable agricultural inert ingredient, wherein component A is cyproconazole and component B is one of methoxyl acrylic ester disinfectant compound containing kresoxim-methyl, azoxystrobin, trifloxystrobin, SYP-1620, metominostrobin, fenazaquin, pyraclostrobin, kresoxim-methyl, etc. The disinfectant compound can be widely applied to protecting meals, vegetables, fruits, cash crops, etc. The compound is different from other agricultural disinfectant agent, promoting the preventing effect, slowing down the generation of resistance, widening the preventing range, promoting the safety, curing, preventing and increasing production of crops.

The invention discloses a superlow-capacity liquid reagent containing ethofenprox. The superlow-capacity liquid reagent is a superlow-capacity liquid reagent which comprises ethofenprox as an active component or composites ethofenprox with an active component II as active components, wherein the rest is replenished to 100% by an additive and a solvent. The active component II is any one of difenoconazole, cyprodinil, hexaconazole, azoxystrobin, prochloraz, epoxiconazole, propiconazole, tebuconazole, flusilazole, isoprothiolane, thifluzamide and fenoxanil. The superlow-capacity liquid reagent containing ethofenprox has the advantages of having high work efficiency, saving water and pesticide, and achieving good pesticide effect, long effectiveness duration period and synergies.

The invention discloses a bactericidal composition containing cupric nonyl phenolsulfonate and a methoxy-acrylate bactericide. The methoxy-acrylate bactericide is selected from azoxystrobin, kresoxim-methyl, metominostrobin, fluoxastrobin, trifloxystrobin, orysastrobin, picoxystrobin, pyraclostrobin, enostrobilurin, SYP-1620, phenylatestrobin, coumoxystrobin, pyraoxystrobin and pyraclostrobin, wherein the weight ratio of the cupric nonyl phenolsulfonate to the methoxy-acrylate bactericide is 1:5-20:1. The bactericidal composition can be prepared into missible oil, microemulsion, water-dispersible granules, wettable powder and a suspending agent which are permitted in the agriculture. The bactericidal composition containing the cupric nonyl phenolsulfonate and the methoxy-acrylate bactericide is reasonable in ingredients, good in bactericidal effect and low in drug cost, and the activity and the bactericidal effect are not formed by the activities of the ingredient simply. Compared with an existing single preparation, the bactericidal composition has remarkable synergistic effect except the remarkable bactericidal effect, is free of pollution to crops and good in safety, meets the safety requirements of pesticide preparations, and has remarkable preventive and control effect on powdery mildew, downy mildew, anthracnose and banded sclerotial blight of the crops.

The invention discloses a fungicide containing tebuconazole. The fungicide is characterized by comprising an active compound by compounding fungicide A and fungicide B, wherein the proportion of the fungicide A to the fungicide B is 1-80:1-80; the fungicide A is the tebuconazole; the fungicide B is any one of the followings: kresoxim-methyl, azoxystrobin, fluoxastrobin, prochloraz, triflumizole and fludioxonil. The fungicide containing the tebuconazole is formed by compounding the fungicide A with the fungicide B for compounded use, so that the efficacy duration is prolonged and the drug resistance is relieved based on the systemic property and the broad-spectrum property of the tebuconazole, and a strong synergistic effect is achieved.

The invention relates to an agricultural composition containing chitosan oligosaccharide and fipronil, the agricultural composition is characterized by also containing one or a plurality of component from an insecticidal component, a sterilization component, a plant growth regulator and a fertilizer component, the insecticidal component is selected from one or a plurality of component of abamectin, chlorpyrifos, fosthiazate, thiamethoxam, phoxim, spinosad, isazofos, ivermectin, profenofos, thiodicarb and imidacloprid, the sterilization component is selected from one or a plurality of component of ethylicin, azoxystrobin, fludioxonil, hymexazol, difenoconazole and propiconazole, the plant growth regulator is selected from one or a plurality of component of mepiquat chloride, naphthylacetic acid, chlormequat chloride, uniconazole, paclobutrazol and indolebutyric acid, and the fertilizer component is selected from one or a plurality of component of nitrogen, phosphorus, potassium, calcium, magnesium, boron, zinc and amino acids. The agricultural composition can be one of a granule agent, a microcapsule agent, an absorbent product, a water agent, a water emulsion agent, a suspending agent, a water dispersible granule agent, a wettable powder agent and a microemulsion agent, and is used for root irrigation, sprinkling and pouring, furrow application pesticide-clay mixture or hole application, and the agricultural composition is used for the control of plant diseases and insect pests and regulation of plant growth.