58 results about "Parent structure" patented technology

A structural system for optimizing the performance of a millimeter wave concealed object detection system is disclosed. In a particular embodiment, a shell is provided to house and protect the millimeter wave concealed object detection system so that the detection system can operate optimally in a controlled and managed environment by eliminating or mitigating spurious millimeter wave emissions or reflections from outside or inside the shell. The shell can be free-standing or attached to a parent structure. The entry and exit to the system is controlled by entry and exit barriers. In addition, an inspection lane is configured according to each particular application to guide a subject through the detection system.

The invention discloses a class of anti-tumor compounds containing a triazole heterocyclic structure and an application thereof, belonging to the technical field of medicinal chemistry. The compounds containing the triazole heterocyclic structure introduce quintuple 1,2,3-triazole ring in the form of side chains through the amino condensation, bromination, nitrine substitution, link reaction and other reactions on the basis of naphthalimide parent structure, select tetrazolium salt reduction to test 7721 hepatocellular in the experiment of inhibiting proliferation of tumor cells, and also select sulfonyl rhodamine B protein staining method to test MCF-7 breast cancer cells. The experiment results show that the anti-tumor compounds have wide anti-tumor activity and good inhibition effect on the normal growth of tumor cells derived from different tissues of liver cancer, breast cancer and the like.

A photosensitive resist (100) for coating on a semiconductor substrate or a mask comprises a photo acid generator (D), a solvent (E) and at least two different base polymers, of which a first base polymer comprises cycloaliphatic parent structures (A) which substantially absorb incident light at 248 nm and are substantially transparent to incident light at 193 nm, and a second base polymer comprises aromatic parent structures (B) which substantially absorb incident light at 193 nm and are substantially transparent to incident light at 248 nm. If such a resist (100) is applied in a coat thickness of from 50 to 400 nm to a substrate and the proportion of the second base polymer having the aromatic parent structure is between 1 and 25 mol %, a relatively high structure contrast, better stability to etching and a reduction of defects are advantageously achieved in an exposure at a wavelength of 193 nm. Exposure over the entire depth range of the resist (100) is ensured thereby.

The present invention provides a photosensitive resin composition, a method of producing a cured film, the cured film, an organic EL display device and a liquid crystal display device. The photosensitive resin composition provided by the invention is characterized by comprising the following components: (component A) a resin which has an ethylidene ether structure and has changeable alkali solubility through acid function; (component B) a photoacid generator, (component C) cross linker and (component D) a solvent. Furthermore the component C comprises end-capped isocyanate compound, wherein the parent structure of the end-capped isocyanate compound is a biuret structure.

The invention relates to a fluorescence detection method and provides a fluorescent probe which has high sensitivity and high selectivity and is used for detecting intracellular hypochloric acid and an application of thiospirolactone in intracellular hypochloric acid detection. The structure of the fluorescent probe for detecting the intracellular hypochloric acid is a triphenylmethane fluorescent probe with a Xanthone ring parent structure; and the fluorescent probes of the thiospirolactone all adopt corresponding spirolactones as raw materials. The thiospirolactone has high-sensitivity fluorescent response characteristics on hypochloric acid, and when being used in the fluorescent probe for detecting the intracellular hypochloric acid, the selectivity is high. The probe has strong lightstability, no illumination self oxidation, rapid response to an aimed compound, good cell permeability and no strong cytotoxicity, and a product formed by combining the fluorescent probe and the aimed compound has strong photobleaching resistance. The thiospirolactone used for detecting the hypochloric acid of the aimed compound has high sensitivity and strong specificity and other active oxygen in cells has no interference on the detection.

The invention discloses a naphthyl two-photon fluorescent probe as well as a preparation method and application thereof. The preparation method of the probe comprises the steps of firstly, heating 1-methyl-4-[2-(6-hydroxyl-2-naphthalene)-vinyl]-pyridium and sodium methylate for 4 hours, then heating the heated materials together with 2,4-dinitrobenzene chlorine sulfonate and triethylamine in acetonitrile for 2 hours, and carrying out silica gel column separation to obtain the pure product. The probe takes a naphthalene ring as a two-photon parent structure, has both a pyridium mitochondrion targeted group and a fluorophore, and uses 2,4-dinitrobenzene sulfonyl as a Cys selective recognition group. The hydroxyl is produced by using sulfydryl to break the 2,4-dinitrobenzene sulfonyl, and fluorescence spectrum redshift occurs, so that the ratio test (F583nm/F485nm) of Cys is realized; during the detection, a maximum value is rapidly obtained within 2min, and the detection line is as low as 29 nm. The probe can be used for selective detection of the Cys in cellular mitochondria.

The invention discloses a mercury ion fluorescence probe compound, a preparation method and an application and relates to the technical field of analytical chemistry. The chemical formula of the mercury ion fluorescence probe compound is obtained through derivatization with 2-(2'-hydroxyphenyl) benzimidazole serving as a parent structure. The probe has good selectivity for mercury ions, is high in sensitivity and easy to prepare and is an ideal mercury ion sensing molecule.

The invention discloses a novel <18>F-marked pyrazolo[1,5-a]pyrimidine compound. The compound is characterized by having a parent structure 3-cyan pyrazolo[1,5-a]pyrimidine, wherein the fifth bit of the compound has substituents R, namely methyl, chloromethyl, (N,N-dimethylamino)methyl, acetoxymethyl, hydroxymethyl and carboxyl; amido on the seventh bit of the compound is connected with fluorine-18 through a carbon chain with n carbon atoms; and the structure of the compound is shown as a formula A. The compound is simple to synthesize and mark with operation easiness. The compound can maintain higher concentration for a longer time in a tumor tissue, and has low absorption rate or high clearing rate in normal tissues and blood. In particular, the compound has very high ratios of tumor to blood ratio and tumor to muscle tissues. The invention also relates to application of the compound serving as a PET (Polyethylene Terephthalate) brain tumor developer. In a formula A of the compound, R=CH3, CH2Cl, CH2N(CH3)2, CH2OCOCH3 and CH2OH; and COOHn=2,3.

The invention discloses a glutaminyl cyclase inhibitor. The structure of the glutaminyl cyclase inhibitor is shown in the following formula ( as shown in the description). The glutaminyl cyclase inhibitor (QC inhibitor) provided by the invention is designed according to the crystal structure of an active center of target pheron. The glutaminyl cyclase inhibitor shows favorable selectivity and specifity, and has higher druggability. The glutaminyl cyclase inhibitor is rich in parent structures, good in water solubility, good in transmembrane properties and high in activity.

The invention relates to a protopanoxadiol derivative shown as formula I in the specification, a preparation method of the derivative, a composition containing the derivative and an application of the derivative, and in particular relates to a derivative acquired by modifying protopanoxadiol which is used as a parent structure, a preparation method of the derivative, a composition containing the derivative and an application of the derivative in preparing a tumor cell multi-drug resistance reversal agent.

The invention relates to a multicoat color and/or effect paint system comprising, lying above one another in this order,

• • (1) at least one first basecoat comprising basecoat material (A),
  • (2) preferably a second color and/or effect basecoat comprising basecoat material (B), and
  • (3) optionally at least one transparent coating comprising clearcoat material (C),

wherein the basecoat material (A) forming the first basecoat comprises at least one binder (a.1), at least one color and/or effect pigment (a.2), and at least one water-soluble or water-dispersible, oligomeric or polymeric component (a.3) which comprises a parent structure (GK) having at least two repeating monomer units (ME) and also at least one uni- and/or multidentate, potentially anionic ligand (L) which is still capable of forming complexes after the multicoat paint system has been thermally cured.

The invention discloses a pore forming substance for a reticular porous material and a preparation method thereof. The molecular structural formula of the pore forming substance is as shown in the description, wherein R1, R2, R3 and R4 are polyoxyethylene ether or hydrophobic groups linked to a parent, and the polyoxyethylene ether and hydrophobic groups must be present in every pore forming substance molecule at the same time. By taking sorbitan as a parent structure, the pore forming substance of the reticular porous material is prepared by introducing the hydrophobic groups and polyoxyethylene ether on hydroxyl through reactions. The selecting range of reaction raw materials is expanded by virtue of the method, and meanwhile, various functional groups can be introduced, so that the specificity of the pore forming substance is increased; the pore forming mode is a micelle occupying method. In a process of removing micelle in the pore forming substance, the pore forming substance only needs to be simply soaked in pure water, so that the requirements on energy conservation and environmental protection are satisfied.

The invention discloses a zinc ion fluorescence probe compound, a preparation method and application and relates to the technical field of analytical chemistry. The chemical formula of the zinc ion fluorescence probe compound is C39H35N7O2, and the zinc ion fluorescence probe compound is obtained by using 2-(2'-hydroxy phenyl) benzoxazole compound as a parent structure and performing derivatization. The zinc ion fluorescence probe compound has good selectivity, high sensitivity and good capability of resisting interference of other metal ions and is an ideal zinc ion sensing molecule.

The invention discloses a synthetic method of 7-amino-3-chloro-3-cephem-4-carboxylic acid. With ENM compound 1 used as the raw material, the 7-amino-3-chloro-3-cephem-4-carboxylic acid is obtained through bromination, cyclization, chlorination, and finally successive removal of a phenylacetyl group at carbon 7 of the parent structure and a benzhydryl group on a carboxyl group at carbon 4 of the parent structure, both of which are protecting groups. The method is easy for operation and low in cost. The yield rate is up to 92.7%. The produced 7-amino-3-chloro-3-cephem-4-carboxylic acid is white solid powder, with a purity greater than 98.0% and good quality. Thus the method is suitable for industrial production.

Coating compositions comprising (a.1) at least one binder with functional groups (Gr); (a.2) at least one pigment; and (a.3) at least one corrosion-inhibiting component which comprises

• • a parent structure (GK),
  • at least one functional group (Gr′) which is attached covalently to (GK) and which, when a multicoat paint system containing the disclosed coating composition is thermally cured, reacts with at least one of functional groups (Gr) of the binder (a.1) or functional groups (Gr″) of at least one constituent of an adjacent coating (B), and
  • at least one uni- and/or multidentate, potentially anionic ligand (L) which is different from the functional group (Gr′), is attached covalently to (GK), and, when the multicoat paint system is thermally cured, does not lose its capacity as a chelating agent. Also disclosed is a process for producing a multicoat paint system using the disclosed coating composition.

The invention relates to a multicoat paint system comprising, lying above one another in this order,

• • (1) at least one first basecoat comprising basecoat material (A),
  • (2) preferably a second, color and/or effect basecoat comprising basecoat material (B), and
  • (3) at least one transparent coating comprising clearcoat material (C),

wherein the basecoat material (A) which forms the first basecoat comprises at least one binder (a.1), at least one color and/or effect pigment (a.2), and a corrosion-inhibiting component (a.3) with a parent structure (GK1), selected from the group of low molecular mass alkyl, aryl, aralkyl, and cycloalkyl radicals and/or heterocyclic radicals, which carries at least one phosphoric acid group as ligand (L1), and/or at least one corrosion-inhibiting component with a parent structure (GK2), selected from the group of alkyl, aryl, aralkyl, and cycloalkyl radicals, heterocyclic radicals and/or polymers, which carries at least one phosphonic acid group as ligand (L2).

The invention discloses a blue strontium active disperse dye and a preparation method thereof. The dye is suitable for a supercritical CO2 fluid dyeing process. A parent structure of the active disperse dye is an anthracene structure, the active disperse dye has an amino group reactive with active groups, the active groups include groups such as dichlorotriazine, monochlorotriazine, alpha-bromoacrylamide, vinyl sulfone and the like which can react with fibers, and the shortcomings that structure of existing active disperse dyes is single, and the variety of the active disperse dyes is insufficient are overcome. The anthraquinone active disperse dye can be used for dyeing of natural fibers and dyeing processing of blended fabrics in the supercritical CO2 fluid dyeing, and have good dyeing effect especially for fibers such as cotton, wool, silk and the like. The fastness indexes of the dyed fabrics are good. The dye synthesis process is simple, the reaction conditions are mild, the manufacturing cost is low, and the applicability is strong.

The invention discloses a white light organic electroluminescent device with a double-layer double-parent structure without a spacer layer, belonging to the technical field of organic electroluminescent devices. The device consists of a substrate, an anode, a hole transport layer, a luminescent layer, an electronic transport layer and a cathode. Between the hole transport layer and the electron transport layer, there are two dual-parent organic light-emitting layers, and the organic light-emitting dyes are doped in the dual-parent materials in the form of dopants. The dual-parent structure iscomposed of hole transport layer material and electron transport layer material. The doping ratio of hole transport layer material in the luminescent layer near the anode is larger than that in the luminescent layer near the cathode. As that luminescent lay adopts a double-layer double-parent structure without space layer, the interface potential barrier is reduced, the balance transmission of carrier and the uniform distribution of excitons in the luminescent lay are facilitated, and the high-efficiency white light emission with stable spectrum is easily realized.

The invention discloses an isoindolinylcarboxylic ester derivative and a preparation method. The isoindolinylcarboxylic ester derivative is characterized in that the derivative is a compound with a structure of general formula (I). The isoindolinylcarboxylic ester derivative can be used as an active structural unit of a novel angiotensin converting enzyme inhibitor, a novel diuretic and a novel multi-medicament resistance inhibitor in the field of medicaments, and also can be used as a parent structure of novel isoindolinyl organic pigments in the coating industry. The preparation method has the advantages of cheap and easily obtained raw reaction materials, mild reaction condition, simple operation, higher yield, lower cost and environmental friendliness.

The invention discloses a small-molecule fluorescent probe, and a preparation method and application thereof. According to the invention, a parent structure formed by connection of triphenylamine oxime and a spiropyran aldehyde structure through nitrogen-nitrogen bonds has strong conjugate pi electrons; a spiropyrane ring is easy to open, and after the spiropyrane ring in the structure is opened,strong fluorescent light can be emitted; the small-molecule fluorescent probe can realize precise detection of hypochlorous acid via a fluorescence technology and can detect endogenous hypochlorous acid in living cells, bacteria and zebra fish bodies; so the small-molecule fluorescent probe has good application prospects in the hypochlorous acid detection. The preparation method of the invention is simple in process and convenient to operate and does not need harsh conditions.

The invention belongs to the technical field of polypeptide drugs in biochemistry, and concretely relates to a polypeptide. The amino acid sequence of the polypeptide is represented by SEQ ID NO:1, the polypeptide is a cationic polypeptide having a high inhibitory activity to drug-resistant bacteria, and the polypeptide is obtained through a solid phase synthesis method by intercepting the former17 amino acids of a parent structure EeCentrocins 1 heavy chain, mutating aspartic acid in the eighth position into lysine and mutating glycine in the fourteenth position into valine. Pharmacodynamictest proves that the polypeptide has a use in inhibition of bacterium and especially drug-resistant bacterium infection.

The invention discloses a novel marine riser lift stub clamping disc. The novel marine riser lift stub clamping disc comprises a main body. The main body comprises two same semicircular bodies, the two ends of the two semicircular bodies are substructures and parent structures which can be riveted with each other, hinge holes are formed in the substructures and the parent structures correspondingly, the two semicircular bodies are fixedly connected together through a connecting structure, and the bottom ends of the two semicircular bodies are all arranged to be acute angle clamping structurescorrespondingly. The novel marine riser lift stub clamping disc has the advantages that the bottom ends of the semicircular bodies are the acute angle clamping structures correspondingly, the acute angles are installed in corresponding tensioning rings in a clamping mode during using, the main body encloses a water-insulation pipe, the contact part of the water-insulation pipe is clamped on the step surface on the panel of the main body, through double cooperation, and the stability of the water-insulation pipe is fully ensured in the using process; when the water-insulation pipe or a drivepipe needs to be replaced, displacement of the overall water-insulation pipe series can be realized through the cooperation of a hydraulic rod, the tensioning rings and the main body, the complex processes of disassembling and reinstalling the water-insulation pipe are omitted, the efficiency of working in the ocean is greatly improved, and the cost of the working in the ocean is further reduced.