Isoindolinylcarboxylic ester derivative and preparation method

Abstract

The invention discloses an isoindolinylcarboxylic ester derivative and a preparation method. The isoindolinylcarboxylic ester derivative is characterized in that the derivative is a compound with a structure of general formula (I). The isoindolinylcarboxylic ester derivative can be used as an active structural unit of a novel angiotensin converting enzyme inhibitor, a novel diuretic and a novel multi-medicament resistance inhibitor in the field of medicaments, and also can be used as a parent structure of novel isoindolinyl organic pigments in the coating industry. The preparation method has the advantages of cheap and easily obtained raw reaction materials, mild reaction condition, simple operation, higher yield, lower cost and environmental friendliness.

Description

A kind of isoindoline carboxylate derivative and preparation method thereof technical field The invention relates to an isoindoline carboxylate derivative and a preparation method thereof. Background technique Isoindoline carboxylate derivatives have important application value and research significance in the fields of medicine and chemical industry. Hypertension can be divided into primary hypertension and secondary hypertension. The pathogenesis of essential hypertension is very complicated, and its pathogenesis has not been fully elucidated so far. Studies have found that it involves many factors including genetics, environment, endocrine, and central nervous system. However, it is generally recognized that the renin-angiotensin-aldosterone system is closely related to the pathogenesis of essential hypertension and the regulation of blood pressure. According to the different parts of the mechanism of action, the antihypertensive drugs targeting the renin-angiotensin...

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Problems solved by technology

The above-mentioned existing synthetic methods of isoindoline carboxylate derivatives all have limitations in varying degrees, such as low yield, difficult separation and purification of products, difficult acquisition of reaction raw materials, poor economic efficiency, and environmental unfriendliness.

At present, take 2-methylbenzaldehyde as the synthetic method of starting raw material to prepare isoindoline carboxylate derivatives and there is no report both at home and abroad

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