Isoindolinylcarboxylic ester derivative and preparation method
A technology of isoindoline carboxylate and isoindoline is applied in the field of isoindoline carboxylate derivatives and preparation, and can solve the problem that isoindoline carboxylate derivatives are not reported and reaction raw materials are difficult to obtain , the product is not easy to separate and purify, etc., to achieve the effect of high yield, low cost and mild reaction conditions
Inactive Publication Date: 2010-08-25
TIANJIN UNIV
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Problems solved by technology
The above-mentioned existing synthetic methods of isoindoline carboxylate derivatives all have limitations in varying degrees, such as low yield, difficult separation and purification of products, difficult acquisition of reaction raw materia
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Abstract
The invention discloses an isoindolinylcarboxylic ester derivative and a preparation method. The isoindolinylcarboxylic ester derivative is characterized in that the derivative is a compound with a structure of general formula (I). The isoindolinylcarboxylic ester derivative can be used as an active structural unit of a novel angiotensin converting enzyme inhibitor, a novel diuretic and a novel multi-medicament resistance inhibitor in the field of medicaments, and also can be used as a parent structure of novel isoindolinyl organic pigments in the coating industry. The preparation method has the advantages of cheap and easily obtained raw reaction materials, mild reaction condition, simple operation, higher yield, lower cost and environmental friendliness.
Description
A kind of isoindoline carboxylate derivative and preparation method thereof technical field The invention relates to an isoindoline carboxylate derivative and a preparation method thereof. Background technique Isoindoline carboxylate derivatives have important application value and research significance in the fields of medicine and chemical industry. Hypertension can be divided into primary hypertension and secondary hypertension. The pathogenesis of essential hypertension is very complicated, and its pathogenesis has not been fully elucidated so far. Studies have found that it involves many factors including genetics, environment, endocrine, and central nervous system. However, it is generally recognized that the renin-angiotensin-aldosterone system is closely related to the pathogenesis of essential hypertension and the regulation of blood pressure. According to the different parts of the mechanism of action, the antihypertensive drugs targeting the renin-angiotensin...
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IPC IPC(8): C07D209/44A61P9/12A61P7/10C09B67/20
Inventor 刘晓菲马辉赵康
Owner TIANJIN UNIV
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