1616results about How to "Facilitate cross-linking" patented technology

An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane that carries a recessed central portion. In another embodiment, the controller coupled to the Rf source is adapted to switch from a power control operational mode to a voltage controlled operational mode at a selected transition impedance level.

An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a conductive-resistive matrix of a conductively-doped non-conductive elastomer. The engagement surface portions thus can be described as a positive temperature coefficient material that has a unique selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The conductive-resistive matrix can be engineered to bracket a targeted thermal treatment range, for example about 60° C. to 80° C., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application—across micron-scale portions of the engagement surface.

An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a variable resistive body of a positive temperature coefficient material that has a selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The variable resistive body can be engineered to bracket a targeted thermal treatment range, for example about 60° C. to 80° C., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application across micron-scale portions of the engagement surface. In another mode of operation, a variable resistive body will focus conductive heating in a selected portion of the engagement surface.

An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a conductive-resistive matrix of a conductively-doped non-conductive elastomer. The engagement surface portions thus can be described as a positive temperature coefficient material that has a unique selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The conductive-resistive matrix can be engineered to bracket a targeted thermal treatment range, for example about 60° C. to 80° C., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application—across micron-scale portions of the engagement surface. In another mode of operation, a conductive-resistive matrix can induce a “wave” of Rf energy density to sweep across the tissue to thereby weld tissue.

An apparatus and the method of its operation for rapid prototyping of a three-dimensional object which includes a radiant energy source of a wide beam of radiant energy of suitable intensity and wavelength for curing a layer of photo-curable resin contained in an open vat, a spatial light modulator (SLM) having an array of pixel elements which are individually digitally controllable by a computer, for modulating the radiant energy beam projected from the radiant energy source on a pixel by pixel basis, to form a series of time sequential images of the cross-sectional laminae of the object, an optical system for focusing each image formed by the SLM, one at a time, onto successive layers of photo-curable resin for predetermined exposure times to thereby form stacked laminae of cured resin, each lamina of cured resin being in the shape of a different one of the cross-sectional laminae, and a piston support for lowering each lamina of cured resin after it is formed by the SLM and for depositing a layer of resin corresponding to the thickness of one cross sectional lamina of the three-dimensional object before the step of projecting a new image by the SLM. The SLM, the piston support for lowering, and the optical system operate repeatedly and sequentially until a complete copy of the object is thereby produced.

A method for reducing odor is provided. The method comprises forming a coordination complex between a transition metal and a polydentate compound, and contacting the coordinated complex with an odorous compound. The transition metal provides one or more active sites for capturing the odorous compound. In some embodiments, the polydentate compound may be a polyalkylimine, such as polyethyleneimine, polypropyleneimine, or a dendrimer thereof.

The present invention relates generally to immunostimulatory nucleic acids, compositions thereof and methods of using the immunostimulatory nucleic acids. In particular the invention relates to palindrome-containing immunostimulatory nucleic acids and the use of these nucleic acids in treating disease.

Disclosed are sterile hydrogel compositions comprising polyvinyl alcohol (“PVA”), polyvinyl pyrrolidone (“PVP”), and a polysaccharide, wherein the combined amount of PVA and PVP present in the hydrogel compositions is from about 2% to about 12% weight by volume, based on the total volume of the composition, and wherein the hydrogel compositions has a gel fraction greater than or equal to 97%. Sterile hydrogel products including such sterile hydrogel compositions, and methods of making such sterile hydrogel compositions and sterile hydrogel products.

A method for the administration of a composition that augments the acidity of gastric fluid such that intra-gastric gelation of the polysaccharide:acid soluble multivalent cation formulation is initiated independent of endogenous acid secretion. The composition includes:(a) at least one of a polysaccharide, modified polysaccharide, or polysaccharide salt, each capable of ionotropic gelation, (b) at least one source of multivalent cations capable of solubilization at an acidic pH, and (c) at least one acid component capable of providing a controlled release of protons sufficient to solubilize the multivalent cations. The composition is capable of hydrating in aqueous media and subsequently forming a gel in a stomach when ingested, which gel resists peristaltic forces and remains in the stomach for an extended time. Also disclosed are edible compositions including this composition, as well as methods of inducing a satiety effect and providing controlled release of various components employing the composition of the invention.

A well treating composition containing a polysaccharide-based water-superabsorbent material has particularly applicability as a thermal insulating, fracturing or acid stimulation fluid. The water-superabsorbent material is capable of absorbing, at a minimum, its own weight. Particularly effective are biodegradable materials containing guar gum and carrageenan. The composition may further contain a crosslinking agent, brine and / or a viscosifying polymer or a gelling agent. As an oil-based fluid, the crosslinking agent is absorbed onto the water-superabsorbent material and serves to effectively delay crosslinking.

The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.

The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.

Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal sterilization. Also provided are methods for producing these compositions and terminally sterilized matrices or scaffolds from these compositions as well as methods of using these matrices or scaffolds as tissue engineering devices.

The invention discloses a preparation method and application of modified polyurethane aqueous dispersions of polyisocyanate curing agents. The preparation method comprises the following steps of: carrying out prepolymerization reaction by using polyester polyol, vulcabond monomer and a polyisocyanate curing agent; reacting with a hydrophilic chain-extending agent and a micro-molecule chain-extending agent to obtain polyurethane prepolymer containing hydrophilic groups (carboxyl or sulfonic groups) and isocyanate(NCO)-terminated groups; neutralizing the polymer into salt, and then dispersing the salt into water; and preparing the modified polyurethane aqueous dispersions of the polyisocyanate curing agents by the chain extending of a polyamine chain-extending agent. The modified polyurethane aqueous dispersions of the polyisocyanate curing agents have self-crosslinking function at room temperature, and the self-crosslinking density is over 85%. Compared with non-modified polyurethane aqueous dispersions prepared under the same condition, the modified polyurethane aqueous dispersions have superior film forming property, water resistance, alcohol resistance, pollution resistance, cold resistance, dry / wet rubbing resistance and chemical solvent resistance; and coating films have especially high drying speed, high hardness increment speed and high final hardness.

A method of repairing damaged cartilage and soft tissue in a patient is provided using a biocompatible, non-immunogenic composition. The composition comprises a hydrophilic polymer and a plurality of crosslinkable components having reactive functional groups. The composition used in the method may be loaded with biologically active agents for delivery to the damaged tissues. Kits for use in carrying out the method of the invention are also provided.

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.

A thermal insulating packer fluid contains water and / or brine, a crosslinkable viscosifying polymer, a crosslinking agent and an optional set retarder. The composition is capable of inhibiting unwanted heat loss from production tubing or uncontrolled heat transfer to outer annuli. The viscosity of the composition is such as to reduce the convection flow velocity within the annulus.

The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.

The present invention provides a multicomponent composition that is substantially isocyanate-free and comprises a polycarbamate as a first component and a polyaldehyde or an acetal or hemiacetal thereof as a second component and further comprises an effective amount of a triggering agent such that the first and second components to cure at a temperature of from 0C to less than 80C to form a crosslinked polyurethane. The multicomponent composition forms an ambient temperature curable composition when all of its components are combined that has a pH of 7.0 or less. The present invention also provides processes crosslinked polyurethanes, and the crosslinked polyurethanes prepared by the processes.

A thermal insulating packer fluid contains water and / or brine, a crosslinkable viscosifying polymer, a crosslinking agent and an optional set retarder. The composition is capable of inhibiting unwanted heat loss from production tubing or uncontrolled heat transfer to outer annuli. The viscosity of the composition is such as to reduce the convection flow velocity within the annulus.

The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.

The present invention relates to a low-oil-permeability super-soft thermally-conductive silica gel composition and a thermally-conductive silica gel gasket, the low-oil-permeability super-soft thermally-conductive silica gel composition comprising a first liquid silica gel, a second liquid silica gel and a thermally-conductive filler, the thermally-conductive silica gel gasket is prepared from the low-oil-permeability super-soft thermally-conductive silica gel composition, the low-oil-permeability super-soft thermally-conductive silica gel composition is prepared from the following components by mass: 7 to 11.9% of a first liquid silica gel and second liquid silica gel mixed liquid, 88 to 92.9% of the thermally-conductive filler, 0.05 to 0.5% of a catalyst and 0.05 to 0.5% of an inhibitor by the preparation method comprising stirring, rolling, vulcanizing and cutting; the low-oil-permeability super-soft thermally-conductive silica gel composition is prepared by mixing the first liquid silica gel, the second liquid silica gel and the thermally-conductive filler, vinyl silicone oil and a platinum catalyst in the first liquid silica gel and vinyl silicone oil and hydrogen-containing silicone oil in the second liquid silica gel can make the prepared plastic material characterized by being low in oil permeability and low in hardness, and the like, the viscosity of the first liquid silica gel and the second liquid silica gel are 3000mPa. s-10000mPa.s, uniform mixing of the material and the thermally-conductive filler during stirring can be guaranteed, and an appropriate crosslinking degree can be achieved during the vulcanizing.

A well treating composition containing a polysaccharide-based water-superabsorbent material has particularly applicability as a thermal insulating, fracturing or acid stimulation fluid. The water-superabsorbent material is capable of absorbing, at a minimum, its own weight. Particularly effective are biodegradable materials containing guar gum and carrageenan. The composition may further contain a crosslinking agent, brine and / or a viscosifying polymer or a gelling agent. As an oil-based fluid, the crosslinking agent is absorbed onto the water-superabsorbent material and serves to effectively delay crosslinking.

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen.

Porous ceramic catalyst supports are pre-coated with a passivation layer prior to applying a catalyst or catalyst support coating, the passivation layer consisting of a coating of a liquid mixture comprising at least one coating material selected from the group of polyvinyl alcohol / vinyl amine copolymer, polyvinyl alcohol / vinyl formamide copolymer, and gelatin.

The invention discloses a high-speed hot stamping gum used for holographic positioning electrochemical aluminium and the preparation method. The gum prepared through the formulation and the method of the invention can achieve good adhesive effect under the appropriate temperature and pressure, and the appropriate release coating is added, thus the holographic image information of the holographic electrochemical aluminium can be stripped and cemented on the surface of the scalded object at the high speed. The fragileness of the gum is moderate, therefore, the trimming performance of the holographic image is good in the hot stamping process, the gum is particularly applied to high-speed hot stamping on the surface of the sheet paper and the printing ink with which the density and the hardness are big, the surface energy is low, the surface wettability is poor, and the general coating liquor is difficult to be transferred and cemented on.

The present invention relates to diionic liquid salts of dicationic or dianionic molecules, as well as solvents comprising diionic liquids and the use of diionic liquids as the stationary phase in a gas chromatographic column.