25 results about "Total dose" patented technology

This invention provides a modified BoNT / A for treating facial wrinkles, wherein the modified BoNT / A is administered via intramuscular injection at multiple sites on an individual's face, wherein the modified BoNT / A is administered at a unit dose of greater than 1754 pg or greater than 8000 pg per site, wherein the multiple sites are selected from: up to two sites on the corrugator supercilii muscle and one site on the depressor supercilii muscle for treating glabellar lines; up to five sites on the frontalis muscle for treating forehead wrinkles; and up to three sites on the orbicularis oculi muscle for treating lateral canthal wrinkles, wherein the total dose of modified BoNT / A administered during treatment is up to 264,000 pg (and optionally greater than 88,000 pg), and wherein the modified BoNT / A comprises a BoNT / A light chain and a translocation domain (H N The structure domain), and the BoNT / B receptor binding domain (H C (structural domain).

This invention belongs to the field of animal model construction technology, specifically relating to a mouse immunosuppressive model that maintains a long-term immunosuppressive state, its construction method, and its application. This invention establishes a stable immunosuppressive state model with reduced neutrophil count and no significant decrease in erythrocyte count by administering different doses of immunosuppressants (10-50 mg / kg body weight) to Balb / c mice via a combination of "reduced total dose + multiple gavage administration + satellite monitoring." The method for constructing this mouse immunosuppressive model reduces drug usage, controls neutrophil count rebound, establishes a stable model of reduced neutrophil count, and avoids deep bone marrow suppression (i.e., does not cause an uncontrollable decrease in erythrocyte or platelet count), which is beneficial for long-term experimental conduct and drug evaluation.

Disclosed are a system, techniques and processes for monitoring and modifying a drug treatment regimen when a user partakes in a ketogenic diet. The disclosed system obtains ketone level measurements of a user and indicates a user's adherence to the ketogenic diet as well as modifying a user's total daily dosage of a drug based on the user's following the ketogenic diet.

A radiotherapy planning apparatus includes processing circuitry. The processing circuitry obtains a medical image relating to a patient. The processing circuitry obtains number of beams and beam directions of a plurality of radiation beams applied substantially simultaneously to an irradiation area of the patient. The processing circuitry generates a total dose rate distribution which is a spatial distribution of total values of predicted dose rates of the radiation beams to be applied to the patient, based on the medical image and the number and the direction of the radiation beams.

Provided herein are methods of treating type 1 diabetes mellitus (T1D). Such methods may comprise administering tilizumab to a subject in need thereof at intervals of about 3 months to about 12 months at a total dose greater than about 9000 [mu] g / m2 for a first 12-day course of treatment and tilizumab at a total dose greater than about 9000 [mu] g / m2 for a second 12-day course of treatment.

One or more example embodiments of the present invention relates to a dose control method for a mobile x-ray detector of a medical x-ray system, comprising generating a data packet having a time stamp of a clock of the mobile x-ray detector and a dose value; sending the data packet via a radio link from the mobile x-ray detector to an x-ray generator; receiving the data packet from the x-ray generator; comparing the time stamp with a clock of the x-ray generator and calculating a latency; and extrapolating an overall dose from the dose value, the time stamp and the latency.

The invention discloses a phase inverter capable of simultaneously resisting total dose and single event effect, which adopts the structural design that a main phase inverter and an auxiliary phase inverter are combined, and the main phase inverter is composed of two PMOS (P-channel Metal Oxide Semiconductor) tubes connected in series and an NMOS (N-channel Metal Oxide Semiconductor) tube. On the basis of a mode that an auxiliary phase inverter provides a level compensation signal at the NMOS source end of a main phase inverter, the high level output by the phase inverter under the total dose effect is prevented from being reduced, and transient upset of the output level of the phase inverter from high to low under the single event effect of an NMOS tube is avoided; on the basis of a double PMOS structure design mode, transient upset of the output level of the inverter from low to high caused by conduction of a PMOS tube under a single event effect is avoided. And finally, stable output of the inverter under the total dose and single-particle system effect can be realized.

The present invention discloses a drug injection device for heart failure, and key technical solutions thereof are as follows: The device includes a delivery catheter and an abutting component disposed at one end of the delivery catheter. Multiple guide holes are formed in the abutting component. A reservoir tube is slidably connected in the delivery catheter. Multiple injection needles in communication with the reservoir tube are disposed at one end of the reservoir tube close to the abutting component. The multiple injection needles are slidably inserted in the multiple guide holes respectively in one-to-one correspondence. A sealing plate is rotatably connected in an inner wall of one end of the reservoir tube close to the injection needle. The present invention has the following technical effects: By providing the reservoir tube, the present invention enables adjustment of the movable tube's extension length from the injection tube during operation. This controls the distance between the injection piston and the sealing plate, where a space volume between the injection piston and the sealing plate is a total dosage of the single-dose medication. In this way, accurate dose control is achieved for each injection.

The invention relates to a board-level ionization total dose effect irradiation test method, and belongs to the technical field of space environment engineering. The method comprises the steps of plate-level electrical parameter testing before irradiation, ionization total dose effect irradiation under a device-level bias condition, room-temperature annealing, high-temperature annealing and plate-level electrical parameter testing after ionization total dose effect irradiation. According to the invention, the technical effect of carrying out the ionization total dose effect irradiation test with high efficiency, accuracy and low cost can be realized.

The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns:a) a first part, G1, comprising from about 5 to about 70% w / w of the total dose of acarbose,b) a second part, G2A, comprising from about 30 to about 95% w / w of the total dose of acarbose,c) a third part, G2B, comprising from about 10 to about 90% w / w of the total dose of orlistat, andd) a fourth part, G3, comprising from about 10 to about 80% w / w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w / w.

This invention discloses a voxel-based system and method for determining the equivalent biological dose of targeted alpha nuclide therapy. The system constructs a patient-specific three-dimensional voxel anatomical model and activity distribution map through an image processing module; an intelligent source term module, based on the decay characteristics of the selected alpha nuclide, calls a pre-built dose point kernel database to generate an equivalent total dose point kernel; a dose calculation module performs rapid convolution calculation based on cumulative activity and the equivalent total dose point kernel to obtain the three-dimensional physical absorbed dose; and a biological dose module integrates a micro-dose kinetic model to convert the physical dose into a three-dimensional biological dose distribution map equivalent to conventional external beam radiotherapy. This invention overcomes the technical shortcomings of standard models, such as large errors, time-consuming Monte Carlo simulations, reliance on multi-timepoint dynamic imaging, and the inability of physical dose to reflect the biological effects of alpha particles. It achieves efficient, accurate, and clinically practical individualized biological dose assessment, significantly improving the accuracy and safety of treatment plans.

The application relates to a method for system-level total dose effect test, which is used for solving the problem that the system radiation resistance performance is difficult to be accurately evaluated in the existing system-level total dose effect test process. The specific steps of the application are as follows: step 1, placing a test system on a rotating unit in an irradiation room; step 2, calibrating and recording the front end, rear end and rear end dose rate of 180 degrees of the test system by using a dose rate calibration device; step 3, irradiating according to the dose rate calibration result of step 2; step 4, segmenting the total dose, and obtaining the total dose D' total ; step 5, calculating the first irradiation time point t'1, the second irradiation time t'2 and the total irradiation time t' of each dose segment; and step 6, combining the calculation results of steps 4 and 5, and irradiating to n segments to complete the irradiation or irradiating the test system to the target total dose value. The test steps of the application are simple and easy to operate.​​

This invention belongs to the field of animal model construction technology, specifically providing a method for constructing and using a mouse radiation dermatitis model. The method involves irradiating localized areas of healthy mice with X-rays at a dose rate of 5.128 Gy / min in fractionated doses every other day, with a total dose of 30-49 Gy, to establish a mouse radiation dermatitis model. This invention uses a fractionated X-ray irradiation mode commonly used in clinical radiotherapy, which can stably induce radiation dermatitis of varying degrees. Skin damage is significantly dependent on the irradiation dose. A total dose of 30 Gy is optimal, and after 35 days of development, a standardized model closely resembling clinical grade II radiation dermatitis can be constructed. This method is simple to operate, has good reproducibility, and a low animal mortality rate. It can realistically simulate the skin damage process of clinical radiotherapy, providing a reliable basis for research on the mechanism of radiation dermatitis and is suitable for the screening and identification of related preventive and therapeutic drugs.

Provided herein are a method of treating type 1 diabetes (T1D). In some embodiments, such method can include administering to a subject in need thereof a 12-day course of teplizumab at a total dose of more than about 9000 μg / m2.

The invention discloses an X-ray total dose determination method for an integrated circuit chip radiation effect evaluation test, and the method comprises the steps: carrying out the simulation modeling of each plate layer structure related to a radiation sensitive region in a to-be-tested integrated circuit chip, and obtaining a real structure model, simulating an X-ray irradiation environment and counting the absorbed dose of a sensitive area in the real structure model of the integrated circuit chip; performing simulation by adopting a balance model body, and layering the balance model body according to each plate layer structure of the real structure model to obtain a simulation structure model; simulating an X-ray irradiation environment and counting the absorbed dose of a sensitive area in the simulation structure model; and calculating a dose conversion factor according to the real structure model and the absorbed dose of the sensitive area of the balance die body, and correcting according to the dose conversion factor to obtain the X-ray total dose of the radiation effect evaluation test. According to the invention, the total X-ray dose is corrected through simulation calculation before the test, so that the dose accuracy in the irradiation test process can be ensured.

The invention discloses a method for evaluating the total ionization dose resistance of a HgCdTe infrared detector. The method comprises the following steps: selecting and processing a sample; selecting an irradiation dose; irradiating a bias condition; testing parameters; annealing test; the evaluation method provided by the invention is suitable for various HgCdTe infrared detectors, can evaluate the total ionization dose resistance of the HgCdTe infrared detector for aerospace, and solves the problem of lack of evaluation methods for the total ionization dose resistance of the HgCdTe infrared detector for aerospace.

To provide a botulinum toxin for treating neuropsychiatric disorders and / or neurological disorders.SOLUTION: Provided is a botulinum toxin for use in the treatment of ASD (autism) in a patient in need thereof. Said treatment comprises administration of botulinum toxin to said patient by subcutaneous / intradermal injection. Administration to adults comprises injecting 2-4 units into and / or around the trigeminal nerve, 2-4 units into and / or around the cervical nerve outside the patient's spine, 2-4 units into and / or around the thoracic nerve outside the patient's spine, 2-4 units into and / or around the lumbar nerve outside the patient's spine, and / or 2-4 units into and / or around the sacral nerve outside the patient's spine. The total dosage of botulinum toxin for an adult human weighing about 150 pounds is no more than about 50 units, adjusted for age, weight, or a combination thereof.SELECTED DRAWING: None

A medication delivery device (MDD) (e.g., injection pen, wearable pump) is paired with an external device (e.g., smart phone, iPad, computer) via wireless link or wireline connection. The MDD provides to the external device captured data from the flow sensor relating to medicine delivery to a patient to ensure complete delivery and minimize MDD misuse or malfunction or inaccuracies in dosing. The MDD can have Bluetooth™ and / or near field communication (NFC) communication circuits for proximity-based pairing and connectivity with the external device for real-time or deferred transfer of captured data to the external device, depending on memory and power availability at the MDD. The MDD or external device can use captured data and corresponding time stamps to determine flow infomatics such as flow rate, total dose delivered, and dose completion status. An LED on the MDD indicates states such as powered on, paired, delivery in progress and delivery completion.

The application discloses a kind of radioactive contaminated clothing intelligent management method and related equipment.The method comprises the following steps: collecting the initial radiation dose of the contaminated clothing and generation time;Based on the nuclide decay formula, a decay tracking calculation process is constructed, the current dose is calculated in real time according to the nuclide half-life parameter, and the total dose is obtained by superimposing the contribution of each nuclide when there is multi-nuclide contamination;The current dose calculated in real time is compared with the preset control threshold, and the washable instruction is pushed to the medical terminal when the control threshold is met, and the remaining decay time prompt is output when the control threshold is not met.It can solve the problem that the management of radioactive contaminated clothing is highly dependent on manual, which can easily lead to waste of manpower, missed or wrong recording, and occupational health hazards caused by frequent close contact of medical staff with high-activity contaminated clothing during manual monitoring.

The application provides a satellite ionization total dose analytical analysis method based on oblique incidence, considers the shielding thickness thickening and total dose low efficiency effect caused by oblique incidence, and significantly reduces ionization total dose data. Specifically, the method comprises the following steps: step one, analyzing the relationship between the satellite ionization total dose and the equivalent shielding thickness under the vertical incidence condition according to the satellite orbit parameter; step two, obtaining a fitting formula and fitting coefficients of the relationship between the satellite ionization total dose and the equivalent shielding aluminum thickness under the vertical incidence condition according to the relationship between the satellite ionization total dose and the equivalent aluminum shielding thickness under the vertical incidence condition; step three, analyzing the calculation formula of the satellite ionization total dose and the equivalent aluminum shielding thickness under the isotropic incidence condition considering the oblique incidence effect by using the fitting formula and the fitting coefficients; and step four, analyzing the ionization total dose of a device in a single machine in the satellite according to the calculation formula.

A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and / or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.

The embodiment of the invention provides a total dose effect modeling method suitable for large-scale digital integrated circuit simulation, and relates to the technical field of circuit simulation, and the method comprises the steps: constructing an equivalent circuit of an MOS device under the effect of a total dose according to the effect of the total dose on the electrical characteristics of the MOS device; constructing a total dose effect model of the MOS device and determining parameters of the total dose effect model based on the equivalent circuit in combination with the BSIM3V3 model and electrical characteristics indicated by a first equivalent MOS tube and a second equivalent MOS tube in the equivalent circuit; determining the value of the parameter corresponding to the first total dose according to the corresponding relationship between the parameter and the total dose; and determining a first total dose effect model of the MOS device according to the numerical value of the parameter corresponding to the first total dose and the total dose effect model. According to the embodiment of the invention, the modeling threshold can be reduced, the modeling process is simplified, and the modeling accuracy is ensured.

The efficacy of a dosing regimen can be altered, and preferably improved, by fractionating the doses. Here fractionating the doses can be regarded as taking a single conventional dose and splitting that dose into two or more dose-fractions delivered at relatively short time intervals, where the dose-fractions add up to the same total dose as the conventional dose. In cases where dose fractionation increases the therapeutic effect, this can result in a greater therapeutic effect from a smaller total dose when the doses are fractionated. This effect has been demonstrated in an ophthalmic application, but is expected to be more generally applicable.

The application discloses an anti-total dose band gap reference circuit, which comprises a total dose effect monitoring circuit, a current compensation circuit, a fixed bias circuit, a temperature compensation circuit and a minimum compensation current current limiting circuit connected in sequence. The application solves the problem that the output voltage of the existing band gap reference circuit is affected by the total dose effect and drifts.

The application provides a dose calculation method, device, medium and product, and relates to the technical field of dose calculation. The method comprises the following steps: determining a dose calculation point and a cylinder string corresponding to the dose calculation point; calculating total dose contribution of the cylinder string to the dose calculation point according to a convolution kernel corresponding to the cylinder string and a line segment of the cylinder string, wherein parameters of the convolution kernel are obtained by fitting dose data calculated based on a Monte Carlo method; and calculating dose data of each dose calculation point based on the total dose contribution. In the application, the dose contribution of each cylinder string to the dose calculation point is directly calculated by using the convolution kernel and the line segment of the cylinder string, so that the introduction of errors can be effectively reduced, the calculation amount can be effectively reduced, the calculation precision can be improved, the time and the calculation resources required for dose calculation can be reduced, and the demand of clinical application can be effectively met.