70 results about "Total dose" patented technology

The invention relates to a commercial spaceflight COTS component irradiation database establishment method. The method comprises the following steps: calculating an anti-radiation index which needs to be met by a component under a current satellite demand; constructing a single-machine module based on a plurality of to-be-evaluated components; performing a total dose assessment test and a single particle assessment test on the single machine module in each working mode to obtain the total dose resistance and the single particle resistance of each component to be evaluated; performing failure protection design on the components with low total dose resistance and single particle resistance lower than the index to obtain corresponding failure protection strategies; obtaining the anti-radiation capability according to the total dose resistance and the single particle resistance of each component, and constructing a component radiation database according to the satellite operation environment parameters, the satellite demand information, the anti-radiation indexes of the components, the anti-radiation capability and the failure protection strategy. The method can reduce the research and development cost of satellites and shorten the research and development period.

The invention provides a method and a device for rapidly detecting nuclide activity concentration of mine barren rock, and relates to the technical field of nuclide detection. According to the method, the total dose rate of each detection point is detected when the to-be-detected mine waste rock passes through the gate-type channel, the dose rate equation set is constructed in combination with the preset dose rate conversion coefficient of each decay system nuclide, the dose rate equation set is combined for solving, and the activity concentration of each decay system nuclide in the mine waste rock is obtained. Rapid detection of the activity concentration of the nuclide in the mine barren rock is realized, and the detection efficiency of nuclide detection in the mine barren rock is improved.

Systems and methods are provided for facilitating the dispensing of a medication from a dispensing station. An order is received and includes the medication and a total dosage for the medication to be dispensed. The medication is mapped to a table that stores a list of a plurality of medications that are available for dispensing at one or more dispensing stations at different physical locations. Each of the plurality of medications are stored in the table with a corresponding unit usable to formulate a dosage. A particular medication is identified in the plurality of medications in the table that corresponds to the medication of the order. The particular medication also corresponds to the total dosage based on the corresponding unit in the table associated with the particular medication. An instruction is communicated to the one or more dispensing stations to dispense the particular medication.

This invention provides a modified BoNT / A for treating facial wrinkles, wherein the modified BoNT / A is administered via intramuscular injection at multiple sites on an individual's face, wherein the modified BoNT / A is administered at a unit dose of greater than 1754 pg or greater than 8000 pg per site, wherein the multiple sites are selected from: up to two sites on the corrugator supercilii muscle and one site on the depressor supercilii muscle for treating glabellar lines; up to five sites on the frontalis muscle for treating forehead wrinkles; and up to three sites on the orbicularis oculi muscle for treating lateral canthal wrinkles, wherein the total dose of modified BoNT / A administered during treatment is up to 264,000 pg (and optionally greater than 88,000 pg), and wherein the modified BoNT / A comprises a BoNT / A light chain and a translocation domain (H N The structure domain), and the BoNT / B receptor binding domain (H C (structural domain).

A computer-based method for optimizing a radiotherapy treatment plan for a patient is proposed, in which an optimization problem including an objective function is used in a process to optimize a complete treatment including both external beam therapy and brachytherapy, the objective function being designed to optimize the total dose distribution as a combination of a first dose distribution to be delivered by a first radiation set and a second dose distribution to be delivered by a second radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy. The optimization is based on the total desired dose for the entire treatment, an image of the patient before the start of the treatment, and an estimated image of the patient after the first radiation set has been delivered.

Provided herein is a method of reducing exogenous insulin use. In some embodiments, such methods may comprise administering tilizumab to a subject in need thereof at a total dose of from about 9000 [mu] g / m2 to about 14000 [mu] g / m2 for a course of 12 to 14 days.

This invention belongs to the field of animal model construction technology, specifically relating to a mouse immunosuppressive model that maintains a long-term immunosuppressive state, its construction method, and its application. This invention establishes a stable immunosuppressive state model with reduced neutrophil count and no significant decrease in erythrocyte count by administering different doses of immunosuppressants (10-50 mg / kg body weight) to Balb / c mice via a combination of "reduced total dose + multiple gavage administration + satellite monitoring." The method for constructing this mouse immunosuppressive model reduces drug usage, controls neutrophil count rebound, establishes a stable model of reduced neutrophil count, and avoids deep bone marrow suppression (i.e., does not cause an uncontrollable decrease in erythrocyte or platelet count), which is beneficial for long-term experimental conduct and drug evaluation.

The utility model relates to the technical field of medical equipment, in particular to a flash therapy device for small animal radiotherapy and a control system. The ray source can emit rays to a treatment area of the flash therapy device, the shielding part is driven by a power mechanism and can move relative to the emitting end of the ray source, and the shielding part has a deviation state in which the rays emitted by the ray source can be irradiated to the treatment area and a shielding state in which the rays cannot be irradiated to the treatment area in the movement process; wherein in a movement period, the shielding part is initially in a shielding state, and after rays emitted by the ray source reach a set dose rate, the shielding part moves at a preset movement speed, so that the shielding part resets to the shielding state and stops moving after the movement of the shielding part is converted to a deviation state. According to the utility model, the influence on the total dose and the dose rate of ray irradiation treatment when the ray source is turned on and turned off can be eliminated, and the accurate total dose and the stable dose rate of the irradiation treatment in flash therapy are ensured.

The embodiment of the present application provides a method, device, equipment and storage medium for adjusting isodose curves in real time, the method comprising: responding to the user's target selection operation, obtaining the first total dose field of the isodose curve before the target moves and the target dose field of the target; calculating the reference adjustment dose field according to the first total dose field and the target dose field; responding to the user's target movement operation, based on the target movement operation, the reference adjustment dose field and the target dose field, obtaining the second total dose field to adjust the isodose curve. The method can calculate and draw the latest isodose curve in real time with a small amount of calculation, so that the user can view the change information of the isodose curve in real time while ensuring that it does not occupy a lot of computing resources, thereby greatly reducing resource consumption and greatly improving the reference effect of the isodose curve.

Disclosed are a system, techniques and processes for monitoring and modifying a drug treatment regimen when a user partakes in a ketogenic diet. The disclosed system obtains ketone level measurements of a user and indicates a user's adherence to the ketogenic diet as well as modifying a user's total daily dosage of a drug based on the user's following the ketogenic diet.

The invention relates to the technical field of aerospace, in particular to a space charged particle total dose detection device which comprises a packaging shell and an integrated acquisition circuit. The packaging shell comprises a main shell (1), a bottom cover plate (2) and a trapezoidal channel (3); a first opening is formed in the bottom of the main shell (1), and a second opening is formed in the top; the bottom cover plate (2) covers the first opening and is connected with the main shell (1); the trapezoidal channel (3) serves as an incident channel of particles, a third opening connected with the second opening is formed in the top of the trapezoidal channel, and a fourth opening is formed in the bottom of the trapezoidal channel and extends into the packaging shell; the integrated acquisition circuit is fixed in the packaging shell and comprises a circuit board and a dose sensitive sensor; the circuit board is provided with a first surface facing the trapezoidal channel (3) and a second surface opposite to the trapezoidal channel (3); and the dose sensitive sensor is used for detecting the total dose of the charged particles, is arranged on the first surface of the circuit board, is positioned under the fourth opening and is used for receiving the charged particles to be detected.

A radiotherapy planning apparatus includes processing circuitry. The processing circuitry obtains a medical image relating to a patient. The processing circuitry obtains number of beams and beam directions of a plurality of radiation beams applied substantially simultaneously to an irradiation area of the patient. The processing circuitry generates a total dose rate distribution which is a spatial distribution of total values of predicted dose rates of the radiation beams to be applied to the patient, based on the medical image and the number and the direction of the radiation beams.

Provided herein are methods of treating type 1 diabetes mellitus (T1D). Such methods may comprise administering tilizumab to a subject in need thereof at intervals of about 3 months to about 12 months at a total dose greater than about 9000 [mu] g / m2 for a first 12-day course of treatment and tilizumab at a total dose greater than about 9000 [mu] g / m2 for a second 12-day course of treatment.

The present invention provides methods, compositions, devices, and kits for treating cystinuria or related disorders, in which tiopronin is administered to a patient according to a modified-release strategy that releases tiopronin in critically-spaced, repeated pulses over time, to provide lower peak plasma levels but consistently higher urine levels of the drug for binding cystine. In particular, use of the present modified-release formulations and systems reduce side effects of tiopronin, thereby increasing patient compliance and quality of life, as well as achieving efficacy with less frequent administrations and / or lower total dosages.

The invention discloses a COTS device total dose irradiation assurance grading method based on in-orbit application scene classification, and the method comprises the steps: firstly carrying out the key grade division of single machines, including I-grade single machines, II-grade single machines and III-grade single machines, then carrying out the COTS device total dose irradiation assurance grade division, and finally carrying out the classification based on application scenes. And enabling different stand-alone grades to correspond to different irradiation assurance grades, and carrying out a total dose irradiation evaluation test. The application-based COTS device total dose irradiation guarantee method is formed according to the characteristics of different COTS devices, the purposes of agility, high efficiency and scientific reduction of test cost are achieved, the use cost of components is reduced, meanwhile, the reliability of on-orbit application is ensured, the problem that the COTS device total dose irradiation evaluation test is expensive is solved, and the method is suitable for popularization and application. The defect that an existing irradiation test method is scientific in process and cost reduction and has no specific implementation path is overcome.

A method for incorporating an extended bolus signal is disclosed. The method includes determining a target dose amount of medicament to deliver for a control cycle. The method also includes obtaining data related to an extended bolus. The method further includes determining an additional medicament amount to deliver during the control cycle corresponding to the extended bolus. The method yet further includes determining a total medicament delivery amount for the control cycle corresponding to the target dose amount and the additional medicament amount. The method still further includes sending a command to a delivery mechanism to cause delivery of the total medicament delivery amount for the control cycle.

The application belongs to the technical field of three-dimensional integrated circuits, and discloses a through-silicon via link total dose effect evaluation method, equipment and medium based on an equivalent circuit model, wherein the method comprises the following steps: establishing a total dose equivalent circuit topology structure according to a through-silicon via structure; determining a parasitic electric parameter calculation equation in the total dose effect equivalent circuit; calculating the value of the electric parameter under normal conditions, and comparing the S parameter obtained through simulation calculation with the actually measured S parameter to verify the total dose effect equivalent circuit model; optimizing the design, extracting the electric parameter in the equivalent circuit under different radiation dose conditions; extracting the electric parameter change curve with the radiation dose; fitting the equation of the material attribute change with the radiation dose; and predicting the S parameter of the through-silicon via link at any radiation dose point. The equipment and medium are used for realizing the through-silicon via link total dose effect evaluation method based on the equivalent circuit model. The evaluation factors are comprehensive, the actual irradiation conditions can be better matched, and the performance of the through-silicon via link under the actual radiation conditions can be more accurately simulated.

One or more example embodiments of the present invention relates to a dose control method for a mobile x-ray detector of a medical x-ray system, comprising generating a data packet having a time stamp of a clock of the mobile x-ray detector and a dose value; sending the data packet via a radio link from the mobile x-ray detector to an x-ray generator; receiving the data packet from the x-ray generator; comparing the time stamp with a clock of the x-ray generator and calculating a latency; and extrapolating an overall dose from the dose value, the time stamp and the latency.

A method for testing the total dose effect of a SiC MOSFET device, realizing verification of the complex total dose effect of the SiC MOSFET. The test steps sequentially comprise: testing a tested device before irradiation; performing annealing treatment on the tested device before irradiation; performing an irradiation test on the tested device; performing annealing treatment on the tested device after irradiation; performing test data analysis and processing on the tested device after irradiation. In the test process, threshold voltage shift caused by total dose radiation-induced defects and threshold voltage shift caused by near interface trap charges inherent near a SiC MOSFET interface are measured respectively, comprehensive analysis and calculation are carried out on the test result, the total dose effect resistance capability of the SiC MOSFET device can be given, and a certain guiding effect on device reinforcement is achieved.

The invention discloses a phase inverter capable of simultaneously resisting total dose and single event effect, which adopts the structural design that a main phase inverter and an auxiliary phase inverter are combined, and the main phase inverter is composed of two PMOS (P-channel Metal Oxide Semiconductor) tubes connected in series and an NMOS (N-channel Metal Oxide Semiconductor) tube. On the basis of a mode that an auxiliary phase inverter provides a level compensation signal at the NMOS source end of a main phase inverter, the high level output by the phase inverter under the total dose effect is prevented from being reduced, and transient upset of the output level of the phase inverter from high to low under the single event effect of an NMOS tube is avoided; on the basis of a double PMOS structure design mode, transient upset of the output level of the inverter from low to high caused by conduction of a PMOS tube under a single event effect is avoided. And finally, stable output of the inverter under the total dose and single-particle system effect can be realized.

The present invention discloses a drug injection device for heart failure, and key technical solutions thereof are as follows: The device includes a delivery catheter and an abutting component disposed at one end of the delivery catheter. Multiple guide holes are formed in the abutting component. A reservoir tube is slidably connected in the delivery catheter. Multiple injection needles in communication with the reservoir tube are disposed at one end of the reservoir tube close to the abutting component. The multiple injection needles are slidably inserted in the multiple guide holes respectively in one-to-one correspondence. A sealing plate is rotatably connected in an inner wall of one end of the reservoir tube close to the injection needle. The present invention has the following technical effects: By providing the reservoir tube, the present invention enables adjustment of the movable tube's extension length from the injection tube during operation. This controls the distance between the injection piston and the sealing plate, where a space volume between the injection piston and the sealing plate is a total dosage of the single-dose medication. In this way, accurate dose control is achieved for each injection.

The invention relates to a board-level ionization total dose effect irradiation test method, and belongs to the technical field of space environment engineering. The method comprises the steps of plate-level electrical parameter testing before irradiation, ionization total dose effect irradiation under a device-level bias condition, room-temperature annealing, high-temperature annealing and plate-level electrical parameter testing after ionization total dose effect irradiation. According to the invention, the technical effect of carrying out the ionization total dose effect irradiation test with high efficiency, accuracy and low cost can be realized.

The invention discloses a system and a method for measuring equivalent biological dose of targeted alpha nuclide therapy based on a voxel model. According to the system, a patient-specific three-dimensional voxel anatomical model and an activity distribution diagram are constructed through an image processing module; the intelligent energy item module calls a pre-established dose point core database according to decay characteristics of the selected alpha nuclide to generate an equivalent total dose point core; the dose calculation module performs fast convolution calculation based on the cumulative activity and the equivalent total dose point kernel to obtain a three-dimensional physical absorbed dose; the biological dose module is integrated with a micro-dose dynamic model and converts physical dose into a three-dimensional biological dose distribution diagram equivalent to conventional external radiation therapy. The technical defects that a standard model is large in error, Monte Carlo simulation consumes time, depends on multi-time-point dynamic imaging, and the physical dose cannot reflect the alpha particle biological effect are overcome, efficient, accurate and clinically practical individualized biological dose evaluation is achieved, and the accuracy and safety of a treatment scheme are remarkably improved.

There is disclosed compositions and methods for treating and preventing Acute Respiratory Distress Syndrome (ARDS) including ARDS caused by viral respiratory disease of zoonotic origin such as coronaviruses. The present disclosure is based on a surprising discovery of significant efficacy in an acute lung injury model using intrapulmonary lipopolysaccharide (LPS) challenge in female CD-I mice. Based on these data, the test compound, denatonium acetate monohydrate (DA) (1) treats or prevents ARDS and, (2) treats severe acute respiratory syndrome (SARS) caused by a coronavirus. Therefore, the data achieved in these studies does have a story to tell and the story is that a DA pharmaceutical composition, administered orally, provided a method to treat or prevent ARDS and treat SARS. Preferably, the pharmaceutical composition for daily administration comprises DA delivering a daily total dose of from about 20 mg to about 2000 mg to a human adult.

The present invention provides a modified BoNT / A for use in treating facial lines, wherein the modified BoNT / A is administered by intramuscular injection at a plurality of sites of the face of the subject, wherein the modified BoNT / A is administered by way of a unit dose of greater than 1754 pg or greater than 8000 pg) of modified BoNT / A per site, wherein the plurality of sites are selected from: up to two sites of a corrugator muscle and one site of a procerus muscle for treating glabellar lines, up to five sites of a frontalis muscle for treating forehead lines, and up to three sites of an orbicularis oculi muscle for treating lateral canthal lines, wherein the total dose of modified BoNT / A administered during the treatment is up to 264,000 pg (and optionally greater than 88,000 pg), and wherein the modified BoNT / A comprises a BoNT / A light-chain and translocation domain (HN domain), and a BoNT / B receptor binding domain (HC domain).

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an LXH-2301 pharmaceutical composition and application of the LXH-2301 pharmaceutical composition in preparation of a medicine for treating gout with hyperuricemia. The LXH-2301 pharmaceutical composition disclosed by the invention comprises the following components: (a) LXH-2301 tablets with the specification of 0.5 g / tablet; (b) febuxostat tablets with the specification of 20 mg / tablet; wherein the LXH-2301 tablet is administered three times a day, two tablets are administered each time, the total dosage is 1.0 g, and the LXH-2301 tablet is combined with the febuxostat tablet for use. Patients suitable for the composition need to simultaneously meet the following screening standards: morning urine pHlt; and 6.0. The LXH-2301 pharmaceutical composition provided by the invention is applied to the preparation of medicines for treating gout with hyperuricemia, and the limitation of insufficient curative effect on patients with uric acid poor excretion type gout is solved; the problem of lack of prevention means for uric acid crystallization kidney injury is solved.

The present invention discloses a gate tunneling current simulation method under the action of total dose, comprising the following steps: step 10, performing three-dimensional device structure modeling on a SOI NMOS device; step 20, modifying a gate dielectric material parameter file of the SOI NMOS three-dimensional device structure model to activate a Radiation model and set an irradiation bias state of the model; step 30, setting an irradiation dose rate and a plurality of different irradiation times, performing irradiation total dose simulation on the SOI NMOS three-dimensional device structure model, and extracting a threshold voltage V corresponding to different irradiation doses. th ; Step 40, the threshold voltage V th The gate tunneling current characteristics under the total dose effect are obtained by inputting the empirical formula of the gate tunneling current for simulation. The present invention obtains the device threshold voltage by changing with time under different bias states and different irradiation doses, and then substitutes the changed threshold voltage into the empirical formula of the gate tunneling current for simulation, so as to accurately obtain the gate tunneling current under different total irradiation doses.

Disclosed in the present invention is an adjustable autoinjector, comprising: a main shaft rotatably provided in a pen body, wherein a push rod assembly is provided in the main shaft; a dose knob used for dose setting and dial-back, and configured to: during dose setting, drive the main shaft to rotate and allow for energy storage of an energy storage assembly, wherein the energy storage assembly is fitted over the main shaft; a connecting assembly provided at the lower portion the main shaft, and configured to: limit reverse rotation of the main shaft when a dose has been set, release the limitation on the reverse rotation of the main shaft when the dose knob rotates reversely due to over-setting of the dose, and be disconnected from the main shaft during injection; a dose limiting assembly provided in the dose knob and configured to prevent a set total dose from exceeding the total dose of liquid medicament; and the energy storage assembly comprising a spiral spring. In the adjustable autoinjector of the present invention, the main shaft is rotatably provided in the pen body; the energy storage assembly is provided on the main shaft; the dose knob is used for dose setting and allowing for energy storage of the energy storage assembly; during injection, the spiral spring drives the main shaft to rotate and provides torque suitable for high-viscosity liquid medicament; and when the dose is set excessively, a dial-back operation can be performed.

The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns:a) a first part, G1, comprising from about 5 to about 70% w / w of the total dose of acarbose,b) a second part, G2A, comprising from about 30 to about 95% w / w of the total dose of acarbose,c) a third part, G2B, comprising from about 10 to about 90% w / w of the total dose of orlistat, andd) a fourth part, G3, comprising from about 10 to about 80% w / w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w / w.

A system for treating a target tissue with a charged particle beam, wherein the target tissue includes tumoral cells surrounded by or encloses healthy cells of healthy tissue, the system comprising a computer configured to receive a total target dose, receive a fraction number irradiation fractions for treating, receive a maximum healthy fraction dose and a maximum healthy total dose, receive an equivalence coefficient (α), divide the total target dose into the target fraction doses, and determine a ratio of a target fraction dose to be deposited at a conventional deposition rate and a complementary ratio of the target fraction dose to be deposited at a high deposition rate based on an equivalent fraction dose, the maximum healthy fraction dose, a total equivalent dose, and the maximum healthy total dose.