2 results about "Animal mortality" patented technology

This invention belongs to the field of animal model construction technology, specifically providing a method for constructing and using a mouse radiation dermatitis model. The method involves irradiating localized areas of healthy mice with X-rays at a dose rate of 5.128 Gy / min in fractionated doses every other day, with a total dose of 30-49 Gy, to establish a mouse radiation dermatitis model. This invention uses a fractionated X-ray irradiation mode commonly used in clinical radiotherapy, which can stably induce radiation dermatitis of varying degrees. Skin damage is significantly dependent on the irradiation dose. A total dose of 30 Gy is optimal, and after 35 days of development, a standardized model closely resembling clinical grade II radiation dermatitis can be constructed. This method is simple to operate, has good reproducibility, and a low animal mortality rate. It can realistically simulate the skin damage process of clinical radiotherapy, providing a reliable basis for research on the mechanism of radiation dermatitis and is suitable for the screening and identification of related preventive and therapeutic drugs.

The utility model discloses a mouse heart radioactivity damage mould based on 3D printing and mould turning process, including frame body structure, the whole is hollow cuboid structure without top, the frame body structure is spliced by left and right two connecting pieces, and this kind of structure is convenient for early processing and later storage, support piece is provided with two rows, and two rows of support pieces are symmetrically placed in the two side wall positions of frame body structure, the utility model discloses through 3D modeling calculation radio source under the lead plate barrier, the real data of accurate irradiation mouse heart, the lead plate mould is made based on three -dimensional structure data 3D printing, and accurate mould turning is carried out to low melting point lead through mould turning technology, realize the production of high accuracy, and X ray can accurately penetrate the radiation hole and form the circular irradiation field of 1cm diameter, realize the accurate radiotherapy of heart, and the radiation dose that other parts bear under the protection of 3cm thick lead plate is lower, and the animal mortality is low, and it is closer to the clinical practice.