864 results about "Mouse Heart" patented technology

The invention relates to the technical field of heart data analysis, in particular to an AI (artificial intelligence)-based heart disease prediction system, which comprises a feature relationship modeling module for mapping each type of information into a multi-dimensional feature space based on collected heart data, analyzing the condition correlation degree between feature nodes, connecting the feature nodes through correlation information, and establishing a model; and quantifying a linkage effect between the features to obtain a feature condition dependency relationship analysis result. According to the method, various types of heart health data are noded by constructing a multi-dimensional feature space, and a correlation structure is established according to condition correlation among data features. And a synergistic effect and an interdependence relationship among the features are disclosed. By analyzing the joint state probability of the feature nodes, the linkage effect of the feature combination on the overall risk is quantified, and the analysis depth of the disease risk is enhanced. In addition, by comparing the independent state probability of a single feature with the joint state probability of the feature combination, a feature combination that makes a significant contribution to the risk can be identified.

A mechanical circulatory support (MCS) system having an axial rotary blood pump with an impeller housing having a cylindrical pocket for receiving a magnet and closed by an end ring, requiring only a single circumferential weld and an axial weld. The impeller includes a shaft and one or more blades extending radially from the shaft. An inner and outer wall extend longitudinally from the shaft defining the pocket therebetween. A magnet array is positioned within the pocket and configured to be magnetically driven by an output shaft of a motor. The end ring is coupled to the end of the pocket opposite the shaft thereby encapsulating the magnet array within the pocket. Alignment holes may be provided within a floor of the pocket for orienting and balancing the impeller.

The invention relates to the technical field of spermidine application, in particular to application of spermidine in preparation of medicine for preventing and treating doxorubicin-induced cardiotoxicity and myocardial aging. Cell proliferation experiments and mouse survival rate experiments show that spermidine can reduce death of myocardial cells and mice caused by adriamycin; a q-PCR experiment shows that spermidine can improve abnormal expression conditions of P53, P21, P16, BAX, TNF-alpha, IFN alpha, IL-10 and IL-18 in myocardial cells caused by adriamycin; a beta-galactosidase staining experiment shows that the spermidine can reduce the condition that the expression of a marker beta-galactosidase for myocardial cell senescence induced by adriamycin is increased; a Western Blot experiment shows that the spermidine can improve the condition that the P53 protein is abnormally increased due to the adriamycin; an Elisa experiment shows that spermidine can improve the condition that myocardial injury markers cTn-I and AST and inflammatory factors IL-1beta are abnormally increased due to adriamycin, and the myocardial injury markers cTn-I and AST and inflammatory factors IL-1beta are abnormally increased due to adriamycin. Therefore, spermidine can improve cardiotoxicity and myocardial aging induced by adriamycin.

Provided herein is a device for simultaneous intraoperative leak testing and visualisation of a heart valve seat, the device comprising an end cap configured to engage with and to sealingly close an opening of a tubular vascular graft, the end cap comprising a backing portion, a connector portion, a view port, and at least one fluid conduit element, the connector portion comprising a distal end dimensioned for placement inside of the opening, a first fastening element comprising an external thread, a second fastening element comprising an internal thread and configured to be rotated onto the first fastening element, and the external and internal threads are adapted such that the first and second fastening elements are fittingly engaged with the tubular vascular graft scalingly secured therebetween by less than one rotation of the second fastening element around the outer circumference.

The transcatheter type artificial polymer heart valve comprises an integrated valve leaflet and a valve frame, the valve frame is of a hollow columnar grid structure, the valve frame is provided with a first end and a second end, the first end is provided with a plurality of stand columns at intervals in the circumferential direction, the integrated valve leaflet comprises a pipe body and a valve leaflet, the pipe body is provided with a third end and a fourth end, and the valve leaflet is arranged in the pipe body. The valve leaflets are arranged in the center of the third end, the valve leaflets are sequentially arranged in the circumferential direction, connecting grooves are formed in the connecting positions of the adjacent valve leaflets, and the connecting grooves are provided with through holes allowing the stand column to penetrate through; a connecting column is arranged on the outer wall of the pipe body, and a connecting hole matched with the connecting column is formed in the petal frame; when the integrated valve leaflet is arranged in the valve frame, the third end and the fourth end correspond to the first end and the second end respectively, the stand columns are inserted into the through holes, and the connecting columns are connected with the connecting holes in a one-to-one correspondence mode. Manual valve sewing is reduced, and the assembly efficiency is improved; stress concentration during opening and closing of the valve leaflet is reduced, and the performance of the valve is optimized.

The invention discloses specific antibodies against cardiac myosin binding protein C. Specifically, the invention discloses a monoclonal antibody aiming at cardiac myosin binding protein C. The antibody has obvious binding activity to a cardiac myosin binding protein C antigen.

The invention discloses a heart AI system based on deep learning, and relates to the technical field of medical image processing, and the heart AI system comprises a two-dimensional fully-supervised left atrium segmentation algorithm module, a three-dimensional semi-supervised left atrium segmentation algorithm module, and a whole heart segmentation algorithm module. Meanwhile, through combination of Transform and a residual network, semantic information in the image is captured in a larger visual field, so that the segmentation precision of the network is improved; a two-dimensional fully-supervised left atrium segmentation algorithm module based on axial attention is provided from a two-dimensional angle by taking UNet as a basic model, the algorithm module firstly constructs a double-layer residual error convolution module, gradient information is transmitted through a plurality of paths, then a task-driven feature enhancement module is introduced to optimize feature representation, and finally, a task-driven left atrium segmentation algorithm is constructed. A multivariate feature fusion module is designed to integrate features, and finally a feature coupling module is designed, so that the limitation of traditional convolution operation is overcome.

The invention provides construction and application of a human pluripotent stem cell-derived heart organoid traditional Chinese medicine extract toxicity test chip. The chip comprises a plurality of micro-cell culture chambers and a micro-fluidic pore channel, heart organoid culture is carried out in the micro-cell culture room, culture media are added in the micro-fluidic channel to maintain the activity of the heart organoid, and traditional Chinese medicine extracts are added to evaluate the toxicity of traditional Chinese medicine. By simulating the reaction of the heart organ, the toxicity of the traditional Chinese medicine can be evaluated, the safety and effectiveness information about the traditional Chinese medicine can be provided, finally, the use of experimental animals can be reduced, and the animal welfare can be improved.

The present invention relates to a system for delivering an annuloplasty device for restoring a heart valve annulus from a dysfunctional configuration to a working configuration wherein the annuloplasty device is configured to expand from a preset configuration corresponding to the working configuration of the valve annulus, the system comprising a delivery device, a delivery device is configured to be removably coupled to an annuloplasty device, where the delivery device includes a structure configured to expand from a first configuration to a second configuration, where the second configuration is substantially equal to or greater than a predetermined configuration of the annuloplasty device.

The invention discloses an application of rilpivirine (RPV) in preparation of a medicine for treating myocardial infarction, and relates to the field of medicines for treating myocardial infarction. The invention belongs to the technical field of biological medicine. According to the present invention, the acute myocardial infarction (AMI) disease mouse model is constructed through the induction of the permanent ligation of the left anterior descending branch; after rilpivirine is orally taken, the conditions of survival, heart function, structure change and the like of the AMI mouse model during X weeks after operation are observed. Results show that rilpivirine (as shown in the formula I) has the effects of remarkably improving the cardiac function of AMI injury, relieving cardiac remodeling and increasing the survival rate of AMI mice. Therefore, a new technical means is provided for treatment of myocardial infarction, and rilpivirine has a wide application prospect in treatment of myocardial infarction diseases. # imgabs0 #

The present invention relates to monoclonal antibodies, or fragments thereof, which bind to MYBPC3 (Myosin binding protein C, cardiac type). Further, the present invention relates to a kit comprising the monoclonal antibodies of the present invention. In some embodiments, the kit is provided as sandwich assay. Further the present invention relates to the in vitro use of the monoclonal antibodies, or fragments thereof, or of the kit of the present invention for the detection of MYBPC3 in a sample. Moreover, the present invention relates to diagnostic methods, such as the assessment of cardiac condition, for example of myocardial infarction.

The invention belongs to the technical field of biological medicine, and particularly discloses an artificial valve tissue calcification model and a preparation method and application thereof. The preparation method comprises the following steps: providing human valvular interstitial cells; the method comprises the following steps: providing a hydrogel system, wherein the hydrogel system comprises type I collagen, fibrinogen and Matrigel matrigel; constructing an engineered heart valve tissue strip by taking the hydrogel system as a skeleton structure between valve interstitial cells; and culturing the engineered heart valve tissue strip by using a calcification induction culture solution, so that the valve tissue generates a calcification phenotype. The model provided by the invention can generate a valve calcification phenotype which is similar to that after human heart valve calcification and is represented by valve interstitial cell activation, extracellular matrix remodeling such as collagen mass secretion and calcium deposition region generation. The model provided by the invention is low in cost, can be produced in batches, meets the research on the pathogenesis of extracorporeal valve calcification, and makes up for the dilemma that no artificial valve calcification model is available for drug research and development at present.

The invention relates to a scanning triggering method, device and system and a storage medium, and the method comprises the steps: obtaining a heart movement signal, collected in real time, of a scanning object; judging whether newest signal data in the heart movement signal meets a preset triggering condition or not; generating a trigger instruction under the condition that the newest signal data meets a preset trigger condition; the trigger instruction is used for triggering the medical imaging equipment to perform medical scanning on the scanned object. According to the method and the device, the problem that accurate scanning triggering cannot be realized is solved, and scanning is accurately triggered by utilizing the acquired heart movement signals.

The invention discloses a construction method and application of a mouse model for specifically tracing heart valve cells, and belongs to the technical field of animal model construction. The model construction method comprises the following steps: (1) constructing a Wid1-Cre hybrid mouse before inserting a Cre recombinase coding gene into a termination codon of a mouse Wid1 gene; and (2) hybridizing the Wid1-Cre hybrid mouse with the Rosa26-tdTomato homozygous report mouse, so as to obtain the double transgenic mouse which simultaneously carries the Wid1-Cre gene and the Rosa26-tdTomato gene. According to the invention, on the basis of the expression characteristic that Wif1 is only limited to a valve area in the heart, Wif1-Cre is constructed; according to the Rosa26-tdTomato mouse model, specific tracing of heart valve cells is achieved, and an important experimental tool is provided for mechanism research of heart valve diseases and development of therapeutic drugs.

The invention discloses a coenzyme Q10-containing medicine for improving heart activity and a preparation method thereof, and particularly belongs to the technical field of biological medicines. The medicine comprises functional components and auxiliary materials, wherein the functional components comprise a cactus extract, a calligonum mongolicum extract, an astragalus membranaceus extract, a sea-buckthorn extract and coenzyme Q10; the hypoxia survival time and the load-bearing swimming time of mice can be remarkably prolonged through low, medium and high dose groups of the medicine for improving the heart vitality, the requirement of fatigue caused by high labor intensity for oxygen is further met by enhancing the immunity of the organism, supply of nutrient substances to the brain, the heart, the bones and the muscles of the organism is enhanced, and the effect of improving the heart vitality is achieved. The composition can regulate the activity of central nervous system, promote the normal operation of the body circulation system, relieve and eliminate fatigue and damage to the body caused by fatigue and chronic fatigue, and quickly recover physical strength.

A prosthetic valve component is disclosed for a valve prosthesis. The valve component includes valve leaflets configured to be operably coupled within a frame of the valve prosthesis, wherein each valve leaflet is shaped and sized to achieve a target pinwheeling score PS. The target pinwheeling score correlates to full contact being made between free edges of the valve leaflets, when the valve leaflets are operably coupled within the frame of the valve prosthesis, such that no central opening and little to no overlap occurs between the valve leaflets.

A precise cardiac data reconstruction method is provided, which may also be referred to herein as radar cardiography (RCG). RCG can reconstruct cardiac data, such as heart rate and / or electrocardiogram (ECG)-like heartbeat waveform signals wirelessly by using advanced radar signal processing techniques. For example, heartbeat and related characteristics can be monitored by isolating cardiovascular activity from strong respiratory interference in spatial spaces: azimuth and elevation. This results in significant improvements to pulse signal-to-noise-ratio (SNR) compared to conventional approaches, facilitating heart-rate variability (HRV) analysis.

Methods of using IL-2 fusion proteins to treat and / or prevent graft rejection, such as cardiac graft rejection, are disclosed.

Echocardiography deep learning and cardiovascular outcomes are described. An echocardiogram analysis module may include a deep learning model to generate a video output for an input echocardiogram video, the deep learning model comprising a convolutional neural network and at least one dense layer. The echocardiogram analysis module may further include a cardiac prediction generator to generate a cardiac prediction based on video outputs generated for a plurality of input echocardiogram videos of an echocardiogram study, the cardiac prediction comprising a measurement prediction or a classification prediction.

Echocardiography deep learning and cardiovascular outcomes are described. An echocardiogram analysis module may include a deep learning model to generate a video output for an input echocardiogram video, the deep learning model comprising a convolutional neural network and at least one dense layer. The echocardiogram analysis module may further include a cardiac prediction generator to generate a cardiac prediction based on video outputs generated for a plurality of input echocardiogram videos of an echocardiogram study, the cardiac prediction comprising a measurement prediction or a classification prediction.

A transient closed-loop system for cardiac pacing and / or defibrillator therapy for a subject includes a bioresorbable module configured to at least partially attach to an epicardial interface of the subject's heart for the cardiac pacing; at least one skin-interfaced module configured to attach to an outer surface of the subject's skin, wherein the bioresorbable module is in wireless communication with the at least one skin-interfaced module; and a control module in wireless communication with the at least one skin-interfaced module.

The application provides an application of a FAP-targeted CAR-T cell in preparation of a drug for treating cardiac fibrosis in a chronic phase of myocarditis. It is found in the application that FAP-specific CAR-T cells can effectively target cells expressing mouse FAP proteins, and the CAR-T cells can effectively eliminate cells expressing mouse FAP proteins after being activated, the chimeric antigen receptor T cells effectively reduce cardiac fibrosis in a chronic phase of myocarditis in mice, and restore the function after inflammatory injury. The application develops a CAR-T therapy for myocardial fibrosis caused by a chronic phase of myocarditis, and the chimeric antigen receptor T cells expressing a targeted fibroblast activation protein can recognize activated myocardial fibroblasts, and significantly reduce cardiac fibrosis after inflammatory injury and restore the function.

Provided is a method for screening myocardial therapeutic targets for ischemic heart failure by using single-cell sequencing, which method comprises the following steps: S1, sample preparation; S2, construction of a single-cell expression matrix; S3, cell quality control; S4, cell type annotation; S5, cell communication analysis; and S6, co-expression network analysis. The provided method for screening myocardial therapeutic targets for ischemic heart failure by using single-cell sequencing comprises performing single-cell sequencing on hearts of healthy mice and IHF mice, screening for cell types with significant differences in cardiac transcriptional profiles of the healthy mice and IHF mice, then exploring interaction characteristics of various types of cells in malignant fibrotic IHF hearts, revealing potential regulatory modules and pathways related to malignant myocardial fibrosis in single-cell expression data of IHF hearts, and performing screening to obtain Pdgfb and Tnfsf12 genes which can be used as therapeutic targets for treating myocardial fibrosis in ischemic heart failure.

Various examples describe a livestock monitoring system and method. A sensor signal may comprise a rotational component describing a rotation of the sensor within an animal and a linear component describing a linear movement of the sensor within the animal. The rotational component may be used to identify an animal respiration signal. The animal respiration signal and the linear component may be used to generate a respiration-corrected linear component. An animal heart signal may be detected from the respiration-corrected linear component.

An embodiment of the invention provides a system for automatically deriving a parameter of a human heart from ultrasound results. A first neural network is arranged to receive a plurality of echocardiographic images and to classify the images into one of at least a two-chamber view and a four-chamber view. A second neural network is arranged to receive echocardiographic images comprising a two- or four-chamber view and to identify the endocardial border of the left ventricle (LV) for each view. End-systole and end-diastole images are then identified and a parameter such as LV volume, ejection fraction, global longitudinal strain and regional longitudinal strain is calculated.

The invention discloses an application of pentagalloylglucose (PGG) in preparation of a medicine for resisting doxorubicin cardiotoxicity. The method comprises the following steps: inducing doxorubicin (DOX), establishing a myocardial cell H9C2 injury model, and determining the DOX-induced myocardial cell injury minimum concentration; after 20 [mu] M of PGG is added into a treatment group, DOX-induced H9C2 cell apoptosis can be significantly improved. A mouse myocardial injury model is induced and established by DOX, and compared with a doxorubicin group, the left ventricular systolic fraction (FS%) and ejection fraction (EF%) of mice in the doxorubicin and pentagalloylglucose group are remarkably increased, the myocardial fiber structure is improved, the cytoplasm vacuolation is reduced, the serum cTnT and BNP levels are reduced, and the ROS level is reduced. The experiment proves that the pentagalloylglucose can obviously reduce the cardiotoxicity induced by the DOX.

Provided in the present disclosure are a model generation method and system, and a device, a storage medium and a program product. The generation method comprises: acquiring several ultrasound images of a target object and corresponding probing position information; extracting a contour feature point set of the target object from each ultrasound image, wherein the contour feature point set comprises a plurality of contour feature points; on the basis of the contour feature point set and probing position information corresponding to each ultrasound image, obtaining spatial position information of each contour feature point; on the basis of the spatial position information of each contour feature point, obtaining a target projection point of each contour feature point on a standard three-dimensional model corresponding to the target object; and on the basis of the spatial position information and target projection point of each contour feature point, calibrating the standard three-dimensional model to obtain a target three-dimensional model of the target object. The present disclosure automatically completes the quick construction of a three-dimensional cardiac model without manual intervention, thereby significantly shortening the time for constructing the three-dimensional cardiac model before surgery.

The invention discloses a conversion model for generating an ECG signal from a PPG signal, which comprises a period sensing module, a Transform extraction framework and an adaptive aggregation module, and is characterized in that the period sensing module is used for identifying and extracting a periodic component in an originally input PPG signal, determining a frequency related to a cardiac cycle, remodeling an input time sequence, and generating an ECG signal in the PPG signal; obtaining a two-dimensional periodic view formed by k different periods; a Transform extraction framework divides a two-dimensional period view formed by k different periods into a plurality of blocks Patchi corresponding to cardiac periods, and sequentially inputs each block Patchi into an embedding layer and a coding layer for processing, and captures output representation X ''i changing in the periods and between the periods in PPG signal data, and a feature sequence # imgabs0 # matched with the length of the original PPG signal is obtained after remodeling, and the adaptive aggregation module adopts a weight aggregation method to aggregate the feature sequence # imgabs1 # to obtain a reconstructed ECG signal X. According to the method, physiological feature capture is enhanced through signal alignment based on the heart cycle, so that the accuracy of generating the ECG signal is improved.

The invention discloses an extraction method of safflower leaf exosome-like nano-vesicles and application of the safflower leaf exosome-like nano-vesicles in preparation of drugs for preventing and treating adriamycin-induced cardiotoxicity, fresh safflower leaves are taken and cleaned, a PBS solution is added for crushing and filtering, filtrate is collected and continuously centrifuged, supernate is taken and subjected to ultracentrifugation, precipitates are collected after centrifugation, and the safflower leaf exosome-like nano-vesicles are obtained; and filtering and sterilizing by using a filter membrane to obtain the safflower leaf exosome-like nano-vesicles. The carthamus tinctorius leaf exosome-like nano-vesicles can significantly improve the heart function of doxorubicin-induced cardiotoxic mice; myocardial injury induced by doxorubicin can be repaired, and myocardial fibrosis induced by doxorubicin can be inhibited; the content of a myocardial injury marker lactic dehydrogenase in body serum can be reduced, a new treatment strategy is provided for preventing and treating adriamycin-induced cardiotoxic diseases, and the application prospect is good.