10results about How to "Improve heart function" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine compound and preparation for treating coronary heart disease and a preparation method and application of the traditional Chinese medicine compound and preparation. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10-30 parts of astragalus membranaceus, 5-15 parts of rhodiola rosea, 10-30 parts of salvia miltiorrhiza, 5-15 parts of ligusticum wallichii, 10-30 parts of trichosanthes kirilowii maxim, 5-15 parts of allium macrostemon, 5-15 parts of folium ginkgo, 10-30 parts of radix puerariae, 10-30 parts of radix ophiopogonis, 3-10 parts of schisandra chinensis, 15-30 parts of oyster, 5-15 parts of cassia twig and 3-10 parts of liquorice. Animal experiment results show that the traditional Chinese medicine composition provided by the invention has remarkable and multi-aspect curative effect advantages in the aspect of treating a coronary heart disease rat model. The traditional Chinese medicine composition not only can enhance myocardial contractility and recover heart blood pumping function, but also can inhibit inflammatory response, relieve myocardial damage, effectively relieve myocardial structure damage and protect myocardial tissue integrity. In addition, a proportional experiment result shows that the effect of the composition provided by the invention can be obviously weakened by losing any medicine pair, so that all the medicines in the formula cannot be absent.

The application relates to application of miRNA and / or a miRNA agonist in preparation of a medicine for preventing and / or treating myocardial ischemia-reperfusion injury, and belongs to the technical field of biological medicine. The medicine is administered through skeletal muscle injection, is secreted to a circulation system after expression on the skeletal muscle, is delivered to heart tissue by taking extracellular vesicles as carriers, and thus regulates myocardial cell functions. According to the animal model verification result, the miRNA can be delivered to the heart by the extracellular vesicles secreted by the skeletal muscle through injection of the medicine into the skeletal muscle, the expression level of the miRNA in the I / RI heart is significantly increased, the myocardial infarction area is effectively reduced, myocardial cell apoptosis is inhibited, myocardial fibrosis is reduced, and heart function is improved, a brand-new intervention strategy is provided for treatment of myocardial ischemia-reperfusion injury and related heart diseases, and a brand-new idea is opened up for research and development of heart failure treatment medicines.

The invention belongs to the technical field of medicines, and particularly relates to application of a CCNL1 inhibitor in preparation of a medicine for treating cardiomyopathy, and the amino acid sequence of CCNL1 is as shown in SEQ ID NO.1. It is found that by knocking down expression of CCNL1, DOX-induced myocardial cell apoptosis can be inhibited, DOX-induced myocardial cell ROS production can be inhibited, the lipid peroxidation level in DOX-induced myocardial cells can be reduced, and DOX-induced myocardial mitochondrial damage can be inhibited, so that application of the CCNL1 inhibitor in preparation of drugs for treating cardiomyopathy is provided.

The invention discloses an application of a neuron-derived neurotrophic factor NDNF in promotion of regenerative repair and functional reconstruction of an injured heart, particularly relates to an application of the NDNF in a medicine for treating or improving the injured heart, a recombinant vector and a medicine, and belongs to the technical field of biological medicines. The invention provides application of NDNF in promotion of regenerative repair and functional reconstruction of damaged heart. The invention proves that the medicine prepared from the NDNF can be used for treating or improving the insufficiency and inflammation of the damaged heart, and particularly has a good treatment effect on the damaged heart caused by myocardial infarction, and the treatment effect specifically comprises the effect of reducing myocardial cell apoptosis and inflammation after myocardial infarction and the effect of inhibiting myocardial cell pathological hypertrophy after myocardial infarction due to overexpression of the NDNF. In addition, overexpression of the NDNF can also promote proliferation of myocardial cells after myocardial infarction.

A surgical annulus, a mechanical valve, and a surgical biovalve are disclosed. The three cardiac surgical valve instruments preferably adopt a high valve ring or short valve angle design. By means of the high-valve-ring surgical valve ring, left ventricular outflow tract obstruction can be avoided during a mitral valve intervention operation in the future. A mechanical valve and a surgical bioprosthetic valve move up a leaflet fixing structure and leaflets through a high annulus or short valve angle design to retain leaflets and subvalvular structures as much as possible in future mitral and tricuspid valve operations to facilitate post-operative heart function improvement.

The invention discloses a screening method of a traditional Chinese medicine monomer composition for resisting heart failure. The method comprises the following steps: 1, carrying out water extraction and enrichment on astragalus membranaceus and monkshood to obtain astragalus membranaceus and monkshood soup enriched components; 2, synthesizing myocardial mitochondrial membrane coated magnetic beads and myocardial lysosome membrane coated magnetic beads; 3, gathering enriched components of the astragalus mongholicus-monkshood decoction, and carrying out ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to obtain components of songorine, neoline, calycosin and formononetin as traditional Chinese medicine monomer composition; the traditional Chinese medicine monomer composition is prepared by dissolving songlin, neoline, calycosin and formononetin in a sodium carboxymethyl cellulose solution. The synthesized myocardial mitochondrial membrane coated magnetic beads and the myocardial lysosome membrane coated magnetic beads are used for adsorbing and identifying active ingredients in the astragalus mongholicus-monkshood decoction, the effective ingredient composition for resisting heart failure is successfully screened, and the preparation method is simple and easy to implement; the traditional Chinese medicine monomer composition plays a role in preparing anti-heart-failure medicines by improving heart functions and the like.

The application discloses application of Piancizhu in preparation of a medicine for preventing and / or treating myocardial infarction. The application first discovers that Piancizhu can play an anti-cardiac ischemic injury role by improving heart function of a mouse model of left anterior descending branch stenosis of coronary artery, inhibiting inflammation levels of a heart, peripheral blood and bone marrow after cardiac infarction, reducing a myocardial infarction area and improving cardiac function disorder. Therefore, the application provides a scientific basis for increasing a clinical treatment indication of Piancizhu in acute myocardial infarction, simultaneously provides a new drug selection for clinical treatment of an acute cardiac infarction patient due to a good anti-inflammatory effect, and has a good application prospect.

The application discloses a new application of a substance increasing the content or activity of PARKIN in treating and / or preventing cardiovascular diseases. The application proves by transgenic and gene therapy means that increasing the content of PARKIN can significantly inhibit the activation of a cGAS-STING signal pathway and the downstream inflammatory response, thereby significantly improving the heart function, reducing the myocardial inflammatory response and myocardial fibrosis. The application provides a new drug target and treatment strategy for the prevention and treatment of cardiovascular diseases, and has important clinical application value.

The invention provides a traditional Chinese medicine composition for treating coronary heart disease as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 4-18 parts of ginseng, 7-28 parts of trichosanthes kirilowii maxim, 7-28 parts of allium macrostemon, 4-18 parts of pinellia ternate, 7-28 parts of radix paeoniae rubra, 7-28 parts of ligusticum wallichii and 4-18 parts of radix scrophulariae. The traditional Chinese medicine composition disclosed by the invention can be used for remarkably improving the heart function, reducing the blood fat level and improving myocardial injury for model rats with the syndrome of phlegm and blood stasis in coronary heart disease.

The application discloses a kind of composition and its application in preparation with improved cardiac function product.The composition described herein, comprising the following components: (1) beta-nicotinamide mononucleotide or 1,6-fructose diphosphate tri-sodium salt, and (2) coenzyme Q 10 And vitamin complex.The composition described herein, beta-nicotinamide mononucleotide or 1,6-fructose diphosphate tri-sodium salt is combined with coenzyme Q 10 And vitamin complex, the composition obtained after combination has good prevention or treatment heart failure effect and the effect of improving cardiac function.Therefore, the composition described herein is used as active ingredient for preparing dietary supplement, health product or drug with prevention or treatment heart failure effect or with improving cardiac function, has important application value.