539results about How to "Slow release rate" patented technology

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

The present invention provides time released markers for use with single reservoir and commingled wells. The invention accomplishes the time release of markers by coating or encapsulating marker particles or by coating a proppant which has been saturated with a marker. After coating or encapsulation, the marker is injected into a well as is known in the art. The marker remains in the well. The marker is released after an elapsed of time. The elapsed time can be in a wide range. After the elapsed time, production is taken from the well and tested for the presence of the marker. Various types of known analyses can be performed to test for the presence and concentration of the marker in the production fluid. The concentration of the marker in the production fluid allows the apportioning of production from the reservoir. In addition, different markers may be added to each zone within a reservoir where each marker has a different elapsed time increment. The zones can be any different layer or area in the reservoir such as different strata or layer of rock, limestone or sand. Differing marker combinations allow contribution from different zones to be monitored over an extended time.

The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally. More particularly, the invention is concerned with the use of such compounds, wherein the compound is delivered to the site of action in the patient to be treated in two or more doses.

The invention discloses a human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive, which is a novel medicine-carried dressing or a novel formulation of Yunnan white drug powder. The invention has the following remarkable characteristics: (1) the dressing can be absorbed by human bodies to lessen the pain added by dressing change and reduce the treatment cost; (2) the dressing can be made into a film solid dressing or an aquagel dressing so as to expand the use modes, the scope of applications and the drug effect of the Yunnan white drug powder; and (3) the curative effect of the dressing is enhanced by selecting a carrier material, auxiliary medicaments and functional accessories and adjusting the microstructure structure. The novel absorbable Yunnan white drug powder dressing overcomes the defects of the traditional Yunnan white drug powder in use and has economic and social values.

The invention relates to a charcoal-based organic fertilizer and a preparation method thereof. The charcoal-based organic fertilizer has the advantages of low cost, environment friendliness, good fertilizer efficiency, wide application range, high fertilizer efficiency utilization rate and pest prevention. The preparation method comprises the steps as follows: adding starter cultures to chicken manure and soybean meal respectively for fermentation, after drying, crushing and mixing crop-residue-derived carbon, the treated chicken manure and soybean meal with ground phosphate rock, adding wood vinegar to the mixture with stirring, performing granulation, and obtaining the charcoal-based organic fertilizer after cooling and drying.

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs / compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed.

Provided is a method of treating a patient suffering from a pain state by administering to the patient a gastric retentive dosage form of gabapentin that is capable of administration in once-daily or twice daily dosing regimens. By reducing the need to administer gabapentin from the thrice-daily administrations characteristic of immediate release gabapentin, the gastric retentive gabapentin dosage forms provided herein have the advantages of improving patient compliance for gabapentin treatment. In addition to the foregoing, the gastric retentive gabapentin dosages forms also exhibit decreased blood plasma concentrations and increased bioavailability throughout the dosing regimen.

The invention discloses an oil-in-water emulsion free of surfactant. The emulsion comprises a metabolizable oil phase, a water phase and oil-water amphipathic solid particles dispersed in the water phase and having biocompatibility, wherein the oil phase comprises squalene or / and tocol; the water phase is any one or a combination of at least two of purified water, water for injection, aqueous liquid of glycerol, buffered saline liquid and clinically available infusion liquid; and the average grain diameter of the solid particles is at nanometer-to-micron grade. The emulsion can be used as a vaccine adjuvant or a medicine delivery or controlled release carrier; the properties of the emulsion can be controlled and regulated; the obtained emulsion is stable; the use of a surfactant is avoided; and harm to the human body and pollution on the environmental can be reduced.

The invention discloses a microcapsule insecticide-fertilizer preparation, a preparation method and application thereof. The preparation consists of the following components in part by weight: 1 to 30 parts of pesticide microcapsules and 70 to 99 parts of nutrient substance. The preparation method mainly comprises the following steps of: after fully dissolving a pesticide with a solvent, adding a wall material monomer into solution and mixing uniformly; transporting a mixture into a shear dispersion reaction kettle which is filled with smashed capsule bodies; stirring the mixture and the capsule bodies so that the capsules fully absorb the solution; performing a shear dispersion reaction to form capsules; performing solid-liquid separation and drying to prepare the pesticide microcapsules; adding the nutrient substances into the pesticide microcapsules; and fully stirring and uniformly mixing to prepare the microcapsule insecticide-fertilizer preparation. By using the microcapsule insecticide-fertilizer preparation and the preparation method, the problems of the chemical compatibility and the physical stability of the conventional insecticide-fertilizer preparation in the same system are solved effectively. A product of the invention has the advantages of: shielding and slow-releasing functions, high chemical compatibility and physical stability, lasting pesticide effect, natural degradability, no environment pollution, low use cost and simple production process.

The invention discloses a 3D printing bionic porous biological ceramic artificial bone and a preparation method thereof. A porous biological ceramic artificial bone model is designed through a TPMS and CSG combined method, slurry capable of being used for printing is prepared through biological ceramic powder and a binding agent, macropores and micropores are distributed in the porous biological ceramic artificial bone prepared through the combination with the 3D filament-free printing process, the pore diameter of the micropores is smaller than 100 micrometers, the pore diameter of the macropores is 200-800 micrometers, the total porosity is 20% to 80%, the communicating rate between the macropores is not lower than 99%, precise design of porosity, communication and homogeneity in the artificial bone is achieved, and meanwhile good pore communication is ensured. Adopted raw materials have good biocompatibility, entry passageways of cells and tissue fluid are provided by the macropores, the micropores can better adsorb tissue fluid nearby for cell growth, the cell growth speed and the new bone generation speed can be increased by combining the micropores with the marcropores, and application of the porous biological ceramic artificial bone in human body large bone defect repair clinic treatment is facilitated.

A method for applying a barrier to a structure to prevent the infiltration of pest species includes providing a composition and associating the coating composition with the structure. The composition is formed from a polymer component having dispersed therein beads formed from colloidal clay and adsorbed pest control agent. Colloidal clays (e.g., nano-clays) adsorb more pest control agent that do standard clays and releases the adsorbed pest control agent at a slower rate than do standard clays.

The invention relates to composite hydrogel and a preparation method thereof. The composite hydrogel is hydrogel which takes a three-dimensional fiber network material as a skeleton, that is, the hydrogel comprises a three-dimensional fiber network material, wherein the three-dimensional fiber network material is a network structured material made of tingled fiber. As the three-dimensional fiber network material of the composite hydrogel is directly combined with the hydrogel, the purpose of strengthening the hydrogel can be achieved without changing the structure of the hydrogel self. Compared with a loosened and porous structure inside the hydrogel, the three-dimensional fiber network structure is dense, and medicines and active factors in the hydrogel can be densely coated, so that a slow-release effect can be achieved, the release velocities of the medicines can be reduced, and the utilization rates of the medicines can be increased.

The invention relates to a sustained-release granular formulation for preventing and treating crop diseases and insect pests and a preparation method thereof. The pesticide sustained-release granular formulation comprises bentonite, an organic modifier, pesticide active ingredients, an inert filler and a binding agent, and is prepared by the preparation method comprising the steps of: (1) with the bentonite as a basic material, modifying the bentonite by the organic modifier to obtain organic bentonite; (2) loading the pesticide active ingredients on the organic bentonite to prepare medicine-carrying organic bentonite; and (3) mixing the medicine-carrying organic bentonite, the inert filler and the binding agent proportionally, and pelleting to obtain the sustained-release granular formulation. The preparation method of the sustained-release granular formulation, provided by the invention, not only overcomes the defect of low pesticide loading rate of the natural bentonite, but also realizes the controlled release of the pesticide by adjusting a chemical structure and the amount of the modifier, so that the sustained-release granular formulation is coincident with an occurrence rule of the plant diseases and insect pests, and the pesticide sustained-release granular formulation is used safely, reasonably, economically and effectively.

A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.

In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released in a prolonged manner at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released whilst a subject is sleeping, shortly before waking and continues to administer the drug during the early waking hours. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for a delayed, followed by a prolonged release of drug.

The invention relates to a microsphere water retention agent and preparation method with polyacrylic acid / attapulgite clay / humic acid, which is characterized in that acrylic acid, attapulgite clay and humic acid are used as main raw materials to produce the microsphere water retention agent with the function of slow release fertilizer through the processes of granulation, absorption, copolymerization, crosslinking, washing and drying. The multiplication factor of the water retention agent for absorbing the distilled water is 300 to 500 g / g. The invention has the advantages that the water retention agent can keep a plurality of advantages of common fertilizer in farming and can also slowly release nutrient to field crops, thus, the product has potential application prospects.

The invention discloses special slow release fertilizer for grapes. The fertilizer is prepared from, by weight, 100-120 parts of brewery wastewater, 50-80 parts of sugar refinery wastewater, 20-30 parts of vinasse, 80-90 parts of corncob powder, 50-60 parts of peanut hull powder, 30-40 parts of wheat bran, 60-90 parts of residues of oil manufacture, 50-60 parts of smooth vetches, 70-80 parts of sweet clovers, 60-80 parts of azoila imbricata, 5-8 parts of zeolite powder, 10-12 parts of activated carbon, 30-50 parts of horse manure, 20-40 parts of goat manure, 35-45 parts of chicken manure, 20-30 parts of silkworm excrement, 1.2-2 parts of superphosphate, 0.08-0.1 part of borax, 3-5 parts of complex enzyme preparations, 8-12 parts of complex fermentation microbial agent, 5-10 parts of nanocarbon, 30-40 parts of residues from a biogas digester, 20-30 parts of humate, 15-35 parts of roots of soybeans, 20-25 parts of dregs of a decoction, 16-25 parts of straw powder and the like. The invention further discloses a preparation method of the special slow release fertilizer for grapes.

Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

The osmotic devices of the present invention include a single core comprising a salt of a drug and an osmotic salt, wherein the drug salt and the osmotic salt have a common ion. The release rate of the active drug is reduced, and the release profile of the active drug is modified, from a first order release profile to a zero order, pseudo-zero order, or sigmoidal release profile, by increasing the amount of the sodium chloride in the core of the device. In one embodiment the sodium chloride is used to modify a controlled release profile to a delayed and controlled release profile.

The invention relates to a method for producing coated acidifier granules for a feed. The method comprises the following steps of: atomizing and adsorbing lactic acid; placing a proper amount of carbon black into a one-step granulator; spraying the lactic acid into the granulator for atomization and adsorption by a peristaltic pump; crushing citric acid, fumaric acid and malic acid and screening the materials with a 60-mesh sieve; mixing the materials and a lactic acid adsorbate; and adding a coating agent into a high-efficiency mixer granulator for coating and granulating to obtain the finished product. The acidifier prepared by the method is combination of organic acids, so that the releasing of the acidifier can be slowed down. The granules are coated with protective films, so that thecontact with an alkaline substance in the feed is reduced and the acidification effect of the granules is enhanced. The organic acid and other antibacterial substances can be produced by promoting the growth and mass propagation of beneficial bacteria such as lactobacillus and the like, so that the pH value in the gastrointestinal tract is further reduced and the growth of harmful bacteria is suppressed. The organic acid gradually released in the alimentary canal has a complexing effect; and the absorption in small intestine can be promoted after the organic acid is complexed with trace elements in the feed.

The invention relates to a method for preparing microencapsulation glucose oxidase, which belongs to the technical field of food processing. The invention aims at improving the quality of flour to researche a method for preparing new flour modifying agent, namely, the microencapsulation glucose oxidase, chitose-calcium alginate-glucose oxidase microcapsule which is obtained through the method is copolymer hydrogel which is obtained through double cross-linking, both amidogen and carboxyl group are fixed, and the whole system is a reticular formation. The method controls the catalytic speed of the microencapsulation glucose oxidase through adjusting the molecular weight and the degree of deacetylation of microcapsule exine chitose, thereby the method is beneficial for oxidation-linking of gluten protein and for increasing the quality of the flour and flour products, simultaneously, the glucose oxidase after microencapsulation avoids the contact between enzyme and the flour and improves storage and the stability, and the microencapsulation glucose oxidase is excellent flour modifying agent and accords with practical production and application. The process of the method is simple, safe and convenient, and accords with the requirements of environmental protection and utility.

The present invention relates to an improved antifungal composition, to a process for preparing it and to its use as a preservative.

The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally. More particularly, the invention is concerned with the use of such compounds, wherein the compound is delivered to the site of action in the patient to be treated in two or more doses.

A preparation method of hydrophobically modified sodium alginate gel belongs to the technical field of biomedical materials. The invention prepares a star polymer which contains inorganic matter and hydrophobic polymers; the prepared polymer is ultrasonically dispersed into a sodium alginate solution by ultrasonic dispersion technology; and a calcium alginate hybrid gel with both hydrophobicity and hydrophilicity is prepared by a dropping liquid method. A hydrophobic drug of ibuprofen has a high embedding rate of up to above 90% in the gel, and has a good sustained release effect with a drug release amount of the first 2 hours being reduced by nearly 45%; the problem is overcome that since sodium alginate has strong hydrophilicity and the loading amount for hydrophobic drugs is less, burst release is easy to occur in an early stage of drug release. The drug-loaded microsphere of the invention is convenient for preparation, controllable in particle size (about 1 mm), good in biocompatibility, has no toxicity to human body, and has potential application value for being used as a drug carrier.

The invention relates to a flower planting nutrient soil and a production method thereof. The method comprises the steps of 1) mixing municipal domestic sludge, food waste residues and yeast liquid waste according to the proportion of (75-85):(15-25):(0.5-1.5), and stirring uniformly; 2), adding a certain amount of active microorganisms into raw materials in the step 1), and conducting continuous fermentation for 15-18 days; 3), placing the raw materials after fermentation into a decomposition bin until the temperature is lowered to the room temperature, and obtaining the flower planting nutrient soil; and detecting N, P and K of the decomposed nutrient soil and the content of organic matters and adjusting the nutrient soil by adding a large amount of elements such as N, P and K. According to the production method of the flower planting nutrient soil, the sources of the raw materials are rich, the production period is short, the cost is low, and the produced flower planting nutrient soil is nutritious and capable of improving the survival of plantlets, prolonging the flower season and improving the quality of the flower.

The invention provides a display panel, a manufacturing method thereof and a display device, relates to the technical field of the display, and aims to solve the problem that in the use process of a display product, water molecules in a flat layer escape and erode a light-emitting functional layer, so that the service life of the display product is shortened. The display panel comprises a substrate and a plurality of pixel units arranged on the substrate, the plurality of pixel units are distributed in an array, and each pixel unit comprises a plurality of sub-pixels; each sub-pixel comprisesa sub-pixel driving circuit, a flat layer and an anode pattern which are sequentially stacked; the anode patterns in at least part of the sub-pixels comprise middle parts and edge parts surrounding the middle parts; the surfaces, back to the substrate, of the flat layers are provided with grooves, the orthographic projections of the grooves on the substrate surrounds the orthographic projections of the middle parts on the substrate, and the orthographic projections of at least parts of the edge parts on the substrate are located in the orthographic projections of the grooves on the substrate.The display panel provided by the invention is used for displaying pictures.

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs / compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

The invention provides camptothecin-adriamycin prodrug. A structural formula of the prodrug is shown as a formula (I), wherein R1 is camptothecin or derivative group thereof, R2 is one of -CH2- or -O-, R3 is one of -CH2- or -O-, X is one of S or -CH2-, and n1 and n2 are numbers of repeated units, and are integers from 0 to 10. The prodrug can be easily wrapped by amphiphilic polymer to form nanoparticles. The nanoparticles are high in drug carrying efficiency and drug carrying capacity and capable of quickly releasing unmodified camptothecin and adriamycin in the presence of glutathione, and the nanoparticles can be effectively taken in by tumor cells to kill the same. The invention further provides a preparation method of the prodrug, a preparation of the prodrug and application of the prodrug in preparing cancer treating drug.

The invention provides a fermentation method for preparing L-lysine products, which comprises the steps: an L-lysine culture solution is produced through three-level culture fermentation, and fine particles are coated by using fractional palm fat after spray drying. In addition, the invention also provides products prepared by the method, and the retention rate of L-lysine is larger than 15% within 24 hours.