The invention belongs to the technical field of biological medicine, and particularly relates to a triazolone-thiadiazole compound capable of promoting regeneration of myocardial cells and a drug use of the triazolone-thiadiazole compound. The compound comprises two 3,6-bis-substituted triazolone-thiadiazole derivatives or salts thereof: a chemical structural formula is C14H15N5S, an average molecular weight is 285.37 g / Mol, and the name is 6-cyclohexyl-3-(pyridine-4-yl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazole; a chemical structural formula is C13H13N5S, an average molecular weight is 271.37g / mol, and the name is 6-cyclopentyl-3-(pyridine-4-yl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazole. An experiment result shows that the small molecular compound is a Wnt / beta-catenin signal channel inhibitor and can effectively promote the proliferation of the myocardial cells and / or restoring the damaged myocardial cells; and an integral-mode animal model experiment shows that the triazolone-thiadiazole compound is hardly toxic, has a further research and application prospect, and can be used for preparing drugs for treating and preventing the diseases such as myocardial infarction, arrhythmia, ischemic cardiomyopathy, cardiac failure and the like.