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Pharmaceutical composition for preventing and treating myocardial ischemia as well as preparation and application thereof

A technology of myocardial ischemia and composition, applied in the directions of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve the problems of unsatisfactory treatment effect, large side effects, aggravated symptoms, etc., and achieve clear prevention and treatment effects and safety. High, clear therapeutic effect

Active Publication Date: 2017-05-10
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned drug treatments often only have the effect of relieving symptoms, and the side effects are relatively large, and even aggravate the corresponding symptoms. Therefore, the treatment effect is not ideal

Method used

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  • Pharmaceutical composition for preventing and treating myocardial ischemia as well as preparation and application thereof
  • Pharmaceutical composition for preventing and treating myocardial ischemia as well as preparation and application thereof
  • Pharmaceutical composition for preventing and treating myocardial ischemia as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1, the capsule of preventing and treating myocardial ischemia

[0066] The capsules have the following composition:

[0067] 4 parts of sphingosine-1-phosphate;

[0068] Naproxen 4 parts;

[0069] 2 parts of dicoumarin;

[0070] 89 parts of microcrystalline cellulose;

[0071] Magnesium stearate 1 part.

[0072] Prepare as follows:

[0073] a) taking by weighing lubricant, sphingosine-1-phosphate, naproxen, anticoagulant and filler except the gelatin capsule shell according to the proportioning, mixing uniformly, pulverizing, passing through a 100-mesh sieve to obtain mixed powder, and setting aside;

[0074] b) add a lubricant to the mixed powder prepared in step a and stir evenly to obtain a filling powder, which is set aside;

[0075] c) Filling the filling powder prepared in step b with the gelatin capsule shell, to obtain.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating myocardial ischemia as well as a preparation and an application thereof. The pharmaceutical composition employs sphingosine-1-phosphate, naproxen and an anticoagulant medicine as medicinal active components, wherein the anticoagulant medicine is selected from heparin, dicoumarol, acetonyl benzyl hydroxycoumarin, aspirin and the like, and preferably dicoumarol. Synergistically interacted multi-path between medicinal active components of the pharmaceutical composition perform effects for prevention and treatment of myocardial ischemia, and improve myocardial ischemic electrocardiogram change and anticoagulation. The pharmaceutical composition can be taken orally or applied parenterally, in order to effectively prevent and treat myocardial ischemia, prevent and alleviate angina pectoris, myocardial infarction or ischemic cardiomyopathy, and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating myocardial ischemia, a preparation method and application thereof. Background technique [0002] In modern society, due to the accelerated pace of life, excessive drinking, excessive nutritional intake, lack of necessary exercise and environmental pollution, cardiovascular and cerebrovascular diseases have become one of the common diseases that threaten human health, with high prevalence and high disability. According to statistics, cardiovascular and cerebrovascular diseases have become the leading cause of death in the world. Myocardial ischemia is one of the common diseases of cardiovascular and cerebrovascular diseases. It generally refers to the pathological state and clinical symptoms that the heart’s oxygen supply is reduced and the myocardial energy metabolism is abnormal due to the reduction of blood perfusion i...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/661A61K31/192A61K31/37A61K9/48A61P9/10
CPCA61K9/4866A61K31/192A61K31/37A61K31/661A61K45/06A61K2300/00
Inventor 徐凤王晓楠商华刘晓欣毛艺纯宋岩涛
Owner MUDANJIANG MEDICAL UNIV
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