23results about How to "Stable and controllable quality" patented technology

The invention discloses an oral solid preparation melogabalin besylate tablet containing an excellent stabilizer and a preparation method thereof. A tablet core contains but is not limited to melogabalin besylate, one or two or more filling agents, one or two or more disintegrating agents, one or two or more flow aids and various stabilizer compositions. According to the invention, the optimal stabilizer composition is selected through investigation, so that the growth of main degradation impurities and oxidation impurities is effectively controlled, the product stability is improved, and the tablets with stable quality are obtained. The product is rapidly dissolved out, the dissolution uniformity is good, the intermediate tabletting is smooth, the compressibility is good, and the prepared finished product is good in appearance, free of small holes and stable and controllable in quality.

The invention discloses a method and a device for producing high-oxygen-content titanium sponge, and the method and the device are characterized in that a vanadium oxychloride solution is added into a refined titanium tetrachloride storage tank filled with the refined titanium tetrachloride solution, the vanadium oxychloride solution is used as a reducing agent and is added into a reduction reactor for reaction, and a titanium sponge target product is obtained. According to the method disclosed by the invention, titanium oxychloride can be subjected to decomposition reaction under a high-temperature condition to generate titanium tetrachloride and titanium oxide, and titanium oxychloride has unique properties in the aspects of structure, chemical reactivity, solubility and the like and has relatively good solubility in titanium tetrachloride; according to the method, the titanium oxychloride solution is selected as an oxygen producer to be mixed into the titanium tetrachloride solution, titanium oxide generated by decomposition is uniformly distributed in the sponge titanium, the oxygen element component in the sponge titanium raw material is uniform from the source, and the high-oxygen-content sponge titanium product with the uniform oxygen element component is finally produced; and the quality of raw materials for titanium ingot and titanium alloy smelting is stable and controllable.

The invention relates to the technical field of material crushers, and discloses a four-shaft integrated ton bag caked material crusher which comprises a rack, a crushing box is fixedly connected to the rack in a penetrating mode, a bag breaking device is arranged in the crushing box, a plurality of crushing shafts are rotatably connected to the crushing box in a penetrating mode, and a fixing shaft is arranged between every two adjacent crushing shafts. A filter screen is arranged in the crushing box, a driving assembly is fixedly connected to one side of the rack, and an overhauling platform is fixedly connected to the rack. By means of the integrated design, manual bag breaking and material transferring links are omitted, the four-shaft meshing breaking efficiency is improved by 50% or above compared with double-shaft equipment, the material handling capacity of a ton bag can reach 5-35 t / h, and the large-scale industrial production requirement is met.

The application discloses a kind of bundled cable forming tool and method, belong to cable forming technical field, including for installing the end of wire to be wound into bundle installation part, installation part includes coaxial and opposite arrangement first installation part and second installation part, second installation part can be coaxially rotated relative to first installation part, to wind several wires into cable bundle of twisted shape, or let already wound cable bundle of twisted shape keep within the range of specified spiral winding tightness;It also includes a moving assembly, moving assembly is connected with two installation parts, to keep synchronous autorotation while with two installation parts synchronous linear movement;Adhesive tape wheel is provided on one side of cable bundle, one end of adhesive tape on adhesive tape wheel can be wound in one end of cable bundle, so that cable bundle is spirally wound together while linearly moving on one side, autorotation on one side.The application can efficiently bundle cable forming processing, and cable forming quality is stable and controllable.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

The invention discloses a traditional Chinese medicine composition for treating diabetic skin itch and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from angelica sinensis, astragalus membranaceus, radix paeoniae rubra, cortex dictamni, rehmannia, ligusticum wallichii, scalded peach kernels, safflower carthamus, fried tribulus terrestris, divaricate saposhnikovia roots and cicada slough according to a specific weight ratio. On the basis of a classic famous formula of the Chinese angelica potion, the Chinese angelica potion is innovatively prepared aiming at the core pathogenesis of qi deficiency, blood stasis, damp-heat and wind-dryness of diabetic skin itch. The radix paeoniae rubra and the radix paeoniae alba are used for enhancing the effects of cooling blood and dissipating blood stasis; peach kernel and safflower are added to strengthen blood circulation activation and collateral dredging; cortex dictamni is added to enhance dampness eliminating and detoxification; cicada slough and herba schizonepetae are used for enhancing wind dispelling and heat clearing, and the nature is Polygonum multiflorum and liquorice are removed, so that the safety is improved. The whole formula has the effects of tonifying qi, promoting blood circulation, eliminating dampness, detoxifying, dispelling wind and moistening dryness. The invention also provides a preparation method of the composition. The composition can be used for preparing medicines for treating skin diseases such as diabetic skin itch and eczema, and is remarkable in curative effect and high in safety.

The invention provides a recombinant anti-BCMA and CD3 fully humanized bispecific antibody injection preparation and a preparation method thereof. The injection preparation is prepared from 1.0 mg / mL to 10 mg / mL of recombinant anti-BCMA and CD3 full human bispecific antibody, 0.02% to 0.04% (w / w) of surfactant, 40 mmol / L to 240 mmol / L of stabilizer, a pH regulator and a solvent, and the pH of the injection preparation is 4.5 to 8.0. The recombinant anti-BCMA and CD3 fully humanized bispecific antibody injection preparation is a liquid which is free of preservatives, colorless to faint yellow and clarified to microemulsion, the physical and chemical stability of the double antibodies can still be maintained within a long time, and the storage life is effectively prolonged.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

The utility model discloses a foundation pit side slope support structure, solved the technical problem of poor deformation resistance, internal waterlogging of side slope in the prior art. Foundation pit side slope support structure, including reinforced mesh, grouting subassembly, surface layer subassembly, the grouting subassembly includes the grouting pipe of interval arrangement, the surface layer subassembly includes the recyclable surface layer, still include: reinforcing component for connecting grouting pipe and reinforced mesh, the reinforcing component includes the first reinforcing bar of being located the upper and lower sides of grouting pipe along the side slope trend arrangement and the second reinforcing bar of being located the left and right sides of grouting pipe along the side slope slope arrangement, the reinforcing component, reinforced mesh and grouting pipe weld, drainage subassembly for discharging the moisture in the side slope, the drainage subassembly includes the drainage pipe of interval arrangement, the recyclable surface layer is equipped with the through -hole of adapting with drainage pipe, sealing component for the sealing of the junction of through -hole and drainage pipe, the sealing component includes the hoop piece of adapting with the outer wall of drainage pipe.

The invention relates to the technical field of antibody conjugate drugs, in particular to a preparation method of an ochratoxin A monoclonal antibody conjugate, which comprises the following steps: step S01, acquiring preparation process data and actual measurement control parameter data in a preparation process every preset time interval, and acquiring a real-time preparation process coefficient based on the preparation process data; and step S02, obtaining a preparation duration ratio Q / M, inputting the composition proportion data of the preparation raw materials, the real-time preparation parameters and the preparation duration ratio Q / M into a pre-constructed first machine learning model for predicting a preparation process coefficient, predicting the preparation process coefficient at the moment P, and recording the preparation process coefficient as the predicted preparation process coefficient. According to the preparation method of the ochratoxin A monoclonal antibody conjugate, provided by the invention, real-time self-adaptive adjustment is carried out on preparation parameters in the preparation process according to a preparation process coefficient in the preparation process, so that the condition of excessive coupling or insufficient coupling when the antibody conjugate is prepared within a set time is avoided.

The invention discloses an instant-use universal NK cell freezing preparation as well as a preparation method and a use method thereof. Umbilical cord blood is separated to obtain mononuclear cells, and a seed bank of NK cells is obtained through in-vitro induction culture and cryopreserved. The cells in the revived seed bank are subjected to secondary large-scale multiplication culture, an NK cell preparation with the purity larger than 90% is obtained, residues in a culture system are removed after multiple times of cleaning, then the cells are resuspended with human serum albumin, a cryopreservation protection solution is added, subpackaging and cryopreservation are conducted, an NK cell cryopreservation preparation bank is obtained, the total amount of cryopreserved cells can reach 1011 orders of magnitude, and the cryopreserved cells can reach 1011 orders of magnitude. And complete cell activity, purity, microorganisms, endotoxin and the like are detected on the stock cells. When required, the NK cell frozen preparation is recovered, the ready-to-use NK cell preparation with high purity and excellent quality can be obtained, the quality of the cell preparation is uniform, and all detection results are perfect. According to the freezing preparation method of the NK cell preparation, required NK cells can be more conveniently and quickly provided for clinical research and disease patients.

The invention discloses a separation process and application of novel dipeptide Flolutsin C with anti-liver injury activity in Chaetotrichum luteo-virens. The specific method comprises the following seven steps: extraction, QuikSep PS medium-pressure chromatography coarse separation, anti-liver injury active component preliminary screening, Megress C18 reversed-phase preparation column preparation, anti-liver injury active component re-screening, ACE Excel C18AR reversed-phase preparation column preparation and anti-liver injury in-vitro activity evaluation. A solvent and a separation material used in the process can be recycled, so that relatively low separation and preparation cost is ensured, and high-pressure preparative chromatographic separation can ensure that the purity of the product is greater than 95%; the activity screening method is simple, and the quality is stable and controllable; the experimental operation is simple, the cost is low, the quality is controllable, and the result is visual and easy to judge; the obtained anti-liver-injury active compound can be used for preparing anti-non-alcoholic fatty liver disease drugs. The preparation process provided by the invention can realize large-scale production.

The invention discloses a separation process and application of novel dipeptide Flolutsin B with anti-liver injury activity in Chaetotrichum luteo-virens. The specific method comprises the following seven steps: extraction, QuikSep PS medium-pressure chromatography coarse separation, anti-liver injury active component preliminary screening, Megress C18 reversed-phase preparation column preparation, anti-liver injury active component re-screening, ACE Excel C18AR reversed-phase preparation column preparation and anti-liver injury in-vitro activity evaluation. A solvent and a separation material used in the process can be recycled, so that relatively low separation and preparation cost is ensured, and high-pressure preparative chromatographic separation can ensure that the purity of the product is greater than 95%; the activity screening method is simple, and the quality is stable and controllable; the experimental operation is simple, the cost is low, the quality is controllable, and the result is visual and easy to judge; the obtained anti-liver-injury active compound can be used for preparing anti-non-alcoholic fatty liver disease drugs. The preparation process provided by the invention can realize large-scale production.

This invention discloses a method for preparing pimozide, which involves acylation of 4-isobutoxybenzylamine acetate with carbonyl diimidazole under alkaline conditions, followed by condensation reaction with N-(4-fluorobenzyl)-1-methylpiperidine-4-amine in a reducing solvent, and then post-treatment to obtain the product. The method uses stable 4-isobutoxybenzylamine acetate as raw material, which avoids the introduction of impurities by 4-isobutoxybenzylamine. Combined with the condensation reaction under a reducing solvent, the generation of impurities can be effectively avoided. The product has stable quality, is simple to operate, has low production cost, and is suitable for industrial production.

The invention relates to the field of medicine crystal forms, in particular to a novel crystal form of a compound shown in the formula I and a preparation method of the novel crystal form, and the crystal form K of the compound shown in the formula I has the comprehensive advantages of excellent physical stability and chemical stability, high solubility and bioavailability, good fluidity and low hygroscopicity and can be developed as a medicinal crystal form. In addition, the crystal form K of the compound shown in the formula I is mild in preparation condition, simple to operate, good in process reproducibility, high in purity and suitable for industrial production. # imgabs0 #

The utility model belongs to the technical field of polyester production, and particularly relates to a DOTP continuous production device. Comprising a slurry preparation tank, the slurry preparation tank is connected with a slurry delivery pump through a slurry intermediate tank, the slurry delivery pump is connected with an esterification process tower through an esterification reaction kettle, the esterification process tower is respectively connected with an esterification condenser and an esterification condensate collecting tank, and the esterification condenser is also connected with the esterification condensate collecting tank; the primary esterification reaction kettle is also connected with a secondary esterification process tower through a secondary esterification reaction kettle, the secondary esterification process tower is respectively connected with a secondary esterification condensate collecting tank and a secondary esterification condenser, and the secondary esterification condensate collecting tank is also connected with the secondary esterification condenser. The device is convenient and efficient in production and low in energy consumption, and the production process is easy to control.

The invention belongs to the technical field of health food and traditional Chinese medicine health preservation, and particularly relates to traditional Chinese medicine composite meal replacement powder with a metabolic regulation function and a production technology thereof.The meal replacement powder is prepared from, by weight, 35%-55% of traditional Chinese medicine conditioning components and 45%-65% of modern functional raw materials, and 0.15%-0.7% of auxiliary components can be selectively added; the traditional Chinese medicine conditioning components comprise 13 medicinal and edible raw materials such as ginseng and poria cocos, the modern functional raw materials comprise purified konjaku flour and skimmed whey protein, the calorie of the product is less than or equal to 150kcal / 100g, the dietary fiber is greater than or equal to 15g / 100g, and the protein is greater than or equal to 12g / 100g; the production technology comprises the steps of raw material pretreatment, graded mixing, low-temperature sterilization and sterile packaging, low-temperature drying and superfine grinding are adopted in the pretreatment, graded stirring is adopted in the mixing, and ultrahigh-temperature instant sterilization is adopted in the sterilization. The defects that existing meal replacement powder is prone to metabolic disorder and body weight rebound are overcome.

The invention discloses a machining method for a forging half-and-half axial flow casing. The machining method comprises the following steps that S1, a cylindrical forging blank is obtained through forging; s2, rough machining is conducted on the forge piece blank; s3, the outer contour of the large end and the outer contour of the small end are sequentially machined to the design size through eccentric milling, the allowance of 1-2 mm is reserved on the boss end face of the forged piece blank, and the allowance of 1-2 mm is reserved on the longitudinal binding face of the forged piece blank; s4, the forging blank is subjected to heat treatment; s5, a runner and an inner groove of the forging blank are subjected to rough machining, the allowance of 1-2 mm is reserved for the runner, and the allowance of 1-2 mm is reserved for the inner groove; s6, the forging blank is linearly cut into a left half casing and a right half casing; s7, the longitudinal binding face is machined to the designed size, then the end face of the boss, the flow channel and the inner groove are machined to the designed size, and the forged half-and-half axial flow case is obtained; compared with the prior art, deformation is small, quality is stable and controllable, the design pattern requirement can be met, the machining period is short, and the new machine development period is greatly shortened.

The present invention relates to a pharmaceutical composition for reducing the harm of ionizing radiation, and belongs to the technical field of traditional Chinese medicine. The pharmaceutical composition is composed of the following components by weight: 570-630 parts of Radix Rehmanniae Preparata, 4-14 parts of crystal orchioides, 17-27 parts of nesitose, 60-80 parts of Radix Ophiopogonis polysaccharides, 75-95 parts of Poria cocos polysaccharides, 1-5 parts of pachymic acid, and 1-3 parts of schisandrae. The pharmaceutical composition of the present invention has the advantages that it can promote the increase of peripheral blood leukocyte count of mice injured by ionizing radiation, reduce the number of micronuclei of bone marrow cells, help the body repair the damage caused by ionizing radiation, and has the effect of reducing the harm of ionizing radiation.

The invention belongs to the technical field of inorganic materials, and particularly discloses a production method of high-quality chemical gypsum, which comprises the following steps: mixing and reacting a material 1 and a material 2, enabling turbid liquid at the upper part of a reactor to enter a clarification section, and taking clarified liquid as a salt and alkali making raw material or mining water; slurry at the bottom of the reactor enters a gypsum slurry collecting system, the gypsum slurry is subjected to primary separation through a cyclone, the top of the gypsum slurry flows back to a reaction barrel to participate in recycling, and the bottom of the gypsum slurry flows to a primary slurry dewatering washing machine; the treated filter material enters a pulping and washing barrel, the washed slurry enters a secondary dewatering washing machine, and the filter material is directly packaged into a product after being moderately refined, or is packaged into a product after being crushed and dried. The gypsum prepared by the process method is high in purity, excellent in whiteness and stable and controllable in quality.

This invention discloses a composite bridge pier suitable for high-altitude and cold regions, comprising an inner core and an outer ring. The outer ring encloses the inner core and is made of ultra-high-strength concrete. The inner core is cast on-site from ordinary concrete, while the outer ring is prefabricated in a factory. This composite bridge pier uses only the more expensive ultra-high-strength concrete in the outer ring, which meets the requirements for freeze-thaw resistance while reducing the amount of ultra-high-strength concrete used, thus balancing project costs. Furthermore, the prefabricated outer ring can be directly used as a formwork for the bridge pier on-site, eliminating the material costs and installation / disassembly costs associated with traditional formwork construction.

The invention discloses a skirt-edge-free composite material panel protection shell and a process thereof, and relates to the technical field of electronic product protection shell production, and the panel protection shell is composed of an appearance material layer, a composite material plate and a lining material layer; the preparation process of the flat plate protection shell comprises two parts of preparation of a composite material plate and veneer pasting of the plate, and the preparation of the composite material plate further comprises material lamination, molding and curing and demolding CNC trimming; and the board veneer gluing comprises the steps of primer brushing, edge covering and forming and lining microfiber hot pasting. Compared with a traditional process needing eight steps, the process only needs six steps, the technological process is short, efficiency is high, materials do not need to be transferred many times in the whole process, and therefore the positioning difficulty is low, the size precision of products is improved, the quality of the products produced in multiple batches is stable and controllable, and meanwhile due to the fact that transferring many times is not needed, the production cost is reduced. Therefore, manpower is saved, the quality problem in the machining process is solved, and machining time is saved.

The invention provides a biological wax tobacco bud inhibition compound formula optimization method, and belongs to the technical field of biological wax tobacco bud inhibition, and the biological wax tobacco bud inhibition compound formula optimization method comprises the following steps: selecting a plurality of biological wax raw materials, and preparing biological wax mixtures with different proportions; mixing the biological wax mixture with tobacco bud inhibition active ingredients according to a preset proportion to obtain an initial formula; carrying out physical and chemical property testing on the initial formula; a tobacco sample is coated with the initial formula through an accurate sprayer according to different application amounts, and the bud inhibition effect is evaluated; according to the physical and chemical performance test result and the bud inhibition effect evaluation result, establishing a formula scoring model; designing a plurality of formula combinations by using an orthogonal test method, and repeating the steps to obtain scores of each formula; the technical problem that certain potential environmental and food safety hazards exist in an existing tobacco bud inhibition technology can be solved.