Sodium-potassium citrate chewing tablet and preparation method thereof
A technology of potassium citrate and sodium citrate, applied in the field of pharmacy, can solve problems such as no research report on potassium and sodium citrate chewable tablets, no product listing, etc., and achieves stable and controllable quality, reasonable prescription design, The effect of treating gout
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Embodiment 1
[0026] prescription:
[0027] components mass (g) Mass percentage (%) potassium citrate 231.5 33.07 sodium citrate 195.0 27.86 Mannitol 203.0 29.00 hypromellose 0.6 0.09 Magnesium stearate 7.0 1.00 Micropowder silica gel 3.5 0.50 citric acid 30.0 4.29 Orange Oil Flavor 1.4 0.20 Hydroxypropyl Cellulose 28.0 4.00 gross weight 700 100
[0028] Preparation:
[0029] a. Grind all components in the prescription except peppermint oil essence into fine powders with a fineness above 80 mesh, and dry at 50°C for 2 hours; dissolve the hypromellose in the prescribed amount with water to make Solution; the hydroxypropyl cellulose of recipe quantity is dissolved with ethanol and made mass fraction is the solution of 15%;
[0030] b. Take the prescribed amount of potassium citrate, sodium citrate, mannitol and citric acid, mix them evenly, make a soft material with a 2% hypromellose solution, granulate...
Embodiment 2
[0035] prescription:
[0036] components mass (g) Mass percentage (%) potassium citrate 231.5 33.07 sodium citrate 195.0 27.86 Mannitol 208.6 30.23 hypromellose 0.9 0.13 Magnesium stearate 7.0 1.00 Micropowder silica gel 2.5 0.36 citric acid 25.0 3.57 stevia 0.7 0.10 peppermint oil flavor 0.8 0.11 Methylcellulose 25.0 3.57 gross weight 700 100
[0037] Preparation:
[0038] a. Grind all components in the prescription except sweet orange oil essence into fine powder with a fineness above 80 mesh, and dry at 50°C for 2 hours; dissolve the hypromellose in the prescription amount with water to make the mass fraction 3% The solution; The methyl cellulose of recipe quantity is dissolved with ethanol and made mass fraction is the solution of 15%;
[0039] b. Take the prescribed amount of potassium citrate, sodium citrate, mannitol, citric acid and stevioside, mix them evenly, use a hypro...
Embodiment 3
[0044] prescription:
[0045] components mass (g) Mass percentage (%) potassium citrate 231.5 33.07 sodium citrate 195.0 27.86 Mannitol 150.0 21.43 Sorbitol 68.0 9.71 Povidone K30 1.5 0.21 Magnesium stearate 7.0 1.00 Micropowder silica gel 2.0 0.29 citric acid 21.0 3.00 sodium saccharin 1.6 0.23 Green Apple Powder Flavor 1.4 0.20 hypromellose 21.0 3.00 gross weight 700 100
[0046] Preparation Process:
[0047] a. Grind each component in the prescription into fine powder with a fineness of 80 mesh or more, and dry at 50°C for 2 hours; dissolve the prescribed amount of povidone K30 in water to make a solution with a mass fraction of 3%; add hypromellose The element is dissolved in ethanol to make a solution with a mass fraction of 15%;
[0048] b. Take the prescribed amount of potassium citrate, sodium citrate, mannitol, sorbitol and sodium saccharin, mix them evenly, make a...
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