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167results about How to "Reasonable prescription design" patented technology

Sodium-potassium citrate chewing tablet and preparation method thereof

The invention provide a sodium-potassium citrate chewing tablet, of which the prescription is composed of the following components by mass percent: 33.0-33.1% of potassium citrate, 27.8-27.9% of sodium citrate, 28-32% of filling agent, 0.05-0.3% of adhesive, 1-1.5% of lubricant, 3-5% of flavoring agent, 0.1-0.3% of aromatizer and 3-4% of moistureproof film coating agent, wherein the filling agentis mannitol or a mixture of mannitol and sorbitol or xylitol; the adhesive is hydroxypropyl methylcellulose or polyvidone K30; the lubricant is magnesium stearate or a mixture of magnesium stearate and micropowder silica gel; the flavoring agent is citric acid or a mixture of citric acid and sodium saccharin, aspartame or steviosin; and the aromatizer is pharmaceutically acceptable essence. The invention also provides a preparation method of the sodium-potassium citrate chewing tablet. The preparation method is simple and convenient to operate, low in cost and suitable for industrial production. The obtained tablet has stable and controllable quality, fresh and cool mouthfeel, sourness and sweetness in taste, mint fragrance or fruit fragrance, smooth and beautiful surface, uniform color, moderate hardness and rapid dissolution, and has good application prospects in treatment of gout and hyperuricemia as well as improvement of children and adult in vivo acidosis symptom and other aspects.
Owner:SOUTHWEST UNIV

Ibuprofen diphenhydramine orally disintegrating tablet and preparation method thereof

The invention provides an ibuprofen diphenhydramine orally disintegrating tablet, comprising the following ingredients, by weight: 40% of ibuprofen, 5% of diphenhydramine hydrochloride or 7.6% of diphenhydramine citrate, 35-40% of filler, 6-12% of disintegrating agent, 0-5% of effervescent disintegrant, 1-2% of adhesive, 1-2.5% of surfactant, 1-1.5% of lubricant, 0.7-2.5% of sweetener and 0-0.5% of perfume. The filler is at least two from microcrystalline cellulose, mannitol and pregelatinized starch; the disintegrating agent is at least one from crospovidone, cross linked sodium carboxymethyl cellulose and sodium carboxymethyl starch; the effervescent disintegrant comprises citric acid and sodium bicarbonate in a mass ratio of 1-2:1; the adhesive is hydroxypropyl methylcellulose; the surfactant is sodium dodecyl sulfate; the lubricant is eleaostearic acid or magnesium stearate and colloid silica; the sweetener is aspartame and / or steviosin; and the perfume is medicinal essence. Theinvention also provides a preparation method of the orally disintegrating tablet and is simply operated, at low cost and suitable for industrialized production; and the obtained product satisfies quality requirement of an orally disintegrating tablet and has beautiful appearance, good mouthfeel and stable quality.
Owner:SOUTHWEST UNIVERSITY

Traditional Chinese medicine composition for treating chronic virulent hepatitis b and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating chronic virulent hepatitis b and a preparation method thereof, and belongs to the technical field of Chinese patent medicine for treating hepatitis b. According to the technical scheme, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 55-72 parts of astragalus membranaceus, 58-75 parts of salvia miltiorrhiza, 40-56 parts of glossy privet fruit, 40-58 parts of Chinese wolfberry, 40-58 parts of rhizoma smilacis glabrae, 30-52 parts of radix bupleuri, 32-48 parts of poria cocos, 30-52 parts of schisandra chinensis, 30-58 parts of codonopsis pilosula, 28-56 parts of pinellia ternate, 28-58 parts of Chinese yam, 30-46 parts of isatis roots, 32-48 parts of bighead atractylodes rhizome, 30-46 parts of curcuma aromatica, 32-46 parts of radix paeoniae alba, 30-49 parts of oldenlandia diffusa, 32-49 parts of angelica sinensis, 35-46 parts of pericarpium citri reticulatae, 35-50 parts of honeysuckle, 30-44 parts of polygonatum sibiricum and 25-35 parts of coke hawthorn. The invention further discloses the preparation method for the traditional Chinese medicine composition for treating chronic virulent hepatitis b. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials, has no toxic or side effect, and is low in cost. Animal experiments and clinical application studies find that the traditional Chinese medicine composition has good anti-HBV activity.
Owner:杨道坤

Diphenhydramine citrate orally disintegrating tablet and preparation method thereof

The invention discloses a diphenhydramine citrate orally disintegrating tablet, the prescription is composed by the following components in mass percent: 19% of diphenhydramine citrate, 45 swung dash 58% of filler, 15 swung dash 25% of disintegrating agent, 4 swung dash 8% of effervescent disintegrant, 0.5 swung dash 1% of lubricant, 1 swung dash 3% glidant, 1 swung dash 2% of sweetner, 0.2swung dash 0.6% aromatic and 0 swung dash 0.5% of surfactant, wherein the filler uses mannitol, or mannitol and lactose or erythritol, the disintegrating agent uses any one of polyplasdone, crosslinking sodium carboxy methyl cellulose and low substitution hydroxyl propyl cellulose together with microcrystalline cellulose, the effervescent disintegrant comprises citric acid and sodium bicarbonate which have the mass ratio of 1 swung dash 2 / 1, the lubricant is magnesium stearate, the glidant is aerosil or talcum powder, the sweetner is aspartame or stevia rebaudianum, the aromatic is the pharmaceutically acceptable essence, and the surfactant is lauryl sodium sulfate; and the invention further discloses a preparation method of the orally disintegrating tablet, which is simple to operate, the cost is low, the obtained product is in accordance with the quality requirement of the orally disintegrating tablet, and has attractive appearance, good taste and stable quality.
Owner:SOUTHWEST UNIV

Ibuprofen diphenhydramine orally disintegrating tablet and preparation method thereof

The invention provides an ibuprofen diphenhydramine orally disintegrating tablet, comprising the following ingredients, by weight: 40% of ibuprofen, 5% of diphenhydramine hydrochloride or 7.6% of diphenhydramine citrate, 35-40% of filler, 6-12% of disintegrating agent, 0-5% of effervescent disintegrant, 1-2% of adhesive, 1-2.5% of surfactant, 1-1.5% of lubricant, 0.7-2.5% of sweetener and 0-0.5% of perfume. The filler is at least two from microcrystalline cellulose, mannitol and pregelatinized starch; the disintegrating agent is at least one from crospovidone, cross linked sodium carboxymethyl cellulose and sodium carboxymethyl starch; the effervescent disintegrant comprises citric acid and sodium bicarbonate in a mass ratio of 1-2:1; the adhesive is hydroxypropyl methylcellulose; the surfactant is sodium dodecyl sulfate; the lubricant is eleaostearic acid or magnesium stearate and colloid silica; the sweetener is aspartame and / or steviosin; and the perfume is medicinal essence. The invention also provides a preparation method of the orally disintegrating tablet and is simply operated, at low cost and suitable for industrialized production; and the obtained product satisfies quality requirement of an orally disintegrating tablet and has beautiful appearance, good mouthfeel and stable quality.
Owner:SOUTHWEST UNIV

Traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application thereof

The invention provides a traditional Chinese medicine composition for treating coronary heart disease. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of poria cocos, 10 to 20 parts of root poria, 40 to 60 parts of caulis polygoni multiflori, 10 to 20 parts of rhizoma cyperi, 15 to 25 parts of rhizoma atractylodis macrocephalae, 15 to 25 parts of radix paeoniae rubra, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of pericarpium citri reticulatae, 10 to 20 parts of loranthus parasiticus, 30 to 50 parts of semen coicis, 15 to 25 parts of dogwood, 15 to 25 parts of achyranthes bidentata, 15 to 25 parts of himalayan teasel root, 30 to 50 parts of endothelium corneum gigeriae galli, 15 to 25 parts of radix aucklandiae, 10 to 20 parts of radix bupleuri, 20 to 30 parts of malt, and 10 to 20 parts of liquorice. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, and promoting Qi circulation to relieve pain, so that the purpose of treating coronary heart disease can be achieved. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.
Owner:王颖翠

Ibuprofen diphenhydramine dispersing tablet and preparation method thereof

The invention provides an ibuprofen diphenhydramine dispersing tablet, which consists of the following components in percentage by mass: 40 percent of ibuprofen, 5 percent of diphenhydramine hydrochloride or 7.6 percent of diphenhydramine citrate, 30-43 percent of a filler, 5-15 percent of a disintegrant, 2-8 percent of a bonding agent, 0.1-1 percent of a surfactant, 1.5-4 percent of a lubricating agent and 0.5-1.5 percent of a flavoring agent, wherein the filler is at least two of microcrystalline cellulose, pre-gelatinized starch, lactose and mannite; the disintegrant is cross-linked sodiumcarboxymethylcellulose and / or cross-linked polyvidone; the bonding agent is polyvidone K30; the surfactant is sodium dodecyl sulfate; the lubricating agent is magnesium stearate and superfine silica gel powder; and the flavoring agent is aspartame and steviosin. The invention further provides a preparation method of the dispersing tablet. The preparation method is easy and convenient to operate, has low cost, and is suitable for industrial production. An obtained product has stable and controllable quality, attractive appearance, good mouthfeel and proper hardness, is fully disintegrated in water at the temperature of 20+ / -1 DEG C within 3 minutes, and passes through a No.2 sieve; and the medicament dissolvability is over 85 percent 30 minutes later.
Owner:SOUTHWEST UNIV
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