The invention discloses simethicone otilonium bromide chewable tablets and a preparing method of the simethicone otilonium bromide chewable tablets. The simethicone otilonium bromide chewable tablets comprise, by mass, 12.5 parts of simethicone, 4 parts of otilonium bromide, 10-40 parts of adsorbent, 25-75 parts of filler, 0.2-10 parts of adhesive, 0.2-5.0 parts of lubricant, 0.5-10 parts of corrigent, 0.05-0.5 part of aromatic and 1.5-7.5 parts of moisture sealer coating materials. According to the simethicone otilonium bromide chewable tablets, the formula is reasonable, the cost is low, and the preparing method is simple and suitable for industrial production. The prepared tablets are good in taste, the surfaces of the tablets are smooth and attractive, the tablets are even in color, appropriate in hardness, stable in quality, convenient to take and carry, and particularly suitable for the elderly, children and patients who cannot swallow solid preparations, the compliance of the patients is improved, and the simethicone otilonium bromide chewable tablets have good application prospects to treatment of the irritable bowel syndrome due to various reasons, especially the irritable bowel syndrome accompanied with abdominal distension and stomachache.