Simethicone dry suspension and preparation method thereof
A technology of simethicone and dry suspension, which is applied in the directions of pharmaceutical formulations, active ingredients of silicon compounds, and medical preparations of non-active ingredients, etc., can solve problems such as unseen products on the market, and achieve good taste, reasonable prescription design and cost. low cost effect
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[0048] The preparation method of Simethicone dry suspension, concrete steps are as follows:
[0049] a. Pre-dry all the solid excipients of the prescription at 40-60°C for 3 hours, and crush them through a 100-mesh sieve;
[0050] b. After grinding Tween 80 and Span 80 in a mortar, add the prescribed amount of simethicone and grind for 30 minutes, then add part of sucrose (40%-60%) to absorb and mix evenly, and then mix with The remaining sucrose, sodium carboxymethylcellulose, xanthan gum and cross-linked sodium carboxymethylcellulose are stirred and then sieved and mixed;
[0051] c. Add an appropriate volume of 75% ethanol solution to make a soft material, pass through a 20-mesh sieve to granulate, place it in an oven at 40-60°C for 2-3 hours, spray the banana essence solution, pass through a 20-mesh sieve for granulation, and obtain Lagata Silicone oil dry suspension.
[0052] Prescription 2
[0053] Simethicone dry suspension, its prescription is as follows:
[0054] ...
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