Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for treating hepatitis B and its preparation, can solve the problems of disease progression, drug resistance variation, and obvious adverse reactions, and achieve the effects of no toxic side effects, definite curative effect, and reasonable design

Inactive Publication Date: 2012-08-08
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages of the former are that the course of treatment is relatively fixed, the HBeAg seroconversion rate is relatively high, the curative effect is relatively long-lasting, and there are few drug-resistant mutations.
The advantage of the latter is oral administration, strong anti-virus effect, few and mild adverse reactions, and can be used for patients with decompensated liver function. Drug-resistant mutations may occur, and the disease may worsen after stopping the drug.

Method used

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  • Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof
  • Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof
  • Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Take capillary wormwood 20g, desmodium 60g, Patrinia 10g, Polygonum cuspidatum 15g, Hedyotis diffusa 20g, Junexue 15g, Atractylodes macrocephala 5g, medlar 30g, Ligustrum lucidum 20g, hawthorn 40g, licorice 5g, Combine eleven medicinal materials, add water to decoct twice, add water for the first time to 8 times the weight of the medicinal materials, decoct for 1 hour, add water for the second time to 6 times the weight of the medicinal materials, decoct for 1 hour, and combine the decoction, 0.07MPa , Concentrate under reduced pressure at 60-70°C to 65°C when the relative density is 1.10, add 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stir, let stand for 24 hours, and decompress the filtrate Ethanol is recovered and concentrated, and the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.30 at 65°C, spray-dried (conditions are that the inlet air temperature is 120°C, the outlet air temperature is...

Embodiment 2

[0025] Example 2: Take capillary 30g, Desmodium 50g, Patrinia 20g, Polygonum cuspidatum 10g, Hedyotis diffusa 30g, Junixue 10g, Atractylodes macrocephala 10g, Lycium barbarum 20g, Ligustrum lucidum 30g, hawthorn 30g, licorice 10g, Combine the eleven medicinal materials, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, add water for the second time to 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoction, 0.07MPa, concentrated under reduced pressure at 60-70°C to 65°C, the relative density is 1.15, add 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stir, let stand for 24 hours, the filtrate Ethanol is recovered under reduced pressure and concentrated, and the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air t...

Embodiment 3

[0026] Example 3: Take capillary 40g, Desmodium 40g, Patrinia 30g, Polygonum cuspidatum 5g, Hedyotis diffusa 40g, Liuyuexue 5g, Atractylodes macrocephala 15g, Lycium barbarum 10g, Ligustrum lucidum 40g, hawthorn 20g, licorice 15g, Combine eleven medicinal materials, add water to decoct twice, add water for the first time to 12 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials, decoct for 2 hours, combine the decoction, 0.07MPa , Concentrate under reduced pressure at 60-70°C to 65°C when the relative density is 1.20, add 95% (v / v) ethanol to make the alcohol content reach 65% (v / v), stir, let stand for 24 hours, and decompress the filtrate Ethanol is recovered and concentrated, and the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, spray-dried (conditions are that the inlet air temperature is 110°C, the outlet air temperature ...

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PUM

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Abstract

The invention provides a traditional Chinese medicine combination, which achieves the aim of treating hepatitis B by clearing away heat and toxic materials and eliminating dampness and phlegm. For achieving the aim, the technical scheme of the traditional Chinese medicine is that active ingredients contained by the combination are prepared by the following raw materials by weight: 20-40 parts of oriental wormwood, 40-60 parts of desmodium, 10-30 parts of patrinia, 5-15 parts of Polygonum cuspidatum, 20-40 parts of Oldenlandia diffusa, 5-15 parts of herb of snow of june, 5-15 parts of Rhizoma Atractylodis Macrocephalae, 10-30 parts of the fruit of Chinese wolfberry, 20-40 parts of fructus ligustri lucidi, 20-40 parts of hawthorn and 5-15 parts of liquorice. By adopting the corresponding preparing method, the traditional Chinese medicine combination has the advantages of clearing away heat and toxic materials, eliminating dampness and phlegm and treating hepatitis B.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hepatitis B and its preparation method and application. Background technique [0002] Hepatitis B virus can be diagnosed as hepatitis B if the hepatitis B virus test is positive, the course of disease exceeds half a year, or the date of onset is not clear and there are clinical manifestations of hepatitis. Clinical manifestations: fatigue, fear of eating, nausea, abdominal distension, pain in the liver area and other symptoms. The liver is enlarged, with moderate hardness and mild tenderness. Severe cases may be accompanied by liver disease face, spider veins, liver palms, splenomegaly, and liver function may be abnormal or persistent. [0003] At present, the effective anti-hepatitis B virus (HBV) drugs recognized at home and abroad mainly include interferons and nucleoside (acid) analogues, and each...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P1/16A61P31/20
Inventor 陈龙王中越吴皓
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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