59 results about "Blood capillary" patented technology

A compound, as shown in Formula I, is a multi-heterocyclic compound. It has been verified that the compound provided by this invention integrates a novel compound targeting the calcitonin gene-related peptide (CGRP) based on ephedrine. Upon contact with the skin, due to photoactivated cell biological function regulation and the blocking effect of the multi-heterocyclic compound I structure on serotonin receptors, it achieves therapeutic effects on cutaneous vascular malformations and telangiectasia, improves the effectiveness of phototherapy in improving chronic cutaneous vascular diseases, and promotes skin wound healing.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention is suitable for the technical field of bio-photonics, and provides a capillary refilling time self-adaptive measurement system and method, and the system comprises a negative pressure adsorption module, a step release module, a modulation module, a detection module, a demodulation module, a signal processing module and a main control unit. Standardized microcirculation stimulation is realized through negative pressure adsorption and step release; adopting a frequency domain modulation and demodulation technology to obtain the phase and the amplitude of the optical signal, and inverting an absolute absorption coefficient and a reduced scattering coefficient by utilizing a frequency domain diffusion equation; and selecting an absolute absorption coefficient under equal absorption point wavelength as a blood volume index, fitting a recovery curve through a system identification model, and calculating to obtain self-adaptive capillary refilling time. According to the collaborative scheme, the problems that in the prior art, stimulation is not standard, the result is greatly influenced by skin color and temperature, and absolute parameter support is lacked are solved, and objective and accurate measurement which is high in repeatability, cross in skin color and resistant to environmental interference is achieved.

In some aspects, the present disclosure relates to compositions and methods comprising ActRII polypeptides for treating, preventing, or reducing the rate of progression and / or severity of postcapillary pulmonary hypertension (PcPH), particularly for treating, preventing, or reducing the rate of progression and / or severity of one or more PcPH-related complications. ActRII polypeptides may include polypeptides including any naturally occurring polypeptide of an ActRII family member, and any variant thereof (including mutants, fragments, fusions, and peptidomimetic forms) that retain useful activity.

A capillary blood collection device includes a body having an internal chamber. The body generally includes a first end, a second end, and a port located between the first and second ends and providing an inlet / outlet between the first and second ends to the internal chamber. The first end defines an opening into the internal chamber, and the second end of the body opposite the first end is compressible and configured to generate a vacuum upon compression. The port can receive at least one of a lancet device or a collection tube.

The present application relates to the technical field of image processing, and provides a blood flow rate measurement method, system, device, product and medium based on images, comprising: selecting a capillary to be measured; selecting a first position and a second position on the capillary to be measured, and measuring horizontal and vertical orientation differences; obtaining a first number of red blood cell images and a second number of red blood cell images, respectively, and calculating a red blood cell spacing difference through the first and second numbers of red blood cell images; constructing a first motion equation and a second motion equation, and obtaining a red blood cell velocity relationship through solving the first and second motion equations; constructing a differential relationship of red blood cell acceleration, substituting the red blood cell velocity relationship and the second motion equation into the differential relationship to obtain a target differential equation, and solving the target differential equation to obtain a blood flow rate. The present application can conveniently measure the blood flow rate.

The invention discloses a traditional Chinese medicine composition for preventing and treating haemorrhoids, a medicine and a preparation method thereof, the traditional Chinese medicine composition is composed of 10-30 parts of red halloysite, 10-30 parts of medical stone and 10-30 parts of calamine, and the active ingredient of the medicine is the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of astringing intestines and stopping bleeding, detoxifying and removing stasis, removing necrotic tissue and promoting granulation, and relieving itching and astringing sores, and can achieve the treatment effect on haemorrhoids by relieving anus swelling, improving capillary permeability, eliminating inflammation, astringing ulcer wounds and accelerating wound healing. Few medicines are used and the curative effect is obvious.

The present invention relates to systems, compositions and methods for multicellular bioprinting vascularized tissue constructs comprising a hierarchical vascular network. The methods employ a dual bio-ink strategy involving fibrous microgel matrix bio-inks with adjustable hardness, self-healing rheology, and microporosity to support capillary self-assembly, and sacrificial bio-inks that define a large pourable channel after removal. The system integrates top-down printing and bottom-up cell self-organization within a programmable bio-printing platform. The key aspect of the invention is to engineer the physical topography of the matrix to actively guide vascular morphogenesis beyond conventional permissive stents. The integrated platform enables the manufacture of complex bionic vascular networks with enhanced mass delivery, cellular viability, and in vivo integration potential. The invention represents an important progress in the aspect of extendable production of functional human tissues, and has application in regenerative medicine, disease modeling and drug discovery.

A percutaneous medical device (110) specifically for sampling capillary blood is proposed, the percutaneous medical device comprising at least one fixed part (118) and at least one movable part (120). The movable part (120) is movably mounted to the fixed part (118). The movable part (120) is movable from a distal position (154) to a proximal position (156). The movable part (120) includes at least one penetrating element (140) configured to penetrate the user's skin. The penetrating element (140) is received within the fixed part (118) at the distal position (154) of the movable part (120). At the proximal position (156) of the movable part (120), the penetrating element (140) protrudes from the application side (168) of the fixed part (118). The movable component (120) further includes at least one magnetic actuation element (138) configured such that movement of the movable component (120) can be driven by at least one external magnetic force. Furthermore, a body mount (112) for attaching the percutaneous medical device (110) to a user's body surface, a percutaneous medical kit (114) including the percutaneous medical device (110) and the body mount (112), and a method for driving a penetrating element (140) are proposed.

The invention discloses a river network flood control situation studying and judging method and system based on blood vessel-nerve collaborative bionics. According to the method, a multi-source monitoring sensing network is constructed in a river network in a bionic mode to collect hydrological data in real time, the river network is divided into three levels of aorta, arteries and capillaries according to human body blood vessel grading characteristics, and a dynamic regulation and storage model is constructed in combination with an improved Saint-Venant equation set and a Manning formula. And calculating a basic conveying index, a dynamic buffer index, a structural stability index and an instantaneous risk pressure index. A comprehensive bearing capacity index is generated through a bearing capacity-pressure framework, five-level situation risk grading is achieved, and finally visual study, judgment and early warning are conducted based on a GIS platform. According to the invention, the accuracy and foresight of river network flood control regulation and control are improved.

The invention discloses an OCTA image multi-target segmentation method based on an attention enhancement full-resolution network. According to the method, OCTA three-dimensional volume data is used as input, a height dimension is mapped to a channel dimension through Squeeze operation, and lossless dimension reduction is carried out; an attention-enhanced full-resolution module ARCB is constructed in combination with an improved Recurrent ConvNeXt module and an improved attention mechanism ES-CPCA, channel relation modeling and global context sensing are enhanced under the condition that downsampling is not carried out, and features of four types of structures including blood capillaries, arteries, veins and central non-vascular regions are considered. According to the method, the average segmentation precision and robustness of multi-target segmentation can be improved under the condition that only OCTA volume data is used, and a reliable basis can be provided for quantitative evaluation of retinal diseases.

When the oxygen isolation type photodynamic therapy device is used, the light-transmitting oxygen isolation type equipment covers the skin lesion surface of a patient to form an oxygen isolation layer, the tissue oxygen concentration of the epidermal layer and the dermal superficial layer of the patient can be reduced, and therefore the singlet oxygen photochemical generation rate of the area is reduced, and the photodynamic therapy effect is improved. The level of photochemical pain reaction caused by singlet oxygen during treatment of a patient is reduced; meanwhile, the method is cooperated with a light modulation technology, so that the singlet oxygen accumulation damage ratio of the targeted tissue and the non-targeted tissue can be further improved. Meanwhile, target cells of the erythema are located on capillary walls, target cells of skin precancerous lesions are located near a basal layer, and the oxygen concentration of the places is higher than that of an epidermal layer, so that the target selectivity of photodynamic therapy can be improved; the material can be used for hypoxia photodynamic therapy of nevus flammeus, skin precancerous lesions and other skin diseases.

The capillary blood pipette tip system of the present invention includes a pipette tip for collecting capillary blood including a sampling unit having a capillary tube having a first diameter so as to sample a capillary blood; a sample storage unit having a first extension end formed from a distal end of the capillary tube of the sampling unit so as to have a larger area than the sampling unit; a sealing unit closely adhered to a distal opening of the sample storage unit and broken by a quantitative syringe introduced from the outside; a shielding wall surrounding the sealing unit to prevent the sample from splashing from the sample storage unit to the outside when the sealing unit is broken by the quantitative syringe; and a handle unit which is held by a user to sample using the sampling unit; an immunoassay cartridge having at least one pipette tip mounting well having a plunger that presses a sample of a sampling unit of the pipette tip from the bottom to the top when the pipette tip is coupled to the top; and a quantitative syringe for quantitatively sampling the capillary blood collected in the upper part thereof by approaching through the upper part of the pipette tip, when the capillary blood from the sampling unit is collected in the upper part by the pressurization of the plunger during the coupling of the pipette tip to the immunoassay cartridge.

The present invention provides a novel pharmaceutical use of compound A or a pharmaceutically acceptable salt thereof for combined pre- and post-capillary pulmonary hypertension.　The present invention pertains to a therapeutic or prophylactic agent for combined pre- and post-capillary pulmonary hypertension, the therapeutic or prophylactic agent containing a compound represented by the chemical structural formula or a pharmaceutically acceptable salt thereof.

The utility model discloses an anastomat assembly with a blood coagulation function. The anastomat assembly comprises a cutting knife assembly, a nail box inner core, a nail bin assembly and a nail abutting seat assembly. Wherein the cutting knife assembly comprises a cutting knife head, a cutting knife middle piece and a cutting knife side piece, the cutting knife head is located at the far end of the cutting knife middle piece, and the cutting knife head, the cutting knife middle piece and the cutting knife side piece are fixed together; the anastomat assembly further comprises a thermocouple assembly and an electric connection assembly, and the thermocouple assembly is connected with the electric connection assembly. The thermocouple assembly is arranged on the cutting tool bit and can heat the cutting tool bit; when the cutting knife assembly moves, the electric connection assembly and the thermocouple assembly keep a circuit closed. The endoscopic anastomat assembly is matched with an electric endoscopic anastomat to achieve a blood coagulation function on cut tissue capillaries, the amount of bleeding in an operation is reduced, postoperative recovery is faster, and the operation risk and the postoperative risk are reduced; the number of times for medical staff to clean errhysis at an operation site during an operation can be reduced, the labor of the medical staff is reduced, the operation duration can be shortened, and the working intensity of the medical staff is reduced.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

A nasal allergen blocking agent. Specifically, the present invention relates to a preparation method for an allergen blocking agent loaded with an umbilical cord mesenchymal stem cell culture medium extract. The provided allergen blocking agent is prepared from the following raw materials: lyophilized powders of the umbilical cord mesenchymal stem cell culture medium extract, hydroxypropyl methylcellulose, a honeysuckle extract, and borneol. By means of adding the honeysuckle extract and the umbilical cord mesenchymal stem cell culture medium extract to the allergen blocking agent, under the interaction of various raw materials, capillary permeability can be reduced by means of dilating capillaries, thereby reducing tissue fluid exudation, helping reduce swelling, inhibiting smooth muscle contraction, alleviating the spasticity in the respiratory tract and other parts, and improving related discomfort symptoms. The dry powder mixture is loaded into a nasal spray reagent bottle for use. The anti-allergen blocking agent can not only physically isolate allergens, but also load a variety of stem cell factors contained in the umbilical cord mesenchymal stem cell culture medium extract, thereby eliminating chronic nasal mucosa inflammation, repairing nasal mucosa damage without any toxic and side effects, and effectively resisting the onset of allergic rhinitis.

The invention relates to the field of medical systems, in particular to a non-injury imaging system and method for the wrist of a child based on an infrared spectrum, and the system comprises an infrared imaging module which is used for carrying out blood oxygen distribution detection on the wrist of the child, and the blood oxygen distribution comprises arteriovenous blood oxygen and blood capillary blood oxygen of the wrist of the child; the initialization module is used for inputting a bone image and a first blood oxygen distribution image at the same time point; the rehabilitation period observation imaging module is used for acquiring a second blood oxygen distribution image based on the infrared imaging module in the fracture rehabilitation period of the child; and the pairing module is used for pairing the second blood oxygen distribution imaging with the bone image based on the first blood oxygen distribution imaging, and removing blood capillary blood oxygen distribution in the first blood oxygen distribution imaging to obtain a bone image formed by feeding back callus by new blood capillary blood oxygen distribution in the second blood oxygen distribution imaging. By the adoption of the technical scheme, multiple CT detection in the fracture rehabilitation period can be replaced, and the radiation influence on children is reduced.

The utility model discloses a dynamic teaching aid for simulating urine and hematuria forming processes. The dynamic teaching aid comprises a teaching aid bracket, a renal artery model, a globular arteriole model, a glomerulus model, a globular arteriole model, a capillary network model, a renal vein model, a renal capsule model and a bladder model, the renal artery model, the renal vein model, the renal capsule model and the bladder model are sequentially arranged on the teaching aid support; the glomerulus model is mounted in the kidney capsule model; a kidney tubule model is arranged at the bottom of the kidney capsule model, the tail end of the kidney tubule model is communicated with the bladder model, and decoloration cotton is distributed in the kidney capsule model; the capillary network is wound on the renal tubule model of the renal capsule model; one end of the ball-entering arteriole model is communicated with the renal artery model, and the other end is communicated with the glomerular model; one end of the bulbous arteriole model is communicated with the glomerulus model, and the other end is communicated with the capillary network model; and the tail end of the capillary network model is communicated with the renal vein model. The teaching aid has the advantages of being simple in structure, convenient to operate and capable of improving teaching quality.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

The invention belongs to the technical field of biology, and particularly relates to a compound composition for inducing cell migration by controlling the curvature of a membrane and application. The preparation method comprises the following steps: by taking hemagglutinin protein as a membrane protein aggregation unit, connecting sialic acid lactose and rhodamine B in an acylhydrazone bond manner to form a binding and driving unit (R-SL small molecule induction ligand), so as to form self-assembled molecular tweezers (ATS); the preparation process is simple, and the equipment and labor cost is reduced. The constructed self-assembled molecular tweezers realize the polymerization / depolymerization process of membrane protein through a simple chemical regulation method, so that the membrane curvature is efficiently regulated; cell migration is obviously induced, and wound healing is promoted. The cell level test verifies that when the self-assembly molecular tweezers are used for adjusting the curvature of cells, the self-assembly molecular tweezers can promote the cells to generate pseudopods and induce the neogenesis of blood capillaries, and the self-assembly molecular tweezers have universality, induce cell migration and promote the healing process of wounds. The self-assembled molecular tweezers hydrogel does not pull a wound during replacement, so that the compliance of a patient is improved.

The utility model discloses a urine formation dynamic demonstration instrument capable of segmentally demonstrating, which comprises a nephrology main body structure model, a display board bracket, a solution collector, a circulating water pump, an appendage part and a liquid simulation part, the renal unit main body structure model comprises a glomerulus model, a renal capsule model, a renal tubule model, a filter screen, a globular arteriole model, a globular arteriole model, a renal vein model and a capillary model; the filter screen is embedded at the bottom of a sphere of the glomerular model; the glomerulus model, the kidney capsule model, the bulblet arteriole model and the capillary model penetrate through the display board bracket and extend to the corresponding solution collectors; wherein one end of one renal tubule model passes through the display board bracket and extends to the corresponding solution collector, and the other end extends to the corresponding solution collector on the front side of the display board bracket. According to the utility model, not only can the urine formation process be visually demonstrated, but also students can understand the occurrence mechanism of diseases such as proteinuria and hematuria caused by urinary organ abnormity.

The invention relates to the technical field of androgen-derived alopecia, and discloses a micro-needle patch based on a hierarchical targeting mechanism as well as a preparation method and application of the micro-needle patch. The finasteride is arranged on the needle tip section of the microneedle, the quercetin is arranged on the needle root section, different cells are targeted through the finasteride and the quercetin in a graded mode, and the microneedle patch with a graded targeting mechanism is formed. After the micro needle pierces into the skin, the water-soluble polymer at the needle tip section is dissolved, finasteride targeted hair papilla cells are released, and then in the process that finasteride acts, the quercetin slowly released at the needle root section gradually acts on endothelial cells in a targeted mode, the proliferation and migration activity of the endothelial cells is promoted, and the effect of the finasteride on the skin is achieved. Endothelial cells are enhanced to form a highly branched capillary network to act on hair papilla cells, the metabolic demand of the hair papilla cells is maintained, and finally the effect of enhancing the finasteride targeting effect is achieved. Therefore, the microneedle patch with the hierarchical targeting mechanism has an excellent AGA curative effect.

The present disclosure provides methods, systems, devices, kits, and reagents for performing single cell sequencing (e.g., single cell RNA sequencing) from a low volume, capillary blood (or any low volume blood sample which is not obtained from a vein or by venipuncture).

The present disclosure relates to a capillary blood collecting device which includes a fixing device including an accommodating cavity for accommodating a blood collection finger and a squeezing member for squeezing blood to a fingertip site. The capillary blood collecting device is configured to detachably accommodate at least one skin puncture part on a blood collection side of the finger, and the skin puncture part includes a blood lancet that may be driven to puncture the blood collection finger, such that a sufficient amount of capillary blood quickly flows out from the capillary blood converged at the fingertip under the action of blood lancet.

A system and method for measuring the percent fill of a blood sampling capillary includes a chamber for receiving a sample capillary containing a blood sample, an illuminator provided for illuminating the sample capillary, an imaging lens aligned with the chamber and the sample capillary, an imaging sensor aligned with the imaging lens for receiving an image of blood in the sample capillary from the imaging lens and converting the image into image data, a microcontroller circuit electrically connected with the imaging sensor, and at least one of a host computer or a user interface electrically connected with the microcontroller unit, the microcontroller circuit processes the image data to obtain a percent fill result that is sent to the host computer or at least one of a user interface.

The human body blood circulation demonstration instrument comprises a human-shaped display board, four transparent containers are fixed to the human-shaped display board, a rubber balloon is installed in each transparent container to simulate four heart chambers, and four one-way valves are installed in each transparent container to simulate heart valves; the red hose, the blue hose and the capillary hose simulate arteries, veins and blood capillaries; the four transparent containers are respectively communicated with an air compressor through four inflating pipes under the control of four electromagnetic valves; the four-way electromagnetic valve is controlled to be opened and closed through a four-way relay; the four relays are connected with the development board to control the opening and closing time, sequence and interval time of the electromagnetic valves, and the transparent container is inflated to enable the rubber balloon to contract to achieve human body blood circulation demonstration. The development board is provided with a gear switch for switching working modes, and the gear switch comprises an explanation mode, a stop mode and an automatic mode. The device can vividly demonstrate physiological phenomena such as spontaneous contraction, heartbeat duration, heartbeat sequence, systolic pressure and diastolic pressure of the heart, realizes high-frequency demonstration, and is visual in demonstration and convenient to operate.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

The application relates to the field of biological medicine, and specifically provides application of SjP40 protein, a composition for promoting skin tissue repair, a preparation method of the composition, and a pharmaceutical preparation. The SjP40 protein from a Japanese blood fluke is applied to the field of skin damage repair, the SjP40 can significantly accelerate wound closure, reduce the level of inflammatory cell infiltration, and enhance capillary and appendage regeneration, and the overall repair quality is superior to that of an existing treatment method. Meanwhile, the SjP40 protein is combined with a hydrogel to realize local controlled release and stable release of the SjP40 protein at a wound surface, the problem of rapid degradation of protein activity in vitro is overcome, and the bioavailability and treatment efficiency are improved.

The invention relates to the technical field of biological medicines, in particular to application of cathepsin K (CTSK) or a coding gene thereof serving as a target to preparation of an ARDS diagnosis product or treatment product or preparation of an ARDS related pulmonary fibrosis diagnosis product or treatment product. The invention discloses that the CTSK level in serum or pulmonary alveolar lavage fluid can be used for accurately evaluating whether ARDS or ARDS-related pulmonary fibrosis occurs or not and the degree of pulmonary alveolar-capillary membrane injury; aRDS caused by different factors can be used as a biomarker; compared with existing evaluation indexes, the CTSK has higher response speed and higher sensitivity to ARDS or ARDS-related pulmonary fibrosis, is beneficial to early diagnosis and prognosis evaluation of acute lung injury, and has good market transformation prospects.