165 results about "Blood capillary" patented technology

The invention discloses a coronary angiography image blood vessel segmentation system based on multi-scale feature fusion. According to the invention, through the innovative design of the adaptive morphological sensing module, the system can dynamically analyze the anatomical structure characteristics of the blood vessel: the differentiable morphological operation layer converts the corrosion expansion operation into a learnable feature extraction process, so that the network can autonomously identify the gradient change and boundary trend of the blood vessel wall; the dynamic nuclear adaptation mechanism adjusts the scale and direction of morphological operation in real time according to the local blood vessel diameter and curvature characteristics, interference of surrounding tissues in a main blood vessel area can be inhibited, and continuous expression can be enhanced for capillary branches. Through deep fusion of dissection driving and data driving, the topological structure integrity of a segmentation result at a blood vessel bifurcation point and a narrow lesion area is remarkably improved, and the common problems of blood vessel fracture and misconnection in a traditional method are effectively avoided.

A compound, as shown in Formula I, is a multi-heterocyclic compound. It has been verified that the compound provided by this invention integrates a novel compound targeting the calcitonin gene-related peptide (CGRP) based on ephedrine. Upon contact with the skin, due to photoactivated cell biological function regulation and the blocking effect of the multi-heterocyclic compound I structure on serotonin receptors, it achieves therapeutic effects on cutaneous vascular malformations and telangiectasia, improves the effectiveness of phototherapy in improving chronic cutaneous vascular diseases, and promotes skin wound healing.

The invention relates to the technical field of medical data analysis, in particular to a sepsis prediction system based on deep learning. The system comprises a sepsis risk assessment module, a capillary barrier injury analysis module, a myocardial inhibition analysis module and a sepsis prediction module, and blood lactic acid concentration data of a patient are obtained through a lactic acid analyzer; acquiring oxygenation state data of a patient through a blood gas analyzer, and performing sepsis risk assessment according to the oxygenation state data of the patient and the blood lactic acid concentration data of the patient, so as to obtain sepsis risk data; obtaining a lung structure image through a high-resolution chest CT; performing alveolar feature extraction according to the lung structure image to obtain alveolar data; according to the pulmonary alveolar data, capillary barrier injury analysis is carried out, so that capillary barrier injury data is obtained; an echocardiogram is obtained by an echocardiograph. The sepsis prediction accuracy is improved based on a medical data analysis technology.

The invention provides a chronic hypoperfusion animal model construction method and application thereof, and relates to the technical field of biomedicine. The construction method of the chronic hypoperfusion animal model, provided by the invention, aims at brain capillary endothelial cells, and the constructed chronic hypoperfusion animal model is global and lasting brain hypoperfusion, has no infection or death risk and is low in cost. The animal model constructed by using the method is more convincing in the aspects of reperfusion research and drug curative effect evaluation.

The invention discloses a laser depilation dynamic parameter adjustment method based on skin typing recognition, and relates to the technical field of laser depilation, and the method comprises the steps: constructing a three-dimensional skin model of a depilation region through multi-dimensional data cross validation; detecting local pigmentation caused by friction in each area; detecting the blood flow signal intensity of capillary vessels around the hair follicles, judging the period of the hair and generating a hair follicle activity thermodynamic diagram in real time; a three-dimensional energy focus is formed through double-beam crossing; skin curved surface data are obtained through a pressure sensor, liquid crystal molecules in a light valve are driven to be arranged, and light spots are adjusted to be in the shape attached to an unhairing area; the basal metabolic rate of the patient is measured through a noninvasive bioelectrical impedance analysis technology, and the energy density is adjusted based on the basal metabolic rate; and establishing a digital twinborn model, and integrating depilation data, skin state and hormone level information. A three-dimensional energy focus is formed through double-beam crossing, energy is accurately focused on the root of the hair follicle, and epidermis damage is avoided.

Porous-based bone implants with the integration of Triply Periodic Minimal Surface, TPMS, porous architectures are designed to support the growth and proliferation of bone tissue, bone marrow, and capillaries. This disclosure intends to reduce the adverse effect of conventional implants such as bone resorption over time, which is called the “stress shielding effect”. The “stress shielding effect” is caused by the mismatch between the implant and natural bone stiffness. Triply Periodic Minimal Surface, TPMS, porous architectures exhibit interconnected pore features. The interconnection of the porous network allows the TPMS to have a higher permeability than that of other porous structures, leading to more favorable nutrient transport. In addition, many physical characteristics of the TPMS structures including surface-to-volume ratio, pore size, elastic modulus, and fluid behaviors can be controlled precisely through mathematical manipulation. As a result, TPMS-based implants could be physical features, which are vaned based on different bone regions. In other words, the medical implants may exhibit non-uniform or gradient physical features, which can match the characteristic of trabecular and cortical bones. Therefore, TPMS-based implants could adjust the features to mimic neighboring bone regions. As a result, we can achieve medical implants, which have superior mechanical and biological responses, resulting in optimal cell growth and better medical treatment.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention discloses a bionic wrist pulse generator, and relates to the technical field of medical instruments, the bionic wrist pulse generator comprises a wrist bionic structure and a blood vessel bionic structure, the wrist bionic structure comprises a bionic skin layer, a mounting layer and a supporting layer, and the mounting layer is arranged between the bionic skin layer and the supporting layer; when the device is used, the peristaltic pump draws liquid from the liquid groove and outputs the liquid into the elastic tube, the purpose of simulating pulse vibration signals of the wrist of the human body is achieved by adjusting parameters of the peristaltic pump, adjusting the flow of the liquid in the elastic tube and reproducing periodic signals, the three-stage branch network structure is designed, the first-stage branch simulates the arteriole, and the second-stage branch simulates the arteriole; the second-stage branch and the third-stage branch simulate a micro artery and a blood capillary respectively, and then a periodic signal is sensed on the bionic skin layer, so that the practice effect is achieved.

The invention relates to the technical field of image processing, and provides an image-based blood flow velocity measurement method, system and device, a product and a medium, and the method comprises the steps: selecting a to-be-measured capillary; selecting a first position and a second position on the capillary to be measured, and measuring a horizontal azimuth difference and a vertical azimuth difference; respectively obtaining a first red blood cell image number and a second red blood cell image number, and calculating a red blood cell interval difference according to the first red blood cell image number and the second red blood cell image number; constructing a first motion equation and a second motion equation, and resolving through the first motion equation and the second motion equation to obtain a red blood cell velocity relationship; and constructing a differential relational expression of the red blood cell acceleration, substituting the red blood cell velocity relation and the second motion equation into the differential relational expression to obtain a target differential equation, and resolving the target differential equation to obtain the blood flow velocity. The blood flow velocity can be conveniently measured.

The invention belongs to the technical field of biosynthesis and traditional Chinese medicine essence extraction, and particularly relates to a biosynthesis Chinese herbal medicine anti-hair loss pilatory and a preparation method thereof. The biosynthetic Chinese herbal medicine hair loss preventing and hair growing agent comprises the following effective components: a pseudomonas subtilis fermentation extract and a saccharomycetes fermentation extract. The hair-loss-preventing and hair-growing shampoo has the effects of preventing hair loss and growing hair through complementation and synergistic interaction of cleaning pores, inhibiting fungal reproduction, penetrating nutrient components into scalp and the like, activating dermis hair follicles, expanding blood capillaries, removing slough and promoting tissue regeneration, and promoting hair cell division, and has a relatively good application prospect.

The invention provides application of alpha-ketobutyrate in preparation of drugs for prevention and / or treatment of skeletal muscle atrophy, and belongs to the technical field of biomedicine.The human endogenous metabolite alpha-ketobutyrate is applied to prevention and treatment of skeletal muscle atrophy, the side effect is small, the safety is high after long-term use, and the effect is obvious. Serious immunoreaction or toxic reaction can be avoided, and skeletal muscle senescence and muscular atrophy can be effectively prevented and treated. The alpha-ketobutyrate can improve the muscle index of skeletal muscles of the old mice, increase the number of muscle fibers, increase the cross sectional area, increase the number of muscle cell nucleuses and the expression of nuclear fiber layer protein LamB1 of the muscle cell nucleuses, and can also increase the capillary angiogenesis rate in muscle tissues of the old mice. Alpha-ketobutyrate has good pharmacological characteristics and low side effects, and provides an important basis for developing clinical drugs for treating amyotrophy.

The utility model relates to the technical field of medical monitoring instruments, in particular to a capillary refilling time test monitor. The utility model provides a capillary refilling time test monitor which comprises a support, an air cylinder and the like, and the air cylinder is installed on the support. A medical worker puts a finger of a patient on a base plate, the telescopic end of an air cylinder drives a pressing block to move downwards, the pressing block makes contact with the finger pulp of the finger of the patient and drives the finger pulp to move downwards, and then the base plate is driven to move downwards and makes contact with a pressure sensor in the moving process of the base plate, so that the pressure sensor sends out a signal, and the signal is received by a display screen; after pressing is conducted for 10 seconds, the telescopic end of the air cylinder drives the pressing block to move upwards, and the pressing block does not press the finger pulp of the finger of the patient any more, so that the blood capillary of the finger pulp of the finger of the patient recovers to the original color; and meanwhile, the camera transmits the monitored time of recovering the original color of the blood capillaries of the finger pulps of the patient to the display screen.

The invention discloses application of SAA1 as a target spot in preparation of a medicine for preventing and treating kidney diseases, and belongs to the field of gene functions, application and biological medicine. In-vivo and in-vitro experiments prove that in an ischemia / reperfusion or ureteral obstruction induced mouse kidney disease model, the knockout of the SAA1 gene can relieve renal interstitial vascular endothelial cell injury, recover a renal capillary network, improve vascular permeability, reduce collagen deposition, inhibit renal fibrosis and effectively delay the progress of kidney diseases; furthermore, by adopting the SAA1 recombinant protein vaccine to immunize mice, the organism can be induced to generate a protective neutralizing antibody, and the SAA1 recombinant protein vaccine has a remarkable protective effect on kidney diseases induced by ischemia / reperfusion and ureteral obstruction. Therefore, the SAA1 is an intervention target for preventing and treating the kidney diseases, the SAA1 recombinant protein vaccine is an effective means for preventing and treating the kidney diseases, and active immunization by adopting the vaccine is an effective strategy for preventing and treating the kidney diseases.

The utility model provides a semiconductor laser earphone device for treatment, specifically, the earphone device comprises a left earphone unit and a right earphone unit, each of the left earphone unit and the right earphone unit comprises an earplug, a front earphone shell and a rear earphone shell, and each earphone unit further comprises a red light and / or near-infrared semiconductor laser module, and laser emitted by the laser module is emitted through the emission hole on the earplug. The earphone provided by the utility model can be used for treating through laser with specific wavelength, so that the effect of improving blood activity is achieved, the laser can directly irradiate blood in blood capillaries through earholes, the absorption rate is high, and the effect is obvious; and the product is small in size, convenient to use and carry and low in power consumption.

The utility model discloses a wearable vascular elasticity detection and evaluation device, the wearable vascular elasticity detection and evaluation device comprises a host, a wearable wrist strap, a detection module and a control module, the detection module is arranged on the wearable wrist strap, and the position of the detection module corresponds to the radial artery of the wrist of a human body and the position nearby the radial artery; the control module is arranged in the host, the control module is in communication connection with the detection module, and the control module is used for controlling the detection module to obtain the pulse wave signal according to a preset instruction so as to generate a pulse wave waveform. According to the wearable vascular elasticity detection and evaluation device, radial artery pulse wave information is directly measured, optical pulse waves, measured by PPG, of arteries or blood capillaries or muscular tissue are more accurate, support is provided for more accurate evaluation of artery and blood vessel elasticity, meanwhile, detection is actively initiated by the wearable vascular elasticity detection and evaluation device, and the detection accuracy is improved. The user compliance and the equipment use efficiency are improved, and the health state of the user can be better detected and evaluated.

The invention relates to the technical field of medical image processing, in particular to a lung vessel tree reconstruction method based on multi-scale watershed segmentation, which comprises the following steps: acquiring lung CT image data; based on the lung CT image data, executing image preprocessing operation to obtain preprocessed image data; based on the preprocessed image data, executing multi-scale analysis to obtain multi-scale feature data; based on the multi-scale feature data, executing a drainage basin segmentation algorithm to obtain a blood vessel segmentation result; based on the blood vessel segmentation result, executing a blood vessel tree reconstruction operation to obtain reconstructed lung blood vessel tree data; according to the method, through innovative combination of multi-scale analysis and drainage basin segmentation, comprehensive processing of blood vessels with different thicknesses is realized. Multi-scale analysis can capture blood vessel characteristics under different scales, and drainage basin segmentation can accurately position blood vessel boundaries, so that the method can process thick and large blood vessels such as main pulmonary artery and the like and capillary vessels around tiny pulmonary alveoli at the same time.

Disclosed are a bio-ink for promoting microangiogenesis, a method for preparing same, and use thereof. The bio-ink is prepared by the following method: 1) preparing a filamentous microgel with a diameter within 20 microns from a sacrificial-phase material A as a porogenic template; 2) seeding vascular endothelial cells and perivascular cells on the surface of the filamentous microgel to give a hydrogel microfilament with the surface loaded with cells; and 3) mixing the hydrogel microfilament with the surface loaded with cells with a solution of a matrix-phase material B to give the bio-ink for promoting microangiogenesis. The bioprinting using the bio-ink can construct a capillary-like structure and cross-scale microvessels. The present invention can achieve the preparation of a micro-channel porous hydrogel structure with an average diameter of 20 microns or less and controllable porosity and the formation of a capillary-like network structure.

The invention is suitable for the technical field of bio-photonics, and provides a capillary refilling time self-adaptive measurement system and method, and the system comprises a negative pressure adsorption module, a step release module, a modulation module, a detection module, a demodulation module, a signal processing module and a main control unit. Standardized microcirculation stimulation is realized through negative pressure adsorption and step release; adopting a frequency domain modulation and demodulation technology to obtain the phase and the amplitude of the optical signal, and inverting an absolute absorption coefficient and a reduced scattering coefficient by utilizing a frequency domain diffusion equation; and selecting an absolute absorption coefficient under equal absorption point wavelength as a blood volume index, fitting a recovery curve through a system identification model, and calculating to obtain self-adaptive capillary refilling time. According to the collaborative scheme, the problems that in the prior art, stimulation is not standard, the result is greatly influenced by skin color and temperature, and absolute parameter support is lacked are solved, and objective and accurate measurement which is high in repeatability, cross in skin color and resistant to environmental interference is achieved.

In some aspects, the present disclosure relates to compositions and methods comprising ActRII polypeptides for treating, preventing, or reducing the rate of progression and / or severity of postcapillary pulmonary hypertension (PcPH), particularly for treating, preventing, or reducing the rate of progression and / or severity of one or more PcPH-related complications. ActRII polypeptides may include polypeptides including any naturally occurring polypeptide of an ActRII family member, and any variant thereof (including mutants, fragments, fusions, and peptidomimetic forms) that retain useful activity.

A capillary blood collection device includes a body having an internal chamber. The body generally includes a first end, a second end, and a port located between the first and second ends and providing an inlet / outlet between the first and second ends to the internal chamber. The first end defines an opening into the internal chamber, and the second end of the body opposite the first end is compressible and configured to generate a vacuum upon compression. The port can receive at least one of a lancet device or a collection tube.

The present invention provides a lateral fibular bone transport external fixator device, which includes a fibular transport device, a tibia fixation device, and a connection device. The fibular transport device drives the synchronous movement of the fibular transport frame through the movement of the adjustment device, so as to realize the position offset of the bone block of the osteotomy segment of the fibula. The tibia fixation device includes a tibia fixation frame and a deviation correction adjustment device, and the deviation correction adjustment device can adjust the fixation position of the tibia fixation frame and the connection device. The connection device connects the fibular transport device and the tibia fixation device. The present invention also provides a method for using the lateral fibular bone transport external fixator device. The present invention only sets the fixed fulcrum on the tibia, reduces the number of wound surfaces on the tibia side, does not affect the load-bearing capacity of the tibia after surgery, and at the same time sets the bone transport operation on the fibular side to realize the lateral fibular bone transport. The fibula is located deep in the skin fascia and is wrapped by the anterior and posterior muscle groups of the fibula. There is a richer capillary basis for bone transport at the fibular end, and the effect of repairing blood circulation is better.

A method of measuring tissue characteristics using a fluid line in fluid communication with subcutaneous tissue includes: applying a pressure distribution or a flow distribution to subcutaneous tissue via the fluid line, wherein the fluid line is isolated from atmospheric pressure; in response to the applied pressure distribution or the applied flow distribution, measuring a pressure value or a flow rate value over time; and calculating, using the at least one processor, at least one of: a time constant of pressure decay; fluid resistance of the tissue; permeability of tissues; mechanical compliance of the tissue; osmotic pressure of tissue interstitial fluid; capillary pressure in subcutaneous tissue; and the ionic strength of the interstitial fluid.

The invention provides application of adrenochromic hydrazone in preparation of a medicine for treating subdural hematoma, and belongs to the technical field of medicines. The invention finds that the adrenochrome can improve the expression level of endothelial connexin of epidural blood vessels, enhance the resistance of blood capillaries to injury, reduce the permeability of the blood capillaries, reduce the bleeding amount of subdural hematoma, relieve inflammatory response caused by hematoma stimulation and accelerate the recovery of subdural hematoma for the first time. Therefore, the compound can be used for preparing medicines for treating subdural hematoma. The medicine can be administrated through oral administration, the risk existing in a traditional drilling drainage operation is avoided, and an alternative or auxiliary treatment scheme is provided for patients who are intolerant to statins or hormones and patients who are ineffective in treatment through combination of statins and hormones.

The invention discloses a construction and evaluation method of an organ chip for evaluating smoke lung injury, which comprises the following steps of: determining the design size and the thickness of the chip, determining to take a corresponding amount of Sylgard 184 base glue according to the design size and the required thickness of the lung organ chip, mixing the base glue and a curing agent according to the weight ratio, and performing extrusion molding to obtain the organ chip for evaluating smoke lung injury. The method comprises the following steps: selecting a PET film with a proper aperture, simulating a gas exchange barrier between pulmonary alveoli and capillaries, cutting according to the size of a cavity constructed by a chip, pretreating the PET film, namely soaking the PET film with absolute ethyl alcohol before use, removing possible impurities and oil stains on the surface of the film, washing with deionized water, and drying to obtain the PET film. The construction method of the smoke lung injury organ chip is simple, stable performance of cells in the chip can be guaranteed in the culture process, and cell culture and gas and nutrient substance exchange simulation are facilitated.

Aspects of the disclosure provide for devices and methods of use thereof for detecting the presence of 14-3-3η protein in capillary blood samples from subjects suspected of having or at risk of developing arthritic conditions. In an example, a method includes obtaining a capillary blood sample from such a subject, and applying the capillary blood sample to a lateral flow device under conditions sufficient for formation of an immunocomplex comprising an immobilized anti-14-3-3η antibody coupled to a 14-3-3η protein that is further coupled to a labeled anti-14-3-3η antibody, wherein formation of the immunocomplex, and visualization thereof, is indicative of the arthritic condition.

The disposable fluid sampling device comprises a body fluid sampling device, and optionally comprises a body fluid sampling device for automatic sampling; and optionally an analysis device for analyzing the fluid using one or more droplets of the sampled fluid; the invention relates to a device for analyzing a fluid sample, comprising at least one vacuum tube or vacuum source, and an interface for at least one sample tube or medical analysis tube adapted to be filled with a fluid sample for analysis at a point of care or in a medical laboratory, the device comprising an interface for at least one vacuum tube or vacuum source, the vacuum tube or vacuum source is adapted to provide a suction force required to fill the at least one sample tube with a fluid.

The present application relates to the technical field of image processing, and provides a blood flow rate measurement method, system, device, product and medium based on images, comprising: selecting a capillary to be measured; selecting a first position and a second position on the capillary to be measured, and measuring horizontal and vertical orientation differences; obtaining a first number of red blood cell images and a second number of red blood cell images, respectively, and calculating a red blood cell spacing difference through the first and second numbers of red blood cell images; constructing a first motion equation and a second motion equation, and obtaining a red blood cell velocity relationship through solving the first and second motion equations; constructing a differential relationship of red blood cell acceleration, substituting the red blood cell velocity relationship and the second motion equation into the differential relationship to obtain a target differential equation, and solving the target differential equation to obtain a blood flow rate. The present application can conveniently measure the blood flow rate.

The invention provides a basement membrane sampling method based on glomerular capillary branch characteristics, and relates to the technical field of image recognition, and the method comprises the steps: employing the center and radius of a glomerular region, carrying out the analysis of the mesangial crossing condition of a basement membrane, obtaining a mesangial crossing result, carrying out the region division and sampling window size calculation, and carrying out the calculation of the size of a sampling window. Obtaining a plurality of sectors and corresponding window areas; random sampling is carried out in the sectors to obtain candidate center points; analyzing the candidate center point based on the window area, if the sampling is not qualified, performing failure retry and annealing strategy to adjust the window, and resampling; otherwise, obtaining a qualified window; and combining all qualified windows to obtain a basement membrane sampling result, and completing the basement membrane sampling based on the glomerular capillary branch characteristics. According to the method, the problem of how to perform balanced, low-deviation, reproducible and efficient sampling and labeling on the glomerular basement membrane under the anatomical priori constraint in the light microscope glomerular pathological image is solved.

The invention discloses a traditional Chinese medicine composition for preventing and treating haemorrhoids, a medicine and a preparation method thereof, the traditional Chinese medicine composition is composed of 10-30 parts of red halloysite, 10-30 parts of medical stone and 10-30 parts of calamine, and the active ingredient of the medicine is the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of astringing intestines and stopping bleeding, detoxifying and removing stasis, removing necrotic tissue and promoting granulation, and relieving itching and astringing sores, and can achieve the treatment effect on haemorrhoids by relieving anus swelling, improving capillary permeability, eliminating inflammation, astringing ulcer wounds and accelerating wound healing. Few medicines are used and the curative effect is obvious.

The present invention relates to systems, compositions and methods for multicellular bioprinting vascularized tissue constructs comprising a hierarchical vascular network. The methods employ a dual bio-ink strategy involving fibrous microgel matrix bio-inks with adjustable hardness, self-healing rheology, and microporosity to support capillary self-assembly, and sacrificial bio-inks that define a large pourable channel after removal. The system integrates top-down printing and bottom-up cell self-organization within a programmable bio-printing platform. The key aspect of the invention is to engineer the physical topography of the matrix to actively guide vascular morphogenesis beyond conventional permissive stents. The integrated platform enables the manufacture of complex bionic vascular networks with enhanced mass delivery, cellular viability, and in vivo integration potential. The invention represents an important progress in the aspect of extendable production of functional human tissues, and has application in regenerative medicine, disease modeling and drug discovery.