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5868results about How to "Improve absorption rate" patented technology

Rapid acting and long acting insulin combination formulations

A combined rapid acting-long acting insulin formulation has been developed wherein the pH of the rapid acting insulin is adjusted so that the long acting glargine remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolus insulin is administered before breakfast, provides adequate bolus insulin levels to cover the meal, does not produce hypoglycemia after the meal and provides adequate basal insulin for 24 hours. Lunch and dinner can be covered by two bolus injections of a fast acting, or a rapid acting or a very rapid acting insulin. As a result, a patient using intensive insulin therapy should only inject three, rather than four, times a day. Experiments have been performed to demonstrate, the importance of the addition of specific acids to hexameric insulin to enhance speed and amount of absorption and preserve bioactivity following dissociation into the monomeric form by addition of a chelator such as EDTA. As shown by the examples, the preferred acids are aspartic, maleic, succinic, glutamic and citric acid. These are added in addition to a chelator, preferably ethylenediaminetetraacetic acid (EDTA). The results show that the citric acid formulation was more effective at dropping the blood glucose rapidly than the identical rapid acting formulation prepared with HCl in swine. Charge masking by the polyacid appears to be responsible for rapid insulin absorption. EDTA was not effective when used with adipic acid, oxalic acid or HCl at hastening the absorption of insulin. These results confirm the results seen in clinical subjects and patients with diabetes treated with the rapid acting insulin in combination with citric acid and EDTA.
Owner:ELI LILLY & CO

Synergistic slow release nitrogen fertilizer and preparation thereof

The invention relates to a nitrogen fertilizer, in particular to a synergistic slow-releasing nitrogen fertilizer and a preparation method thereof. The fertilizer comprises: urea nitrogen fertilizer, biochemical inhibitors and a synergist, wherein, the weight portion ratio of the urea nitrogen fertilizer to the biochemical inhibitors to the synergist is equal to 1:0.001 to 0.1:0.0005 to 1; the biochemical inhibitors are a nitrification inhibitor and a urease inhibitor and the synergist is poly (aspartic acid), wherein, the weight portion ratio between the urease inhibitor and the nitrification inhibitor is equal to 0.5 to 2:0.5 to 2. The preparation method is as follows: during the operation process of the nitrogen fertilizer, the biochemical inhibitor and the synergist are added into the fertilizer under the molten state of the fertilizer. The synergistic nitrogen fertilizer of the invention is suitable for various plants and soils. The fertilizer has notable disease-resistant, drought-resistant and lodging resistant effects on crops after being applied in soils, can effectively improve nutrients reserving power of soils and has certain effect on succession crops. Gain production can be increased by 8% to 30%, vegetable production can be increased by 14% to 60% and cash crop production can be increased by more than 30% by using the synergistic slow-releasing nitrogen fertilizer.
Owner:SINOCHEM AGRI LINYI R&D CENT CO LTD

Laser impact tiny bulk forming method and apparatus for tiny apparatus

InactiveCN101269440AEasy to achieve microplastic formingImprove absorption rateLaser beam welding apparatusOptical pathForming force
The invention provides a laser impulse micro-bulk forming method and a device thereof, being suitable for the micro-bulk forming of a planchet and belonging to the laser micro-processing field and micro-bulk forming field. The forming method is as follows: impulse wave induced by laser is used as a forming force source for micro-device micro-bulk forming; laser burst generated by a laser generator according to requirements is irradiated at a flying-piece surface layer passing through a transparent restraint layer through an external light path system; a high temperature and high pressure plasma body is generated and the impulse wave is formed; overhigh pressure of the impulse wave is used for driving the flying-piece and a micro-plastic forming system connected with a flying piece; a micro-workpiece is pressed; the micro-bulk forming of the workpiece is finished. The device applied to the method comprises six parts of the laser generator, an external light path system, an induction impulse wave generation system, a micro-plastic forming system, a control system and an operating platform. The laser impulse micro-bulk forming method can be used for realizing the micro-bulk forming of any complex shaped micro-devices, and can be repeatedly impacted and loaded on, and has good repeatability and easy realization of automatic production.
Owner:JIANGSU UNIV

A cordyceps sinensis enzyme and a preparation method thereof

The present invention provides a cordyceps sinensis enzyme and a preparation method thereof. The enzyme is prepared by fermenting the following ingredients in parts by weight: fruits and vegetables 55-70 parts, fungi 8-12 parts, cordyceps sinensis 1-2 parts and sugar 15-20 parts with the addition of probiotic 0.2-0.8 part. The preparation method comprises the following steps: preparing cordyceps sinensis sporoderm-broken powder, preparing primary enzyme solution, fermenting the powder and the solution for preparing the cordyceps sinensis enzyme, etc. The enzyme uses ultramicro crushing technology to crush the cordyceps sinensis, and low temperature or room temperature sporoderm-breaking technology to conduct sporoderm-breaking on the cordyceps sinensis so that the nutrition loss of the cordyceps sinensis is prevented and the absorption rate of the cordyceps sinensis is improved; the enzyme utilizes rich enzyme systems of enzymes to conduct additional sporoderm-breaking on the sporoderm-broken powder, which facilitates the release and homogenization of active ingredients in the cordyceps sinensis, and improves the effect of drugs. The prepared enzyme contains proteins, amino acids, vitamins, enzyme substances, etc. essential for human bodies, effectively accumulates functional components of the cordyceps sinensis, and effectively improves various health-care effects of the enzymes.
Owner:西藏月王药诊生态藏药科技有限公司

Multi-functional slow-release urea fertilizer and preparation method

The invention relates to nitrogen fertilizers, in particular to a multi-functional slow-release urea fertilizer and a preparation method. The fertilizer comprises urea, a biochemical inhibitor, synergist, water-soluble salt ions of secondary and trace elements necessary for plants and / or beneficial elements for plant growth. By weight percentage, the weight percentage of the urea to the biochemical inhibitor to the synergist is equal to 1: 0.001-0.1: 0.0005-0.05, the salt ions of the secondary and trace elements necessary for the plants comprises one kind or a plurality of kinds of calcium, magnesium, sulfur, ferrum, copper, zinc, manganese, boron, molybdenum and chlorine, the weight percentage of the urea to all the secondary and trace elements necessary for the plants is equal to 1: 0-0.1: 0-0.1: 0-0.06: 0.001-0.03: 0.001-0.01: 0.001-0.01: 0.001-0.008: 0.001-0.01: 0.001-0.005: 0-0.006, the beneficial elements for the plant growth comprise silicon and selenium, and the weight percentage of the urea to all beneficial elements for the plant growth is equal to 1: 0-0.1: 0.001-0.08. The multi-functional slow-release urea fertilizer can promote growth of root systems, invigorate plants, enhance disease resistance, drought resistance and lodging resistance, and stimulate prematurity.
Owner:SHENYANG INST OF APPL ECOLOGY CHINESE ACAD OF SCI
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