5results about How to "Efficient excitation" patented technology

The invention relates to a novel coronavirus SARS-CoV-2 mutant vaccine and application, the vaccine comprises a fusion protein, and the fusion protein comprises: (1) interferon or a functional fragment thereof; (2) a novel coronavirus SARS-CoV-2Omicron mutant strain S protein or a functional fragment of the novel coronavirus SARS-CoV-2Omicron mutant strain S protein; and (3) an immunoglobulin Fc region. Molecule and process optimization of the fusion protein comprises improvement of process developability and immunogenicity, and the vaccine can improve immunogenicity and antibody titer of a mutant new crown antigen through convergence mutation design, efficiently generate a neutralizing antibody, significantly improve defense ability to a variant strain, and can be massively and industrially produced.

The present invention provides a Raman spectroscopy gas detection device with long optical path and high convergence excitation, comprising: a light source module, used to emit a shaped excitation light beam to the reflective surface of a second parabolic reflector through a laser incident channel; a gas chamber, the cavity in the chamber serving as a sample pool; an excitation and collection module, built into the sample pool, used to excite the sample with the excitation light beam and to collect the Raman scattered light generated by the excitation, comprising a first parabolic reflector, a second parabolic reflector and a dichroic mirror; a lens group, provided with a pair, used to receive the Raman scattered light reflected by the dichroic mirror, and to transmit the received Raman scattered light to a Raman spectrometer; a Raman spectrometer, used to perform spectroscopic identification of the Raman scattered light input by the lens group and convert it into a Raman spectrum. The present invention can simplify the device structure and improve the system stability on the basis of simultaneously realizing the excitation and collection of high-efficiency Raman signals.

The invention provides a cell nucleus dye molecule with aggregation-induced emission activity as well as a preparation method and application thereof, and relates to the technical field of fluorescence labeling. The cell nucleus dye molecule with the aggregation-induced emission activity is a fluorescent molecule dye material which is modified by pyridinium and hydroxamic acid based on triphenylamine or triphenylamine aryl as a mother nucleus and has the aggregation-induced emission activity, and can be used for cell nucleus specific fluorescent labeling of biological tissues such as brain and the like. The dye molecule can rapidly, simply and conveniently carry out specific fluorescence labeling on a cell nucleus, fluorescence signal emission is obviously enhanced, low-background fluorescence is provided, and meanwhile, the dye molecule has a washing-free function.

The invention provides a surface acoustic wave gyroscope chip structure based on a graphene acoustoelectric effect, and relates to the technical field of semiconductor sensor chips, the surface acoustic wave gyroscope chip structure comprises a piezoelectric substrate, and a surface acoustic wave resonator and a surface acoustic wave detector which are arranged on the surface of the piezoelectric substrate, the surface acoustic wave resonator comprises two oppositely arranged driving interdigital transducers, a wave energy modulation area is arranged between the two driving interdigital transducers, a first surface acoustic wave reflecting grating is arranged on the outer side of each driving interdigital transducer, and the surface acoustic wave resonators are used for generating primary surface acoustic waves on the piezoelectric substrate through the driving interdigital transducers. Standing waves corresponding to the primary surface acoustic wave reflecting grating are generated on the first surface acoustic wave reflecting grating; the surface acoustic wave detector comprises two graphene piezoresistive strips which are symmetrically arranged on the two sides of the wave energy modulation area, and a second surface acoustic wave reflecting grating is arranged on the outer side of each graphene piezoresistive strip. According to the invention, the sensitivity and the signal-to-noise ratio of the surface acoustic wave gyroscope chip can be improved.

This invention relates to the field of fluorescence lifetime imaging, and discloses a wide-field fluorescence lifetime imaging system and method based on a streak camera. The system includes an excitation source, a wide-field excitation module, a synchronous detection module, and a synchronous matching module. The wide-field excitation module is positioned along the transmission path of a pulsed laser. The synchronous detection module includes a collection and beam splitting component, a reference camera, and a streak camera component. The input end of the collection and beam splitting component receives the fluorescence beam emitted by the sample, and the output end of the component splits the fluorescence beam into a first detection optical path and a second detection optical path. The reference camera is positioned in the first detection optical path, and the streak camera component is positioned in the second detection optical path. The synchronous matching module is electrically connected to the excitation source, the reference camera, and the streak camera component, respectively. This invention avoids the complex optical encoding scheme and resulting fluorescence photon loss problems of traditional DMD systems, and eliminates the need for complex reconstruction algorithms, thus improving imaging efficiency.