64 results about "Molecular spectroscopy" patented technology

The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer.

Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.

Described herein is a spectroscopic system and method for measuring and monitoring the chemical composition and/or impurity content of a sample or sample stream using absorption light spectroscopy. Specifically, in certain embodiments, this invention relates to the use of sample pressure variation to alter the magnitude of the absorption spectrum (e.g., wavelength-dependent signal) received for the sample, thereby obviating the need for a reference or ‘zero’ sample. Rather than use a reference or ‘zero’ sample, embodiments described herein obtain a spectrum/signal from a sample-containing cell at both a first pressure and a second (different) pressure.

The invention discloses a synchronous acquisition device and method of an atom and molecular spectrum. The method comprises the following steps: striking the surface of a to-be-detected sample repeatedly by focused energy of a laser device, stimulating the to-be-detected sample to be at a plasma state, and collecting an atom spectrum transmitted by the to-be-detected sample at the plasma state by an optical fiber collector via a visible spectrograph; striking the surface of the to-be-detected sample repeatedly by the focused energy of the laser device, and collecting an infrared spectrum transmitted externally by the surface of the to-be-detected sample by an infrared optical fiber collector via the visible spectrograph so as to obtain a molecule spectrum; transmitting the molecular spectrum to a signal collecting control system by the atom spectrum and the infrared spectrograph via the visible spectrograph; and matching the atom spectrum and the molecular spectrum by the signal collecting control system so as to obtain the corresponding relationship between the atom spectral line and a functional group. The method can be used for obtaining the molecule and atom spectrum with the same size synchronously within a short time, and achieving the correlation of the characteristic relation of the atom spectrum and the molecular spectrum.

The invention discloses a broadband single-frequency fiber laser intensity noise suppression device for achieving a nearly schottky noise limit. The broadband single-frequency fiber laser intensity noise suppression device comprises a single-frequency fiber laser resonator, a wavelength division multiplexer, a single-mode semiconductor pump light source, an optical fiber isolator, a polarization controller, a laser saturated amplification device, an optical fiber filter module, an optical fiber coupler, a photoelectric detector and a feedback control system. According to the broadband single-frequency fiber laser intensity noise suppression device disclosed by the invention, the broadband intensity noise of output laser can be reduced through the laser saturated amplification device; feedback control is carried out on the laser saturated amplification device, so that the intensity noise of the output laser can be further reduced; the frequency range of intensity noise suppression can be further expanded; and finally, the effects of keeping the intensity noise of a single-frequency laser within a broadband and simultaneously reducing the intensity noise close to schottky noise limit are achieved. The broadband single-frequency fiber laser intensity noise suppression device for achieving the nearly schottky noise limit has a broad application prospect and great application value in the fields of ultra-high precision and ultra-long distance laser ranging, optical fiber sensing, atomic and molecular spectroscopy and the like.

The invention discloses a molecular spectrum imaging device applied in clinical medicine, biology, hylology, microelectronics and other subject fields. The invention is characterized in that: light sources are connected to dispersion units through optical fibers; the dispersion units are connected to a dark field optical collector through optical fibers and used for illumination of a microscope; a signal of an image sensor CCD is connected to a computer through a cable; a control wire of the computer is connected to a dispersion unit controller which is connected to the dispersion units; the computer changes the wavelength of the light sources through control of the dispersion units, acquires image data through the image sensor CCD and finally obtains molecular spectrum data of a sample. The molecular spectrum imaging device has high technical index and quick imaging speed, does not need a push-broom component, is easy to be combined with the general microscope for use and has wide imaging spectrum range covering visible light and near infrared light, thereby being favorable for detection and analysis of biological tissues.

The invention provides a fiber laser intensity noise suppressing device and a working method thereof. The device comprises a single mode semiconductor pump light source, a wavelength division multiplexer, a fiber resonator, a fiber coupler, a fiber isolator, a fiber circulator and a laser intensity noise suppressing device. Through a self-injection locking structure of a fiber laser, laser signals are injected into the fiber resonator after conventional intensity noise suppressing treatment, so that the finally output laser intensity noise is greatly reduced. The device with a relatively simple structure can realize high performance fiber laser output with ultralow intensity noise, thereby being of great importance for expansion of the application of fiber lasers in the field of high-precision optical fiber sensing, coherent light communication and atomic and molecular spectroscopy.

The invention relates to a system (1) for detecting analytes of interest present in a gas sample. The detection system comprises a layer (30) of porous material positioned along the fluidic flow path for the gas, the material containing probe molecules capable of reacting with the analyte of interest. The detection system also comprises an optical device (50) capable of successively detecting a change in the spectral properties of the probe molecules at different detection areas (32) of the porous material layer (30).

The invention relates to a microscope for the molecular spectroscopic analysis of a sample (2), having a beam path having at least one quantum cascade laser (QCL) (3) which emits an infrared (IR) radiation, a phase modulator (5) which is arranged between the QCL (3) and the sample (2), at least one optical element (6) which is arranged between the phase modulator (5) and the sample (2) and a sensor (4) which detects an IR radiation which is transmitted and/or reflected by the sample (2). The invention relates further to a method for the molecular spectroscopic analysis of a sample (2) comprising the steps of irradiating the sample (2) with an infrared (IR) radiation by means of a quantum cascade laser (QCL) (3), wherein the IR radiation is directed onto the sample (2) via a phase modulator (5) and at least one optical element (6), and detecting the IR radiation which is reflected and/or transmitted by the sample (2).

The invention relates to a portable mid-infrared high-sensitivity multi-component gas measurement and analysis system and a working method thereof, and belongs to the technical field of laser measurement, the portable mid-infrared high-sensitivity multi-component gas measurement and analysis system comprises an optical parametric oscillator, an absorption cell and a data processing system; light of the optical parametric oscillator is divided into two paths through a beam splitter A, one path is connected with a data processing system and a digital lock-in amplifier through an absorption celland a detector A, and the digital lock-in amplifier is connected with the data processing system; the other path is connected with a beam splitter B and is divided into two paths, and the two paths are respectively connected to a data processing system through a detector B and a Michelson interferometer; the data processing system is further connected with a current driving module and a temperature control module, and the current driving module and the temperature control module are both connected with the optical parametric oscillator. According to the system, various narrow-molecule and wide-molecule spectral substances can be detected with high sensitivity in real time.

A device includes a substrate (100) that includes a resonant cavity (125). The resonant cavity (125) includes dipolar molecules that have an absorption frequency. The resonant cavity (125) resonates at a frequency that is equal to the absorption frequency of the dipolar molecules. The device further includes a first port (110) on the resonant cavity (125) configured to receive a radio frequency (RF) signal.

A method includes forming a plurality of layers of an oxide and a metal on a substrate. For example, the layers may include a metal layer sandwiched between silicon oxide layers. A non-conductive structure such as glass is then bonded to one of the oxide layers. An antenna can then be patterned on the non-conductive structure, and a cavity can be created in the substrate. Another metal layer is deposited on the surface of the cavity, and an iris is patterned in the metal layer to expose the one of the oxide layers. Another metal layer is formed on a second substrate and the two substrates are bonded together to thereby seal the cavity.

The invention provides a method for identifying tumor boundaries by performing molecular spectral imaging on cancer tissues by using a laser-induced breakdown spectroscopy technology, and belongs to the field of imaging. The method comprises the following steps: (1) carrying out molecular spectral imaging on a sample tissue by utilizing a laser-induced breakdown spectroscopy technology, and collecting an LIBS spectrum; (2) after performing baseline calibration on the LIBS spectrum, extracting a CN molecular spectral line or a C2 molecular spectral line to obtain an intensity relative value of the spectral line; (3) drawing a CN molecule or C2 molecule distribution heat map in the sample tissue; (4) carrying out clustering analysis on the CN molecule or C2 molecule distribution heat map to identify the boundary of the tumor region and the necrosis region in the sample tissue. By utilizing the method, the boundary of the tumor area and the necrosis area in the cancer tissue or para-carcinoma tissue of the lung cancer patient can be successfully displayed, and tissue space heterogeneity information is obtained. The method provided by the invention realizes molecular spectral imaging analysis of lung cancer tissues and tumor boundary identification, and has good application prospects and values.