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298 results about "Multivariate analysis" patented technology

Multivariate analysis (MVA) is based on the statistical principle of multivariate statistics, which involves observation and analysis of more than one statistical outcome variable at a time. Typically, MVA is used to address the situations where multiple measurements are made on each experimental unit and the relations among these measurements and their structures are important. A modern, overlapping categorization of MVA includes...

Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye

InactiveUS6574501B2Reduced energy/density exposure ratingImproved margin of safetyRaman scatteringDiagnostic recording/measuringConjunctivaNon invasive
A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier. Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam (e.g., at a wavelength of 600 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum. In certain embodiments, the detecting step may be followed by the step of subtracting a confounding fluorescence spectrum from the Raman spectrum to produce a difference spectrum; and determining the blood level and/or brain level of the analyte of interest for the subject from that difference spectrum, preferably using linear or nonlinear multivariate analysis such as partial least squares analysis. Apparatus for carrying out the foregoing methods are also disclosed.
Owner:CHILDRENS HOSPITAL OF LOS ANGELES +1

Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals

InactiveUS7398119B2Fast “ triage ” assessmentReliable and faster treatment decisionRadiation pyrometrySpectrum investigationNon invasivePhysics
A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier.
Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam at a selected wavelength (e.g., at a wavelength of about 400 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum. In certain embodiments, the detecting step may be followed by the step of subtracting a confounding fluorescence spectrum from the Raman spectrum to produce a difference spectrum; and determining the blood level and/or brain level of the analyte of interest for the subject from that difference spectrum, preferably using linear or nonlinear multivariate analysis such as partial least squares analysis. Apparatus for carrying out the foregoing methods are also disclosed.
Owner:CALIFORNIA INST OF TECH +1

Machine vision technology based method for rapidly detecting egg freshness

The invention relates to a machine vision technology based method for rapidly detecting egg internal quality, belonging to non-destructive testing technologies for agricultural and animal products. According to the method, a machine vision technology is used for acquiring characteristics on three aspects including a color space, an eggshell shape and an egg density from an egg transmission image so as to comprehensively judge the freshness characteristic of the egg. The machine vision technology based method specifically comprises the steps: acquiring the transmission image of an egg under a certain illumination condition, transmitting the transmission image to a computer through image acquisition equipment, acquiring the information on the three aspects including the color space, an egg yolk area and the egg density from the acquired egg image, fusing and screening the information on the three aspects, and finally obtaining a detection result of the egg freshness by means of a multi-variable analysis model in a standard library, wherein the information on the three aspects including the color space, the egg yolk area and the egg density is in one-to-one correspondence to three phenomena of diluted concentrated egg white, enlarged egg yolk area and raised gas cell height which are expressed under an egg freshness drop condition. In addition, grading can be carried out according to standards so that the egg freshness can be detected more objectively and accurately.
Owner:JIANGSU UNIV

Building method for rhubarb medicinal material trueness/falseness and species prediction model

The invention provides a building method for a rhubarb medicinal material trueness/falseness and species prediction model. According to the model, category identification of quality rhubarb, fake rhubarb and three rhubarb species is realized on the basis of a gas chromatography-mass spectrum technology in combination with partial least square discriminant analysis. The building method comprises the following steps: (1) collecting samples; (2) preparing the samples; (3) acquiring GC-MS data; (4) performing data processing and multivariate analysis, wherein cluster analysis and principal component analysis are performed by comparing the differences of chromatographic behaviors of rhubarb of different sources; (5) building the prediction model; and (6) verifying the model. Two built category prediction models are proved to have 100 percent identification accuracy and prediction accuracy. Through adoption of the method, trueness/falseness and species identification of rhubarb are realized by modeling, so that a reliable conclusion and high integrity are achieved; the defects of an existing method are overcome; and a more feasible and reliable new thought is provided for the trueness/falseness and species identification of rhubarb medicinal materials and decoction pieces.
Owner:青岛市食品药品检验研究院
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