183results about How to "Facilitate early detection" patented technology

The invention provides systems and methods for detection, grading, scoring and tele-screening of cancerous lesions. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of prostate cancer on serial sections / slides of prostate core images, or biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each system utilizes a different approach with a different feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest. Additionally, the invention provides sub-systems and methods for accurate detection and mapping of disease in whole slide digitized images by extracting new features through integration of one or more of the above-mentioned classification systems. The invention also addresses the modeling, qualitative analysis and assessment of 3-D histopathology images which assist pathologists in visualization, evaluation and diagnosis of diseased tissue. Moreover, the invention includes systems and methods for the development of a tele-screening system in which the proposed computer-aided diagnosis (CAD) systems. In some embodiments, novel methods for image analysis (including edge detection, color mapping characterization and others) are provided for use prior to feature extraction in the proposed CAD systems.

Methods for assessing the risk of developing Type 2 diabetes and other related disorders include obtaining an NMR derived reference spectrum for a known glucose concentration sample and storing this information as a reference standard. A patient blood sample is collected and NMR derived patient spectrums for the blood sample are obtained. The two NMR data sets (the reference and the patient) are compared and a glucose concentration is determined for the patient sample. The glucose concentration can be evaluated with a blood sample undergoing lipoprotein cholesterol evaluation. The NMR based test can be used to concurrently provide a glucose concentration and lipoprotein constituent values based on a single testing event. The disclosure also includes a multi-purpose test, i.e., a test which concurrently provides lipoprotein screening and coronary heart disease risk evaluation along with a diabetes screening and risk assessment for developing Type 2 diabetes. A method for assessing diabetes includes identifying the presence of diabetic dyslipidemia based on the values of predetermined NMR measured lipoprotein constituents.

Ambulatory monitoring of human health is provided by a multi-component multi-sensor wireless wearable biosignal acquisition system comprising a torso device and a peripheral device communicating wirelessly, and a mobile phone for receiving collected data and uploading it over cellular network or WiFi to a remote computer for multivariate analysis. Biosignals include EKG and PPG, from which a determination of pulse transit time can be made.

An asymmetric geometry headlamp for vehicular use is built as a multifaceted three dimensional body which has multiple light emitting devices (LEDs and / or laser emitters) installed on its angled facets, hence forming a multipurpose illumination apparatus within a single assembly which is designed to provide; a low beam with a wide illuminated area covering 2PiSteradians, a high beam all position and signaling lights. A microprocessor based system runs real time, continuously adaptive control routines for day and night conditions and provides the electric signals necessary for the independent control of the luminous intensity, direction and color spectrum to each facet of the headlamp's LEDs (light emitting diodes) and for the high beam. Multiple photo-sensors, CCD or CMOS video cameras, position encoders and accelerometers provide the feedback signals used in the automation of all lighting functions in a system designed to completely replace the manual actuation of lights on vehicles.

The present invention is directed to a system and method for countering terrorism by monitoring shipping containers using an advanced communication system network for tracking and monitoring the container as it travels over international seas.

Systems and methods for detection, grading, scoring and tele-screening of cancerous lesions are described. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of prostate cancer on serial sections / slides of prostate core images, or biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each system utilizes a different approach with a different feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest.

The invention discloses a real-time multi-mode photoacoustic human eye imaging system and an imaging method thereof. The imaging system comprises a laser device, a front optical path, a reflecting mirror, a focusing lens, a light-transmitting acoustic reflection device, a scanning mirror, a water trough, an ultrasonic probe, an ultrasonic transmitter-receiver set, an amplifier and a computer. A light-transmitting acoustic reflection film and the scanning mirror are placed in the water trough. The imaging system has a photoacoustic imaging mode and an ultrasonic imaging mode. Mechanical scanning is replaced through the scanning mirror, imaging time is greatly shortened, and pain of a patient is relieved. Meanwhile, due to the optical and ultrasonic confocal design, an existing pure optical focusing imaging mode or an existing pure ultrasonic focusing imaging mode is changed, sensitivity is improved on the basis that the optical resolution is achieved, and full-eye imaging from the front of the eye to the bottom of the eye can be carried out. Due to dual-wavelength use, the limitation that imaging is only carried out on the eye vascular structure at present is broken through, functional imaging of the degree of blood oxygen saturation can be carried out, and early detection of a part of eye diseases is facilitated.

The invention discloses a bridge dynamic health real-time monitoring device. The monitoring device includes a monitoring module, data processing module, a security state evaluation module, an early warning and alarm module and a simulation display module, wherein the monitoring module includes a wireless sensor network, a strain sensor assembly and a displacement sensor, the data processing module includes a collection center station, a signal conditioner and a signal transmission device, the security state evaluation module includes a microprocessor, the early warning and alarm module includes an analysis processor and an alarm, and the simulation display module includes a 3D GIS simulation platform. According to the bridge dynamic health real-time monitoring device of the invention, the sensors are applied to the bridge health monitoring filed, and therefore, real-time monitoring on the health of a bridge can be realized, and the remaining life of the structure of the bridge can be monitored according to monitoring data. The bridge dynamic health real-time monitoring device is unprecedentedly advantageous in full coverage and around-the-clock monitoring.

The invention discloses a mental disorder related intestinal tract microbial marker and application thereof. The intestinal tract microbial marker refers to one or more combinations of intestinal tract microbial florae of Prevotella and Bacteroides. The invention further discloses application of the mental disorder related intestinal tract microbial marker in preparing reagents for diagnosing mental disorders and methods for screening food, probiotics or drugs capable of intervening with mental disorders. Particularly, the methods include comparing proportion of microbial florae of Prevotella to microbial florae of Bacteroides before and after treatment or interference of the food, probiotics or drugs and / or comparing relative quantity of microbial florae of Prevotella and microbial florae of Bacteroides in feces specimens.

The invention belongs to the technical field of tumor medicine, and particularly discloses an autoantibody joint detection ELISA kit for screening early esophageal cancer. The kit comprises a solid-phase carrier and tumor-associated antigens coated on the solid-phase carrier, wherein the tumor-associated antigens are EYA4, ABL1, ATF2, CD38, NOTCH1, ZBTB20, BCL2L1 and P53. Furthermore, the kit alsocomprises a sample diluent, a second antibody, a second antibody diluent, positive control serum, negative control serum, a color developing solution, a stop solution and a washing solution. The ELISA kit provided by the invention can effectively detect esophageal cancer, especially early esophageal cancer, has the detection sensitivity of 94% and the specificity of 79%, can be used for large-scale screening of asymptomatic people in high-incidence areas of esophageal cancer, and is beneficial to screening and early discovery of asymptomatic high-risk population.

The present invention provides an intelligent auxiliary diagnosis system. The intelligent auxiliary diagnosis system includes a cloud platform and a plurality of terminals connected to the cloud platform through a network, wherein the cloud platform includes a cloud platform algorithm module, and the cloud platform algorithm Based on the huge amount of lesion pictures in the early stage, the module uses artificial intelligence technology to train an intelligent diagnostic auxiliary model. After clinical testing, the sensitivity and specificity have reached the accurate diagnostic level, and the model is embedded in the cloud platform to implement intelligent auxiliary diagnosis. The lesion image can automatically and synchronously feed back the intelligent diagnosis result consistent with the lesion image, and transmit the diagnosis result to the terminal for the doctor's reference. The intelligent auxiliary diagnosis system of the present invention promotes the intelligence and informatization of relevant medical services; establishes a telemedicine artificial intelligence service network, realizes hierarchical diagnosis and treatment services, and can ensure performance and safety; reduces use and maintenance costs; contributes to Strengthen the ability of first-diagnosis of diseases at the grassroots level, and improve the hierarchical diagnosis and treatment system.

Ambulatory monitoring of human health is provided by a multi-component multi-sensor wireless wearable biosignal acquisition system comprising a torso device and a peripheral device communicating wirelessly, and a mobile phone for receiving collected data and uploading it over cellular network or WiFi to a remote computer for multivariate analysis. Biosignals include EKG and PPG, from which a determination of pulse transit time can be made.

The invention relates to a detection method and a detection device of internal faults of a switch cabinet, belonging to the field of power transformation and distribution. For the switch cabinet which is in hot-line operation when a cabinet door is in a closed state, the gas in the internal space of the cabinet body is extracted by utilizing a through hole of the cabinet body of the switch cabinet from the external part of the cabinet body; and by extraction, measurement and data comparison of the gas in the internal space of the cabinet body in the hot-line operation state, each numerical value of the unbalanced voltage representing a characteristic gas concentration item is compared with the numerical value of the unbalanced voltage representing the characteristic gas concentration itemof ambient environment air and / or other switch cabinet freight spaces, thereby discovering the accident in the early stage or early accident potential in the switch cabinet as soon as possible to prevent the accident from expanding or further spreading. By adopting a gas acquisition mode, the invention can sensitively detect the common operation faults of the switch equipment in the cabinet. Whenthe switch cabinet operates, the switch cabinet in the operation state does not need to be stopped, and the existing switch cabinet equipment does not need to be changed, thus the implementation costis low, and the normal operation of the existing equipment can not be affected.

The invention discloses a disease concrete bridge bearing capability evaluation method, which supposes various uncertainties influencing disease concrete bridge bearing capability evaluation to possess random variables of certain probability distribution characteristics, and defines disease index influence degrees to a bridge bearing capability as bearing capability partial checking computation coefficients according to a bearing capability calculation method. Based on an actual disease index detection result and mathematical statistics, the method employs monte carlo random simulation calculation and a fuzzy comprehensive evaluation principle to obtain a probability distribution characteristic approximating the disease concrete bridge bearing capability to be evaluated, an furthermore obtain a bearing capability evaluation result possessing a certain probability guarantee. The method overcomes the uncertainty influences caused by neglecting randomness of various factors and fuzzyness of evaluation grade division in a present highway bridge bearing capability evaluation standard, thereby realizing more scientific and rational evaluation results.

Agents and methods for imaging a cell and / or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and / or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and / or diagnosis a condition or disease.

The invention belongs to the technical field of medical oncology, and particularly discloses an autoantibody joint detection ELISA kit for early screening of esophageal squamous carcinoma. The kit comprises a solid-phase carrier and a tumor-associated antigen coated on the solid-phase carrier, wherein the tumor-associated antigen consists of P53, TP53, CDKN2B and NPM1. Furthermore, the kit comprises sample diluent, a second antibody, second antibody diluent, positive control serum, negative control serum, developing solution, stop solution and washing solution. The ELISA kit is capable of effectively detecting the esophageal squamous carcinoma, especially the early esophageal squamous carcinoma, has detection sensitivity up to 88.8% and specificity up to 86.3%, can be used for the large-scale screening of asymptomatic groups in high-risk areas of the esophageal squamous carcinoma, and is beneficial for the esophageal squamous carcinoma screening and early discovery of the asymptomatichigh-risk groups.

A system and method for monitoring the status of an optical switch that includes at least one electrically addressable element operative to provide the switching action. The system comprises an electrical monitoring circuit operative to periodically test each such electrically addressable element while the switch is set to an ON, OFF or intermediate switching configuration, and a mechanism for effecting the periodic testing. The effecting mechanism may be for example a pulse width modulation algorithm. Optical monitoring that taps input and output optical fibers and checks pigtails may be added optionally to the electrical monitoring.

Individual health vulnerability is assessed by obtaining health risk prevalence level data containing health risk prevalence levels for one or more health risks over a given geographical area. The health risk prevalence level data to generate for each health risk a prevalence level forecast as a function of time and location. A health risk prevalence level map is generated for the given geographical area illustrating current and future health risk prevalence levels for each health risk at a plurality of locations within the given geographical area. Personal health status data are obtained for a given individual along with a proposed travel itinerary f covering at least a portion of the geographical area over a given time duration. The personal health status data, travel itinerary and map generate a personal health risk vulnerability model containing a quantification of vulnerability to the one or more health risks resulting from the travel itinerary.

An exhaust gas temperature detection sensor is arranged at a predetermined position outside a muffler, or at a predetermined position outside an exhaust pipe constituting an exhaust gas flow passage on a more downstream side than the muffler in an exhaust direction. The sensor detects that an atmosphere temperature at the predetermined position outside the muffler has reached a predetermined temperature based on an increase in a temperature inside the muffler, or detects that an atmosphere temperature at the predetermined position outside the exhaust pipe has reached a predetermined temperature based on an increase in a temperature of an exhaust gas inside the exhaust pipe.

The invention discloses a mental disorder biomarker and application thereof. Microorganism gene chip hybridization research is conducted on intestinal flora microbial genomes in fecal samples of a mental disorder group and fecal samples of a healthy control group to describe characteristics of fecal microflorae and functional genes. By means of difference testing, discriminant analysis and machine learning, fifteen functional genes are recognized finally and can serve as biomarkers to highly accurately distinguish the mental disorder group. The biomarker is selected from at least ten genes in the fifteen functional genes. The fifteen functional genes have obvious differences in mental disorder people and the healthy people. The invention further discloses a drug which is capable of changing the number or expression of genes and is used for treating mental disorder, a method for producing or screening the drug for treating mental disorder and a kit for detecting mental disorder.

The invention discloses a detection kit for identifying and diagnosing whether an equine animal is infected with piroplasmosis or not, and a preparation method and a using method thereof. A detection film for detecting equine piroplasmosis and a piroplasmosis universal primer are arranged in the kit for detecting the equine piroplasmosis. The using method of the kit comprises the following steps:extracting DNA (deoxyribonucleic acid) from blood of a horse to be detected, further using the piroplasmosis universal primer to perform amplification, combining an amplification product with the detection film, enabling biotin at the terminal of a PCR (polymerase chain reaction) product to be in action with streptavidin-peroxidase, and then playing a catalysis role in enabling a substrate of peroxidase, namely an enhanced chemiluminescence reagent (ECL-detection) to emit fluorescence, thereby exposing an X-photosensitive film; and performing development and fixing treatment on the film so asto emerge a shadow in a region corresponding to specificity hybridization of a probe on the detection film and the PCR product, and further judging whether the detected animal is infected with the piroplasmosis or not according to whether the shade is left on the film or not.

The fixing and measuring compressor for soft X-ray mammary gland photography is in box-shaped, and includes a front vertical surface to close the breast wall and box bottom serving as the mammary gland compressing surface. It features the mammary gland compressing surface so shaped to fit the physiological curve of mammary gland. Shaping the compressing surface of compressor as the arc surface to fit the physiological curve of womení»s mammary gland results in well contact to the mammary gland surface during mammary gland examination, dispersed and homogeneous pressure distribution, reduced pressure to and pain of the patient under examination, raised X-ray image quality and raised diagnosis accuracy.

Individual health vulnerability is assessed by obtaining health risk prevalence level data containing health risk prevalence levels for one or more health risks over a given geographical area. The health risk prevalence level data to generate for each health risk a prevalence level forecast as a function of time and location. A health risk prevalence level map is generated for the given geographical area illustrating current and future health risk prevalence levels for each health risk at a plurality of locations within the given geographical area. Personal health status data are obtained for a given individual along with a proposed travel itinerary f covering at least a portion of the geographical area over a given time duration. The personal health status data, travel itinerary and map generate a personal health risk vulnerability model containing a quantification of vulnerability to the one or more health risks resulting from the travel itinerary.

The invention discloses a road, bridge and tunnel monitoring and prewarning device. The road, bridge and tunnel monitoring and prewarning device comprises a monitoring module, a data processing module, a safety state evaluation module, a prewarning alarm module and a simulation display module, wherein the monitoring module comprises a wireless sensor network, a strain sensor assembly and a displacement sensor; the data processing module comprises a collecting center station, a signal conditioner and a signal transmitting device; the safety state evaluation module comprises a microprocessor; the prewarning module comprises an analysis processor and an alarm; the simulation display module comprises a three-dimensional GIS (geographic information system) simulation platform. The road, bridge and tunnel monitoring and prewarning device has the advantages that the sensors are applied to the road, bridge and tunnel prewarning field, so that the real-time monitoring on the health of the road, bridge and tunnel structure is realized; the residual life of the road, bridge and tunnel structure can be predicted according to the monitoring data; an unprecedented height is reached in the full-coverage and all-weather monitoring.

Individual health vulnerability is assessed by obtaining health risk prevalence level data containing health risk prevalence levels for one or more health risks over a given geographical area. The health risk prevalence level data to generate for each health risk a prevalence level forecast as a function of time and location. A health risk prevalence level map is generated for the given geographical area illustrating current and future health risk prevalence levels for each health risk at a plurality of locations within the given geographical area. Personal health status data are obtained for a given individual along with a proposed travel itinerary f covering at least a portion of the geographical area over a given time duration. The personal health status data, travel itinerary and map generate a personal health risk vulnerability model containing a quantification of vulnerability to the one or more health risks resulting from the travel itinerary.

The invention belongs to the technical field of the tumor medicine, and specifically discloses an autoantibody joint detection ELISA kit for gastric cardiac adenocarcinoma early screening. The kit comprises a solid-phase carrier and tumor-associated antigen coated on the solid-phase carrier; the tumor-associated antigen is composed of Dock10, IVL, CDH1 and P53; furthermore, the kit further comprises sample diluent, a second antibody, second antibody diluent, positive control serum, negative control serum, a developing solution, a stop solution and a washing solution. The ELISA kit disclosed bythe invention can effectively detect the gastric cardiac adenocarcinoma, especially the early gastric cardiac adenocarcinoma; the detection sensitivity is up to 87.5%, and the specificity reaches 75%; and the kit can be used for the large-scale screening of the asymptomatic population at the high incidence area of the gastric cardiac adenocarcinoma, thereby facilitating the gastric cardiac adenocarcinoma screening and early discovery of the asymptomatic high-risk group.

A system that routes nets within an integrated circuit. During operation, the system receives a representation for the integrated circuit, which includes block boundaries for physical partitions of the IC generated from a hierarchical design placement of the integrated circuit. The system then classifies each net in the integrated circuit based on the location of pins associated with the net. Next, the system generates routing constraints for each net based on the classification of the net and applies a feedthrough constraint to the physical partitions to restrict nets from feeding through physical partition boundaries. Finally, the system routes each net using the routing constraints for the net and the feedthrough constraints for the physical partitions. This routing is performed based on these block boundaries prior to finalizing the hierarchical design placement, thereby facilitating early detection of congestion or timing violations which can be corrected early in the design process.

The invention discloses a gene marker for screening early gastric cancer. The gene marker comprises a peripheral blood gastric cancer characteristic gene sequence shown as SEQ ID NO.1-SEQ ID NO.6. The invention also discloses application of the gene marker in preparation of products for screening early gastric cancer. The gene marker disclosed by the invention is used for screening early gastric cancer and is high in sensitivity and specificity; and moreover, because the peripheral blood which can be easily collected in clinical application is taken as a detection sample, the detection is convenient, the gene marker is applicable to screening and early diagnosis of a large population for gastric cancer, and the application prospects are wide.