15results about How to "Reduce mortality" patented technology

This utility model relates to the field of aquaculture technology, specifically a buffer-type salmon and trout transfer device, including a conveying chamber with a fish storage box fixedly connected inside. This utility model features a first transport trough, a second transport trough, a rotating shaft, and a turntable. When the operator pulls the second transport trough outward, a slider inside the trough moves outward, extending the second transport trough so that its length contacts the water surface, reducing salmon and trout mortality due to height limitations. Pressing down on the second transport trough causes the first transport trough to rotate downward, which in turn causes the rotating shaft to rotate, allowing the second transport trough to contact the water surface. Pulling up the lifting block raises the gate, allowing the salmon and trout to flow from the fish storage box into the first transport trough. The cushioning effect of the rubber pad reduces salmon and trout mortality and improves the device's efficiency.

This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.

This invention discloses the application of a Trichinella spiralis cysteine ​​protease inhibitor in acute myocardial infarction and subsequent ventricular remodeling, belonging to the field of medicinal chemistry. This invention provides a drug that can prevent, alleviate, and / or treat acute myocardial infarction and subsequent ventricular remodeling. The active ingredient of this drug is the Trichinella spiralis cysteine ​​protease inhibitor cystatin, abbreviated as rTs-Cys. rTs-Cys can effectively delay acute myocardial infarction and inflammatory response in mice, reduce the infarct area, improve cardiac function deterioration, and reverse organ pathological damage, providing a new approach for the clinical treatment of acute myocardial infarction and subsequent ventricular remodeling.

The present application relates to the technical field of disease risk prediction, and particularly relates to a ten-year risk prediction method, system and device for sudden cardiac death, the method comprising: obtaining 48-hour electrocardiogram data of an individual sample and a risk classification evaluation result based on a China-PAR risk assessment model; splitting and combining the electrocardiogram data to obtain a preset multi-dimensional waveform graph; constructing a convolutional neural network model, taking the waveform graph as input and the corresponding risk classification evaluation result as output to train the model and obtain a sudden cardiac death risk prediction model; inputting the processed waveform graph of 48-hour electrocardiogram data of a subject into the prediction model, and outputting the result as a ten-year sudden cardiac death risk prediction level result. The present application can create a non-linear, high-precision, and iterative sudden cardiac death risk deep learning model for the general population and doctors, improve the detection rate of sudden cardiac death, and reduce the recurrence rate and mortality.

This application relates to a method and apparatus for emergency resource matching and rescue decision-making based on injury situation. The method includes: acquiring real-time data from the disaster site; constructing a dynamic situational awareness model based on the real-time data and generating a multi-objective, multi-constraint rescue task model; solving the rescue task model using an intelligent matching algorithm and a hybrid multi-objective evolutionary algorithm to generate an initial casualty-resource matching scheme and a rescue route planning scheme; continuously monitoring situational indicators during the execution of the initial scheme, and performing a replanning operation to adjust resource matching and rescue routes when any indicator triggers a preset dynamic grading threshold. This method can significantly shorten the waiting time for critically injured patients, improve resource utilization, and reduce the expected mortality rate. It achieves efficient, robust, and adaptive rescue decision-making in large-scale emergency scenarios.

The utility model relates to agricultural waste treatment equipment technical field especially based on light and heat dual drive's black soldier fly larvae and insect sand separation system, include: frame, upper layer separation bin and upper layer separation bin. Upper layer separation bin sets up in the frame top, including the netted conveyer belt of horizontal operation, the flattening scraping thin device of feed end, the light and heat source above netted conveyer belt and the screen mesh anti -blocking device on the return path, the lower layer collection bin sets up in the lower layer separation bin below, including the entity conveyer belt of horizontal operation. The flattening scraping thin device will viscous or too thick insect sand even spread thin, promote light and heat penetrability and larvae drill out efficiency, the screen mesh anti -blocking device passes through the brush penetration and cleans the conveyer belt screen mesh hole, avoids the screen mesh blockage and leads to the conveyer belt shutdown. The above based on light and heat dual drive's black soldier fly larvae and insect sand separation system can realize the efficient and stable separation of larvae and insect sand.

This invention discloses an intracellular imaging system for simultaneously detecting UDG and miR-375 expression levels and its applications. The intracellular imaging system uses a tetrahedral DNA nanostructure as a carrier, loading a HAT-UDG probe with an on / off conformation, and coupling it with a split CRISPR / Cas12a detection component for recognizing miR-375. The split CRISPR / Cas12a detection component includes at least Cas12a protein, scaffold RNA, spacer RNA / equivalent split crRNA components, and a fluorescent reporter substrate. This invention is the first to perform a logical AND operation between two key indicators: UDG enzyme activity and miR-375 expression level. The system can only ultimately trigger a complete fluorescence signal when both are simultaneously highly expressed. This multi-target synergistic activation design constructs a precise molecular recognition logic gate, enabling extremely accurate differentiation between prostate cancer cells (RV-1) and normal cells (293T), as well as other cancer cells (5637) that highly express UDG, fundamentally avoiding misjudgments caused by fluctuations in a single indicator or non-specific expression, resulting in extremely high imaging specificity.

The application provides a wind-driven box lifting suitable temperature aquaculture device and method based on pumped storage. The device is composed of a fan water pumping, water storage, buoyancy device and box lifting device. The wind-driven generator drives the water pump to work, water enters the water tank from the water pumping pipe, and the fan water pumping is realized. When the water level reaches the upper water level sensor, the water pumping controller controls the water pump to stop pumping, and the water storage is realized. When the temperature reaches the low temperature line or the normal temperature line of the temperature sensor, a signal is sent to the valve controller, the valve is opened, water is discharged to generate electricity, the low temperature control motor releases the tight state of the rope, and the net cage is gently lowered. When the temperature is high, the control motor contracts the rope to the tight state, and the net cage is gently lifted. The application is suitable for multiple water areas, combines wind power with pumped storage, and realizes stable and uniform power generation. The application combines wind power with fishery, realizes suitable temperature aquaculture of fish population, reduces manual input, and improves resource utilization rate and ecological benefits.

This invention relates to the field of animal model construction technology, and more particularly to a method for constructing a zebrafish coronary artery microcirculation injury model based on enzyme stripping and its application. This invention, for the first time, utilizes a rationally composed mixture of collagenases to specifically strip coronary artery endothelial cells, minimizing non-specific damage to cardiomyocytes and stably inducing coronary artery injury to construct a zebrafish model of coronary artery injury, particularly coronary artery microcirculation injury. This model not only has a highly localized injury area and minimal impact on the myocardium, but also exhibits a low mortality rate. Furthermore, the zebrafish model of coronary artery injury constructed by this invention demonstrates significant regenerative potential, with its blood vessels exhibiting strong regenerative capacity. It also shows high sensitivity and responsiveness to drugs, making it potentially valuable in drug screening and mechanism research.

This utility model proposes a cold-proof and warm cattle shed structure for suckling calves, relating to the field of animal husbandry technology. It includes two sets of support columns, with two columns in each set. A lower crossbar and an upper crossbar are fixed between the two support columns. A support frame is fixed to the top of the upper crossbar, and a set of heat lamps is installed at the top of the support frame. Cold-proof cloth is fixed to the outer surface of the support frame and the support columns. This cold-proof and warm cattle shed structure for suckling calves can store electricity through photovoltaic panels during the day and turn on the heat lamps at night to heat the inside of the shed. Simultaneously, a first and second magnetic stripe is used to close the windbreak curtain, effectively blocking cold air from entering without affecting the cattle's entry and exit, preventing heat loss from the inside of the shed, and reducing the morbidity and mortality rates of suckling calves. After adjusting the two sets of support columns to a suitable distance, they are inserted into the ground, allowing for quick installation and disassembly of the cattle shed, facilitating its storage and transportation.

The application discloses primers, a kit and a method for detecting pathogenic bacteria of fever with hemorrhage syndrome, and nucleotide sequences of the primers are shown as SEQ ID NO. 1 to SEQ ID NO. 262. In the application, 131 pairs of specific primers are designed according to highly-conserved regions of 26 pathogenic bacteria of fever with hemorrhage related diseases, and a 26-pathogenic-bacteria detection method for fever with hemorrhage is established. The detection method can more completely cover the detection of pathogenic bacteria of fever with hemorrhage related diseases, has high accuracy, strong specificity and high sensitivity, can realize rapid detection in a short TAT (time to answer) of 15 hours, reduces mortality, and improves precise medication.

The present invention discloses a lamprey serum globular lectin, a preparation method thereof and its application in the detection of liver cancer, belonging to the technical field of cancer detection. The present invention discovers that glycosylation modification is abnormally highly expressed in liver cancer patients. The lamprey serum globular lectin is isolated and purified from lamprey serum. The lamprey serum globular lectin can specifically bind to glycan structures such as Galβ1-3GlcNAc, GlcNAcβ1-2Man and Manα1-2Man of glycoproteins in liver cancer tissues, and can be used for the diagnosis of liver cancer. The lamprey serum globular lectin of the present invention can diagnose liver cancer efficiently and specifically, is particularly sensitive to the diagnosis of intrahepatic cholangiocarcinoma, has high reference value for the diagnosis of liver cancer, and is suitable for popularization and application.

The utility model discloses a mouse heart radioactivity damage mould based on 3D printing and mould turning process, including frame body structure, the whole is hollow cuboid structure without top, the frame body structure is spliced by left and right two connecting pieces, and this kind of structure is convenient for early processing and later storage, support piece is provided with two rows, and two rows of support pieces are symmetrically placed in the two side wall positions of frame body structure, the utility model discloses through 3D modeling calculation radio source under the lead plate barrier, the real data of accurate irradiation mouse heart, the lead plate mould is made based on three -dimensional structure data 3D printing, and accurate mould turning is carried out to low melting point lead through mould turning technology, realize the production of high accuracy, and X ray can accurately penetrate the radiation hole and form the circular irradiation field of 1cm diameter, realize the accurate radiotherapy of heart, and the radiation dose that other parts bear under the protection of 3cm thick lead plate is lower, and the animal mortality is low, and it is closer to the clinical practice.