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190results about How to "Reduce mortality" patented technology

Acute kidney injury risk early warning system

The invention discloses an acute kidney injury risk early warning system, and relates to the technical field of clinical decision support systems. In order to solve the problems that in the prior art, due to the fact that a large amount of data preprocessing and model training need long-time data processing and model operation, the early warning opportunity is not accurate, the real-time performance is low, personalized early warning prompting cannot be carried out for patient groups, and early warning fatigue and early warning desensitization are likely to be caused. Through data preprocessing, model construction and risk analysis, real-time monitoring and accurate prediction of the AKI risk of a patient are realized, the early recognition rate is improved, the early warning decision unit generates specific early warning information according to risk scores and kidney function change rules and provides targeted treatment suggestions, and meanwhile, through an early warning threshold adjustment and approach matching module, the early warning decision unit can perform early warning on the AKI risk of the patient. The early warning strategy is optimized, the response speed of medical staff and the compliance of patients are improved, and the user interaction unit continuously optimizes the early warning system through a feedback mechanism.
Owner:NORTHERN JIANGSU PEOPLES HOSPITAL

Intelligent disinfection system for farm

The invention relates to the technical field of farm disinfection, in particular to an intelligent disinfection system for a farm. The system comprises an initial determination module, a periodic disinfection module, an environment monitoring module, a first analysis control module, a second analysis control module and a feedback correction module. According to the method, the initial disinfection parameter cluster of each breeding area in the target breeding farm is determined according to the actual growth stages of the breeding targets and the actual number corresponding to each actual growth stage, each breeding area is periodically disinfected according to the initial disinfection parameter cluster, and each breeding area is monitored in real time so as to be singly judged; and performing first-class adjustment and second-class adjustment on the initial disinfection parameter cluster based on a first verification result and a second verification result in combination with the first verification result and the second verification result to determine whether the initial disinfection parameter cluster is subjected to first-class adjustment and second-class adjustment. And according to the first analysis control result and the second analysis control result, determining whether to perform feedback correction on a preset initial disinfection period of each breeding area.
Owner:CHONGQING HAILIN PIG DEV CO LTD

Primer probe combination for simultaneously detecting different serotypes of aviadenoviruses, kit and application

The invention provides a primer probe combination for simultaneously detecting different serotypes of aviadenoviruses, a kit and application. The different serotypes of aviadenoviruses comprise C4 type, E8a type, E8b type and D11 type. Wherein the sequences of the primer probes for the C4 type fowl adenovirus are respectively shown as SEQ ID NO.1-3, the sequences of the primer probes for the E8a type fowl adenovirus are respectively shown as SEQ ID NO.4-6, the sequences of the primer probes for the E8b type fowl adenovirus are respectively shown as SEQ ID NO.4-5 and SEQ ID NO.7, and the sequences of the primer probes for the D11 type fowl adenovirus are respectively shown as SEQ ID NO.8-10. The kit can be used for quickly and accurately detecting multiple serotypes of the fowl adenovirus, and is high in specificity and good in repeatability. In addition, only about one hour is needed for completing one-time sample detection and result interpretation, and the detection cost can be controlled to be 1-3 yuan / sample.
Owner:WENS FOODSTUFF GROUP CO LTD

Fry transportation method

The invention discloses a fry transportation method, and belongs to the technical field of fry transportation. According to the fry transportation method, a fry transportation anesthesia test is introduced, the appropriate anesthetic type and concentration are determined through research of four parameter indexes, the death rate of released fries, especially small-size and stress-prone fries in the transportation process is reduced, and the method has positive significance on smooth enhancement and release.
Owner:CHANGJIANG SURVEY PLANNING DESIGN & RES CO LTD

Application of LGG exosome in preparation of medicine for preventing and treating sepsis acute lung injury

The invention relates to the field of acute lung injury caused by sepsis, in particular to application of lactobacillus rhamnosus exosome in preparation of medicine for treating and / or preventing acute lung injury caused by sepsis of subjects, and the acute lung injury caused by sepsis is acute complication of sepsis. The sepsis is caused by bacterial infection, and the particle size of the lactobacillus rhamnosus exosome ranges from 50 nm to 120 nm. The lactobacillus rhamnosus exosome provided by the invention can prevent and / or timely and effectively prevent the development of the disease course of a subject at the initial stage of sepsis acute lung injury, and finally, the treatment success rate of the subject is increased, and the prognosis of the subject is improved.
Owner:成都市第五人民医院

Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease as well as preparation method and application of traditional Chinese medicine composition

The invention discloses a traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease, which is prepared from the following raw materials in parts by weight: 6-9 parts of honey-fried ephedra, 30-40 parts of gypsum, 6-9 parts of fried semen armeniacae amarae, 9-15 parts of fructus perillae, 9-15 parts of semen lepidii, 9-15 parts of radix asteris, 9-12 parts of radix peucedani, 9-12 parts of cynanchum glaucescens, 9-15 parts of thunberg fritillary bulb, 9-15 parts of honey-fried folium eriobotryae, 6-12 parts of rhodiola rosea and 6-9 parts of liquorice. Through scientific compatibility of the traditional Chinese medicine raw materials, clinical symptoms of patients in the acute exacerbation period of the chronic obstructive pulmonary disease can be effectively relieved, the acute exacerbation frequency and degree of the patients with the chronic obstructive pulmonary disease are reduced, and lung function decline is delayed. The traditional Chinese medicine composition is free of toxic and side effects and has the advantages of being good in curative effect, fast in effect taking, high in medicine effect, not prone to relapse and the like in the aspect of treating chronic obstructive pulmonary acute exacerbation.
Owner:BEIJING UNIV OF CHINESE MEDICINE THIRD AFFILIATED HOSPITAL

Scophthalmus maxima PN-Ta3 sourced from intestinal tract of turbot and application of psychrophilus maxima PN-Ta3

The invention discloses a psychrobacter haeli PN-Ta3 derived from turbot intestinal tracts and application of the psychrobacter haeli PN-Ta3, and belongs to the technical field of microorganisms. The psychrophilus haeli PN-Ta3 is separated from the intestinal tract of a healthy cultured turbot, and is preserved in the China Center for Type Culture Collection, the preservation address is Wuhan, China, the preservation date is January 25, 2024, and the preservation number is CCTCC NO: M2024201. The psychrobacter nivalis PN-Ta3 disclosed by the invention has the beneficial effects that the psychrobacter nivalis PN-Ta3 has no pathogenicity to healthy turbots and has good colonization performance, and after the psychrobacter nivalis PN-Ta3 is prepared into freeze-dried bacterial powder and is mixed with and added to feed the turbots, not only can the growth and intestinal development of the cultured turbots be promoted, but also the intestinal microbial structure is optimized; the composition can also delay the morbidity and death of turbots caused by infection of aeromonas salmonicida BHAS-1.
Owner:YANTAI MARINE ECONOMIC RES INST (YANTAI FISHERY TECH PROMOTION STATION YANTAI MARINE FISHING ENHANCEMENT MANAGEMENT STATION)

Composition for resisting porcine viral diarrhea and application thereof

The invention discloses a composition for resisting porcine viral diarrhea and application of the composition. The composition for resisting porcine viral diarrhea is prepared from the following components in parts by mass: 2 parts of phloretin, 1 part of N-acetyl-D-galactosamine and 100 parts of proline. The composition can further comprise one or more auxiliary materials of absolute ethyl alcohol, propylene glycol, dimethyl sulfoxide, edible oil, water, tween-80, lactose, defatted rice bran, corncob powder, soluble starch, bran, silicon dioxide, montmorillonite, vermiculite, medical stone, zeolite powder, white carbon black and the like. The composition can significantly inhibit the proliferation of PEDV, TGEV and PoRV, and inhibit the infection of PEDV, TGEV and PoRV on cells, and further, the composition can be used for preparing drugs or feed additives for resisting porcine diarrhea diseases caused by viruses such as PEDV, TGEV and PoRV.
Owner:WUHAN POLYTECHNIC UNIVERSITY

A strain of Riemerella anatipestifer phage PT15, its phage composition and its application

The present invention discloses a strain of Riemerella anatipestifer phage PT15, a phage composition thereof and its application. The phage PT15 has a deposit number of CGMCC No. 22377 and was deposited in the China General Microbiological Culture Collection Center on April 12, 2021. The present application also provides a phage composition comprising the above-mentioned phage. The above-mentioned phage and phage composition can be used as active ingredients for the preparation of therapeutic drugs and feed additives, and are used in the prevention and treatment of duck bacterial serositis. The phage composition has the advantages of safety, high efficiency and non-toxic side effects, and can be used as an active ingredient of a new type of environmental disinfectant to effectively prevent and control the pollution of breeding environment and feeding facilities, and has good application prospects.
Owner:QINGDAO PHAGEPHARM BIO TECH CO LTD

Lifesaving device throwing system

The invention provides a lifesaving device throwing system, and relates to the technical field of emergency rescue equipment. The ejection mechanism comprises a rack, a first elastic piece, a spring plate, a first gear, a first rack and a first motor, the upper end of the first elastic piece is connected with the rack, the lower end of the first elastic piece is connected with the spring plate, the first rack is vertically arranged and connected with the spring plate, and the first gear is connected with the first motor and engaged with the first rack; the trigger mechanism comprises a trigger block, a second elastic piece, a pull rod and a second motor, the first rack is provided with a clamping groove, the trigger block is rotatably connected to the rack and connected with the rack through the second elastic piece, one end of the pull rod is rotatably connected with the trigger block, and the other end of the pull rod is connected with the second motor. And the second motor can drive the trigger block to rotate, so that the trigger block is separated from the clamping groove. The unmanned aerial vehicle has the beneficial effects that the accuracy and speed of releasing the life buoy by the unmanned aerial vehicle are improved, and the probability of rescue failure of drowners is reduced.
Owner:CHINA UNIV OF GEOSCIENCES (WUHAN)

Medical system and scheduling method based on remote data center

The present invention provides a medical system and a scheduling method based on a remote data center. The medical system includes at least one remote data center. The remote data center includes: a remote diagnosis system configured to receive detection data about a patient received from at least one detection device, and perform predetermined processing on the detection data to obtain a diagnosis result indicating a disease of the patient; and a scheduling system configured to determine a target transport tool and a target hospital within a predetermined range according to the patient's location information and the diagnosis result, and push task information to the determined target transport tool and target hospital, so as to schedule the target transport tool to transport the patient to the target hospital.
Owner:ASTRAZENECA INVESTMENT CHINA CO LTD

Application of Cpeb3 gene inhibitor and copper death inhibitor in preparation of medicine for treating myocardial ischemia-reperfusion injury

The invention discloses application of a Cpeb3 gene inhibitor and a copper death inhibitor in preparation of a medicine for treating myocardial ischemia-reperfusion injury, and relates to the technical field of myocardial ischemia-reperfusion injury. By specifically reducing or knocking out Cpeb3 expression, myocardial repair can be remarkably promoted, action potential stability is improved, and the death rate is reduced. Therefore, Cpeb3 is a specific intervention target spot of copper death in Gpc6 + CMs. The small molecule inhibitor of Cpeb3 can remarkably reverse changes of copper death, aerobic respiration and / or glycolysis caused by Cpeb3 activation. In addition, the copper death inhibitor can improve the survival rate of myocardial cells, reverse the change of aerobic respiration and / or glycolysis induced by Cu, and reverse the change of glycolysis, pentose phosphate pathway and tricarboxylic acid cycle metabolites caused by Cu stimulation. Therefore, the invention provides a new solution for prevention and treatment of myocardial ischemia reperfusion injury, and has a good application prospect.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL

Biomarker for predicting prognosis of intrahepatic cholangiocarcinoma patient, prediction model and application

The invention discloses a biomarker for predicting prognosis of an intrahepatic cholangiocarcinoma patient, a prediction model and application, and belongs to the field of biomedicine. According to the invention, single cell sequencing is carried out on matched intrahepatic cholangiocarcinoma and para-carcinoma tissues by using a BD Rhapsody platform, a tumor cell subset taking SPINK1 as a representative gene is screened out by using single cell sequencing data, and differential expression analysis is carried out on the subset and other epithelial cell subpopulations to obtain 249 differential genes. The differential genes are subjected to machine learning, a GBM model with the optimal prediction efficiency is selected, and a prediction model which contains 205 genes and is used for predicting the prognosis of the intrahepatic cholangiocarcinoma patient is established according to the GBM model. According to the prognosis prediction model, the prognosis prediction efficiency of the intrahepatic cholangiocarcinoma patient is improved, high-risk people can be more sensitively found, and key monitoring and more personalized treatment are carried out on the people, so that the death rate of the intrahepatic cholangiocarcinoma patient is reduced, and the lifetime of the patient is prolonged.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV

Cervical cancer prediction method based on adaptive KNN noise recognition

The invention discloses a cervical cancer prediction method based on adaptive KNN noise recognition, and the method comprises the steps: firstly obtaining a cervical cancer data set, carrying out the missing value processing, newly building target features, and carrying out the feature correlation analysis and standardization processing; performing mark classification on data in the standardized cervical cancer data set by using noise identification based on adaptive KNN, and performing oversampling by using a category-based mixed sampling algorithm; and finally performing classification training and predicting a test set to obtain a prediction result. According to the method, the K value is adaptively determined through kernel density estimation, recognition is carried out through neighborhood information in the noise recognition process, noise recognition is carried out through adjacent sample information of a certain sample, noise data can be more effectively recognized, meanwhile, the data can be reasonably divided, and when balance data is calculated through oversampling, the noise data can be more effectively recognized. New noise generated in synthetic data is reduced, and the method has high prediction precision in cervical cancer prediction, so that the death rate of women caused by cervical cancer is reduced.
Owner:XIAN UNIV OF TECH

Large-scale tea lesser leafhopper cultivation and preservation method suitable for cicada tea production

The invention discloses a large-scale tea lesser leafhopper cultivation and preservation method suitable for cicada tea production. The method comprises the following steps: step 1, preferably selecting Jinxuan, jade or Fuding white tea as a host plant variety, and determining the specification of the host plant; step 2, establishing a tea lesser leafhopper adult maintenance area, a nymph maintenance area and an egg incubation area, performing partition maintenance, and preferably selecting optimal maintenance conditions and culture density of different maintenance areas; step 3, preferably selecting a collection mode of tea lesser leafhopper eggs: preferably selecting an adult male-female ratio, and preferably selecting egg laying population density, egg collection duration and the like; 4, a tea lesser leafhopper egg storage chamber is established, and storage conditions are optimized; and step 5, preferably selecting incubation conditions and incubation time of the tea lesser leafhopper eggs after low-temperature storage. According to the large-scale production method, the tea branches to be trimmed in the tea garden are utilized, and the cost is low. The tea branches are used for culture, and the death rate caused by the fact that the leafhoppers need to adapt to host plants again during release is reduced.
Owner:INST OF ZOOLOGY GUANGDONG ACAD OF SCI

Mud dice breeding and breeding method

The invention relates to the technical field of mud dice breeding, and particularly discloses a mud dice breeding and breeding method which comprises the following steps: step 1, selecting a site of a mud dice breeding farm; 2, building a culture pond; building a culture pond according to the terrain, including ditching, ridging, soil turning and leveling, and burying a water inlet and drainage pipeline on the mud flat; 3, cleaning the pond and applying a base fertilizer; 4, fry stocking; step 5, breeding management; according to the method, the acre yield of mud dice culture can be increased, the weight of a single mud dice is increased, the death rate and the disease and pest rate are reduced, the income is increased, the reproduction rate of the mud dice can be increased, the method is very simple in the mud dice culture process, and enemies can be prevented from entering the culture pond.
Owner:ZHANJIANG TANGDONG BREEDING PROFESSIONAL COOP

Application of binding molecule of actin binding protein LASP1 in prevention and treatment of acute respiratory distress syndrome

The invention belongs to the technical field of medicines, and particularly discloses application of binding molecules of actin binding protein LASP1 in prevention and treatment of acute respiratory distress syndrome (ARDS). According to the invention, the LASP1-loaded nanoparticles are constructed, so that the problems that the drug is difficult to penetrate and easy to remove and degrade and the ARDS is difficult to treat are solved. According to the invention, through intranasal instillation of the HA-DA / BP / LASP1 nanoparticles, the level of inflammatory factors can be reduced, the alveolar epithelial barrier structure and function can be repaired, and the death rate of ARDS model mice can be reduced.
Owner:CENT SOUTH UNIV

Application of creatine in preparation of medicine or feed additive for treating or preventing swine pathogenic diarrhea

The invention discloses an application of creatine in preparation of a medicine or a feed additive for treating or preventing pig pathogenic diarrhea, the medicine is creatine or is prepared into oral liquid, granules, tablets and powder by taking the creatine as an active ingredient and adding auxiliary materials, and the use dosage is that the content of the creatine is 30-300mg / kg of pig body weight; or the feed additive is directly added into the feed, and the adding amount is that the content of creatine accounts for 0.05-0.5% of the total weight of the pig feed. The medicine or the feed additive provided by the invention is high in safety and free from toxic and side effects, can effectively prevent and treat pathogenic diarrhea caused by infection of one or more pathogens of porcine epidemic diarrhea virus, porcine transmissible gastroenteritis virus, porcine rotavirus and enterotoxigenic escherichia coli, improves the intestinal morphological structure and the absorption function of diseased pigs, and improves the immunity of the pigs. The morbidity and mortality of piglets are reduced.
Owner:WUHAN POLYTECHNIC UNIVERSITY

Application of compound rociletinib in preparation of medicine for treating acute liver injury by inhibiting ferroptosis

The invention discloses an effect of a compound rociletinib in acute liver injury by inhibiting ferroptosis, and belongs to the technical field of programmed cell death (ferroptosis) inhibitors. When acute liver injury is treated, the intracavitary injection dosage is 20 mg / kg, and intraperitoneal injection is performed twice at an interval of 1 h during treatment. The application of the rociletinib in treating the acute liver injury has the beneficial effects that the application of the rociletinib in treating the acute liver injury is provided, and particularly, the ferroptosis inhibitor rociletinib can be applied to treating / relieving the acute liver injury. According to the application disclosed by the invention, a ferroptosis inhibitor rociletinib acts on a mouse acute liver injury model caused by ConA to improve liver histology, liver inflammation tissues, ALT / AST levels and the like, so that a treatment effect is achieved. The application has the main advantages that evidence of rociletinib in the ferroptosis inhibition process is provided, a new theoretical basis is provided for treatment of acute liver injury, and the application has profound application value.
Owner:INST OF HEALTH & MEDICINE HEFEI COMPREHENSIVE NAT SCI CENT

Rapid crab cleaning equipment

The invention relates to the technical field of crab cleaning, in particular to quick crab cleaning equipment which comprises an operation table, a fixed inclined plate is fixed to the top end of the operation table, a round rod is fixed to the bottom end of the fixed inclined plate, a cleaning brush is arranged on one side of the round rod, and a connecting rod is fixed to one side of the cleaning brush; a first cleaning roller and a second cleaning roller are rotatably inserted into the L-shaped column, a first gear fixedly sleeves the surface of the first cleaning roller, a second gear fixedly sleeves the surface of the second cleaning roller, a square column is fixed to one side of the moving plate, and a bidirectional ball screw is rotatably inserted into the square column through threads. Through cooperative use of the fixed inclined plate, the cleaning brush, the round rod, the second cleaning roller and the moving block, the purpose of cleaning the back and the abdomen of a crab at the same time can be achieved, the device can clean the back and the abdomen of the crab at the same time, and the cleaning efficiency can be improved.
Owner:ANHUI ZUITUOHU FOOD CO LTD

Grease composition for resisting swine envelope virus infection and application of grease composition

The invention discloses a grease composition for resisting porcine envelope virus infection and application of the grease composition. The grease composition comprises at least two of glyceryl monovalerate, glyceryl monolinoleate and glyceryl monomyristate. The grease composition can also comprise absolute ethyl alcohol, propylene glycol, dimethyl sulfoxide, edible oil, lactose in Tween 80, mannitol, soluble starch, water and other auxiliary materials, and is used for preparing a grease composition preparation. The grease composition can inhibit envelop viruses in a multi-way and multi-layer mode, and the antiviral effect is improved. By adding the grease composition into pig feed, not only can the antiviral capability be improved, but also inflammatory response caused by pathogenic infection can be reduced through the anti-inflammatory and immune regulation effects of the grease composition, and the infection of swine envelope viral diarrhea can be effectively prevented and treated, so that the incidence rate of the swine envelope viral diarrhea and the death rate of diseased pigs are reduced. The grease composition can be used for preparing a medicine or a feed additive for treating and preventing swine envelope viral diarrhea.
Owner:HUBEI HAOHUA BIOTECH

Lactobacillus brevis with broad-spectrum antibacterial activity as well as separation method and application thereof

PendingCN121852261Adiameter significant <other></other>Broad spectrum and strong in vitro inhibitory activityAntibacterial agentsBacteriaBiotechnologyLactobacillus crustorum
The invention discloses a lactobacillus brevis with broad-spectrum bacteriostatic activity and a separation method and application thereof, and belongs to the technical field of microorganisms, in particular to a lactobacillus brevis AW04 with broad-spectrum bacteriostatic activity, which is characterized in that the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, and the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection. The address is Wuhan University Campus, Wuchang District, Wuhan City, Hubei Province; the postcode is 430072; the preservation number of the strain is CCTCC M 20241970; the preservation date is September 13, 2024. The strain provides a novel, safe and efficient strain resource for developing microecological preparations, feed additives or veterinary drugs for preventing and treating bacterial diarrhea of animals such as calves and the like, and has important value for reducing the use of antibiotics in the breeding industry and coping with bacterial drug resistance crisis. The strain can be produced on a large scale by using the existing fermentation technology and is convenient to apply.
Owner:SHIHEZI UNIVERSITY

A method for artificial propagation of bullfrogs

PendingCN122498465AEfficient spawningOvercome the problem of lack of concentration in estrus
This invention provides a method for the artificial breeding of bullfrogs, including bullfrog selection, pairing, breeding, artificial spawning induction, artificial insemination, fertilized egg hatching, and tadpole rearing. This invention uses precise control of water temperature and quality in the breeding water to stimulate the gonadal development of the bullfrogs. It utilizes artificial spawning induction, insemination, fertilized egg hatching, and seedling rearing techniques to solve the problems of existing bullfrog germplasm degradation and difficulties in artificial breeding. By adding *Lactobacillus rhamnosus* to the feed, the mortality rate of bullfrogs is effectively reduced, the hatching rate of fertilized eggs is high, and the seedling growth rate is fast. This allows for a stable and continuous supply of high-quality bullfrog stock, meeting the effective demand for bullfrog seedlings throughout the year, and providing a technical foundation for the artificial breeding of bullfrogs.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY +2

A salmon transport device

This utility model relates to the field of aquaculture technology, specifically a buffer-type salmon and trout transfer device, including a conveying chamber with a fish storage box fixedly connected inside. This utility model features a first transport trough, a second transport trough, a rotating shaft, and a turntable. When the operator pulls the second transport trough outward, a slider inside the trough moves outward, extending the second transport trough so that its length contacts the water surface, reducing salmon and trout mortality due to height limitations. Pressing down on the second transport trough causes the first transport trough to rotate downward, which in turn causes the rotating shaft to rotate, allowing the second transport trough to contact the water surface. Pulling up the lifting block raises the gate, allowing the salmon and trout to flow from the fish storage box into the first transport trough. The cushioning effect of the rubber pad reduces salmon and trout mortality and improves the device's efficiency.
Owner:国信工船(青岛)海洋科技有限公司 +1

Efficient resource utilization and conversion method based on agricultural and forestry wastes, feed and application

PendingCN119404711Aefficient conversionpromote growthAnimal feeding stuffAccessory food factorsProtaetia brevitarsisPleurotus pulmonarius
The invention discloses an efficient resource utilization and conversion method based on agricultural and forestry waste, feed and application, and belongs to the field of ecological cycle agriculture. The protaetia brevitarsis larva feed is prepared by utilizing crop straws and / or pruned branches of forest trees, a pleurotus pulmonarius strain-pleurotus geesteranus 18 is selected in the process, the biodegradation rate is high, efficient degradation of agricultural and forestry wastes is realized, and mushroom residues after three times of mushroom harvesting are crushed to serve as the protaetia brevitarsis larva feed, so that the yield of the protaetia brevitarsis larva feed is improved. And when the prepared feed is used for feeding the protaetia brevitarsis larvae, the death rate of the protaetia brevitarsis bodies is relatively low, the weight gain is relatively fast, and the speed of feeding the agricultural and forestry wastes is obviously accelerated. The method provided by the invention can realize efficient conversion of agricultural and forestry wastes.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

A high temperature resistant pigeon-derived Salmonella typhimurium phage, a phage composition thereof and application thereof

The invention discloses a high temperature resistant pigeon-source Salmonella typhimurium phage, a phage composition and an application thereof, wherein the high temperature resistant pigeon-source Salmonella typhimurium phage is named PC204, and its deposit number is CGMCC No. 22368. The phage PC204 belongs to a long-tailed phage, has the characteristics of high temperature resistance, exhibits strong lysis and wide lysis spectrum characteristics to pigeon-source Salmonella typhimurium, can effectively prevent and treat pigeon-source Salmonella typhimurium diseases, has a specific lysis advantage to the pigeon-source Salmonella typhimurium, and can effectively reduce the mortality rate of pigeons and the positive rate of pigeon-source typhoid antibodies. It can be prepared into drugs for preventing and treating pigeon paratyphoid disease, environmental disinfectants, pigeon feed and pigeon water additives, and detection kits for application. The phage is safe and has no toxic side effects, will not produce drug-resistant bacteria, and has a good market application prospect.
Owner:QINGDAO PHAGEPHARM BIO TECH CO LTD

Ruditapes philippinarum miR-263b inhibitor and application thereof

PendingCN121950803ADisinhibition effectEnhance immune defenseAntibacterial agentsOrganic active ingredientsVibrio anguillarumSignalling pathways
The invention discloses a Ruditapes philippinarum miR-263b inhibitor and application thereof, and finds that Ruditapes philippinarum miR-263b can regulate and control innate immune response of a host by targeting RpSC2, negatively regulates activation of an immune-related signal channel in a vibrio infection process, and further, on the basis of a molecular regulation and control mechanism, the Ruditapes philippinarum miR-263b inhibitor can be used for inhibiting the infection of vibrio. The invention discloses a specific inhibitor which is completely complementary with a miR-263b mature body sequence. Experimental data show that after Ruditapes philippinarum is injected with the miR-263b inhibitor, the expression level of miR-263b in vivo is reduced, and the inhibition effect of miR-263b on RpSC2 is effectively relieved, so that the expression level of a target gene RpSC2 is up-regulated, an NF-kappa B immune signal channel is activated, the immune defense capability of the Ruditapes philippinarum on vibrio anguillarum is enhanced, the death rate after infection is remarkably reduced, and the Ruditapes philippinarum is prevented from being infected. The in-vivo bacterium loading amount is obviously reduced, and the pathological injury of hepatopancreas tissue is obviously relieved.
Owner:DALIAN OCEAN UNIV

A potential molecular marker to aid in the diagnosis of cancer

ActiveCN115612735BImprove the effect of early diagnosis and treatmentreduce mortalityMicrobiological testing/measurementHybridisationCD44Hematological test
The application discloses a potential molecular marker for assisting in diagnosing cancer. The application provides application of a methylation CD44 gene as a marker in preparation of a product; the product is used for at least one of the following: assisting in diagnosing cancer or predicting a cancer morbidity risk; assisting in distinguishing a benign nodule and cancer; assisting in distinguishing different subtypes of cancer; assisting in distinguishing different stages of cancer; assisting in distinguishing different cancers; determining whether a to-be-tested substance hinders or promotes occurrence of cancer; and the cancer can be lung cancer or breast cancer. The application finds a low methylation phenomenon of the CD44 gene in blood of lung cancer and breast cancer patients, and has important scientific significance and clinical application value for improving early diagnosis and treatment effect of lung cancer and breast cancer and reducing mortality.
Owner:NANJING TANTICA LTD