6results about How to "Prevent relapse" patented technology

This invention discloses a method for eliminating moss growth on macadamia nut leaves, relating to the field of agricultural planting technology. The specific method involves spraying a moss-removing agent onto the macadamia nut leaves during the moss occurrence period, applying moss inhibitor I to the main stem, and applying moss inhibitor II to the soil surface around the main stem. The moss-removing agent comprises the following raw materials in parts by weight: 40-50 parts of allicin, 15-24 parts of urea, 5-18 parts of calcium propionate, 20-27 parts of calcium sulfate, 10-17 parts of calcium chloride, 20-35 parts of vegetable oil, 1-10 parts of titanium dioxide, 1-5 parts of glutathione, and 1-3 parts of dispersant. This invention solves the problems of slow effectiveness, short duration of action, and low plant safety in current macadamia nut leaf moss control methods, achieving highly efficient control.

This invention provides a nucleic acid aptamer that targets and binds to the IGF2BP2 protein and its application, belonging to the field of pharmaceutical technology. This invention is the first to design a highly specific nucleic acid aptamer targeting the RNA recognition protein IGF2BP2, obtaining a nucleic acid aptamer that can target and specifically bind to the IGF2BP2 protein (see SEQ ID No. 1-2). This nucleic acid aptamer can effectively inhibit the activity of tumor cells, tumor stem cells, and breast cancer brain metastases, breast cancer lung metastases, breast cancer liver metastases, breast cancer kidney metastases, and breast cancer bone metastases, providing a new drug component for the treatment of malignant and refractory tumors (especially glioblastoma and distant metastatic breast cancer). Furthermore, it was discovered that modification with N6-methyldeoxyadenosine monophosphate can further enhance the specificity of the nucleic acid aptamer and strengthen its efficacy in inhibiting tumor cell activity.

This invention relates to an AI model backdoor defense system and its detection method. The technical solution includes a model security detection module, a backdoor location and tracing module, a backdoor removal and hardening module, a real-time inference protection module, and a security verification and auditing module. These modules are interconnected to form a closed-loop defense architecture. Based on this system, the method identifies model backdoors through multi-dimensional fusion detection, linking the entire process of location and tracing, removal and hardening, real-time protection, and security verification to achieve accurate detection, thorough removal, and real-time protection against various AI model backdoors. This invention overcomes the shortcomings of existing technologies, such as single detection dimensions, lack of closed-loop defense, poor scenario adaptability, and poor real-time performance. It is adaptable to various deep learning models, including large language models and multimodal models, and is applicable to multiple scenarios such as model development, deployment, and supply chain security, improving model security and possessing broad application value.

This invention provides a compound plaster for promoting blood circulation and relieving pain, and its preparation method. It relates to the field of pharmaceutical technology and is made from a variety of medicinal materials, including white-flowered snake, red peony root, peach kernel, centipede, aconite, scorpion, and drynaria, combined with litharge and sesame oil. The optimal ratio was determined through scientific screening, forming a compound system that "dispels wind and unblocks meridians, invigorates blood and removes blood stasis, eliminates dampness and relieves pain, and strengthens the body's resistance." It balances rapid onset of action with consolidation of therapeutic effects while reducing the risk of skin irritation. The preparation method includes raw material pretreatment, 30-day sealed soaking in sesame oil, gradient temperature cooking to remove residue, and forming the plaster. Through long-term soaking and gradient cooking processes, the dissolution rate of effective ingredients is significantly improved. This invention is suitable for relieving pain and limited limb movement caused by bone, joint, and soft tissue diseases such as frozen shoulder, cervical spondylosis, and lumbar muscle strain. It is convenient to use, has definite curative effects, and has good application prospects.

A keloid mechanical balance microneedle, a preparation method and an application in preparing a product for preventing keloid recurrence, wherein the preparation method of the keloid mechanical balance microneedle is as follows: firstly, according to the average thickness of postoperative scar tissue of an object, a preliminary skin-scar finite element model composed of a scar structure and a skin structure is constructed, and the thickness of each position of the whole scar structure is the same; then, the keloid mechanical balance microneedle is finally obtained through four steps. The keloid mechanical balance microneedle is prepared according to the postoperative scar tissue of an object, and through the keloid mechanical balance microneedle, the stress distribution between the keloid and the surrounding skin can be uniform, and the keloid recurrence can be effectively prevented.

The invention belongs to the technical field of biological medicines, and particularly relates to a GM-CSF loaded tumor cell vaccine and application thereof in prevention and treatment of liver cancer. In order to enhance the immunogenicity of the existing tumor cell vaccine, a liver cancer cell line is modified through genetic engineering, and a key cell factor GM-CSF capable of regulating and controlling differentiation, maturation, migration and functions of DCs is introduced, so that the GM-CSF is stably overexpressed, and the whole-cell tumor vaccine capable of efficiently secreting the GM-CSF is successfully constructed. And the antigen presentation and T cell starting capability of the DCs are further enhanced through ionization irradiation. Experiments prove that the GM-CSF loaded tumor cell vaccine can effectively activate specific T cell immune response, induce long-acting immune memory, inhibit immune tolerance and obviously inhibit growth of liver cancer tumors and tumor recurrence, and is high in safety. The method is hopeful to enter the development and application of clinical tumor vaccines.