16results about How to "Prevent relapse" patented technology

This invention discloses a method for eliminating moss growth on macadamia nut leaves, relating to the field of agricultural planting technology. The specific method involves spraying a moss-removing agent onto the macadamia nut leaves during the moss occurrence period, applying moss inhibitor I to the main stem, and applying moss inhibitor II to the soil surface around the main stem. The moss-removing agent comprises the following raw materials in parts by weight: 40-50 parts of allicin, 15-24 parts of urea, 5-18 parts of calcium propionate, 20-27 parts of calcium sulfate, 10-17 parts of calcium chloride, 20-35 parts of vegetable oil, 1-10 parts of titanium dioxide, 1-5 parts of glutathione, and 1-3 parts of dispersant. This invention solves the problems of slow effectiveness, short duration of action, and low plant safety in current macadamia nut leaf moss control methods, achieving highly efficient control.

The invention relates to an acne-removing composition containing natural plant components and a preparation method of the acne-removing composition, and belongs to the technical field of cosmetics. The invention provides an acne-removing composition containing natural plant components. The acne-removing composition is prepared from rhodomyrtus tomentosa fruit extract, hydrolyzed red algae extract, hydrangea crassifolia leaf extract, Lagopsis supina extract and ceramide. Wherein the antibacterial and anti-inflammatory effects of the rhodomyrtus tomentosa fruit extract and the anti-inflammatory and soothing effects of the Lagopsis supina extract directly resist the core etiology and symptoms of acne; the hyperactivity of sebum is reduced by the hydrangea crassifolia leaf extract; the hydrolyzed red algae extract can buffer potential stimulation and maintain skin hydration; ceramide can strengthen the self-defense capability of the skin and prevent relapse during treatment; the five components supplement each other and have a good acne removing effect.

The invention discloses a thrombus suction and storage device for vascular surgery, and relates to the technical field of medical instruments, the thrombus suction and storage device comprises a handheld control gun, and further comprises a driving mechanism, a stirring mechanism, a liquid injection mechanism and a recovery and storage mechanism, the stirring mechanism comprises a catheter and a stirring head, and the catheter is arranged in the middle of the front end of a driving box; the stirring head is arranged at the bottom end of the guide pipe, the recycling and storing mechanism comprises a storage bottle, and the storage bottle is arranged below the handheld control gun. The stirring head is conveyed to the thrombus blockage position through the catheter, the medical rotating wire rotates to stir the thrombus, the stirred thrombus is sucked into the storage bottle through the recycling pipe and the second connecting pipe in combination with the negative pressure of the storage bottle, dredging and suction are conducted synchronously, incomplete suction is avoided, meanwhile, liquid medicine is released to the thrombus position through the liquid injection pipe, and re-coagulation is restrained; and the liquid medicine bin continuously maintains negative pressure to ensure that thrombus is continuously sucked in, so that the problem that the thrombus easily blocks the catheter is solved, and the working efficiency of thrombus suction is improved.

This invention provides a nucleic acid aptamer that targets and binds to the IGF2BP2 protein and its application, belonging to the field of pharmaceutical technology. This invention is the first to design a highly specific nucleic acid aptamer targeting the RNA recognition protein IGF2BP2, obtaining a nucleic acid aptamer that can target and specifically bind to the IGF2BP2 protein (see SEQ ID No. 1-2). This nucleic acid aptamer can effectively inhibit the activity of tumor cells, tumor stem cells, and breast cancer brain metastases, breast cancer lung metastases, breast cancer liver metastases, breast cancer kidney metastases, and breast cancer bone metastases, providing a new drug component for the treatment of malignant and refractory tumors (especially glioblastoma and distant metastatic breast cancer). Furthermore, it was discovered that modification with N6-methyldeoxyadenosine monophosphate can further enhance the specificity of the nucleic acid aptamer and strengthen its efficacy in inhibiting tumor cell activity.

The application discloses a blackhead-removing composition, a blackhead-removing skin care product and a preparation method and application thereof, and comprises the following components in parts by mass: illite 1.0-30 parts, plant liposome 0.1-10 parts, sodium stearate 1-10 parts, mowrah seed oil 0.1-1 part and hydroxyl asiaticoside 0.1-1 part. In the composition, the mowrah seed oil small molecule oil dissolves the oil secreted by the skin, the illite plays a role in deep adsorption of the oil in pores, the plant liposome plays a role in increasing the water content of the cuticle, strengthening the skin barrier and improving the oil secretion condition of the skin, thereby reducing the probability of generation of blackheads, the hydroxyl asiaticoside plays a role in bacteriostasis, cleaning and anti-inflammation, and the problem of sebum cleaning and regulation of keratin metabolism is solved from the root, so that the three effects of blackhead removal, cleaning and care are combined, and the obvious defect of single function of the commercially available blackhead-removing products is completely made up.

This invention relates to an AI model backdoor defense system and its detection method. The technical solution includes a model security detection module, a backdoor location and tracing module, a backdoor removal and hardening module, a real-time inference protection module, and a security verification and auditing module. These modules are interconnected to form a closed-loop defense architecture. Based on this system, the method identifies model backdoors through multi-dimensional fusion detection, linking the entire process of location and tracing, removal and hardening, real-time protection, and security verification to achieve accurate detection, thorough removal, and real-time protection against various AI model backdoors. This invention overcomes the shortcomings of existing technologies, such as single detection dimensions, lack of closed-loop defense, poor scenario adaptability, and poor real-time performance. It is adaptable to various deep learning models, including large language models and multimodal models, and is applicable to multiple scenarios such as model development, deployment, and supply chain security, improving model security and possessing broad application value.

The application discloses a kind of red blood cell biomimetic MOFs and its preparation method and application, belong to biomaterial technical field. Including drug-loaded MOFs and the red blood cell membrane layer coated outside MOFs;The MOFs are selected from UiO-66-NH2;The UiO-66-NH2 is the microparticle that amino functional group is connected on UiO-66;The drug-loaded MOFs are loaded with double apparent genetic drugs;The double apparent genetic drugs are CM272 and MA. By targeting three kinds of epigenetic modification, simultaneously control DNA methylation in leukemia cell, histone methylation and RNA methylation to enhance the immune response to acute myeloid leukemia, and utilize biomimetic MOFs microparticle to overcome the hypoxic microenvironment of leukemia, enhance the therapeutic activity of loaded drug, and induce leukemia cell and leukemia cell mesenchymal stem cell death.

The present application relates to the technical field of nanobody, in particular to anti-FcRH5 nanobody and its application. The present application provides a kind of anti-FcRH5 nanobody with high affinity and specificity, which is based on the single domain heavy chain variable region structure of camelid origin, with the advantages of small molecular weight, high stability, strong tissue penetration, easy to be engineered and the like. The nanobody specifically recognizes and binds to the target point highly expressed and stably expressed on the surface of multiple myeloma cells through its complementarity determining region. The nanobody of the present application can be used as a core recognition element to construct a variety of therapeutic or diagnostic tools such as chimeric antigen receptor T cells, bispecific antibodies, antibody drug conjugates or immunodetection probes. The technical scheme can solve the technical problem that there is a lack of high-quality, functionally clear anti-FcRH5 antibody in the prior art. The nanobody of the present application has significant clinical transformation and industrialization advantages, and promotes the treatment of multiple myeloma to multiple target points.

The application discloses a chimeric antigen receptor CAR targeting human Epstein-Barr virus, a CAR-NK cell and application, and the chimeric antigen receptor CAR targeting human Epstein-Barr virus comprises the following structure: a single-chain antibody aiming at gH / gL of the Epstein-Barr virus, a transmembrane region and an intracellular signal transduction region. The CAR-NK cell targeting human Epstein-Barr virus can effectively recognize and kill nasopharyngeal carcinoma and B lymphoma infected by the Epstein-Barr virus, effectively kill tumor cells, can produce a long-lasting immune response ability, does not produce serious toxic side effects, and is helpful to prevent tumor recurrence.

This invention provides a compound plaster for promoting blood circulation and relieving pain, and its preparation method. It relates to the field of pharmaceutical technology and is made from a variety of medicinal materials, including white-flowered snake, red peony root, peach kernel, centipede, aconite, scorpion, and drynaria, combined with litharge and sesame oil. The optimal ratio was determined through scientific screening, forming a compound system that "dispels wind and unblocks meridians, invigorates blood and removes blood stasis, eliminates dampness and relieves pain, and strengthens the body's resistance." It balances rapid onset of action with consolidation of therapeutic effects while reducing the risk of skin irritation. The preparation method includes raw material pretreatment, 30-day sealed soaking in sesame oil, gradient temperature cooking to remove residue, and forming the plaster. Through long-term soaking and gradient cooking processes, the dissolution rate of effective ingredients is significantly improved. This invention is suitable for relieving pain and limited limb movement caused by bone, joint, and soft tissue diseases such as frozen shoulder, cervical spondylosis, and lumbar muscle strain. It is convenient to use, has definite curative effects, and has good application prospects.

The invention discloses synergistic compound essential oil for treating and preventing tinea pedis and a preparation method of the synergistic compound essential oil, and belongs to the technical field of skin care and antifungal of essential oil. The compound essential oil takes jojoba oil as base oil (added to 100%), and is compounded with the following single essential oil in percentage by weight: 0.5-9.0% of juniper essential oil, 0.5-8.9% of lemongrass essential oil, 0.5-9.3% of geranium essential oil and 0.5-8.7% of chamomile essential oil. The compound essential oil has dual effects of treatment and prevention, can quickly relieve symptoms such as pruritus, desquamation and blister caused by tinea pedis, can inhibit fungus breeding and reduce the recurrence rate after being used for a long time, is mild and non-irritant, is skin-friendly and easy to absorb, is convenient to use, and is suitable for daily foot care and prevention and adjuvant treatment of tinea pedis. The product is natural, safe and remarkable in effect, and an excellent natural solution is provided for solving the problem that drug resistance and side effects are easily generated when tinea pedis is treated by chemical drugs.

The invention discloses an anti-gout traditional Chinese medicine composition, which is prepared from the following raw material medicines in parts by weight: 10 to 20 parts of sunflower disc, 3 to 6 parts of radix puerariae, 1 to 4 parts of plantain herb, 5 to 14 parts of corn stigma, 2 to 8 parts of semen coicis, 2 to 8 parts of poria cocos, 2 to 8 parts of dandelion and 1 to 4 parts of pawpaw, preferably 15 parts of sunflower disc, 5 parts of radix puerariae, 2 parts of plantain herb, 8 parts of corn stigma, 4 parts of semen coicis, 5 parts of poria cocos, 5 parts of dandelion and 3 parts of pawpaw, and discloses a preparation method of the anti-gout traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of resisting inflammation, diminishing swelling, relieving pain, reducing blood uric acid and dissolving sodium urate, and has a good effect on patients with hyperuricemia, red, swollen and hot pain of joints and uric acid crystal deposition.

The present application relates to a kind of medicine food for treating acne, preparation method, composition and application, medicine food is by sweet almond, Chinese yam, wax gourd seed, lily, fuzilong, jasmine, lotus seed, prepared wumei flesh, safflower, cypress seed, sweet leaf chrysanthemum and prepared yuzi, which are safe medicine of food and medicine composition;Preparation method is to be ground into fine powder, stir-fried, mixed to obtain;Composition includes medicine food for treating acne and peroxide benzoyl;The above medicine food is applied to the preparation of medicine food for treating acne;The medicine food for treating acne of the present application is more explicit than the curative effect of traditional Chinese medicine, more suitable in taste, more harmonious in nature and taste, convenient to serve, more suitable for long-term use.

A keloid mechanical balance microneedle, a preparation method and an application in preparing a product for preventing keloid recurrence, wherein the preparation method of the keloid mechanical balance microneedle is as follows: firstly, according to the average thickness of postoperative scar tissue of an object, a preliminary skin-scar finite element model composed of a scar structure and a skin structure is constructed, and the thickness of each position of the whole scar structure is the same; then, the keloid mechanical balance microneedle is finally obtained through four steps. The keloid mechanical balance microneedle is prepared according to the postoperative scar tissue of an object, and through the keloid mechanical balance microneedle, the stress distribution between the keloid and the surrounding skin can be uniform, and the keloid recurrence can be effectively prevented.

The invention belongs to the technical field of biological medicines, and particularly relates to a GM-CSF loaded tumor cell vaccine and application thereof in prevention and treatment of liver cancer. In order to enhance the immunogenicity of the existing tumor cell vaccine, a liver cancer cell line is modified through genetic engineering, and a key cell factor GM-CSF capable of regulating and controlling differentiation, maturation, migration and functions of DCs is introduced, so that the GM-CSF is stably overexpressed, and the whole-cell tumor vaccine capable of efficiently secreting the GM-CSF is successfully constructed. And the antigen presentation and T cell starting capability of the DCs are further enhanced through ionization irradiation. Experiments prove that the GM-CSF loaded tumor cell vaccine can effectively activate specific T cell immune response, induce long-acting immune memory, inhibit immune tolerance and obviously inhibit growth of liver cancer tumors and tumor recurrence, and is high in safety. The method is hopeful to enter the development and application of clinical tumor vaccines.

The invention discloses a traditional Chinese medicine composition for treating gout and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating gout comprises the following raw materials in parts by weight: 1-20 parts of eucommia ulmoides, 1-20 parts of radix achyranthis bidentatae, 1-20 parts of radix angelicae pubescentis, 1-20 parts of corydalis tuber and 1-20 parts of notopterygium root. According to the traditional Chinese medicine composition, eucommia ulmoides and radix achyranthis bidentatae serve as monarch drugs, radix angelicae pubescentis and rhizoma corydalis serve as ministerial drugs, notopterygium root serves as an adjuvant drug, all the drugs are combined, the effects of tonifying liver and kidney, strengthening muscles and bones, dispelling wind, eliminating dampness, promoting blood circulation to arrest pain are achieved, the effects of reducing uric acid, eliminating swelling and relieving pain are achieved, the good treatment effect on gout is achieved, meanwhile, gout recurrence can be prevented, and the traditional Chinese medicine composition is safe and free of side effects.