54results about How to "Prevent relapse" patented technology

The invention discloses an underground engineering dynamic water step grouting plugging and leakage stopping method capable of detecting a water flow channel, and belongs to the technical field of underground engineering grouting and water plugging. The method comprises the steps that firstly, in the underground engineering mining process, a water leakage area is surveyed and detected, and the general channel and position of flowing water flow are judged; a grouting hole arrangement scheme is set, and step-by-step grouting is carried out; in the water leakage area, viscous slurry obtained by mixing a first grouting material A and a first grouting material B is used for blocking the flowing water channel; after the flowing water channel is blocked, a second grouting material is injected to reinforce the total cross section of the water leakage area; finally, the flowing water and gushing conditions of the grouting holes and the water flow channels are observed, theoretical knowledge is combined for checking, and the grouting and water plugging effect is analyzed. According to the method, the grouting and water plugging effects are improved by adopting the methods of reconnaissance and detection, step-by-step grouting and nondestructive detection, effective plugging and reinforcement of a water leakage area are realized, and the safety and stability of an underground structure are ensured.

The invention relates to application of fecal microbe transplantation (FMT) in depressive disorder treatment, in particular to application of a fecal microbe transplantation (FMT) composition based on a human intestinal tract fecal microbe composition in depressive disorder treatment. The invention also relates to application of the pharmaceutical composition or the medicine box in preparation of a medicine for treating depressive disorder, and the pharmaceutical composition or the medicine box contains a therapeutically effective amount of the human intestinal tract coprophilous fungus composition.

The invention belongs to the technical field of medical auxiliary instruments, and particularly relates to a bone repair fixing and bundling device and application thereof and application of magnesium wires as bone repair products, the bone repair fixing and bundling device comprises a bundling belt and a fixing buckle, the bundling belt is formed by at least one magnesium wire, the fixing buckle and the magnesium wires are made of degradable pure magnesium, and the magnesium wires are made of degradable pure magnesium. The strapping tape surrounds a target bone, and the two ends of the strapping tape are tightened and fixed in the fixing buckles; the diameter of each magnesium wire ranges from 0.5 mm to 1.5 mm. The binding device is applied to internal fixation or auxiliary internal fixation of traumatic bone fractures and is combined with an external cortical bone bridge to be applied to bone tumor repair and fixation, and the degradation product in the magnesium degradation process is used for inhibiting tumor recurrence and promoting osteogenesis to promote formation of the external cortical bone bridge. Therefore, the magnesium wire has a great application prospect as a bone repair product.

The utility model provides a needle instrument for skin, which relates to the technical field of medical instruments and comprises a needle head, a sleeve and a digging spoon, the needle head is inserted into the sleeve, the length of the needle head is larger than that of the sleeve so as to drive the sleeve to be inserted into the skin of a patient, and the digging spoon is arranged on the outer side of the sleeve so as to facilitate people to dig out hard secretions in a bag-shaped structure. One end of the digging spoon is hinged to the sleeve, the other end of the digging spoon is connected with the sleeve through an elastic piece, so that a certain angle is formed between the digging spoon and the sleeve, the digging spoon brings out hard secretions, a wound at the skin position of a patient has elastic force, and the opened digging spoon can go out of the wound with the elastic force. The hard secreta in the bag-shaped structure can be taken out through the bag-shaped structure, the hard secreta in the bag-shaped structure can be completely taken out through the repeated operation, the situation that medical workers extrude out the hard secreta with hands is greatly reduced, the problem of hard secreta residue is reduced, and the problem of secondary relapse is prevented.

This invention discloses a method for eliminating moss growth on macadamia nut leaves, relating to the field of agricultural planting technology. The specific method involves spraying a moss-removing agent onto the macadamia nut leaves during the moss occurrence period, applying moss inhibitor I to the main stem, and applying moss inhibitor II to the soil surface around the main stem. The moss-removing agent comprises the following raw materials in parts by weight: 40-50 parts of allicin, 15-24 parts of urea, 5-18 parts of calcium propionate, 20-27 parts of calcium sulfate, 10-17 parts of calcium chloride, 20-35 parts of vegetable oil, 1-10 parts of titanium dioxide, 1-5 parts of glutathione, and 1-3 parts of dispersant. This invention solves the problems of slow effectiveness, short duration of action, and low plant safety in current macadamia nut leaf moss control methods, achieving highly efficient control.

The present invention relates to the field of medical technology, and provides a PMC nanozyme and a preparation method thereof; the PMC nanozyme comprises: a core layer, the core layer comprises oxygen atoms, phosphate ions and polyoxometalate nanoclusters of a first transition metal element; a coating layer, at least part of the coating layer is fixed on the outer surface of the core layer, and the coating layer is formed by the coordination between a second transition metal and the oxygen atoms on the core layer; wherein the first transition metal element comprises Mo; the second transition metal element comprises Mn, and the coating layer comprises a CO donor for controlling the release of CO gas. The PMC nanozyme of the present invention can utilize polyoxometalate nanoclusters in combination with CO gas therapy to synergistically treat IBD, and on the basis of endowing the nanoclusters with anti-inflammatory and intestinal epithelial barrier repair functions, the catalytic activity is enhanced, and CO is released in an environment of overexpression of reactive oxygen species, thereby alleviating oxidative stress, inhibiting inflammatory responses, restoring intestinal immune balance, and promoting the repair of mucosal damage.

The invention discloses a traditional Chinese medicine composition for treating rhinitis and nasosinusitis, relates to the technical field of traditional Chinese medicine compositions, and is technically characterized in that the traditional Chinese medicine composition is prepared from 5-15 g of fructus chebulae, 1-5 g of herba asari, 5-15 g of herba schizonepetae, 5-15 g of radix platycodonis, 3-10 g of ramulus cinnamomi, 3-10 g of flos magnoliae, 5-15 g of radix angelicae and 5-15 g of radix codonopsis. The traditional Chinese medicine composition can effectively help to regulate lung functions and relieve symptoms caused by lung qi deficiency or cold evil invasion in rhinitis and nasosinusitis, and is especially suitable for patient groups with symptoms such as nasal obstruction, running nose and cough caused by wind-cold invasion.

The present invention provides a chimeric receptor comprising: a first polypeptide having (i) a first extracellular region bound to a ligand, (ii) a first transmembrane region, and (iii) a first intracellular region derived from an IL-2 receptor beta chain, and wherein a mutation is introduced at a tyrosine residue of the first intracellular region; and a second polypeptide having (iv) a second extracellular region bound to a ligand, (v) a second transmembrane region, and (vi) a second intracellular region derived from the IL-2 receptor gamma chain.

A preparation method of a 4D printed intelligent near-infrared responsive bone filling implant, belonging to the field of orthopedic biomedical materials, comprises the following steps: step one: preparation of a composite material for 4D printing; step two: construction of a near-infrared responsive intelligent deformable cross-mesh structure 4D filler; the present invention selects a PLA / PCL / β-TCP complex containing magnesium nanoparticles and prints a filler for filling irregular tumor postoperative bone defects through 4D printing technology, the filler can achieve minimally invasive implantation into the bone defect cavity and then expand in volume under the irradiation of near-infrared light, thereby achieving seamless filling of the cavity; by controlling the power of an infrared instrument, the dual functions of killing residual tumor cells and tissues around the cavity and promoting osteogenesis in later stages can be achieved, and the support force generated by the volume expansion of the filler at the lesion defect on the surrounding bone tissue can effectively promote the regeneration and repair of the surrounding bone.

The invention discloses bionic MOFs of red blood cells as well as a preparation method and application of the bionic MOFs, and belongs to the technical field of biological materials. Comprising drug-loaded MOFs and an erythrocyte membrane layer coated outside the MOFs, the MOFs is selected from the group consisting of UiO-66-NH2; the UiO-66-NH2 is a particle formed by connecting an amino functional group to UiO-66; a dual epigenetic drug is loaded in the drug-loaded MOFs; and the dual epigenetic drugs are CM272 and MA. By targeting three epigenetic modifications and simultaneously regulating and controlling DNA methylation, histone methylation and RNA methylation in leukemia cells, the immune response aiming at acute myelogenous leukemia is enhanced, the hypoxia microenvironment of leukemia is overcome by using the bionic MOFs particles, the therapeutic activity of the loaded medicine is enhanced, and the application prospect is broad. And inducing death of leukemia cells and leukemia cell mesenchymal stem cells.

The application provides a data processing system and fluidized bed reactor, comprising: a data acquisition module, a data processing module and a man-machine interaction module; the data acquisition module is used for collecting process parameters of the fluidized bed reactor; the data processing module is used for filtering and engineering unit conversion of the collected process parameters, and real-time control according to a preset process logic; the man-machine interaction module is used for determining a process flow chart, parameter values and alarm information based on the process parameters, and displaying the process flow chart, parameter values and alarm information. In this way, full-link accurate tracing can be realized, the system supports multi-dimensional data association, the root cause can be quickly locked and the problem can be prevented from recurring; data deep value mining can also be realized, and intuitive trend curves, flexible data export and advanced analysis tools are provided.

The invention relates to an acne-removing composition containing natural plant components and a preparation method of the acne-removing composition, and belongs to the technical field of cosmetics. The invention provides an acne-removing composition containing natural plant components. The acne-removing composition is prepared from rhodomyrtus tomentosa fruit extract, hydrolyzed red algae extract, hydrangea crassifolia leaf extract, Lagopsis supina extract and ceramide. Wherein the antibacterial and anti-inflammatory effects of the rhodomyrtus tomentosa fruit extract and the anti-inflammatory and soothing effects of the Lagopsis supina extract directly resist the core etiology and symptoms of acne; the hyperactivity of sebum is reduced by the hydrangea crassifolia leaf extract; the hydrolyzed red algae extract can buffer potential stimulation and maintain skin hydration; ceramide can strengthen the self-defense capability of the skin and prevent relapse during treatment; the five components supplement each other and have a good acne removing effect.

The invention discloses the application of pine pollen polysaccharide in preventing and treating atopic eczema, and belongs to the technical field of atopic eczema prevention and treatment. The pine pollen polysaccharide is prepared by the following method: adding broken wall masson pine pollen to petroleum ether, heating and refluxing extraction, collecting filter residue by suction filtration, drying and removing solvent, and obtaining defatted masson pine pollen; heating and refluxing extraction of defatted masson pine pollen with 95% ethanol, collecting filter residue by suction filtration, and drying and removing residual solvent to obtain impurity-removed masson pine pollen; adding water to the impurity-removed masson pine pollen, heating and boiling, repeatedly extracting and combining filtrates, heating and concentrating to obtain a concentrated solution; removing protein from the concentrated solution, precipitating with alcohol, centrifuging and precipitating, and freezing and decompressing to obtain pine pollen polysaccharide. Pine pollen polysaccharide is used to prevent and treat atopic eczema. Pine pollen polysaccharide comes from natural plants. Compared with traditional drugs, pine pollen polysaccharide has higher safety and lower side effects, and is particularly suitable for long-term use and sensitive populations such as infants and young children.

The invention belongs to the technical field of biomedicine, and particularly relates to a bionic T cell secreting type engineering bacterium lung targeted delivery system based on respiratory tract atomization and a construction method and application. The delivery system comprises engineering bacteria and a coated bionic biological membrane, the coated bionic biological membrane is a T cell membrane, and the engineering bacteria can secrete IL-12. The delivery system disclosed by the invention can realize intelligent, precise, visual and non-invasive efficient delivery of exogenous engineering bacteria drugs; by utilizing a gradient freeze-drying technology and an advanced aerosol inhalation technology, local delivery of an exogenous engineering bacterium drug in a host lung is realized, and focus targeted colonization of the engineering bacterium drug is realized; by utilizing an accurate cell membrane coating technology, monitoring and killing of immune cells are reduced, and the colonization efficiency of engineering bacteria is improved; and an engineering bacterium secretion system after biological modification and optimization is synthesized, so that the space-time accuracy of immune regulation of an exogenous engineering bacterium medicine can be further realized in a synergistic manner.

The invention discloses a selenium-iron co-doped hydroxyapatite reinforced polylactic acid scaffold and a preparation method thereof, and the preparation method comprises the following steps: co-doping SeO3 < 2-> and Fe < 3 + > into HAP through a co-precipitation method to obtain SF-HAP powder; sF-HAP and PLLA are dispersed in ethyl alcohol, and PLLA / SF-HAP composite powder is obtained through stirring, centrifuging, drying and the like; the PLLA / SF-HAP biological scaffold is prepared through an additive manufacturing technology, in order to endow the PLLA / HAP bone scaffold with an anti-tumor function, Fe is doped into HAP, a Fenton reaction can be promoted in an osteosarcoma environment so that ROS can be generated to kill tumor cells, but overexpressed GSH existing in the tumor cells can consume the ROS to weaken the anti-tumor effect, and doping of Se and Fe can reduce the crystallinity of HAP crystals, so that the anti-tumor effect is improved. The SeO3 < 2-> and the Fe < 3 + > are added into the tumor cells, so that the sustained release of functional ions is facilitated, meanwhile, the consumption of the SeO3 < 2-> and the Fe < 3 + > on the over-expressed GSH and H2O2 in the tumor cells can effectively destroy the redox balance in the tumor cells, and the death of the tumor cells is promoted.

The utility model is suitable for the technical field of agricultural planting, and provides a vegetable soilless culture pesticide spraying device which comprises a plurality of detachable pesticide spraying pipes arranged on a vegetable soilless culture frame. The pesticide storage box is used for containing pesticide liquid, and the pesticide storage box is arranged on one side of the vegetable soilless culture frame; the pesticide pump is used for pumping pesticide liquid, the pesticide pump is fixedly installed on one side of the pesticide storage box, a pesticide pumping pipe is fixedly installed at the liquid inlet end of the pesticide pump, and the liquid inlet end of the pesticide pumping pipe is fixedly communicated with the pesticide storage box. According to the vegetable soilless culture pesticide spraying device, pesticide liquid can be evenly sprayed to soilless culture vegetables, it is ensured that each vegetable can be prevented and controlled through pesticide, spreading and relapse of diseases and pests are effectively avoided, and the problem of disease and pest invasion in the current soilless culture field is solved.

The invention discloses application of pine pollen polysaccharide in prevention and treatment of atopic eczema, and belongs to the technical field of atopic eczema prevention and treatment. The pine pollen polysaccharide is prepared by the following method: adding wall-broken masson pine pollen into petroleum ether, performing heating reflux extraction, performing suction filtration to collect filter residues, and drying to remove a solvent to obtain degreased masson pine pollen; heating, refluxing and extracting the degreased pinus massoniana pollen by using 95% ethanol, carrying out suction filtration, collecting filter residues, and drying to remove a residual solvent, so as to obtain impurity-removed pinus massoniana pollen; adding water into the impurity-removed masson pine pollen, heating and boiling, repeatedly extracting, combining filtrate, and heating and concentrating to obtain a concentrated solution; and removing protein from the concentrated solution, and carrying out alcohol precipitation, centrifugal separation and precipitation, freezing and drying under reduced pressure to obtain the pollen pini polysaccharide. The pine pollen polysaccharide is used for preventing and treating the atopic eczema, the pine pollen polysaccharide is derived from natural plants, and compared with traditional medicines, the pine pollen polysaccharide has higher safety and lower side effects and is particularly suitable for sensitive people such as infants and the like after being used for a long time.

The invention belongs to the technical field of medical instruments, and particularly discloses an anti-tumor electrospinning stent and a preparation method thereof. The drug-loaded electrospinning stent is characterized by comprising a drug-loaded electrospinning stent main body and tumor cell-derived drug-loaded microparticles loaded on the surface of the drug-loaded electrospinning stent main body. The drug-loaded electrospinning stent main body comprises an amino polymer, a hydrophilic polymer and celecoxib which are prepared by using an electrospinning technology and have a mass ratio of (2-10): (2-13): 1, and the drug-loaded electrospinning stent main body has high specific surface area and high porosity; the loading capacity of the tumor cell source doxorubicin-loaded microparticles on the anti-tumor electrospinning bracket is 0.6 mu g / mg to 6.1 mu g / mg. The drug is directly delivered to a tumor resection cavity in an in-situ implantation mode, and long-acting drug retention, continuous drug release and complete degradation of a stent material are achieved. The tumor immune microenvironment is remodeled while residual tumor cells are effectively killed, and recurrence and metastasis of tumors are inhibited.

The invention discloses an intelligent fault detection method for a dual-mode communication unit, relates to the technical field of communication fault detection, and aims to solve the problems that the installation environment of the dual-mode communication unit currently working in a complex environment is cramped, and workers cannot enter the dual-mode communication unit conveniently, so that time and labor are wasted in daily detection, and the detection efficiency is high. In order to solve the technical problems of low detection efficiency, low accuracy and incapability of finding faults in time in the prior art, the intelligent fault detection method for the dual-mode communication unit comprises the following steps: data acquisition: monitoring the working state of the dual-mode communication unit in real time through a sensor, acquiring parameter data including signal strength, communication frequency, temperature and voltage, and sending the parameter data to a server; the temperature and the voltage are directly read by the temperature sensor and the voltage sensor respectively, data are modeled and predicted, then real-time monitoring is performed to find faults, and the faults are diagnosed and processed, so that the daily detection efficiency of the dual-mode communication unit in a severe environment is greatly improved, and time and labor are saved.

The invention belongs to the technical field of chilblain medicines, and particularly relates to a traditional Chinese medicine composition for treating chilblain and a preparation method thereof.The traditional Chinese medicine composition for treating chilblain is prepared from 15-25 parts of a chilblain bag, 10-20 parts of a blood-activating and moisturizing bag, 8-13 parts of a whitening and itching-relieving bag, 3-7 parts of a pre-promoting bag and 1 part of triethanolamine; the pure coconut oil is rich in unsaturated fatty acid and can be used as a biological oleophylic surfactant, the pure coconut oil, the jojoba oil and the linseed oil are mutually combined to form an oil-based oil structure, rapid transfer of the pure coconut oil between skin layers is improved, and chilblain can be rapidly eradicated; the aloe and the horse oil can replenish water and preserve moisture, have a protection effect on the skin, accelerate the regeneration process of skin cells and repair damaged skin cells; the white mulberry root-bark, the willow bark, the bunge pricklyash leaves, the ginger slices and the pine needle oil can remove surface cutin, promote nutrient absorption, avoid bacterial reinfection, promote skin healing, repair scars after healing and avoid subsequent reattack.

The invention discloses a traditional Chinese medicine composition for preventing and treating cerebral infarction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from herba epimedii, radix clematidis, hairyvein agrimony, pseudo-ginseng, leech, astragalus membranaceus, Chinese yam, pulp of dogwood fruit, fried malt, safflower, rheum officinale, raw hawthorn, liquorice, acorus calamus and rosemary. Different from the traditional therapy, the traditional Chinese medicine dialectical thinking is utilized, the comprehensive thought of eliminating phlegm and blood stasis, dredging meridians and collaterals to treat symptoms, strengthening body resistance to eliminate pathogenic factors, restoring consciousness and promoting intelligence, tonifying spleen and kidney and consolidating basis to treat root causes is provided, and the root-treating, infarction-preventing and encephalatrophy-preventing effects of tonifying spleen and kidney, nourishing qi and blood and restoring consciousness are more emphasized while blood stasis is removed and thrombolysis is performed. The traditional Chinese medicine composition has the advantages that the medicines are used together, the compatibility is proper, the effects of strengthening the body resistance to eliminate pathogenic factors, invigorating the spleen, replenishing qi, dissolving turbidity, restoring consciousness, dispersing blood stasis and dredging collaterals are achieved together, the ideal effects of relieving cerebral infarction symptoms, preventing cerebral infarction relapse, preventing and treating middle-aged and elderly cerebral infarction, dementia and the like are achieved, the curative effect is remarkable, the traditional Chinese medicine composition is obviously superior to common western medicine therapy, and the traditional Chinese medicine composition is worthy of clinical popularization and application.

The invention discloses a thrombus suction and storage device for vascular surgery, and relates to the technical field of medical instruments, the thrombus suction and storage device comprises a handheld control gun, and further comprises a driving mechanism, a stirring mechanism, a liquid injection mechanism and a recovery and storage mechanism, the stirring mechanism comprises a catheter and a stirring head, and the catheter is arranged in the middle of the front end of a driving box; the stirring head is arranged at the bottom end of the guide pipe, the recycling and storing mechanism comprises a storage bottle, and the storage bottle is arranged below the handheld control gun. The stirring head is conveyed to the thrombus blockage position through the catheter, the medical rotating wire rotates to stir the thrombus, the stirred thrombus is sucked into the storage bottle through the recycling pipe and the second connecting pipe in combination with the negative pressure of the storage bottle, dredging and suction are conducted synchronously, incomplete suction is avoided, meanwhile, liquid medicine is released to the thrombus position through the liquid injection pipe, and re-coagulation is restrained; and the liquid medicine bin continuously maintains negative pressure to ensure that thrombus is continuously sucked in, so that the problem that the thrombus easily blocks the catheter is solved, and the working efficiency of thrombus suction is improved.

This invention provides a nucleic acid aptamer that targets and binds to the IGF2BP2 protein and its application, belonging to the field of pharmaceutical technology. This invention is the first to design a highly specific nucleic acid aptamer targeting the RNA recognition protein IGF2BP2, obtaining a nucleic acid aptamer that can target and specifically bind to the IGF2BP2 protein (see SEQ ID No. 1-2). This nucleic acid aptamer can effectively inhibit the activity of tumor cells, tumor stem cells, and breast cancer brain metastases, breast cancer lung metastases, breast cancer liver metastases, breast cancer kidney metastases, and breast cancer bone metastases, providing a new drug component for the treatment of malignant and refractory tumors (especially glioblastoma and distant metastatic breast cancer). Furthermore, it was discovered that modification with N6-methyldeoxyadenosine monophosphate can further enhance the specificity of the nucleic acid aptamer and strengthen its efficacy in inhibiting tumor cell activity.

The invention belongs to the technical field of medicine, and particularly relates to a nasal cavity dredging gel and a preparation method thereof.The nasal cavity dredging gel is prepared from, by weight, 1-2 parts of flos magnoliae, 1-2 parts of fructus xanthii, 1-2 parts of platycodon grandiflorum, 1-2 parts of mint, 2-3 parts of centipeda minima, 2-3 parts of schizonepeta, 1-2 parts of notopterygium roots, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials and 20-30 parts of water. The traditional Chinese medicine composition has the advantages that the medicines are combined and matched with one another, the effects of eliminating phlegm, diminishing inflammation, relieving symptoms of patients, dispelling wind, relieving exterior syndrome, clearing away lung heat, dispelling wind-cold, enhancing the curative effect and avoiding relapse are achieved, the effects of treating both symptoms and root causes are achieved, the compatibility is strict, the formula is reasonable, the treatment effect is remarkable, the clinical treatment cycle is short, and the cure rate is high.

The invention discloses a nuclide silk film as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The nuclide silk film provided by the invention is a silk film marked with radionuclide iodine 125. The preparation method comprises the following steps: labeling mulberry silk with iodine 125, and then spinning to form a film; or the mulberry silk is woven into a film and then labeled with iodine 125. The invention discloses an application of a nuclide silk film in preparation of a tumor local radiotherapy material. The nuclide silk film can cover wounds after various cancer resection operations, gamma rays released by radioactive isotope iodine 125 on the nuclide silk film are used for killing residual cancer cells in an operation area or remaining essence and cross sections of visceral organs and cancer cells possibly remaining in adjacent vascular nerve gaps, and therefore the cancer resection effect is achieved. Therefore, the purpose of brachytherapy is achieved, tumor recurrence after cancer operation can be effectively reduced, and external radiation therapy after operation can be partially replaced.

The invention provides a broad-spectrum anticancer traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The broad-spectrum anti-cancer traditional Chinese medicine composition is composed of a basic formula and an additive formula, and the basic formula is composed of rhizoma smilacis glabrae, piper cubeba, trichosanthes kirilowii maxim, fritillaria cirrhosa, exocarpium citri grandis, fructus citri sarcodactylis, citrus chachiensis hortorum, coix seeds, spina date seeds, herba epimedii, cistanche, morinda officinalis, codonopsis pilosula, astragalus membranaceus, Chinese yam and rehmannia. The traditional Chinese medicine composition has the advantages of conventional and easily available materials, quick effect, stable effect, no toxic or side effect, simple application and operation, alleviation of the medical workload of patients and family members, reduction of the fear of the patients, enhancement of the nutrition state of each internal organ, acceleration of the metabolism speed in vivo, acceleration of the cleaning of toxins in vivo, improvement of the survival ability of the patients and improvement of the life quality; the traditional Chinese medicine composition can be used for curing and treating various cancers and various stages in the cancer treatment process, and can effectively prevent relapse and metastasis of the cancers.

The invention relates to an exosome oral spray and a preparation method thereof, and relates to the technical field of oral sprays.The exosome oral spray is prepared from, by weight, 0.2-0.7 part of human umbilical cord mesenchymal stem cell exosome, 1-5 parts of natural extract, 8-15 parts of moisturizing solubilizer, 0.1-0.5 part of preservative, 0.1-0.5 part of essence and 78-90 parts of deionized water; the natural extract is obtained by performing water extraction on raw materials of clinacanthus nutans and xanthoceras sorbifolia bunge kernels in a weight ratio of (14-20): (5-11). According to the invention, the human umbilical cord mesenchymal stem cell exosome and the natural extract with specific composition are taken as functional components, and the exosome and the natural extract cooperate with each other and act together, so that the repairing effect of the exosome oral spray on skin injury is remarkably improved, the treatment of common oral diseases such as oral ulcer and oral mucositis is facilitated, and the application is wide.

The purpose of the present invention is to provide an agent for inhibiting the proliferation of cancer stem cells, and to provide a composition and a method for treating cancer, inhibiting the recurrence of cancer, and inhibiting the metastasis of cancer. The purpose is achieved by a compound represented by general formula (I) (in the formula, R1 represents a chlorine atom or a bromine atom, R2 represents an alkyl group, and R3 represents an aryl group. ) A composition for inhibiting proliferation of cancer stem cells, which comprises, as an active ingredient, a triazolohalogenated pyrimidine compound represented by formula (1). # imgabs0 #

The invention provides a nano sponge immune medicament as well as a preparation method and anti-tumor application thereof. A novel cellular nano sponge is designed, a low-inflammation photothermal therapy and a metabolic regulation function are combined, and metastasis and relapse of tumors are systematically inhibited by neutralizing and combining lactic acid metabolism interference through inflammatory cytokines. The nano sponge is modified by surface positive charges of photo-thermal core mesoporous polydopamine and then carries siRNA and M1 type macrophage membrane fragments, so that targeted therapy and multi-functional intervention on inflammatory lesions can be realized. A nano sponge treatment mode is innovatively applied to the anti-tumor field, and low-inflammation photo-thermal treatment is realized by utilizing a strategy of neutralizing cytokines by a biological membrane surface receptor. In-vivo and in-vitro experiments prove that the nano sponge has the characteristic of inflammation homing, inhibits tumor growth, prevents metastasis and recurrence, can effectively regulate the primary tumor microenvironment and the inflammation microenvironment of the ecological niche (PMN) before tumor metastasis at the secondary part, and brings new breakthrough and possibility to the field of tumor treatment.

The invention relates to a partially absorbable intelligent hernia repair net and a preparation method thereof, and belongs to the technical field of textile materials. The partially absorbable intelligent hernia repair net comprises monofilament units, an antibacterial unit and a monitoring unit, the monofilament units can be partially absorbed by a human body, the multiple monofilament units are connected to form a hernia repair net body, at least part of the antibacterial unit is formed on the surfaces of the monofilament units, and the monitoring unit is connected with the hernia repair net body. The monitoring unit monitors the strain and position of the hernia repair net. According to the hernia repair net, the pain of a patient after hernia repair can be greatly relieved, the hospitalization time and the rehabilitation cycle of the patient can be shortened, the position of the hernia repair net can be monitored in real time, the recurrence risk of hernia repair is reduced, and the life quality of the patient after hernia repair is improved.