21results about How to "Promote infiltration" patented technology

The present application relates to the field of pharmaceutical preparation and nanomedicine, and particularly relates to a kind of nano-drug composition, its combined drug delivery system and application.The nano-drug composition comprises alpha 1-AR blocker and amphiphilic nano-carrier;The alpha 1-AR blocker is loaded in the hydrophobic core formed by amphiphilic nano-carrier;The alpha 1-AR blocker is selected from one or more of prazosin, terazosin, doxazosin;The average particle size of the nano-drug composition is 220-260 nm, the polydispersity index is less than 0.3, and the encapsulation efficiency is greater than 50%.The nano-drug composition of the present application has dual functions of anti-tumor proliferation and immune microenvironment remodeling, improves the dispersion stability of the drug in physiological medium, effectively reduces the in vivo clearance rate, prolongs the circulation time, and realizes the efficient in vivo delivery of the drug.The preparation process of the nano-preparation is stable and can be produced on a large scale.

This application discloses an electrolyte solute, its preparation method, and its application. The electrolyte solute comprises an olefinic cyclohexene carboxylic acid compound obtained by the reaction of conjugated diene carboxylic acids. The conjugated diene carboxylic acid includes at least one compound having the structure shown in Formula III: wherein X and Y are each independently selected from H, -RO-COOH, substituted or unsubstituted C1-10 saturated hydrocarbon groups, etc., and at least one of X and Y is -RO-COOH; RO represents a directly bonded or C1-10 saturated hydrocarbon group. The electrolyte solute of this application, comprising an olefinic cyclohexene carboxylic acid compound with unsaturated hydrocarbon functional groups, can both improve the flash voltage of the electrolyte and maintain low viscosity and high conductivity.

The utility model provides a kind of farmland type ecological buffer zone structure, it is related to agricultural ecological environment management technical field, including land buffer area one, ecological regulation pond, land buffer area two and concave green land, land buffer area one, ecological regulation pond, land buffer area two and concave green land are sequentially distributed from farmland side to river embankment side, land buffer area one and land buffer area two are planted with arbor shrub and grass flower mat, the ecological regulation pond is sequentially provided with impermeable layer, adsorption layer and plant layer from bottom to top, the concave green land is laid with buffer base, the concave green land is planted with herbaceous plant and shrub. This structure effectively intercepts farmland non-point source pollution, reduces river pollutant, helps to strengthen river self-purification capacity, promotes aquatic animal and plant diversity development, and guarantees ecological benefit to play well.

The application provides a modified polypropylene material and a preparation method thereof, a modified polypropylene film and an oil-immersed capacitor. The preparation method of the modified polypropylene material comprises the following steps: mixing and soaking an antioxidant 1010 and natural ester insulating oil with a polypropylene material to obtain the modified polypropylene material; wherein the mass of the antioxidant 1010 is 0.1%-1% of the mass of the natural ester insulating oil. The modified polypropylene material prepared by the above method has at least the advantages of good compatibility with the natural ester insulating oil, high AC breakdown strength, high tensile strength and high elongation at break.

The application discloses a resin composition and application thereof, and the resin composition comprises, in terms of solid weight, 10-70 parts of a benzoxazine resin containing unsaturated bonds, and 20-100 parts of a maleimide resin; wherein the benzoxazine resin containing unsaturated bonds is a mixture of a benzoxazine resin containing double bonds and a benzoxazine resin containing triple bonds. Compared with the prior art, the resin composition and application thereof can not only control the reactivity between the maleimide resin and the benzoxazine resin, improve the crosslinking network density, but also is beneficial to controlling the production speed of prepreg, and the prepreg has good apparent quality, and meanwhile has excellent high heat resistance, high modulus, low water absorption, low thermal expansion coefficient and low curing shrinkage.

The present application relates to the technical field of biological medicine, in particular to a kind of nano-molecular probe with targeting and its preparation method and application.The plasmid of immune checkpoint corresponding receptor of stable expression tumor surface negative regulation molecule is synthesized in the present application, which is prepared into targeted nano-molecular probe with cell membrane nanocapsule of enhancing T cell activity ligand and being marked with fluorescence, and melanin nanosphere of simultaneously loading therapeutic drug.The targeted nano-molecular probe provided in the present application can be long-circulated in vivo, reduce the dosage and administration frequency of chemotherapeutic drug.It also has the advantages of improving the drug resistance of tumor site to therapeutic drug, targeting tumor DNA damage and significantly enhancing the infiltration and activation of immune cells in tumor site.

This invention relates to the field of composite material preparation technology, specifically to a method for preparing a high-performance thermoplastic polyaryletherketone (PAEK) wide-width fabric prepreg. The method includes the following steps: passing the fiber fabric sequentially through an unwinding device, a first horizontal high-temperature furnace, a first impregnation guide roller, a first vertical high-temperature furnace, a second vertical high-temperature furnace, a second impregnation guide roller, a third impregnation guide roller, a third vertical high-temperature furnace, a fourth vertical high-temperature furnace, a fourth impregnation guide roller, a second horizontal high-temperature furnace, a high-temperature pressure roller, a traction roller, and a winding device; the first and second impregnation guide rollers are both located in a first suspension glue tank, and the third and fourth impregnation guide rollers are both located in a second suspension glue tank; after traction begins, each heating device is heated to a higher temperature; after heating to a higher temperature, the fiber fabric is wound up. The purpose of this method for preparing a high-performance thermoplastic PAEK wide-width fabric prepreg is to solve the problems of poor wetting between the resin and the fabric and low resin content in the fabric prepreg.

This invention belongs to the field of semiconductor materials and discloses a processing technology for the reuse of gallium antimonide seed crystals. The processing technology includes: grinding and cleaning the gallium antimonide seed crystal, then immersing the gallium antimonide seed crystal in a first etching solution and a second etching solution sequentially, followed by cleaning and drying. Through a synergistic process of mechanical grinding, ultrasonic hydrolysis, chemical passivation, and selective etching, contaminants are thoroughly removed while protecting the seed crystal itself.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

This invention relates to a CAR T cell that secretes CTLA-4 nanobody targeting FAP, its preparation method, and its application. The CAR T cell is a T cell modified with chimeric antigen receptor FAP VHH-HIStag-CD8-CD137-CD3ζ-CTLA-4VHH-GFP, the nucleotide sequence of which is shown in SEQ ID NO.1. The preparation method of the CAR T cell includes: constructing a recombinant lentiviral vector, packaging lentivirus, infecting T cells with lentivirus, inducing in vitro, expanding and culturing, and obtaining engineered CAR T cells that secrete CTLA-4 nanobody targeting FAP. FAP-CTLA-4 / Nb CAR T cells have a good killing effect on FAP-positive tumor cells. The killing effect of FAP-CTLA-4 / Nb CAR T cells on tumor cells is related to the expression level of FAP in tumor-associated cells, providing a new strategy for adoptive immunotherapy of tumors.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

This invention relates to a rapid drying method, apparatus, and sodium-ion battery for Prussian blue analogue sodium-ion battery electrodes, belonging to the field of sodium-ion battery manufacturing technology. The rapid drying method includes the following steps: S1: Preparing the wet electrode sheet and feeding it into a drying chamber for drying; S2: Transferring it to an internally heated dehydration section for gradient temperature dehydration; S3: Transferring it to an instantaneous high-temperature dehydration section for instantaneous high-temperature dehydration; S4: Transferring it to a heat-preserving dehydration section for further deep dehydration; S5: Cooling the electrode sheet after step S4 to obtain a dried electrode sheet. This drying method has the advantages of being rapid and low-cost, and can minimize structural damage to the Prussian blue analogue material.

The application relates to the technical field of biology, and particularly discloses an artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch as well as a preparation method and application thereof. The artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch has the advantages of convenient raw material source, no immune rejection, no supply area complications, no disease transmission risk and the like. Moreover, the composite patch provides initial mechanical support, and improves the tendon-bone interface microenvironment through the paracrine effect (including pro-angiogenic related factors) of the subacromial synovial mesenchymal stem cells, promotes host cell infiltration and blood vessel ingrowth, and enhances tissue integration and rotator cuff healing.

The application discloses application of a retinoid analogue ZSH-512 in preparation of a liver cancer immunotherapy drug. Cell and animal model experiments show that the compound ZSH-512 can regulate an immune microenvironment of hepatocellular carcinoma, increase drug efficacy of an immune checkpoint inhibitor such as an anti-PD-1 antibody, and also improve anti-tumor efficacy of the ZSH-512 itself, so that a synergistic anti-tumor effect is achieved, the defect that liver cancer is not sensitive to single immunotherapy is overcome, and the ZSH-512 has a clinical development and application prospect.

The utility model provides a kind of pole piece structure, roll core pole group and cylindrical battery, including pole piece body, pole piece body has coating area, several pole lug areas are arranged at interval along the length direction of pole piece body, at least one pole lug area is equipped with at least 2 pole lug arranged at interval between pole lug area, and pole lug is connected to the long side of pole piece body;Pole piece structure is after participating in winding and forms roll core pole group, and the pole lug area on pole piece structure is arranged at radial in the center hole of roll core pole group towards one end surface of roll core pole group. It improves the space utilization of battery shell, improves the infiltration problem of electrolyte, improves internal resistance and heat dissipation, and improves electrochemical performance.

The application discloses a double-sided hydrogel scaffold for urethral repair and a preparation process thereof, and belongs to the technical field of biomaterials. The PCH@PVA scaffold is constructed, a base layer on the tissue side creates a eutrophication and guiding microenvironment for regeneration by using heparin, and a functional layer on the lumen side effectively blocks the penetration of harmful components in urine and the colonization of bacteria by a polyvinyl alcohol coating, and by optimizing the crosslinking degree of PVA, the PVA has excellent mechanical toughness and elasticity, can not only withstand the periodic expansion of the urethra without breaking, but also can transmit mechanical stimulation close to the physiological range, guide cells to functional regeneration instead of pathological fibrosis. The PCH@PVA scaffold provided by the application has excellent effects in promoting re-epithelialization, angiogenesis, inhibiting fibrosis and preventing stenosis. The application also provides a new design paradigm and theoretical basis for tissue regeneration strategies in other complex physiological microenvironments.

This invention discloses a traditional Chinese medicine composition for atopic dermatitis and its application. The composition is made from the following raw materials in parts by weight: 10-20 parts of dried plum, 5-15 parts of licorice root, 10-20 parts of Imperata cylindrica root, 5-15 parts of Smilax glabra rhizome, 5-15 parts of Coix seed, 5-15 parts of Angelica dahurica root, 3-9 parts of peppermint, 3-10 parts of Astragalus membranaceus root, 5-15 parts of dried tangerine peel, and 5-15 parts of Siraitia grosvenorii fruit. The composition can be prepared by soaking in water, decocting, and filtering to obtain a decoction, or further processed into granules, pills, tablets, capsules, or oral liquids for oral administration. Experimental results show that the composition of this invention can alleviate skin tissue damage in mice with DNFB-induced atopic dermatitis, reduce the area of ​​pathological skin tissue damage, and decrease the abnormal increase in mast cells. The raw materials of this invention are readily available, easy to prepare, and suitable for oral use, and can be used to prepare drugs for the treatment or adjuvant treatment of atopic dermatitis.

This invention belongs to the field of soft-pack battery wetting technology, and particularly relates to a method and apparatus for accelerating electrolyte wetting of soft-pack batteries, comprising the following steps: S1, side-sealing the battery chip with completed tab welding using an aluminum-plastic film. S2, injecting electrolyte into the side-sealed battery pack in one go, followed by sealing. S3, heating two pressure plates, and placing the injected soft-pack battery between the two pressure plates. S4, applying pressure to one of the pressure plates, causing the two plates to work together to compress the injected soft-pack battery for accelerated wetting. This allows the electrolyte to better wet the battery, significantly reducing the wetting time after electrolyte injection.

This application provides a variable-thickness, high-pressure-resistant composite-metal shell for deep-sea equipment and its preparation method, belonging to the field of pressure-resistant structure design and manufacturing technology for deep-sea equipment. The method includes the following steps: determining the overall structure of the pressure-resistant shell; designing the variable thickness and layup of the composite shell; performing finite element verification and structural optimization; flange design and pretreatment; integral winding molding; integral curing molding; and demolding. Through the variable-thickness partitioning and continuous gradual transition design of the composite main load-bearing shell, and adopting a symmetrical layup-winding scheme with circumferential load bearing as the main characteristic, the load-bearing path distribution under external pressure loads is improved, reducing stress concentration and local instability risks in the transition and end areas, and improving overall external pressure resistance stability. By configuring axial and ±45° layups at the ends and transition areas, the end load can be gradually transitioned and smoothly introduced into the composite main load-bearing structure, improving the uniformity of force transmission at the ends and enhancing structural reliability.

The invention belongs to the technical field of biological medicines, and particularly relates to a GM-CSF loaded tumor cell vaccine and application thereof in prevention and treatment of liver cancer. In order to enhance the immunogenicity of the existing tumor cell vaccine, a liver cancer cell line is modified through genetic engineering, and a key cell factor GM-CSF capable of regulating and controlling differentiation, maturation, migration and functions of DCs is introduced, so that the GM-CSF is stably overexpressed, and the whole-cell tumor vaccine capable of efficiently secreting the GM-CSF is successfully constructed. And the antigen presentation and T cell starting capability of the DCs are further enhanced through ionization irradiation. Experiments prove that the GM-CSF loaded tumor cell vaccine can effectively activate specific T cell immune response, induce long-acting immune memory, inhibit immune tolerance and obviously inhibit growth of liver cancer tumors and tumor recurrence, and is high in safety. The method is hopeful to enter the development and application of clinical tumor vaccines.

The invention discloses an application of subprostrate alkali in preparation of a melanoma immunotherapy drug, and relates to the technical field of medicines, and the subprostrate alkali is used for immunotherapy of melanoma by down-regulating the PD-1 protein level in T cells. Downregulation of the PD-1 protein level in T cells is realized by promoting ubiquitination of PD-1 through subprostrate alkali and inducing degradation of PD-1 through an endosome-lysosome way; the subprostrate alkali inhibits growth of melanoma by enhancing immune killing ability of T cells on melanoma cells and promoting immune infiltration of the T cells, can effectively promote ubiquitination modification of PD-1 protein in the T cells and induce degradation of the PD-1 protein in an endosome-lysosome way, so that the protein expression level of PD-1 is remarkably reduced, and the subprostrate alkali can be used for preparing a medicine for treating melanoma. The action does not depend on gene transcriptional regulation, the subprostrate alkali can obviously enhance the immune killing ability of the T cells to melanoma cells, and the survival rate of the tumor cells is obviously reduced in a co-culture system.