77results about How to "Promote infiltration" patented technology

The invention belongs to the technical field of talc, and provides a method for detecting fluorescent substances in talc raw ore, which comprises the following steps: S1, carrying out ball milling on the talc raw ore in a ball mill, sieving to obtain sieved powder, and adding deionized water into the sieved powder to obtain slurry; s2, adding the slurry into the mixture to enable the pH value of the slurry to be 5, stirring, and standing in a water bath for 2-3 hours to obtain a first precipitate; s3, adding a thiourea-ascorbic acid solution into the first precipitate to obtain a second precipitate; and S4, carrying out secondary ball milling on the second precipitate, and spreading the second precipitate in an enamel plate to detect whether the talc raw ore contains the fluorescent substances or not. The hydrochloric acid can dissolve quartz and mica to avoid generation of background fluorescence or quenching effect, and the nonionic surfactant polyethylene glycol can be adsorbed on the surface of the mineral to reduce interfacial tension, so that the hydrochloric acid is easier to infiltrate tiny pores, the pit defect caused by local over-corrosion is reduced, the pickling uniformity is improved, and the detection sensitivity is improved.

The invention discloses a cooling assembly, a heat dissipation device and a vehicle. The cooling assembly comprises a shell and a partition plate. The partition plate is arranged in the shell to divide the shell into a first sub-cavity and a second sub-cavity, and a plurality of spraying holes are formed in the partition plate to spray a cooling medium in the first sub-cavity to the second sub-cavity, so that bubbles generated by the second sub-cavity are separated from the shell. Therefore, the cooling medium is introduced through the first sub-cavity and forms jet flow in the jet hole, so that the jet flow can break bubbles generated by the second sub-cavity, the bubbles are changed into small bubbles, the bubbles are prevented from gathering to form large bubbles, the cooling medium can always infiltrate the bottom surface of the circulation channel, and the heat dissipation capability of the cooling assembly is enhanced.

The present application relates to the field of pharmaceutical preparation and nanomedicine, and particularly relates to a kind of nano-drug composition, its combined drug delivery system and application.The nano-drug composition comprises alpha 1-AR blocker and amphiphilic nano-carrier;The alpha 1-AR blocker is loaded in the hydrophobic core formed by amphiphilic nano-carrier;The alpha 1-AR blocker is selected from one or more of prazosin, terazosin, doxazosin;The average particle size of the nano-drug composition is 220-260 nm, the polydispersity index is less than 0.3, and the encapsulation efficiency is greater than 50%.The nano-drug composition of the present application has dual functions of anti-tumor proliferation and immune microenvironment remodeling, improves the dispersion stability of the drug in physiological medium, effectively reduces the in vivo clearance rate, prolongs the circulation time, and realizes the efficient in vivo delivery of the drug.The preparation process of the nano-preparation is stable and can be produced on a large scale.

The application discloses a kind of nano-permeable resin coating for construction in high-humidity water environment of desulfurization chimney lining anticorrosion, chimney lining includes reducing agent layer, reinforcing agent layer, primer layer, topcoat layer in turn from inside to outside, nano-permeable resin primer and topcoat can be permeated into the concrete matrix to form the anticorrosion layer of "matrix-coating", "mixing element integration", so that it not only has excellent acid corrosion resistance, but also has high and low temperature alternation and airflow scouring performance, solve the problem that chimney lining anticorrosion layer fails due to stress corrosion, also has good construction performance, solve the difficult problem that chimney lining anticorrosion layer construction period is short.

The application discloses a kind of high-efficiency super-soft organic solar cell of top incidence structure, it includes flexible substrate, anode, anode modification layer, active layer, cathode modification layer, cathode and antireflection layer from bottom to top, wherein the cathode is based on the transparent electrode of ultrathin silver.Especially by preferred cathode modification layer and introducing not more than 2nm thick gold as seed layer, make ultrathin silver surface more smooth and uniform, the transparent electrode can further improve the photoelectric energy conversion efficiency (PCE) of organic solar cell.Meanwhile, using the wide adaptability of top incidence structure to different substrates, the organic solar cell can also achieve comparable PCE (17.32%) with mm level rigid glass substrate on the polyimide flexible substrate with thickness of only 1.3 μm.Therefore, the highest efficiency of super-soft organic solar cell so far is obtained, and the highest power density (39.72W g ‑1 ) in all photovoltaic technologies at present is also obtained.

This application discloses an electrolyte solute, its preparation method, and its application. The electrolyte solute comprises an olefinic cyclohexene carboxylic acid compound obtained by the reaction of conjugated diene carboxylic acids. The conjugated diene carboxylic acid includes at least one compound having the structure shown in Formula III: wherein X and Y are each independently selected from H, -RO-COOH, substituted or unsubstituted C1-10 saturated hydrocarbon groups, etc., and at least one of X and Y is -RO-COOH; RO represents a directly bonded or C1-10 saturated hydrocarbon group. The electrolyte solute of this application, comprising an olefinic cyclohexene carboxylic acid compound with unsaturated hydrocarbon functional groups, can both improve the flash voltage of the electrolyte and maintain low viscosity and high conductivity.

The utility model discloses a polygonal road structure which comprises a roadbed structure, an assembly type concrete prefabricated slab is laid on the top of the roadbed structure, and the roadbed structure comprises a plain soil covering layer laid on the ground in a tamping mode and a stone powder laying layer covering the left side of the surface of the top of the plain soil covering layer. The right side of the top surface of the plain soil covering layer is covered with the dry hard ash filling layer. According to the scheme, through trapezoidal concave-convex interlocking and L-shaped hooking, quick assembly and top leveling are achieved, the leveling procedure is reduced, the laying efficiency is improved, a reinforcing mesh is arranged in the prefabricated slab, mechanical meshing and curbstone coating are combined, and the compression resistance and displacement resistance are enhanced; the symmetrical prefabricated plates support length expansion, and the curbstone notches and the protruding blocks are coupled to adapt to various road layouts. The water permeable bricks are higher than the prefabricated slabs and matched with the dry hard ash filling layer, rainwater infiltration is promoted, waterlogging is relieved in combination with the green belt design, and the service life of the plates is prolonged through the double-lock-catch design.

The utility model provides a kind of farmland type ecological buffer zone structure, it is related to agricultural ecological environment management technical field, including land buffer area one, ecological regulation pond, land buffer area two and concave green land, land buffer area one, ecological regulation pond, land buffer area two and concave green land are sequentially distributed from farmland side to river embankment side, land buffer area one and land buffer area two are planted with arbor shrub and grass flower mat, the ecological regulation pond is sequentially provided with impermeable layer, adsorption layer and plant layer from bottom to top, the concave green land is laid with buffer base, the concave green land is planted with herbaceous plant and shrub. This structure effectively intercepts farmland non-point source pollution, reduces river pollutant, helps to strengthen river self-purification capacity, promotes aquatic animal and plant diversity development, and guarantees ecological benefit to play well.

The present invention relates to 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (i), wherein x, r1, r2, r3, r4, and r5 are as defined in the description. The invention also relates to methods for preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular cancer or diseases with dysregulation of immune responses or other disorders associated with aberrant AHR signals, as monotherapy or in combination with other active ingredients.

The application discloses a method for preparing lithium pre-doped amine coordination manganese iron phosphate precursor from lithium manganese iron phosphate, and belongs to the field of battery recycling. The method comprises the following steps: stirring and reacting lithium manganese iron phosphate battery material with a high-valence iron salt solution and a surfactant, and filtering to obtain filtrate and phosphorus iron residue; mixing the filtrate with a phosphate, adjusting the pH of the solution to 2-6, then mixing with an oxidizing agent A, and adding a mixed solution containing an organic amine compound to perform nucleation precipitation reaction, and aging to obtain the lithium pre-doped amine coordination manganese iron phosphate precursor. The application utilizes the surfactant and the high-valence iron salt to efficiently replace divalent iron under acid-free or weak acid conditions, generates a metal solution containing Li + , Fe 2+ , Mn 2+ , performs oxidation to form nucleation precipitation, adds an organic amine compound to control the morphology of the generated particles in the solution, generates the lithium-doped amine coordination manganese iron phosphate precursor, the reaction condition is mild, the energy consumption in the treatment process is low, and the economic utilization value of a manganese byproduct is improved.

The invention relates to a preparation method and application of a novel TIL with a TOX gene knocked out, in particular to an engineered immune cell, and the TOX gene in the engineered immune cell is knocked out or knocked down. The ferroptosis resistance of the immune cell provided by the invention is remarkably enhanced, the immune cell can be better infiltrated into a tumor microenvironment, and the immune cell has a remarkable anti-tumor effect.

The invention belongs to the technical field of biology, and particularly relates to application of an Mgst2 gene serving as a target to preparation of a product for treating rheumatoid arthritis related interstitial lung diseases. According to the invention, it is found for the first time that Mgst2 can be used as a biomarker for treatment of rheumatoid arthritis related interstitial lung diseases, targeted knock-down is carried out on Mgst2 in neutrophils through an AAV9-shRNA vector (AAV9-shRNA-Mgst2) driven by a Cd11b promoter, and lung lesion progress can be effectively relieved by inhibiting NET formation. The Mgst2 inhibitor provided by the invention can directly intervene in the occurrence and development process of diseases from a molecular level, and has the advantages of accurate effect, remarkable curative effect, low side effect and the like. Compared with a traditional non-specific treatment mode, the product takes effect only aiming at specific molecular targets, damage to normal cells and tissues is remarkably reduced, and therefore the risk of toxic and side effects is reduced.

The application provides a modified polypropylene material and a preparation method thereof, a modified polypropylene film and an oil-immersed capacitor. The preparation method of the modified polypropylene material comprises the following steps: mixing and soaking an antioxidant 1010 and natural ester insulating oil with a polypropylene material to obtain the modified polypropylene material; wherein the mass of the antioxidant 1010 is 0.1%-1% of the mass of the natural ester insulating oil. The modified polypropylene material prepared by the above method has at least the advantages of good compatibility with the natural ester insulating oil, high AC breakdown strength, high tensile strength and high elongation at break.

The application discloses a resin composition and application thereof, and the resin composition comprises, in terms of solid weight, 10-70 parts of a benzoxazine resin containing unsaturated bonds, and 20-100 parts of a maleimide resin; wherein the benzoxazine resin containing unsaturated bonds is a mixture of a benzoxazine resin containing double bonds and a benzoxazine resin containing triple bonds. Compared with the prior art, the resin composition and application thereof can not only control the reactivity between the maleimide resin and the benzoxazine resin, improve the crosslinking network density, but also is beneficial to controlling the production speed of prepreg, and the prepreg has good apparent quality, and meanwhile has excellent high heat resistance, high modulus, low water absorption, low thermal expansion coefficient and low curing shrinkage.

The invention relates to a modified graphite negative electrode material and a preparation method thereof, a negative electrode and a lithium ion battery. The modified graphite negative electrode material comprises graphite particles and an SEI precursor layer which is uniformly coated on the surface of each graphite particle and is constructed by lithium salt, wherein the lithium salt is of a crystalline state structure, and the thickness of the SEI precursor layer is 1-500 nm; during the first charging and discharging process of the battery, the lithium salt of the SEI precursor layer is subjected to electrochemical reaction prior to electrolyte, and an inorganic phase SEI with LiF and / or Li3PO4 as a main component is formed on the surface of graphite particles in situ. The negative electrode material disclosed by the invention realizes active formation and uniform distribution of SEI, even in a thick electrode, a continuous SEI layer can be formed on the surface of a deep graphite particle in the first charge-discharge and cycle process of a battery, the first-cycle coulombic efficiency is remarkably improved, the cycle life is remarkably prolonged, and the low-temperature and rate performance is improved; in addition, the electrolyte can more easily infiltrate the electrode, so that Li < + > is more smoothly transmitted in the thick electrode, and the electrochemical performance of the electrode is improved.

The present application relates to the technical field of biological medicine, in particular to a kind of nano-molecular probe with targeting and its preparation method and application.The plasmid of immune checkpoint corresponding receptor of stable expression tumor surface negative regulation molecule is synthesized in the present application, which is prepared into targeted nano-molecular probe with cell membrane nanocapsule of enhancing T cell activity ligand and being marked with fluorescence, and melanin nanosphere of simultaneously loading therapeutic drug.The targeted nano-molecular probe provided in the present application can be long-circulated in vivo, reduce the dosage and administration frequency of chemotherapeutic drug.It also has the advantages of improving the drug resistance of tumor site to therapeutic drug, targeting tumor DNA damage and significantly enhancing the infiltration and activation of immune cells in tumor site.

The application relates to the technical field of molecular beam epitaxy equipment, in particular to an aluminum source furnace structure which comprises a heat preservation shell, a crucible embedded in the heat preservation shell, a first heater arranged between the heat preservation shell and the crucible and a water cooling cover one arranged outside the heat preservation shell, and the crucible is provided with a loading cavity, and the opening end of the loading cavity is annularly provided with a flared climbing step. The flared climbing step is arranged to solidify the climbing aluminum liquid, provides space for the solidification of the aluminum liquid, does not affect the diffusion channel of the aluminum atomic beam formed in the crucible to outward diffusion, and does not form aluminum liquid drops. Even if the flared climbing step forms aluminum liquid drops, the aluminum liquid drops will not directly drop onto the liquid surface of the aluminum liquid in the loading cavity, and the liquid surface of the aluminum liquid will not be fluctuated, so that the aluminum atomic beam can effectively maintain uniformity and stability in the time scale, and the uniformity of the deposited film of the substrate and the film forming quality are effectively improved.

The application provides a preparation method of isotropic coke and a product and graphite obtained by the method, and belongs to the technical field of coke material preparation. The preparation method of the isotropic coke comprises the following steps: 1) mixing a water-soluble carbon source, a surfactant and water to obtain an aqueous solution; 2) under physical emulsification conditions, slowly adding an oil phase into the aqueous phase to form an oil-in-water emulsion; and 3) performing a coking reaction on the oil-in-water emulsion obtained in the step 2) to obtain the isotropic coke. The application adopts an oil-in-water emulsion limited coking strategy to control the microtexture of the coke from the source, so that the coke is mainly in the form of small flake isotropic structure, and the defects of poor fast-charging performance and easy cycle attenuation caused by the traditional needle-shaped coke fiber structure are overcome, so that the coke has high capacity, high rate and long cycle life after graphitization.

The invention relates to a structural battery based on integration of a honeycomb composite material and an electrochemical energy storage unit. According to the structural battery, a force bearing function and an electric energy storage function are combined. According to the battery, a bionic honeycomb composite material is adopted as a matrix, and a lithium ion electrochemical unit is embedded into the matrix, so that the multifunctional structure battery with high mechanical strength and excellent electrochemical performance is formed. The honeycomb composite material is used as a carrier and an ion transmission channel of an electrode active material, and is also used as a bearing structure of a mechanical load. According to the design, the energy density, the safety and the cycle life of the battery are remarkably improved, and the battery is particularly suitable for the fields of electric automobiles, aerospace and the like with relatively high requirements on light weight and space utilization rate.

The invention relates to the technical field of building construction, in particular to a novel anti-floating anchor rod waterproof joint treatment method which comprises the steps that an anti-floating anchor rod and peripheral inter-pile soil are cleaned, the end of the anchor rod is treated, pile heads are chiseled, and a waterproof base layer is obtained; determining whether the qualification of the waterproof base layer meets the requirement or not based on the flatness deviation ratio of the waterproof base layer at the end of the anchor rod; the base layer is subjected to concrete pouring, the surface of the base layer is coated with a cement-based capillary crystalline waterproof coating to obtain a waterproof groove, and an SBS coiled material reinforcing ring is arranged on the periphery of the waterproof groove; filling the waterproof groove with a non-cured rubber asphalt waterproof coating to obtain a waterproof filling layer; the filling compactness of the waterproof filling layer is obtained, and the brushing thickness of the waterproof additional layer is determined; the surfaces of the waterproof filling layer and the reinforcing ring are coated with asphalt waterproof paint to obtain a waterproof additional layer; and determining the temperature correction value of the hot melting edge of the SBS coiled material based on the deviation value of the lap width of the waterproof additional layer. The sealing impermeability of the waterproof joint at the end of the anti-floating anchor rod is improved.

The present application relates to the field of biological medicine, and specifically provides an anti-LILRB4 monoclonal antibody injection preparation, which comprises an anti-LILRB4 monoclonal antibody, a buffer salt, a protein protective agent, and a surfactant, wherein the pH of the injection preparation is 5.5-6.5. The injection preparation provided by the present application provides a good storage environment for the anti-LILRB4 monoclonal antibody through the synergistic interaction of different contents of the buffer salt, the protein protective agent, and the surfactant, and guarantees the biological activity of the anti-LILRB4 monoclonal antibody. The anti-LILRB4 monoclonal antibody can effectively inhibit the combination of the LILRB4 antigen and its ligand complex, thereby blocking the interaction with the ligand ApoE complex, preventing the activation of the downstream NF-kappa B signal pathway and the release of ARG1, preventing the inhibition of T cell proliferation and the promotion of tissue infiltration, and can be used for treating cancer.

This invention relates to the field of composite material preparation technology, specifically to a method for preparing a high-performance thermoplastic polyaryletherketone (PAEK) wide-width fabric prepreg. The method includes the following steps: passing the fiber fabric sequentially through an unwinding device, a first horizontal high-temperature furnace, a first impregnation guide roller, a first vertical high-temperature furnace, a second vertical high-temperature furnace, a second impregnation guide roller, a third impregnation guide roller, a third vertical high-temperature furnace, a fourth vertical high-temperature furnace, a fourth impregnation guide roller, a second horizontal high-temperature furnace, a high-temperature pressure roller, a traction roller, and a winding device; the first and second impregnation guide rollers are both located in a first suspension glue tank, and the third and fourth impregnation guide rollers are both located in a second suspension glue tank; after traction begins, each heating device is heated to a higher temperature; after heating to a higher temperature, the fiber fabric is wound up. The purpose of this method for preparing a high-performance thermoplastic PAEK wide-width fabric prepreg is to solve the problems of poor wetting between the resin and the fabric and low resin content in the fabric prepreg.

The present application belongs to the technical field of biological medicine, and particularly relates to an esterase-responsive PEGylated conjugate containing a sulfonamide group and a preparation method and application thereof. The esterase-responsive PEGylated conjugate comprises: a PEGylated hydrophilic segment; an esterase-cleavable linker arm, the linker arm comprising at least one ester bond; a copper death sensitization functional structure containing a sulfonamide group; wherein the copper death sensitization functional structure containing a sulfonamide group is covalently connected to the PEGylated hydrophilic segment through the esterase-cleavable linker arm. The esterase-responsive PEGylated conjugate containing a sulfonamide group provided by the present application can self-assemble to form nanoparticles (EsCu@NPs), and through an esterase response mechanism, L-BSO and copper ions are accurately released at a tumor site, GSH is efficiently consumed and copper death is induced, thereby triggering immunogenic cell death (ICD), promoting the maturation of dendritic cells and CD8 + T cell infiltration, and significantly enhancing the therapeutic effect of an anti-PD-1 immune checkpoint inhibitor.

The application discloses application of L-histidine in preparation of an auxiliary synergist for enhancing the curative effect of an immune checkpoint inhibitor in treatment of colorectal cancer, and belongs to the field of biological medicines. The application combines L-histidine with anti-PD-1 monoclonal antibodies, supplements L-histidine through oral administration, improves the levels of histidine-rich glycoprotein and histamine in plasma, promotes the polarization of tumor-related macrophages to M1 type, increases CD8 + T cell infiltration, reduces regulatory T cell infiltration, up-regulates the expression of anti-tumor effect molecules, thereby synergistically enhances the anti-tumor immune effect, and improves the drug resistance or poor response problem caused by the use of PD-1 monoclonal antibodies alone. In the application, L-histidine can be used as an amino acid adjuvant to synergistically use a first-line clinical immune checkpoint inhibitor for tumor immunotherapy, thereby providing a new solution for the problem of drug resistance of the use of ICIs alone, and having a wide clinical application prospect.

The application relates to a secondary battery and a power utilization device. The secondary battery comprises a positive electrode sheet, a negative electrode sheet and an electrolyte. The positive electrode sheet comprises a positive electrode active layer, the positive electrode active layer comprises a positive electrode active material and a first binder, the first binder comprises polytetrafluoroethylene; the tortuosity of the positive electrode active layer is tau; the electrolyte comprises a lithium salt, a solvent and an additive, the solvent comprises a carboxylic acid ester, and the additive comprises a nitrile compound; the mass content of the carboxylic acid ester is b and the mass content of the nitrile compound is c based on the mass of the electrolyte; wherein 2 <= tau <= 8, 0.5*tau <= b <= 15*tau, 0.02*b <= c <= 0.2*b. The secondary battery of the application improves the cycle life while maintaining a faster charging speed of the battery.

The application relates to the field of medical technology, in particular to application of PTPRT as a biomarker and target point for predicting the curative effect of lung cancer immunological checkpoint treatment. The application provides application of the expression amount of PTPRT in curative effect prediction or evaluation of immunological checkpoint treatment of cancer. The experiment of the application shows that low expression of PTPRT can accurately predict the progression-free survival (PFS) of lung cancer patients after receiving immunological checkpoint treatment as a marker for predicting the curative effect of lung cancer immunological checkpoint treatment. Inhibition of PTPRT can increase the proportion of CD8+ T cells infiltrating tumors, and synergistically enhances the anti-tumor effect of an immunological checkpoint inhibitor.

The invention provides a variable-thickness high-pressure-resistant composite-metal shell of deep-sea equipment and a preparation method thereof, and belongs to the technical field of design and manufacturing of pressure-resistant structures for deep-sea equipment.The preparation method comprises the following steps that the total structure of the pressure-resistant shell is determined, variable-thickness design of the composite shell and layering design of the composite shell are conducted, and the total structure of the pressure-resistant shell is obtained; finite element checking and structure optimization are carried out; flange design and pretreatment; laying and winding are integrally formed; integrally curing and forming; and demolding. Through the variable-thickness partition and continuous gradual transition design of the composite main bearing shell and the adoption of a symmetrical laying-winding scheme with annular bearing as a main part, the bearing path distribution under external pressure load is improved, the stress concentration and local instability risks of a transition area and an end area are reduced, and the overall external pressure resistance stability is improved. Axial and + / -45-degree laying layers are arranged at the ends and the transition areas, so that end loads can be transited step by step and smoothly introduced into a composite main bearing structure, the end force transmission uniformity is improved, and the structural reliability is improved.

The application discloses a soil and water conservation method for camellia oleifera forest in hilly areas, which comprises the following steps: zoning and land preparation of the forest land in the hilly areas, setting intermittent terraces and original soil belts along contour lines in the slope cultivation area, constructing a soil stabilizing structure and a water seepage buffer layer on the water-facing side of the terraces to reduce erosion and promote seepage, setting a water collecting and releasing ditch in the inner side of the terraces to slow down runoff, setting a soil and water preserving composite layer in the camellia oleifera planting hole, and setting a sand sink in the slope foot water collecting area to recover runoff. The method can weaken the slope runoff scouring by zoning and land preparation of the forest land in the hilly areas and setting intermittent terraces and original soil belts along contour lines in the slope cultivation area. The soil stabilizing structure, the water seepage buffer layer and the water collecting and releasing ditch are combined to realize runoff reduction and water storage. The soil and water preserving composite layer in the camellia oleifera planting hole can enhance the root zone stability and water holding capacity, so that the soil and water loss can be effectively controlled and the water use efficiency can be improved without large-scale hard engineering.

The invention discloses an application of a benzo-aza derivative in preparation of a medicine for preventing or treating atherosclerosis, the benzo-aza derivative is a compound with a chemical structure as shown in a formula I, or a pharmaceutically acceptable salt, a precursor or a metabolite of the compound, and in the formula I, X is halogen or H. The traditional Chinese medicine composition has the technical effects that the plaque stabilizing effect is obvious, the plaque composition is improved, the necrosis core area in the plaque is reduced, the total plaque load can be effectively reduced, the lesion progress is delayed / reversed, the dependence on lipid reduction is avoided, the treatment blank is filled, a brand new plaque stabilizing treatment strategy is provided, and the clinical problem of residual cardiovascular risks is expected to be solved. The safety is good, the organ specificity is high, and the whole body toxicity is low. The invention provides a new treatment normal form, new use of old medicines and large clinical transformation potential, and can be used as a supplement and enhancement of a basic therapy (such as statin lipid reduction) to form a combined treatment scheme of lipid reduction and spot stabilization, thereby realizing multi-channel cooperative control of atherosclerosis.

Disclosed in the present invention are a use of a combination of an anti-PD-L1 nanobody and a TLR7 small molecule agonist in anti-tumor treatment, and a PD-L1 and TLR7 double-targeting nanobody coupling drug, a preparation method therefor, and a use thereof. Specifically, disclosed in the present invention are a use and solution of a combination of an anti-PD-L1 nanobody and a derived protein thereof as well as a TLR7 small molecule agonist and a derived compound thereof in anti-tumor treatment. Meanwhile, disclosed in the present invention are design, preparation, and identification solutions for a novel PD-L1 and TLR7 double-targeting-nanobody drug conjugate and a derived molecule thereof, and an effect of the novel PD-Ll and TLR7 double-targeting nanobody drug conjugate in anti-tumor treatment. The PD-L1 and TLR7 double-targeting nanobody drug conjugate of the present invention can yield a significant antineoplastic efficacy in various transplantation tumor models.