123 results about "Sonodynamic therapy" patented technology

Sonodynamic therapy systems and methods use short, high-pressure ultrasound pulses that produce small (and therefore clinically safe) increases (up to 1-2° C.) in tissue temperature but nonetheless activate sonodynamic agents, allowing isolated single-cav-itation events to produce therapeutically beneficial effects (e.g., cytotoxicity) on diseased tissue. An escalating sonication strategy may be employed whereby the focal pressure is gradually increased until maximum clinically tolerable parameters such as the degree of heating of intervening tissue (e.g., the skull when treating brain cancer) or undesired induced cavitation effects are reached.

Disclosed herein are activatable inactive sonosensitizer compounds, referred to as locked sonosensitizer compounds, designed with a detachable stimuli-responsive tether acting as a trigger or safety, as these compounds restore their inherent sonosensitization activity upon the detachment of the tether. The invention further encompasses pharmaceutical compositions comprising the same, offering a strategic approach to sonodynamic therapy, whereas the compounds and compositions are formulated to be administered and applied under favorable conditions, enhancing their efficacy in the context of therapeutic applications, since the therapeutic methods presented herein are more versatile and efficient compared to presently known SDT methods due to the controlled activation of the sonosensitizer.

The invention belongs to the technical field of medical nano-materials, and particularly relates to a lactoferrin nano-material for sonodynamic regulation and control of blood-brain barrier permeability as well as a preparation method and application of the lactoferrin nano-material. The nanomaterial is nanoparticles LCe6 formed by self-assembly of lactoferrin and chlorin e6, can target brain microvascular endothelial cells, and can temporarily, reversibly and targeting open BBB by using the sonodynamic effect of the LCe6 in combination with transcranial ultrasonic stimulation, so that the accumulation of the nanoparticles LCe6 at a focus part is improved; in addition, the nanoparticle LCe6 also has a targeting property on brain tumor cells, the tumor cells can be accurately killed by utilizing the sonodynamic effect of the nanoparticle under secondary transcranial ultrasound, and the effect of sonodynamic treatment on brain glioma is exerted to the maximum extent; the nanoparticles LCe6 have excellent biocompatibility and low toxicity; according to the invention, the intracerebral delivery efficiency of the drug can be obviously improved, and a novel method for targeting open brain disease BBB is provided.

The invention relates to a preparation method of a tumor microenvironment response type nano drug delivery system, which comprises the following steps: forming MnO2 nanoclusters through biomineralization induction under an alkaline condition, modifying HSA nanoparticles, then loading Ce6 through a carbodiimide method, and finally combining with a PD-L1 antibody by adopting a copper-free click chemistry method to obtain nanoparticles HMC and anti-PD-L1. The nanoparticle can be retained in a tumor tissue in a passive targeting manner through an EPR effect, and is decomposed into Mn < 2 + >, O2 and a small molecule drug through a high H2O2 and low pH microenvironment of the tumor tissue, so that the tumor permeability is greatly enhanced, the tumor immunogenicity is enhanced by combining sonodynamic therapy, the release of a tumor specific antigen and the aging of antigen presenting cells are promoted, and the tumor treatment effect is enhanced. The infiltration of tumor T cells is increased, and cold tumors are changed into hot tumors; the nanoparticles can generate O2 in situ at the same time, and the immunosuppressive ability and drug resistance caused by tumor hypoxia are overcome.

The invention discloses an ultrasonic controllable multifunctional microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The preparation method comprises the following steps: preparing crystalline CoW-LDH nanosheets from Co (NO3) 2.6 H2O, Na2WO4. 2H2O and NaOH, dispersing the crystalline CoW-LDH nanosheets in PBS (Phosphate Buffer Solution), centrifuging and collecting the crystalline CoW-LDH nanosheets, and re-dispersing the crystalline CoW-LDH nanosheets in ultrapure water to obtain amorphous CoW-LDH nanosheets; adding PEG (Polyethylene Glycol), ultrasonically dispersing, stirring at room temperature, centrifuging, collecting and centrifugally washing with ultrapure water to obtain a PEG modified amorphous CoW-LDH nanosheet; and adding microalgae and an amorphous CoW-LDH nanosheet modified by PEG (Polyethylene Glycol) to prepare the ultrasonic controllable multifunctional microneedle patch. The multifunctional microneedle patch disclosed by the invention is high in biological safety, can realize ultrasonic controllability, has a sonodynamic treatment effect and an oxygen supply effect, remarkably inhibits melanoma recurrence and remarkably promotes wound healing, and has a wide application prospect.

The invention relates to a preparation method and application of a targeted pancreatic cancer immune checkpoint diagnosis and treatment integrated nanoprobe, which can realize integration of sonodynamic therapy and MRI imaging of pancreatic cancer cells with high expression of VISTA, realize targeted SDT therapy of pancreatic cancer and visual evaluation of the therapeutic effect, have good biological safety, and can be applied to diagnosis and treatment of pancreatic cancer cells with high expression of VISTA. SDT visual treatment of targeted pancreatic cancer is realized at a cellular level, and SDT combined immunotherapy of pancreatic cancer is realized at an animal level. The method comprises the following steps: (1) preparing Fe3O4 nanoparticles by using a solvothermal method; (2) preparing Fe3O4 (at) SiO2 nano particles; (3) preparing Fe3O4 (at) SiO2 (at) TiO2 nano particles; (4) preparing Fe3O4 (at) TiO2 by adopting an alkaline hydrothermal corrosion auxiliary crystallization method; and (5) modifying the nanoprobe with a VISTA antibody through an electrostatic adsorption method, and finally successfully constructing the garland-shaped nanoprobe.

The invention discloses an aptamer-modified lipid nano delivery platform as well as a preparation method and application thereof, and belongs to the field of biomedicine. The platform is prepared by taking DPPC, DOTAP and cholesterol as basic lipid components, Ce6 as a sound-sensitive agent and Flt3L as an immune agonist, controlling the particle size through gradient extrusion, and coupling cholesterol with an EpCAM aptamer for surface modification. The method has the core advantages that active targeting enrichment of tumors is realized by virtue of the aptamer, tumor cell immunogen cell death (ICD) is induced in combination with a sonodynamic therapy (SDT), and damage-related molecular patterns (DAMPs) are released; meanwhile, Flt3L is released in a tumor microenvironment, collection and activation of type 1 classical dendritic cells (cDC1) are specifically promoted, an'endogenous cDC1 vaccine 'is constructed, and CD8 + T cell mediated anti-tumor immune response is enhanced. Experiments prove that the platform can significantly improve the cDC1 infiltration level of a tumor site, effectively inhibit the progress of prostate cancer (PCa), and provide a new normal form for immune'cold tumor 'treatment.

The invention discloses an ionic iridium complex sonosensitizer as well as a preparation method and application thereof, belongs to the technical field of metal complex preparation, provides four ionic iridium complex sonosensitizers with excellent treatment effects, and provides a preparation method of the ionic iridium complex and application of the ionic iridium complex sonosensitizers in tumor sonodynamic therapy. The ionic iridium complex sonosensitizer prepared by the invention shows remarkable affinity to mitochondria, and due to more negative potentials in cancer cells, the cationic iridium complex targeting cancer cells is more favorably realized, and meanwhile, due to the introduced triphenylamine structure, the AIE behavior of the triphenylamine structure is realized, so that the targeting effect of the cationic iridium complex on the cancer cells is improved. The ionic iridium complex sonosensitizer can activate the sonosensitizer in an aggregation state to promote the generation of ROS, the triplet excited state energy level of the ionic iridium complex sonosensitizer can be well matched with the excited state energy level of oxygen, and meanwhile, the ionic iridium complex sonosensitizer has a relatively long triplet excited state life, so that the ROS generation capability of the ionic iridium complex sonosensitizer is relatively high; and the material is a candidate material of a sound-sensitive agent with an excellent sonodynamic therapy effect.

The invention discloses a composite nano sound-sensitive agent as well as a preparation method and application thereof. According to the composite nano sound-sensitive agent provided by the invention, a conjugated system of the narrow-gap semiconductor nano sound-sensitive agent core / the ferric oxide nano functional layer / the surface targeting antibody is constructed, so that multi-mode synergy integrating sonodynamic therapy, ferroptosis induction and immunoregulation is realized. The composite nano sonosensitizer further has precise targeting, efficient sonodynamic effect, ferroptosis enhancement effect and good biocompatibility, a targeting antibody on the surface of the composite nano sonosensitizer can specifically recognize high-expression antigens on the surfaces of tumor cells, and dual-targeting enrichment of a treatment system is achieved in combination with magnetic responsiveness guidance; the coating of the iron oxide nanoparticles obviously enhances the sound-sensitive performance of the inner core of the sound-sensitive agent, improves the ROS generation efficiency, and overcomes the hypoxia limitation of the tumor microenvironment; iron oxide is used as an iron source to continuously release Fe < 2 + >, and cooperates with ROS generated by sonodynamic therapy to induce ferroptosis, so that a ferroptosis enhancing effect is generated.

The invention relates to the technical field of research and development of photosensitizers for tumor photodynamic therapy, acoustic sensitizers for sonodynamic therapy and photothermal reagents for photothermal therapy, and provides a bithiophene benzo-bridged ligand and a preparation method thereof as well as a bithiophene benzo-bridged binuclear metal complex as well as a preparation method and application of the bithiophene benzo-bridged binuclear metal complex. According to the invention, on the basis of a bithiophene benzo-bridged ligand dtdpip, a bithiophene benzo-bridged binuclear ruthenium complex, a bithiophene benzo-bridged binuclear osmium complex and a bithiophene benzo-bridged binuclear iridium complex are respectively designed and invented. The bithiophene benzo-bridged binuclear metal complex has extremely high stability and excellent two-photon absorption characteristic, and has excellent biotoxicity and photothermal conversion capability under the action of infrared exciting light and ultrasonic waves. The conjugated bithiophene binuclear metal complex provided by the invention is a potential novel infrared photodynamic photosensitizer, a sound-sensitive agent and a photo-thermal reagent, and has a wide application prospect in photodynamic therapy, sonodynamic therapy and photo-thermal therapy of tumors.

The application belongs to the technical field of medicine, and particularly relates to a La2(WO4)3 / CuWO4 composite sonosensitizer, a preparation method thereof and application thereof in sonodynamic therapy. The La2(WO4)3 / CuWO4 composite sonosensitizer contains 5-40% of La2(WO4)3 in terms of mass percentage. The application takes U251 glioma cells as a model target, and explores the application of the La2(WO4)3 / CuWO4 composite sonosensitizer in sonodynamic therapy of tumors. The results show that the La2(WO4)3 / CuWO4 composite sonosensitizer has a good sonodynamic therapy effect on U251 glioma cell lines after 1MHz US irradiation for 1min.

The invention provides an activatable semiconductor polymer as well as a preparation method and application thereof. The activatable semiconductor polymer disclosed by the invention can be efficiently accumulated at a tumor site, due to the existence of a side chain electron withdrawing group, the fluorescence of the polymer is in a quenched state, the fluorescence of the polymer is recovered after tumor markers such as biological mercaptans, active oxygen and cathepsin B are respectively responded, and accurate imaging and sonodynamic therapy can be carried out at the tumor site. Meanwhile, the activatable semiconductor polymer can mark immune cells (such as dendritic cells and macrophages) and track the process of transferring the immune cells from tumors to tumor drainage lymph nodes.

The present invention provides a glutathione-activated co-assembled nanoprobe and a preparation method and application thereof, belonging to the technical fields of chemical synthesis, biological analysis and detection, tumor imaging and treatment. In the present invention, amphiphilic small molecule probes 1-Zn-PPA and 1-NLG are constructed, and the probes 1-Zn-PPA and 1-NLG can be co-assembled in a solution to form co-assembled nanoprobes 1-NPs. The nanoprobes 1-NPs can accumulate at the tumor site under the tumor EPR effect and the targeting action of cRGD on the probe surface, and disassemble under the action of GSH present in the tumor reducing environment to release Gd-containing hydrophilic small molecule 2-Gd, light / sound-sensitive drug Zn-PPA-SH and immune adjuvant drug NLG919. The nanoprobes 1-NPs can realize combined sonodynamic therapy / photodynamic therapy / immunotherapy of living tumors. The nanoprobes 1-NPs have good applications in fluorescence imaging, magnetic resonance imaging, and the preparation of tumor treatment drugs and tumor-killing devices.

The present invention discloses an ultrasound-responsive CO-releasing nanoformulation and a preparation method thereof. First, a vanadium tetrasulfide nanoformulation with sonodynamic and chemodynamic effects is prepared. Then, a CO-releasing molecule is loaded to construct an ultrasound-responsive CO-releasing nanoformulation, realizing the controllable release of CO. The preparation process of the ultrasound-responsive CO-releasing nanoformulation is simple, and it can achieve the combination of CO therapy / sonodynamic therapy / chemodynamic therapy for tumors. Using it for tumor treatment has safety and effectiveness, and has broad application prospects.

The present disclosure relates generally to methods of utilizing sonosensitizers in the presence of thiamine or a derivative thereof for the purpose of cross-linking animal tissue, producing singlet oxygen within or at the site of animal tissue, or treating a condition in a subject, wherein the condition is an aneurysm, cancer, and / or a scleral condition.

The present invention belongs to the technical field of sonodynamic therapy, and discloses a two-dimensional TiO2 nanomaterial with peroxidase activity and its application in sonodynamic therapy. The present invention firstly proposes to design ultrathin 2D TiO2 nanosheets with peroxidase activity as efficient sonosensitizers for sonodynamic cancer therapy. The ultrathin Ti3C2 nanosheets obtained by acid etching treatment are oxidized to 2D TiO2 through simple heat treatment. Surprisingly, 2D TiO2 has peroxidase activity, and when used as a sonosensitizer, the 2D TiO2 nanosheets exhibit excellent ROS generation activity under US irradiation. In vitro experiments show that the 2D TiO2 nanosheets can effectively induce apoptosis of cells under US irradiation.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention discloses a nano-drug CTS-S-CPT-IR 780NPs for treating tumors as well as a preparation method and application of the nano-drug CTS-S-CPT-IR 780NPs, and belongs to the technical field of medicines. Camptothecin and chitosan (CTS) are connected through a long chain, a prodrug CTS-S-CPT in an aqueous solution can be self-assembled and entrapped with a sound-sensitive agent IR 780 to form CTS-S-CPT at IR 780NPs, the covalently-bound prodrug can prevent the drug from leaking in a circulatory system and monitor drug distribution in a body in real time, ROS generated by IR 780 can enable covalent bonds to be broken, the drug is limited to a tumor site, CPT release is controlled, and the drug delivery effect is improved. The toxicity is also generated on tumor cells. Therefore, the CPT-mediated chemotherapy and the IR 780-induced sonodynamic therapy can act together to generate an excellent tumor inhibition effect. This topical, controllable, and on-demand drug release system can provide an alternative option for CPT formulations.

The invention relates to a substance with a Prussian blue structure, which can generate hydroxyl radicals, superoxide anions and singlet oxygen in parallel under ultrasonic irradiation, and in the presence of ultrasonic irradiation and H2O2, the substance with the Prussian blue is used as a sonodynamic therapy (SDT) means to kill focus cells by generating sonotoxic and cytotoxic free radicals, so as to achieve the purpose of improving the therapeutic effect of the substance with the Prussian blue structure. Therefore, diseases are effectively treated.

A porphyrin compound for bioimaging and sonodynamic therapy, as well as its preparation method and application, has a chemical formula shown in Formula 2. The preparation method comprises the following steps: adding p-methylthiobenzaldehyde, a compound of Formula 1, and pyrrole to a reaction flask, evacuating the flask and introducing nitrogen gas, followed by adding anhydrous dichloromethane to obtain a reaction solution; bubbling nitrogen gas through the reaction solution, stirring at 25°C, adding boron trifluoride etherate, maintaining the temperature while continuing to stir, adding DDQ, continuing stirring, adding triethylamine, filtering, concentrating, and purifying to obtain the target product. This method features mild reaction conditions, a short reaction time, and simple operation. The resulting porphyrin compound exhibits excellent sonosensitivity and biocompatibility, can efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effects. The compound also exhibits fluorescence emission in the near-infrared region and can be excited by visible light, enabling confocal imaging to detect changes in cell morphology before and after, resulting in excellent bioimaging results. #imgabs0#

The present invention relates to the technical field of pharmaceutical chemistry, and particularly relates to a zinc complex and its preparation method and application. The chemical structural formula of the zinc complex is As a sonosensitizer, it has the advantages of good biosafety, clear structure, and easy metabolism. Under the condition without ultrasound, its killing ability to cells is extremely small and the biosafety is good; under the condition of ultrasound irradiation, it can generate a large amount of singlet oxygen <supgt;1< / supgt;O<subgt;2< / subgt>, thereby destroying the intracellular redox balance, resulting in the death of cancer cells. Its IC50 value for 4T1 cells can reach 2.45 μM, showing excellent anti-tumor effects and is expected to be used in the sonodynamic therapy of tumors.

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.

The invention relates to a preparation method of a PEDOT-based nano composite material. The preparation method comprises the following steps: S10, preparing PEDOT nano particles; s20, preparation of the PEDOT / AB nano particles; and S30: preparing the PEDOT / AB (at) CMs nano particles, wherein the obtained material is the PEDOT-based nano composite material. According to the preparation method of the PEDOT-based nano composite material and the material, a homologous cancer cell membrane is introduced to construct a gas-wrapped vesicle structure, the immunological rejection can be reduced while the ultrasonic imaging effect is enhanced, and ultrasonic imaging and sonodynamic therapy are combined, so that the tumor detection precision is improved, and the detection sensitivity is improved. And precise targeted therapy can also be realized.

The application belongs to the technical field of biomedical materials, and particularly relates to a supramolecular coordination complex with sonodynamic activity and a preparation method and application thereof. The application proposes a new supramolecular coordination complex formed by self-assembly of a phthalocyanine compound and Ru-dbq, and finds that the supramolecular coordination complex has excellent ROS yield in response to US, and also has the characteristics of multifunctional integration such as CAT enzyme-like activity and antioxidant activity, which endows the material with great application potential in response to complex biological environments and excellent sonodynamic therapy prospects.

The invention discloses a responsive nano-drug controlled release system based on sonodynamic therapy and application thereof, and belongs to the technical field of tumor immunotherapy, the responsive nano-drug controlled release system based on sonodynamic therapy comprises barium titanate nanoparticles; the hydrogel responds to active oxygen, and the hydrogel is connected through active oxygen sensitive bonds and fractures under the action of ROS (reactive oxygen species), so that wrapped barium titanate nanoparticles are released. As a further optimization scheme of the invention, the particle size of the barium titanate nano-particles is 10-100nm, and the barium titanate nano-particles are cubic. As a further optimization scheme of the invention, the hydrogel is composed of TPA and PVA. The tumor treatment responsive nano-drug provided by the invention shows huge potential in the field of tumor immunotherapy, provides theoretical and experimental basis for design and application of a nano-drug controlled release system in the future, and is expected to bring new breakthrough to tumor treatment.

The present invention relates to an enhanced sonodynamic therapeutic agent using a liposome having the ability to transfer oxygen, and more particularly, to lipid nanoparticles having the ability to transfer oxygen in which perfluorocarbon (PFC) and indocyanine green (ICG) are loaded inside liposomes to increase the efficiency of sonodynamic therapy.

The invention belongs to the field of biological materials, and particularly relates to an ultrasonic responsive oxygen-carrying and traditional Chinese medicine microcapsule and a preparation method and application thereof in treatment of infected wounds, two glass tubes with different inner diameters are coaxially sleeved and fixed, the glass tube with the larger inner diameter is used as an outer phase channel, and the glass tube with the smaller inner diameter is used as an inner phase channel; the preparation method comprises the following steps: dissolving sodium alginate and curcumin into deionized water to prepare a mixed pre-gel solution; oxygen is introduced into the liquid fluorocarbon, and oxygen-enriched fluorocarbon liquid is obtained after treatment; the prepared mixed pre-gel solution and the oxygen-enriched fluorocarbon liquid are simultaneously introduced into the external phase channel and the internal phase channel respectively, electric field force is applied to outlets of the channels, and the mixed pre-gel solution and the oxygen-enriched fluorocarbon liquid fall into a collection liquid after being subjected to electronic injection to obtain the oxygen-carrying and traditional Chinese medicine microcapsule. The loaded traditional Chinese medicine curcumin and oxygen dissolved in the fluorocarbon achieve simultaneous delivery of traditional Chinese medicine and oxygen, and controllable oxygen release and sonodynamic therapy can be achieved.

The invention provides a sound-sensitive-agent-loaded targeted adipose tissue extracellular vesicle for assisting sonodynamic treatment of obesity as well as a preparation method and application of the sound-sensitive-agent-loaded targeted adipose tissue extracellular vesicle, and particularly belongs to the technical field of obesity drug preparation. The invention provides an application of an extracellular vesicle of a targeted adipose tissue loaded with a sound-sensitive agent in preparation of a medicine for assisting sonodynamic treatment of obesity. The sound sensitive agent is hematoporphyrin monomethyl ether; the extracellular vesicle of the targeted adipose tissue is an extracellular vesicle of which the surface expresses targeted adipose tissue sequence peptide ATS, and the amino acid sequence of the ATS is as shown in SEQ ID NO. 1. The extracellular vesicle loaded with the haematoporphyrin monomethyl ether surface expression targeting adipose tissue sequence peptide ATS can accurately induce adipose tissue browning, finally safe and effective fat reduction is achieved, and the effect of treating obesity is achieved.

The invention relates to an organic metal framework ultrasonic contrast agent for activating tumor immunity as well as a preparation method and application of the organic metal framework ultrasonic contrast agent. The organic metal framework ultrasonic contrast agent comprises a zeolite imidazole framework 8, an azo initiator loaded on the zeolite imidazole framework 8 and targeted mucopolysaccharide modified on the surface of the zeolite imidazole framework 8, and the particle size of the organic metal framework ultrasonic contrast agent is 165-201 nm. The invention also provides a preparation method of the ultrasonic contrast agent. According to the organic metal framework ultrasonic contrast agent for activating tumor immunity, the enrichment of the contrast agent at a tumor part is enhanced through specific binding of targeted mucopolysaccharide and tumor high-expression CD44, the azo initiator is decomposed to generate nitrogen and alkyl radicals after ultrasonic irradiation, the nitrogen and the alkyl radicals are changed into micron-sized bubbles to play a role, and the tumor immunity is activated. The compound has good tumor killing effect and ultrasonic imaging effect, can be used for preparing tumor sonodynamic therapy drugs, and realizes integration of tumor diagnosis and treatment.

The invention discloses a tumor treatment synergistic interaction system and method based on the acoustic cavitation effect of a phase-change nano-droplet. The system comprises the phase-change nano-droplet entrapped with a chemotherapeutic drug and a sound-sensitive agent and a cavitation effect intelligent monitoring and adjusting system. The method is characterized in that cavitation noise signals of a tumor target area are collected in real time through a cavitation monitoring system integrated in an ultrasonic probe, the inertial cavitation dosage is rapidly calculated through a signal processing system and compared with a preset threshold value, then a feedback instruction is generated to dynamically regulate and control ultrasonic irradiation parameters, and intelligent closed-loop control is formed. According to the method, the cavitation effect can be accurately maintained in an ideal treatment window, targeted release and deep penetration of the medicine and activation of the sound-sensitive agent are synchronously achieved through cavitation mechanical energy, and time-space synchronous synergistic interaction of chemotherapy and sonodynamic therapy is achieved.