86 results about "Sonodynamic therapy" patented technology

The invention discloses an ultrasonic controllable multifunctional microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The preparation method comprises the following steps: preparing crystalline CoW-LDH nanosheets from Co (NO3) 2.6 H2O, Na2WO4. 2H2O and NaOH, dispersing the crystalline CoW-LDH nanosheets in PBS (Phosphate Buffer Solution), centrifuging and collecting the crystalline CoW-LDH nanosheets, and re-dispersing the crystalline CoW-LDH nanosheets in ultrapure water to obtain amorphous CoW-LDH nanosheets; adding PEG (Polyethylene Glycol), ultrasonically dispersing, stirring at room temperature, centrifuging, collecting and centrifugally washing with ultrapure water to obtain a PEG modified amorphous CoW-LDH nanosheet; and adding microalgae and an amorphous CoW-LDH nanosheet modified by PEG (Polyethylene Glycol) to prepare the ultrasonic controllable multifunctional microneedle patch. The multifunctional microneedle patch disclosed by the invention is high in biological safety, can realize ultrasonic controllability, has a sonodynamic treatment effect and an oxygen supply effect, remarkably inhibits melanoma recurrence and remarkably promotes wound healing, and has a wide application prospect.

The invention discloses an aptamer-modified lipid nano delivery platform as well as a preparation method and application thereof, and belongs to the field of biomedicine. The platform is prepared by taking DPPC, DOTAP and cholesterol as basic lipid components, Ce6 as a sound-sensitive agent and Flt3L as an immune agonist, controlling the particle size through gradient extrusion, and coupling cholesterol with an EpCAM aptamer for surface modification. The method has the core advantages that active targeting enrichment of tumors is realized by virtue of the aptamer, tumor cell immunogen cell death (ICD) is induced in combination with a sonodynamic therapy (SDT), and damage-related molecular patterns (DAMPs) are released; meanwhile, Flt3L is released in a tumor microenvironment, collection and activation of type 1 classical dendritic cells (cDC1) are specifically promoted, an'endogenous cDC1 vaccine 'is constructed, and CD8 + T cell mediated anti-tumor immune response is enhanced. Experiments prove that the platform can significantly improve the cDC1 infiltration level of a tumor site, effectively inhibit the progress of prostate cancer (PCa), and provide a new normal form for immune'cold tumor 'treatment.

The invention discloses a composite nano sound-sensitive agent as well as a preparation method and application thereof. According to the composite nano sound-sensitive agent provided by the invention, a conjugated system of the narrow-gap semiconductor nano sound-sensitive agent core / the ferric oxide nano functional layer / the surface targeting antibody is constructed, so that multi-mode synergy integrating sonodynamic therapy, ferroptosis induction and immunoregulation is realized. The composite nano sonosensitizer further has precise targeting, efficient sonodynamic effect, ferroptosis enhancement effect and good biocompatibility, a targeting antibody on the surface of the composite nano sonosensitizer can specifically recognize high-expression antigens on the surfaces of tumor cells, and dual-targeting enrichment of a treatment system is achieved in combination with magnetic responsiveness guidance; the coating of the iron oxide nanoparticles obviously enhances the sound-sensitive performance of the inner core of the sound-sensitive agent, improves the ROS generation efficiency, and overcomes the hypoxia limitation of the tumor microenvironment; iron oxide is used as an iron source to continuously release Fe < 2 + >, and cooperates with ROS generated by sonodynamic therapy to induce ferroptosis, so that a ferroptosis enhancing effect is generated.

The application belongs to the technical field of medicine, and particularly relates to a La2(WO4)3 / CuWO4 composite sonosensitizer, a preparation method thereof and application thereof in sonodynamic therapy. The La2(WO4)3 / CuWO4 composite sonosensitizer contains 5-40% of La2(WO4)3 in terms of mass percentage. The application takes U251 glioma cells as a model target, and explores the application of the La2(WO4)3 / CuWO4 composite sonosensitizer in sonodynamic therapy of tumors. The results show that the La2(WO4)3 / CuWO4 composite sonosensitizer has a good sonodynamic therapy effect on U251 glioma cell lines after 1MHz US irradiation for 1min.

The present disclosure relates generally to methods of utilizing sonosensitizers in the presence of thiamine or a derivative thereof for the purpose of cross-linking animal tissue, producing singlet oxygen within or at the site of animal tissue, or treating a condition in a subject, wherein the condition is an aneurysm, cancer, and / or a scleral condition.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention relates to a substance with a Prussian blue structure, which can generate hydroxyl radicals, superoxide anions and singlet oxygen in parallel under ultrasonic irradiation, and in the presence of ultrasonic irradiation and H2O2, the substance with the Prussian blue is used as a sonodynamic therapy (SDT) means to kill focus cells by generating sonotoxic and cytotoxic free radicals, so as to achieve the purpose of improving the therapeutic effect of the substance with the Prussian blue structure. Therefore, diseases are effectively treated.

A porphyrin compound for bioimaging and sonodynamic therapy, as well as its preparation method and application, has a chemical formula shown in Formula 2. The preparation method comprises the following steps: adding p-methylthiobenzaldehyde, a compound of Formula 1, and pyrrole to a reaction flask, evacuating the flask and introducing nitrogen gas, followed by adding anhydrous dichloromethane to obtain a reaction solution; bubbling nitrogen gas through the reaction solution, stirring at 25°C, adding boron trifluoride etherate, maintaining the temperature while continuing to stir, adding DDQ, continuing stirring, adding triethylamine, filtering, concentrating, and purifying to obtain the target product. This method features mild reaction conditions, a short reaction time, and simple operation. The resulting porphyrin compound exhibits excellent sonosensitivity and biocompatibility, can efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effects. The compound also exhibits fluorescence emission in the near-infrared region and can be excited by visible light, enabling confocal imaging to detect changes in cell morphology before and after, resulting in excellent bioimaging results. #imgabs0#

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.

The application belongs to the technical field of biomedical materials, and particularly relates to a supramolecular coordination complex with sonodynamic activity and a preparation method and application thereof. The application proposes a new supramolecular coordination complex formed by self-assembly of a phthalocyanine compound and Ru-dbq, and finds that the supramolecular coordination complex has excellent ROS yield in response to US, and also has the characteristics of multifunctional integration such as CAT enzyme-like activity and antioxidant activity, which endows the material with great application potential in response to complex biological environments and excellent sonodynamic therapy prospects.

The present invention relates to an enhanced sonodynamic therapeutic agent using a liposome having the ability to transfer oxygen, and more particularly, to lipid nanoparticles having the ability to transfer oxygen in which perfluorocarbon (PFC) and indocyanine green (ICG) are loaded inside liposomes to increase the efficiency of sonodynamic therapy.

The invention belongs to the field of biological materials, and particularly relates to an ultrasonic responsive oxygen-carrying and traditional Chinese medicine microcapsule and a preparation method and application thereof in treatment of infected wounds, two glass tubes with different inner diameters are coaxially sleeved and fixed, the glass tube with the larger inner diameter is used as an outer phase channel, and the glass tube with the smaller inner diameter is used as an inner phase channel; the preparation method comprises the following steps: dissolving sodium alginate and curcumin into deionized water to prepare a mixed pre-gel solution; oxygen is introduced into the liquid fluorocarbon, and oxygen-enriched fluorocarbon liquid is obtained after treatment; the prepared mixed pre-gel solution and the oxygen-enriched fluorocarbon liquid are simultaneously introduced into the external phase channel and the internal phase channel respectively, electric field force is applied to outlets of the channels, and the mixed pre-gel solution and the oxygen-enriched fluorocarbon liquid fall into a collection liquid after being subjected to electronic injection to obtain the oxygen-carrying and traditional Chinese medicine microcapsule. The loaded traditional Chinese medicine curcumin and oxygen dissolved in the fluorocarbon achieve simultaneous delivery of traditional Chinese medicine and oxygen, and controllable oxygen release and sonodynamic therapy can be achieved.

The invention provides a sound-sensitive-agent-loaded targeted adipose tissue extracellular vesicle for assisting sonodynamic treatment of obesity as well as a preparation method and application of the sound-sensitive-agent-loaded targeted adipose tissue extracellular vesicle, and particularly belongs to the technical field of obesity drug preparation. The invention provides an application of an extracellular vesicle of a targeted adipose tissue loaded with a sound-sensitive agent in preparation of a medicine for assisting sonodynamic treatment of obesity. The sound sensitive agent is hematoporphyrin monomethyl ether; the extracellular vesicle of the targeted adipose tissue is an extracellular vesicle of which the surface expresses targeted adipose tissue sequence peptide ATS, and the amino acid sequence of the ATS is as shown in SEQ ID NO. 1. The extracellular vesicle loaded with the haematoporphyrin monomethyl ether surface expression targeting adipose tissue sequence peptide ATS can accurately induce adipose tissue browning, finally safe and effective fat reduction is achieved, and the effect of treating obesity is achieved.

The invention discloses a tumor treatment synergistic interaction system and method based on the acoustic cavitation effect of a phase-change nano-droplet. The system comprises the phase-change nano-droplet entrapped with a chemotherapeutic drug and a sound-sensitive agent and a cavitation effect intelligent monitoring and adjusting system. The method is characterized in that cavitation noise signals of a tumor target area are collected in real time through a cavitation monitoring system integrated in an ultrasonic probe, the inertial cavitation dosage is rapidly calculated through a signal processing system and compared with a preset threshold value, then a feedback instruction is generated to dynamically regulate and control ultrasonic irradiation parameters, and intelligent closed-loop control is formed. According to the method, the cavitation effect can be accurately maintained in an ideal treatment window, targeted release and deep penetration of the medicine and activation of the sound-sensitive agent are synchronously achieved through cavitation mechanical energy, and time-space synchronous synergistic interaction of chemotherapy and sonodynamic therapy is achieved.

Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and / or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

The invention relates to a preparation method of a conjugated microporous polymer type sonosensitizer and application of the conjugated microporous polymer type sonosensitizer in sonodynamic therapy (SDT), and belongs to the crossing field of organic optoelectronic materials and biomedicine. A conjugated microporous polymer with triphenylamine (TPA) as a main body and connecting molecules with different lengths is designed. A series of conjugated microporous polymer sonosensitizers with different pores are constructed by taking triphenylamine with a trident structure as a main body and connecting monomers with different lengths, and have a good sonodynamic treatment effect.

The invention relates to the technical field of research and development of tumor photodynamic therapy photosensitizers, photothermal therapy photothermal reagents and sonodynamic therapy sonosensitizers, and provides a preparation method and application of a binuclear metal complex of a polythiophene bridging ligand. The invention relates to a ruthenium complex TBLRu3a-TBLRu6a and a ruthenium complex TBLRu3b-TBLRu6b of a polythiophene bridged tri-bidentate ligand, a ruthenium complex TTLRu1-TTLRu12 of a polythiophene bridged bis-tridentate ligand, and an osmium complex TTLOs1-TTLOs6 of a polythiophene bridged bis-tridentate ligand, which are respectively designed and invented by the invention. The invention further relates to a preparation method of the ruthenium complex TBLRu3a-TBLRu6a and the ruthenium complex TBLRu3b-TBLRu6b of the polythiophene bridged tri-bidentate ligand and a preparation method of the ruthenium complex TTLRu1-TTLRu12 of the polythiophene bridged bis-tridentate ligand. The polythiophene bridged metal complex has extremely high stability and excellent two-photon absorption characteristic, has excellent biotoxicity and photothermal conversion capability under the action of infrared exciting light, and can induce A549R cell apoptosis. The polythiophene bridged metal complex provided by the invention is a potential novel two-photon absorption photodynamic therapy photosensitizer, a photothermal therapy photothermal reagent and a sonodynamic therapy sonosensitizer, and has a wide application prospect in photodynamic therapy, photothermal therapy and sonodynamic therapy of tumors.

The invention discloses efficient tumor sonodynamic therapy nanoparticles based on carbon-doped nano-zinc oxide as well as a preparation method and application of the efficient tumor sonodynamic therapy nanoparticles. Belongs to the field of biomedicine. On the basis of MOF-5, carbon-doped hollow-hole-shaped nano-particles C-ZnO are formed after calcination in a nitrogen atmosphere, then chloroplatinic acid hexahydrate and sodium borohydride are added into a C-ZnO nano-particle solution, so that Pt nano-particles are loaded on the surface of C-ZnO, in addition, AB is loaded in a CZP hollow structure, HA-AA modification is carried out on the surface of the CZP hollow structure, and the CZP hollow structure loaded with the AB is obtained. Therefore, the effects of hydrogen treatment, consumption of excessive glutathione in a biological microenvironment and targeting are achieved, and the effect of treating cancers is achieved from multiple aspects. The nano particles are uniform in size, the average particle size is about 200 nm, good biocompatibility is achieved, and the material prepared through the method has excellent ROS generation capacity, so that the material has excellent sonodynamic therapy potential and has wide application prospects in the field of tumor therapy.

This invention discloses a FA-ICG-NBs nanobubble, its preparation method, and its application in the preparation of tumor-targeted therapeutic agents. The FA-ICG-NBs nanobubble employs a composite phospholipid shell, with folic acid (FA) covalently bonded to the surface and indocyanine green (ICG) loaded onto it, encapsulating a mixture of oxygen and sulfur hexafluoride. The preparation method includes: preparing a lipid solution for forming the composite phospholipid shell; mixing the lipid solution with the oxygen and sulfur hexafluoride mixture, and then performing a reciprocating shearing gas-liquid interface self-assembly to obtain the FA-ICG-NBs nanobubble. The FA-ICG-NBs nanobubble prepared by this invention utilizes dual-wavelength photoacoustic imaging for non-invasive assessment of tumor blood oxygenation and hypoxia improvement, combined with ICG fluorescence timing for screening the optimal therapeutic window, and synergistic oxygen-enhanced sonodynamic therapy. It exhibits good biocompatibility, structural stability, and integrates targeted enrichment, blood oxygenation assessment, hypoxia monitoring, timing regulation, and enhanced therapeutic effects.

This invention provides a multifunctional biomaterial, its preparation method, and its application, relating to the field of biomaterials technology. The multifunctional biomaterial is characterized by comprising: a biocompatible polymer matrix; and a sonosensitive agent complex dispersed in the biocompatible polymer matrix. The sonosensitive agent complex comprises a metal-insulator phase change material and an MXene two-dimensional material, wherein the metal-insulator phase change material and the two-dimensional material form a heterostructure. The metal-insulator phase change material undergoes a phase transition under thermal stimulation to alter the band structure and built-in electric field of the heterostructure. The multifunctional biomaterial according to embodiments of this invention can achieve a significant synergistic improvement in carrier generation efficiency, separation efficiency, and migration efficiency, solving the problem of a fixed upper limit for carrier concentration in traditional static heterostructures, achieving a secondary amplification of ROS generation, and improving the efficiency of sonodynamic therapy.

The present application relates to the technical field of nanobiomedicine, and particularly relates to a porphyrin oxygen-carrying polymer sonosensitizer, a preparation method and application thereof; the porphyrin oxygen-carrying polymer sonosensitizer takes porphyrin as a main body structure and takes polyheptafluorobutyramide as a polymer side chain. The polyheptafluorobutyramide contained in the porphyrin oxygen-carrying polymer sonosensitizer can carry oxygen, and under the activation of ultrasound, the perfluoroalkyl-modified polymer can release oxygen explosively, the perfluoroalkyl-modified polymer triggered by visible light increases oxygen supply to relieve tumor hypoxia, reverses a low-oxygen microenvironment, enhances the generation of reactive oxygen species in the SDT process, further improves the accumulation efficiency at a tumor site, improves the effect of SDT in treating tumors, and becomes an effective method for enhancing the chemical sonodynamic therapy of hypoxic tumors.

This invention provides an activatable semiconductor polymer, its preparation method, and its applications. The activatable semiconductor polymer of this invention can efficiently accumulate at tumor sites. Due to the presence of electron-withdrawing groups on its side chains, the polymer's fluorescence is quenched. Upon response to tumor markers—biothiols, reactive oxygen species, and cathepsin B—the polymer's fluorescence recovers, enabling precise imaging and sonodynamic therapy at the tumor site. Simultaneously, the activatable semiconductor polymer of this invention can label immune cells (such as dendritic cells and macrophages) and track their metastasis from the tumor to the draining lymph nodes.

The invention discloses a preparation method and application of a zinc-gallium layered double oxide (ZGPEG) sound-sensitive agent. The preparation method of the ZGPEG sound-sensitive agent is simple and controllable, the overall reaction condition is not harsh, the difficulty of industrial application is low, and the threshold of industrial production is low. Moreover, the ZGPEG material prepared by the preparation method is a sound-sensitive material with narrow-band-gap semiconductor characteristics, and the ZGPEG material shows excellent antibacterial performance in sonodynamic therapy due to the optimized energy band structure and efficient ROS generation capability of the ZGPEG material; and meanwhile, the stable repeatability and the good penetration adaptability provide potential application value for deep bone tissue infection treatment.

The invention discloses a preparation method and application of IBFO (at) high-entropy alloy heterojunction piezoelectric hydrogel (IBHA-SAPS), and the preparation method comprises the following steps: preparing high-entropy alloy (HEA) powder through sol-gel and calcination, compounding the HEA powder with bismuth-doped bismuth ferrite (IBFO) to construct an IBFO (at) HEA heterojunction (IBHA), and finally carrying out cross-linking molding with a sodium alginate-phenylboronic acid polymer. Under ultrasonic stimulation, the piezoelectric effect of the hydrogel can synergistically enhance the sonodynamic performance and the nano-enzyme activity, and in an acidic microenvironment, efficient antibiosis and biological membrane removal can be achieved through high-intensity ultrasound; in a neutral physiological microenvironment, low-intensity ultrasound can trigger the composite material to remove active oxygen so as to relieve oxidative stress and generate an electric signal to promote osteoblast differentiation, and the composite material has good biocompatibility, injectability and intelligent responsiveness and has wide application prospects in the fields of sonodynamic therapy, tissue engineering scaffolds, infectious bone defect repair and the like.

The invention discloses a degradable microneedle patch co-loaded with a sound sensitive agent and an STING agonist as well as a preparation method and application of the degradable microneedle patch. The invention provides a microneedle raw material composition. The microneedle raw material composition comprises a sound-sensitive agent and an STING agonist, the mass ratio of the sound sensitive agent to the STING agonist is (0.2-1): 1. Furthermore, the invention provides a microneedle patch which comprises a back weighing layer and a needle body array arranged on the back weighing layer, and a microneedle raw material composition is loaded in an aqueous solution of a degradable polymer of the needle body array. According to the invention, co-delivery of the sound-sensitive agent and the STING agonist is utilized, penetration of the drug to the deep part of the tumor tissue can be enhanced through a sonodynamic therapy, more accurate drug release is realized, a stronger immune effect is caused, in-situ tumors are eliminated, growth of far-end tumors is inhibited, and the immunotherapy effect of the drug is synergistically improved.

The application discloses a hydrogel device and method for oral pH detection and sonodynamic therapy. The device comprises a hydrogel packaging layer and a pH sensing coupled sonodynamic therapy module; the hydrogel packaging layer is formed by two layers of network crosslinking, the first layer of network acts as a rigid but fragile skeleton, and the second layer of network is soft and stretchable, so that the hydrogel device has excellent mechanical properties and deformation ability; the pH sensing coupled sonodynamic therapy module is a wrapped structure, the outside is used for pH sensing, and reflects the caries damage condition of the oral cavity; the inside of the pH sensing coupled sonodynamic therapy module is a sonodynamic therapy module, which is used for generating active oxygen under ultrasonic stimulation, realizes the double effect of disinfection and tooth whitening on oral cariogenic bacteria, and the method provides an instant detection and nursing platform for oral health condition, and has the advantages of adhesion type, customizability, in-situ sensing and non-invasive treatment.

The present invention discloses a near-infrared fluoroboron dipyrrole compound for bioimaging and sonodynamic therapy and a preparation method thereof. The chemical structural formula of the compound is shown in Formula 4; the preparation method is: first, para-substituted benzaldehyde, 2,4-dimethylpyrrole and boron trifluoride ether are prepared under acid catalysis by the fluoroboron dipyrrole compound; then the obtained fluoroboron dipyrrole compound and the para-substituted benzaldehyde are dehydrated and condensed under the catalysis of acid and base to obtain a target product. The near-infrared difluoroboron pyrrole compound disclosed in the present invention has mild synthesis conditions, short reaction time, high yield, simple post-processing and a wide range of structural applications. The present invention connects thiomethylbenzaldehyde and aniline derivatives to the fluoroboron dipyrrole skeleton, and the prepared compound has absorption and fluorescence emission in the near-infrared region, and has good bioimaging effect; in addition, it can also efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effect.

The invention discloses a preparation method and application of a titanium-based nano material for enhancing osteosarcoma sonodynamic therapy. The preparation method comprises the following steps: 1, preparing a titanium dioxide nano material; 2, calcining after drying to obtain oxygen vacancy modified titanium dioxide; 3, preparing palladium modified titanium dioxide rich in oxygen vacancies; and 4, dispersing the palladium-modified titanium dioxide rich in oxygen vacancies into a folic acid-polyethylene glycol-sulfydryl solution, violently stirring, and then centrifuging and washing to obtain the titanium-based nano material. Titanium dioxide with sound-sensitive performance is used as a carrier, oxygen vacancies are introduced to modify the surface of the carrier, the sonodynamic performance of the material is remarkably enhanced, the palladium element is further loaded to improve the generation efficiency of active oxygen, folic acid is used for surface modification, so that the biocompatibility and tumor targeting ability of the material are improved, and the preparation method is simple and easy to implement. Functional integration of tumor targeted delivery and sonodynamic treatment is achieved, and the comprehensive treatment effect on osteosarcoma is remarkably enhanced.

This invention discloses a bismuth-copper bimetallic coordination nanomaterial, its preparation method, and its applications, belonging to the technical field of biofunctional materials. The prepared bismuth-copper bimetallic coordination nanomaterial can efficiently generate reactive oxygen species (ROS) under ultrasonic stimulation, initiating the sonodynamic therapy (SDT) process; the Cu in this material... 2+ The weakly acidic environment of the tumor microenvironment can also trigger a Fenton-like reaction, generating cytotoxic hydroxyl radicals (•OH) and oxygen in situ, thus initiating the chemokinetic therapy (CDT) process. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), they jointly inhibit cancer cell proliferation and promote T cell generation.

The invention belongs to the technical field of sonodynamic therapy, and particularly discloses an intravascular ultrasound integrated catheter, a drug delivery method, a sonodynamic therapy system and a use method. The intravascular ultrasound integrated catheter is used for the sonodynamic therapy system and comprises an outer sheath tube, an inner sheath tube and an outer sheath tube, the ultrasonic transduction assembly is arranged in one end of the outer sheath tube; the drug balloon wraps the outer side of one end of the outer sheath tube and is located outside the corresponding ultrasonic transduction assembly; the water injection assembly is used for injecting water into the outer sheath tube and further used for injecting water into an inner cavity of the medicine balloon so that the medicine balloon can be expanded for in-situ administration. According to the intravascular ultrasound integrated catheter, intravascular ultrasound imaging, in-situ drug delivery and drug excitation can be achieved, and the imaging precision, the drug delivery precision, the drug excitation rate, the treatment efficiency and the like are improved.