276 results about "Lymph" patented technology

The invention relates to the field of image analysis, in particular to a colon cancer lymph node metastasis risk prediction method and system based on image analysis. The method comprises the following steps: acquiring a pathological section scanning image, carrying out layer-by-layer downsampling and feature reconstruction, and generating pathological section topological features; carrying out adaptive clustering analysis and multi-parameter fusion evaluation on the basis of the pathological section topological features to obtain independent migration evaluation values of individual tumor cells; performing tumor metastasis branch analysis according to the independent migration evaluation value, and constructing a metastasis branch path distribution diagram; extracting an immunohistochemical staining image of a patient to obtain immune cell space distribution data; and performing multi-region lymphatic metastasis simulation and metastasis risk situation prediction based on the immune cell spatial distribution data and the metastasis branch path distribution diagram to obtain a final metastasis risk assessment result. According to the method, the lymph node metastasis risk is accurately and efficiently analyzed, and the credibility of a pathological analysis result is improved.

A spore of a bacillus subtilis B.subtilis WB600 strain is used as an antigen delivery carrier, spore coat protein C (CotC) is used as anchoring protein, a key protein ATPase gene and a CotC gene of micropterus salmoides iridovirus are fused through a gene fusion technology, a recombinant spore surface display system is constructed, the ATPase antigen is stably displayed on the spore surface, and an oral vaccine is prepared. After being orally applied to fishes, the vaccine can tolerate the gastrointestinal tract environment and is accurately delivered to intestinal related lymphatic tissues to stimulate fish immunity, and finally prevention and control of the iridovirus of the micropterus salmoides are achieved.

A kit for detecting expression of AIRE and Treg in lymphatic tissue infected by EB virus comprises colloidal quantum well antibody conjugates, including a colloidal quantum well and protein AIRE and GITR conjugates and a colloidal quantum well and antibody CD25 and Foxp3 conjugates. The detection method comprises the following steps: (1) carrying out slicing treatment on a lymphatic tissue, and carrying out antigen repair by using an antigen repair liquid; (2) respectively adding colloidal quantum well proteins or antibodies coupled with different targets to dye the sections; (3) carrying out nucleus staining; and (4) collecting multi-channel fluorescence image information of the tissue slice, and judging expression levels and mutual relations of AIRE, Treg cells and dendritic cells in immune tolerance in combination with spatial positioning and intensity distribution of fluorescence signals of different channels. According to the invention, qualitative or quantitative multi-parameter and high-precision detection of the immune tolerance related cells in the lymph tissue is realized.

The invention discloses an intelligent classification and recognition method for ear-nose-throat lesion images, and relates to the technical field of image recognition, and the method comprises the steps: synchronously collecting a nasopharynx white light image and an i-Scan image, screening an image meeting a quality standard, carrying out the correlation of pathology and grading labeling, and constructing a data set containing a multi-center case; the white light image and the i-Scan image are subjected to denoising processing, key mark points are extracted, image registration is completed, a mucous membrane surface area, a submucous membrane blood vessel area and a lymphatic tissue enrichment area are divided through semantic segmentation, and feature enhancement is carried out on different areas; extracting morphological features and textural features from the enhanced image, calculating feature importance weights and fusing the feature importance weights into low-dimensional feature vectors; the benign and malignant dichotomy model and the pathological type multi-classification model are respectively constructed, and classification results are output in combination with a doctor diagnosis rule base and verification indexes, so that the accuracy and clinical practicability of ear-nose-throat lesion diagnosis are remarkably improved.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

This invention discloses a method for constructing a biological model of tertiary lymphoid structures, which can rapidly and efficiently induce the generation of in situ TLS, without relying on specific tissues or organs, and without the need for complex and expensive preparation processes such as cell editing and transgenic mice. It can generate stable, mature, and long-lasting TLS structures within 2 to 3 weeks, and has the characteristics of short cycle, low cost, simple operation, reproducibility, safety and effectiveness.

Presented herein are systems and methods that provide automated analysis of 3D images to classify representations of lesions identified therein. In particular, in certain embodiments, approaches described herein allow hotspots representing lesions to be classified based on their spatial relationship with (e.g., whether they are in proximity to, overlap with, or are located within) one or more pelvic lymph node regions in detailed fashion.

The present invention relates to anti-CD 103 antibodies, as well as use of these antibodies in diagnosis, prognosis, monitoring, and treatment of diseases. Also disclosed is an imaging agent comprising the anti-CD 103 antibody and a detectable label, wherein the antibody either does not block CD 103 binding to E-cadherin or at least partially blocks CD 103 binding to E-cadherin. The methods of treatment involve administering the anti CD 103 antibody which may be optionally coupled to a cytotoxic agent. Diseases to be treated include e.g. Hairy Cell leukemia, HCLv, intestinal and extraintestinal lymphomas, enteropathy-associated T-cell lymphoma (EATL), T-lymphoblastic leukemia / lymphoma (T-ALL), T-cell prolymphocytic leukemia (T-PLL), adult T cell leukemia / lymphoma (ATLL), mycosis fungoides (ME), anaplastic large cell lymphoma ALCL, cutaneous T-cell lymphoma (CTCL), Sezary Syndrome (SS), Alzheimer's disease, Parkinson's disease or multiple sclerosis.

The invention discloses a culture method of in-vitro uniform monolayer cells of prawns, and belongs to the technical field of biology. The method comprises the following steps: (1) obtaining lymphatic tissues of a last-stage prawn at the early stage of shelling, completely stripping an outer membrane to obtain internal tissues, and cutting the internal tissues into small tissue blocks; (2) cleaning the small tissue blocks, inoculating the small tissue blocks to a culture plate coated with a gelatin solution, adding a complete culture solution into an inoculation system at intervals within 12 hours after inoculation for culture, replacing the complete culture solution 24-48 hours after inoculation, and inducing tissue cells to continuously migrate to form an in-vitro cell layer; (3) blowing and beating the cell culture to obtain a cell suspension, and centrifuging to obtain a cell monolayer; and (4) suspending the cell monolayer by adopting a complete culture solution, then inoculating the cell monolayer into a culture plate coated with a gelatin solution, and culturing to obtain the in-vitro uniform monolayer cells of the prawns. According to the method, the prawn monolayer cells which are long in in-vitro survival time, uniform and stable and are cultured in vitro can be obtained, and an important tool is provided for related virology research.

1. The name of the design product: breast lymphatic dredging instrument. 2. The use of the design product: for massaging the breast and dredging the breast lymph. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The application discloses a kind of lymphedema wearable type baking therapy drainage devices, including pressure sleeve, pressure sleeve includes multiple independent control outer layer air bag and multiple independent control inner layer air bag, outer layer air bag and inner layer air bag staggered arrangement and along the axial distribution of limb;Each outer layer air bag and each inner layer air bag independent control, along the direction of far end to near end, in turn, air bag is inflated and deflated control, to complete a cycle air bag progressive drainage pressurization.The pressure sleeve of the application has double-layer air bag, each air bag is independently controlled, and can extrude tissue fluid from far end to near end, so that tissue fluid moves to near end, and pushes and extrudes tissue fluid from limb to trunk direction.Because inner layer air bag and outer layer air bag are staggered arrangement, can avoid effusion to remain in the gap of adjacent annular air bag;The pressure sleeve of the application is provided with inner support tube, and forms circumferential block.

Processing generated sensor data of a lymphedema device may include identifying use of the lymphedema device corresponding to a user. Sensor data associated with the user's identified use of the lymphedema device may be generated. At least some of the generated sensor data may comprise use data associated with a duration of use of the lymphedema device by the user. A protocol associated with use of the lymphedema device may be processed. The generated use data and the protocol associated with use of the lymphedema device may be correlated. Based on correlating the generated use data and the protocol, an alert associated with the generated use data and the protocol may be generated.

The present disclosure provides compositions and methods for the treatment and prevention of macrophage activation syndrome (MAS) or hemophagic lymphocyte hyperplasia (HLH). The methods involve administering to a patient in need thereof an antibody or fragment thereof that is specific for human GM-CSF protein.

Metastasis is a major cause of fatality and expense in cancer. Many metastatic patients express calcified, fibrotic, or deep-seated (lymph / Jung / brain) lesions that are not easily profiled. For such patients, decision-making regarding treatment selection is population-based and heavily reliant on standards of care and are not tailored to the individual's tumor. The present disclosure provides methods of identifying treatment protocols for cancer patients using released tumor cells (RTCs). Method described herein include isolating / enriching RTCs, profiling RTCs and comparing RTCs to reference RTC profile libraries.

This invention relates to a method for calculating and correcting the volume of a limb with lymphedema. The method involves acquiring the outer contour data of the limb with lymphedema under a first and second standard measurement position, and dividing the limb into segments along its length with equal intervals to obtain two sets of corresponding volume segments. The volume of each corresponding segment is calculated, and the volume difference for the same segment number is determined. The volume segment whose absolute value of the volume difference is greater than a preset threshold is identified as the target volume segment. Based on the correspondence of the local volume distribution of the target volume segment in the two sets of volume segments, the volume difference is determined to be either a solid increment or a positional drift increment. Using the volume of each volume segment under the first standard measurement position as a benchmark, the solid increment is retained in the target volume segment, and the positional drift increment is corrected. The volumes of each volume segment after correction are summed to obtain the corrected volume of the limb with lymphedema.

A simulation system for hands-on training for medical diagnostic and treatment techniques is provided. The simulation system is provided with a manikin of a human body having a first side and a second side. The second side has a transparent simulated skin, an internal organ simulated model, and a sensor module configured to collect and transmit data based on an input by a user. In addition, the system has a processor with an implemented computer program configured to receive and interpret the data from the sensor module and provide a feedback to the user based on the interpretation of the data.

1. Name of the designed product: measuring instrument (lymphedema). 2. Use of the designed product: for measuring lymphedema. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The invention relates to the field of treatment instruments, and discloses a pressure-adjustable breast cancer postoperative lymphedema wearable treatment device which comprises a tail end positioning mechanism located on a shoulder circumference sleeve frame, a second damping hydraulic part and an extending hinge frame are matched and used for fixing the forearm area of a patient, and the straight state of the arm is guaranteed; the pressing and limiting mechanism is located on the shoulder circumference sleeve frame and is matched with the big arm opposed frame, the double-helix screw and the limiting sleeve to form a multi-direction pressing structure for the big arm edema part of the patient; the pressing driving mechanism is located on the shoulder circumference sleeve frame and matched with a fixed shaft structure of the limiting sleeve, the oppositely-arranged parallel channels, the embedded ring frame and the inward-extending sliding frame. Through the independent air bag structure of the forearm ring sleeve and the attached arc plate, automatic inflation and deflation are achieved according to the perimeter of the limb, postoperative limb swelling changes are adapted, basic mechanical pressure is provided through radial movement of the inward-extending sliding frame, pressure distribution is finely adjusted through air bag filling, and compression blind areas are eliminated.

The utility model relates to the technical field of acupuncture equipment, and provides an acupuncture needle with sticking and pricking performance, which comprises an acupuncture needle handle, an acupuncture needle body, a fixer, kinesio and isolation paper, the isolation paper is stuck below the kinesio, the kinesio and the kinesio are arranged on the kinesio in a penetrating manner, and the acupuncture needle handle is connected with the fixer. The filiform needle handle and the filiform needle body are integrally formed, the fixator is arranged at the combined part of the filiform needle handle and the filiform needle body, the size of the filiform needle body is 0.25 * 40mm, and the fixator is a soft fixing band piece with a changeable shape. After acupuncture acupoint selection and needle insertion of a fixed filiform needle body are performed, a fixator and isolation paper are removed, kinesio tape is downwards fixed to acupoint skin along the needle body, then the kinesio tape is properly pulled, and local tissue is fixed in an attached and pricked mode, so that the acupoint stimulation effect is achieved, the local tissue is fixed, and the acupoint stimulation effect is achieved. Lymphatic reflux is improved, so that swelling and pain are relieved, and the treatment effect is improved.

The present disclosure addresses the problem of providing a therapeutic agent for a disease in which formation of tertiary lymphoid tissue occurs in a lesion.　This prophylactic or therapeutic agent for a disease in which formation of tertiary lymphoid tissue occurs in a lesion contains an anti-CD153 antibody having cytotoxicity or an antigen-binding fragment of the antibody.

The invention relates to the technical field of medical instruments, and provides a lymphedema therapeutic apparatus with a self-cleaning device and a cleaning method.The lymphedema therapeutic apparatus comprises a therapeutic apparatus body, a cleaning device body is movably arranged in the therapeutic apparatus body, a vibration device is fixedly arranged in the therapeutic apparatus body, and a sweeping device and a spraying device are arranged in the cleaning device body; through the arrangement of the cleaning device and other structures, a double-shaft motor is started, the double-shaft motor drives a first chain wheel, a chain and a second chain wheel to rotate through a rotating shaft, the chain drives a sliding block to move, the sliding block drives a fixing block to move, and when the fixing block moves to one end of the chain, the sliding block slides in the fixing block so as to move to the chain on the lower portion; and then the fixed block is continuously driven to move reversely, so that the cleaning block is driven to move back and forth to clean the bottom of the therapeutic apparatus body, and the effect of automatic cleaning is achieved. By means of the technical scheme, the problems that in the prior art, no self-cleaning device exists, water resources are wasted during cleaning, and cleaning is inconvenient are solved.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The invention belongs to the technical field of medical dressings, and particularly relates to a gel dressing for relieving postoperative lymphedema of breast cancer and a preparation method thereof.The gel dressing is prepared from, by weight, 0.1-0.5 part of active medicine, 8-12 parts of modified matrix, 0.2-0.8 part of dopamine hydrochloride, 2 parts of dispersing agent and 0.5-1.5 parts of enhancer, menthol with functions of promoting infiltration and inducing diuresis to alleviate edema is used for modifying mussel mucoprotein with good biocompatibility, the crosslinking gelling property of the mussel mucoprotein is improved, meanwhile, along with hydrolysis breakage of covalent bonds, gel slowly collapses to release active drugs, and the active drugs and the menthol cooperate with each other, and the postoperative lymphedema of breast cancer is treated from various mechanism ways.

The utility model belongs to the technical field of medical experiment auxiliary equipment, and provides a resuscitation device for small animals after anesthesia, which comprises a control base, a touch screen arranged on one side of the control base, a box body fixedly mounted at the top end of the control base, a support frame fixedly mounted in the box body, and a sponge cushion layer arranged at the top end of the support frame; the multiple sets of massage rollers are arranged in the supporting frame, blood circulation and drug metabolism of the small animals are promoted, hard contact with the bodies of the small animals is avoided through slow rotation of the massage rollers and the buffering effect of the damping springs, blood circulation and lymphatic reflux are accelerated through mild physical stimulation, and the small animals are prevented from being injured. By means of the design, the recovery speed is increased, and side effects caused by medicine residues are reduced.

The present application relates to the field of biotechnology, in particular to biomarkers for predicting the risk of central nervous system paralymphoid dysfunction and application thereof. The biomarkers for predicting the risk of central nervous system paralymphoid dysfunction are astrocyte-derived migratory bodies isolated from peripheral blood. An increase in the number of peripheral blood astrocyte-derived migratory bodies can be used as a marker for predicting the risk of paralymphoid dysfunction. The peripheral blood astrocyte migratory bodies provided by the present application can be used as an index for predicting the risk of central nervous system paralymphoid dysfunction, which can help to prompt central nervous system paralymphoid dysfunction when a patient cannot complete a head magnetic resonance DTI-ALPS sequence scan. The peripheral blood astrocyte migratory bodies can help doctors to formulate appropriate prevention or treatment plans for patients in combination with clinical symptoms, medical history or other examination information in a timely manner, and have extremely important clinical application potential and value.

Provided is a method for diagnosing the prognosis and therapeutic effect for chemotherapy in patients with rheumatoid arthritis-associated lymphoproliferative disorder (RA-LPD), who have developed a lymphoproliferative disorder (LPD) during the treatment of rheumatoid arthritis (RA). This is a kit for diagnosing the prognosis and therapeutic effect for chemotherapy in rheumatic arthritis-associated lymphoproliferative disorder (RA-LPD) patients, who have developed LPD during RA treatment. The kit comprises: means for detecting an inositol 1,4,5-triphosphate receptor (ITPR) type 2 (ITPR2) gene mutation in a biological sample from a patient; and instructions for determining that the prognosis and therapeutic effect for chemotherapy are poor when an ITPR2 gene mutation is present in the biological sample from the patient. The LPD is diffuse large B-cell lymphoma (DLBCL). For the ITPR2 gene mutation, Chr12:rs26744460 is GT or GG. Use for the diagnosis of non-RA lymphoma patients is also possible.

A kit for improving disorders related to adipocyte inflammation, venous lymphatic pathology and for muscle rehabilitation comprises a compression micro-vibration device having a body element (110) with a recess (111) suitable for storing at least one hand piece (150), a screen (112) adapted to provide a communication interface between a user and a computer terminal contained in said body element (110), an electrical connection cable (120) for connecting said hand piece (150) to said body element (110), an electrical stimulation device housed inside said body element (110) and connected via an electrical cable (260) to a common electrode (250) which can be positioned in the vicinity of a body part affected by treatment with said hand piece (150), and a digital thermography camera (300) connected via a common wireless connection system (310) or by an inlet plug (361) to a dedicated outlet (330) made in said body element (110).

Inventors have first investigated the impact of PIK3CA inhibition in NZBWF1 / J mice a model of lymphoproliferative disorders. They randomly assigned 30 females aged of 24 weeks to receive either vehicle (n=15) or alpelisib (n=15) during 4 weeks. At the time of sacrifice, alpelisib treated mice demonstrated significantly reduced spleen size. Flow cytometry analysis revealed that B cells were significantly reduced in alpelisib treated mice and CD8 cells count corrected. They then decided to explore the relevance of alpelisib in MRL / MpJ-Faslpr / J mice (referred here as MRL-lpr), another mouse model of lymphoproliferative disorder. These mice with homozygous Fas mutation usually develop severe lymphadenoproliferation. At the time of sacrifice. MRL-lpr mice treated with alpelisib demonstrated a reduction on their spleen and lymph node sizes. Flow cytometry analysis showed correction of B cells. T cells and other immune cells in peripheral blood mononuclear cells (PBMC), lymph nodes and spleen. The invention relates to a method for treating lymphoproliferative disorder in a subject in need thereof comprising a step of administering the subject with a therapeutically effective amount of a PIK3CA inhibitor.

The application discloses application of a killer cell lectin-like receptor G1 (KLRG1) gene as a marker in preparation of a systemic lupus erythematosus (SLE) secondary hemophagocytic lymphohistiocytosis (HLH) detection preparation, and the preparation is used for detecting the expression level of the KLRG1 gene in a biological sample. Research finds that the expression level of the KLRG1 gene in SLE secondary HLH patients is significantly lower than that of healthy control groups and SLE patients, and has good diagnostic sensitivity and specificity. The application also discloses a preparation for detecting the expression level of the KLRG1 gene in a biological sample of a patient, the preparation contains a primer pair for detecting the mRNA level of the KLRG1 gene expression, or contains an antibody for detecting the protein level of the KLRG1 gene expression, and only needs to extract peripheral blood mononuclear cells (PBMC) after blood drawing to detect whether SLE patients are secondary to HLH, and the preparation is simple, rapid, and accurate in result.