582 results about "Lymph" patented technology

The invention relates to the field of image analysis, in particular to a colon cancer lymph node metastasis risk prediction method and system based on image analysis. The method comprises the following steps: acquiring a pathological section scanning image, carrying out layer-by-layer downsampling and feature reconstruction, and generating pathological section topological features; carrying out adaptive clustering analysis and multi-parameter fusion evaluation on the basis of the pathological section topological features to obtain independent migration evaluation values of individual tumor cells; performing tumor metastasis branch analysis according to the independent migration evaluation value, and constructing a metastasis branch path distribution diagram; extracting an immunohistochemical staining image of a patient to obtain immune cell space distribution data; and performing multi-region lymphatic metastasis simulation and metastasis risk situation prediction based on the immune cell spatial distribution data and the metastasis branch path distribution diagram to obtain a final metastasis risk assessment result. According to the method, the lymph node metastasis risk is accurately and efficiently analyzed, and the credibility of a pathological analysis result is improved.

A spore of a bacillus subtilis B.subtilis WB600 strain is used as an antigen delivery carrier, spore coat protein C (CotC) is used as anchoring protein, a key protein ATPase gene and a CotC gene of micropterus salmoides iridovirus are fused through a gene fusion technology, a recombinant spore surface display system is constructed, the ATPase antigen is stably displayed on the spore surface, and an oral vaccine is prepared. After being orally applied to fishes, the vaccine can tolerate the gastrointestinal tract environment and is accurately delivered to intestinal related lymphatic tissues to stimulate fish immunity, and finally prevention and control of the iridovirus of the micropterus salmoides are achieved.

The invention provides an application of a T lymphatic activation related cytokine as a biomarker in prediction of children immune globulin non-reactive Kawasaki disease. The team finds that in patients of an IVIG sensitive group and an IVIG non-response group, differences of expression levels of IL-6 and IL-17 before and after treatment have statistical significance; meanwhile, ROC curve analysis shows that IL-6 and IL-17 serve as early warning signals, and the prediction efficiency of the IVIG-unreacted Kawasaki disease is remarkably superior to that of existing prediction factors. Particularly, the levels of IL-6 and IL-17 are re-evaluated after initial treatment, so that the early prediction accuracy of the IVIG unresponsive Kawasaki disease can be further improved. By introducing IL-6 and IL-17 as novel biomarkers, early accurate prediction of the IVIG unresponsive Kawasaki disease is realized. Compared with the prior art, the method can provide a quicker and more accurate risk assessment basis for clinicians, so that early recognition of high-risk patients, optimization of subsequent treatment schemes and reduction of serious complications are facilitated, and a new thought and direction are provided for clinical diagnosis and treatment.

The invention relates to a lymphatic system regulation and control method and application. A lymphatic system modulator and / or a physical stimulus is provided to the subject to modulate the lymphatic system. The method provided by the invention is applied to organisms and can effectively improve the circulation function of a lymphatic-like system in a biological brain, so that an effective strategy is provided for treatment of brain function diseases.

The invention relates to the technical field of medical data management and analysis, in particular to a lymphedema treatment monitoring data management method and system. Comprising the following steps: synchronously acquiring bioelectrical impedance, tissue thermodynamic characteristics and subcutaneous tissue morphological data of a patient through multi-modal data acquisition equipment; transmitting the data to a cloud processing platform in a distributed manner, and generating a three-dimensional illness state assessment map containing edema quantitative indexes through a machine learning assessment model; generating a personalized treatment strategy adjustment scheme with a confidence score based on dynamic comparison between the current evaluation map and historical data; feeding back the evaluation map and the adjustment scheme to the medical staff through the interaction terminal, and receiving a clinical correction instruction; according to the method, on the premise of strictly protecting patient data privacy, cross-mechanism multi-modal knowledge sharing can be realized, and the contradiction between a data island and a model effect is solved.

The embodiment of the invention discloses a lymphedema identification method and device applied to breast cancer postoperation. A specific embodiment of the method comprises the following steps: constructing an upper limb three-dimensional model according to an acquired upper limb image sequence; performing upper limb state recognition according to the upper limb image sequence and the upper limb three-dimensional model to generate upper limb state information; according to the upper limb state information, the collected chief complaint information, breast cancer operation treatment information corresponding to the to-be-recognized object and a pre-trained lymphedema recognition model, lymphedema recognition information is generated; and in response to the lymphedema identification information, representing that the to-be-identified object has lymphedema, and according to the lymphedema identification information, generating rehabilitation suggestion information corresponding to the to-be-identified object. By means of the implementation mode, the patient after the breast cancer operation can find out the lymphedema of the patient as soon as possible, and the patient can be prevented and treated as soon as possible when the lymphedema occurs.

A kit for detecting expression of AIRE and Treg in lymphatic tissue infected by EB virus comprises colloidal quantum well antibody conjugates, including a colloidal quantum well and protein AIRE and GITR conjugates and a colloidal quantum well and antibody CD25 and Foxp3 conjugates. The detection method comprises the following steps: (1) carrying out slicing treatment on a lymphatic tissue, and carrying out antigen repair by using an antigen repair liquid; (2) respectively adding colloidal quantum well proteins or antibodies coupled with different targets to dye the sections; (3) carrying out nucleus staining; and (4) collecting multi-channel fluorescence image information of the tissue slice, and judging expression levels and mutual relations of AIRE, Treg cells and dendritic cells in immune tolerance in combination with spatial positioning and intensity distribution of fluorescence signals of different channels. According to the invention, qualitative or quantitative multi-parameter and high-precision detection of the immune tolerance related cells in the lymph tissue is realized.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by\operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

The invention provides a response liposome for treating traumatic brain injury by targeting a blood-brain barrier loaded drug and a preparation method of the response liposome, and belongs to the field of traumatic brain injury treatment.The response liposome is prepared by preparing TfR-T12 target peptide firstly, then preparing nano-particles with hydrophobic molecular drugs wrapped inside, and finally preparing the TfR-T12 target peptide with the hydrophobic molecular drugs wrapped inside. And finally, preparing the response liposome for treating traumatic brain injury by the targeted blood-brain barrier loaded medicine. According to the application, the TfR-T12 target peptide which is highly expressed in cerebral cortex microvessels and can help a nano-drug to pass through a blood brain barrier through endocytosis is prepared as a target spot, meanwhile, the liposome is subjected to polypeptide modification, and the self-assembly driving force of the nano-particles is improved through process control; the outer surface of the response lipidosome is a target peptide, and the response lipidosome is internally coated with a nano-drug; the liposome can repair the blood brain barrier after injury, improve the blood flow of the brain, improve the drainage of the colloidal lymphatic system, improve the motor and cognitive functions of mice after injury, and reduce the dosage of drugs and various possible side effects caused by the drug dosage.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The invention relates to a three-level lymphoid structure model and a preparation method thereof, and belongs to the technical field of cell biology. The method for preparing the three-stage lymphoid structure model comprises the following steps: S1, inducing and activating peripheral blood mononuclear cells by using an extracellular matrix to obtain activated peripheral blood mononuclear cells; s2, the peripheral blood mononuclear cells and the mesenchymal stem cells activated in the step S1 are coated with hydrogel, and hydrogel microspheres are obtained; and S3, culturing T cells and B cells by using the hydrogel microspheres obtained in the step S2 to obtain the three-stage lymphatic structure. The three-level lymphoid structure model obtained by the invention maintains long-term stability in vitro, the form is normal, and the activity of T cells and B cells is strong. The method can be used for dynamically observing the three-level lymphoid structure in the subsequent research immunotherapy and drug screening process, is used for high-throughput experiments, effectively improves the efficiency of drug screening experiments, and is high in accuracy.

The invention discloses an intelligent classification and recognition method for ear-nose-throat lesion images, and relates to the technical field of image recognition, and the method comprises the steps: synchronously collecting a nasopharynx white light image and an i-Scan image, screening an image meeting a quality standard, carrying out the correlation of pathology and grading labeling, and constructing a data set containing a multi-center case; the white light image and the i-Scan image are subjected to denoising processing, key mark points are extracted, image registration is completed, a mucous membrane surface area, a submucous membrane blood vessel area and a lymphatic tissue enrichment area are divided through semantic segmentation, and feature enhancement is carried out on different areas; extracting morphological features and textural features from the enhanced image, calculating feature importance weights and fusing the feature importance weights into low-dimensional feature vectors; the benign and malignant dichotomy model and the pathological type multi-classification model are respectively constructed, and classification results are output in combination with a doctor diagnosis rule base and verification indexes, so that the accuracy and clinical practicability of ear-nose-throat lesion diagnosis are remarkably improved.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

The invention provides a piezoelectric microneedle preparation for non-invasive and non-drug treatment of lymphedema as well as a preparation method and application of the piezoelectric microneedle preparation. The piezoelectric microneedle preparation comprises a substrate with piezoelectric performance and a microneedle array which is distributed on one side of the substrate and has conductive performance. Wherein the substrate is prepared from a piezoelectric material and is subjected to polarization treatment; the microneedle array is prepared from a degradable material or a conductive polymer material, the degradable microneedle array is loaded with or coated with a conductive material, and the conductive polymer material can generate local charges. The micro-needle is high in penetration strength and small in invasion, and the pain of a patient is reduced; meanwhile, complex wire and electrode connection is not needed, so that the infection problem caused by a traditional power supply system is avoided; therefore, the cost is low, and long-term storage is facilitated; and a larger wound is not caused, so that the pain of a patient is relieved.

This invention discloses a method for constructing a biological model of tertiary lymphoid structures, which can rapidly and efficiently induce the generation of in situ TLS, without relying on specific tissues or organs, and without the need for complex and expensive preparation processes such as cell editing and transgenic mice. It can generate stable, mature, and long-lasting TLS structures within 2 to 3 weeks, and has the characteristics of short cycle, low cost, simple operation, reproducibility, safety and effectiveness.

The invention discloses a head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation and control. The device comprises a nerve-lymph-blood vessel multi-mode imaging monitoring module, a multi-dimensional brain information quantitative analysis module, a closed-loop control module, a light / sound brain regulation and control module and a detachable head-mounted module. The method comprises the following steps: firstly, acquiring brain nerve, lymph and blood vessel information in real time by utilizing a multi-modal imaging monitoring module, then sending data to a multi-dimensional brain information quantitative analysis module, decoding and analyzing multi-dimensional data, extracting key features, performing multi-modal data feature fusion, and establishing an analysis method for quantitatively evaluating the brain microenvironment; therefore, the brain function state is accurately represented. The head-mounted device has the advantages that photoacoustic imaging, fluorescence imaging, optical regulation and control and ultrasonic regulation and control are added into the head-mounted device, closed-loop regulation and control parameters are achieved in a combined mode, and the functions of miniature, wearable and multi-parameter detection of the cerebral vessel-nerve-lymph microenvironment and closed-loop photoacoustic regulation and control are achieved.

The present invention provides a system for drug delivery that utilizes a hydrogel to deliver a bioactive agent to stimulate three-level lymphatic structure formation within a mature tumor and enhance immune checkpoint blocking. Provided herein is an injectable hydrogel that can stimulate the formation of immune structures within a tumor, improve cancer prognosis and therapeutic response. The invention provides application of the system to treatment of cancer. Methods of making the drug delivery system are also provided.

The invention belongs to the technical field of organ chips, provides an in-vitro brain lymphatic system chip construction method and a brain lymphatic system chip, and makes up the blank of brain lymphatic system in-vitro model construction. The method comprises the following steps: firstly, carrying out flushing treatment, disinfection and sterilization treatment, rinsing treatment and cell culture on a micro-fluidic channel in the chip; then, in the treated micro-fluidic channel, blood vessel channel cell inoculation and brain parenchyma channel cell inoculation are carried out; and finally, in the blood vessel channel, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, basic formation of in-vitro cerebral vessels is achieved after continuous perfusion, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, and in-vitro cerebral vessels are formed. Intermittent liquid flow simulating arterial fluctuation is achieved.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The invention discloses a ganoderma lucidum peptide for enhancing immunity as well as a preparation method and application thereof, and belongs to the technical field of functional peptide preparation. The ganoderma lucidum peptide provided by the invention contains various active ingredients / nutritional ingredients, is high in utilization rate of ganoderma lucidum, can improve the health level of intestinal tracts, promotes absorption and utilization of nutrient substances by the intestinal tracts, and provides a fundamental material guarantee for improving the immunity of the organism; immune cells are activated, and related lymphatic tissues of intestinal tracts are stimulated, so that the effects of regulating cellular immunity and humoral immunity levels are achieved; the preparation method provided by the invention does not use high-temperature, high-pressure and toxic and harmful reagents, has mild conditions, and is simple, easy to operate and environment-friendly; no toxic and harmful substances are generated, and generated filter residues can be directly used as animal feed or plant fertilizer; the prepared ganoderma lucidum peptide is small in molecule, high in activity, rich in active substance variety, high in yield and easy to absorb and utilize by organisms.

The invention relates to the technical field of intelligent monitoring medical treatment of senile chronic diseases, and discloses a hypertensive brain injury early-stage monitoring and evaluation system and method based on multi-mode MRI data, and the system comprises a data collection module, a data preprocessing module, a virtual elastography analysis module, a microcirculation analysis module, a feature extraction and prediction model module, and a data visualization and report module. The method further comprises the steps of multi-modal MRI data collection, data processing, virtual elastic tensor calculation, lymphatic-like system function analysis, image feature extraction, prediction model construction, quantitative report generation and personalized suggestion providing. According to the method, virtual elastography analysis and microcirculation analysis technologies are combined, multi-dimensional data such as cerebrovascular elasticity modulus, blood flow velocity and lymphatic-like system function indexes are integrated, more comprehensive hypertension cerebrovascular injury assessment is provided, and in addition, the accuracy of hypertension cerebrovascular injury assessment is improved by combining a machine learning algorithm and radiomics characteristics. And a high-precision cerebrovascular injury prediction model is constructed.

The present invention provides therapies for the treatment of CCR9 positive cancers, such as T cell acute lymphoblastic leukemia. In particular, the present invention provides a CCR9 targeting moiety. The invention also relates to a CCR9 targeting moiety comprising another targeting moiety, preferably a CD1a targeting moiety, to a dual CAR comprising CCR9 and CD1a targeting moieties, to the use thereof in the treatment of CCR9 and / or CD1a positive cancers, and to the use of a CCR9 targeting moiety and a CD1a targeting moiety alone for such treatments.

Presented herein are systems and methods that provide automated analysis of 3D images to classify representations of lesions identified therein. In particular, in certain embodiments, approaches described herein allow hotspots representing lesions to be classified based on their spatial relationship with (e.g., whether they are in proximity to, overlap with, or are located within) one or more pelvic lymph node regions in detailed fashion.

The invention discloses a breast cancer postoperative upper limb function rehabilitation assisting method and system, and the method achieves the precise rehabilitation through multi-dimensional data collection and intelligent scheme generation: collecting the joint movement range, muscle strength index, lymphedema data, VAS pain score and Borg fatigue index of the upper limb of a patient, and carrying out the fusion to generate an upper limb function feature set; dividing the rehabilitation process into four stages, and generating a rehabilitation target corresponding to each stage by means of a preset mapping mechanism based on the feature set; generating a candidate rehabilitation scheme by applying a rehabilitation scheme generation model based on machine learning according to the staged rehabilitation target; through a prediction model based on multi-dimensional evaluation, rehabilitation prediction scores are generated in combination with the upper limb function feature set and the candidate rehabilitation schemes, and the candidate scheme with the highest score is selected as the optimal rehabilitation scheme. Personalized and dynamic management of upper limb rehabilitation after the breast cancer operation is achieved, and adaptability and effectiveness of a rehabilitation scheme are improved.

The invention discloses a noninvasive brain lymphatic network assessment method and system based on magnetic resonance imaging, and relates to the field of medical image processing, and the system comprises a data acquisition module which obtains a 3D-T1WI image, a 3D-T2WI image, a DWI image and a DTI image; the data preprocessing module preprocesses the image; the multi-dimensional function analysis module is used for determining multi-dimensional parameters of a gap around a blood vessel according to the preprocessed 3D-T1WI image and the preprocessed 3D-T2WI image; performing perfusion and dispersion component separation on the preprocessed DWI image to obtain incoherent motion imaging parameters in voxels, and calculating a free water fraction; calculating a diffusion tensor imaging index along the peripheral gap of the blood vessel based on the preprocessed DTI image; and the evaluation analysis module performs evaluation according to an output result of the multi-dimensional function analysis module, and can non-invasively, comprehensively and systematically evaluate the function state of the brain lymphatic system.

Provided herein are compositions of NK-92® cells that express a CD19 CAR, CD16 and IL2, and the method of using these cells to and treat cancer in a patient.

The present invention relates to anti-CD 103 antibodies, as well as use of these antibodies in diagnosis, prognosis, monitoring, and treatment of diseases. Also disclosed is an imaging agent comprising the anti-CD 103 antibody and a detectable label, wherein the antibody either does not block CD 103 binding to E-cadherin or at least partially blocks CD 103 binding to E-cadherin. The methods of treatment involve administering the anti CD 103 antibody which may be optionally coupled to a cytotoxic agent. Diseases to be treated include e.g. Hairy Cell leukemia, HCLv, intestinal and extraintestinal lymphomas, enteropathy-associated T-cell lymphoma (EATL), T-lymphoblastic leukemia / lymphoma (T-ALL), T-cell prolymphocytic leukemia (T-PLL), adult T cell leukemia / lymphoma (ATLL), mycosis fungoides (ME), anaplastic large cell lymphoma ALCL, cutaneous T-cell lymphoma (CTCL), Sezary Syndrome (SS), Alzheimer's disease, Parkinson's disease or multiple sclerosis.

The disclosure is directed to synthetic lymphoid organoids, methods of making a synthetic lymphoid organoid, and their uses.

Two plasmids are transformed in the bacterium, one plasmid is a gene editing plasmid which is used for expressing CRISPR / Cas9 gene editing tools in the bacterium, the sgRNA sequence is shown in SEQ ID NO.1, and the other plasmid is an X174E-CKS9 expression plasmid which is used for expressing targeting peptide shown in SEQ ID NO.2 and IPTG (isopropyl-beta-d-thiogalactoside) induced expression splitting gene X174E in the bacterium. The invention further discloses a cracking vesicle obtained after induction of the engineering bacterium and application of the cracking vesicle. CKS9-loaded lysing vesicles with M cell targeting are generated in situ, and a gene editing tool is transferred to antigen presenting cells by using the characteristic that the M cells can completely transfer antigens to lymphatic follicles. Compared with a strategy of mannose modification and other targeted antigen-presenting cells, the method has the advantages that the targeting property is more accurate, and a new choice is provided for the antigen-presenting cells of targeted intestinal tracts.