464 results about "Lymph" patented technology

The invention relates to the field of image analysis, in particular to a colon cancer lymph node metastasis risk prediction method and system based on image analysis. The method comprises the following steps: acquiring a pathological section scanning image, carrying out layer-by-layer downsampling and feature reconstruction, and generating pathological section topological features; carrying out adaptive clustering analysis and multi-parameter fusion evaluation on the basis of the pathological section topological features to obtain independent migration evaluation values of individual tumor cells; performing tumor metastasis branch analysis according to the independent migration evaluation value, and constructing a metastasis branch path distribution diagram; extracting an immunohistochemical staining image of a patient to obtain immune cell space distribution data; and performing multi-region lymphatic metastasis simulation and metastasis risk situation prediction based on the immune cell spatial distribution data and the metastasis branch path distribution diagram to obtain a final metastasis risk assessment result. According to the method, the lymph node metastasis risk is accurately and efficiently analyzed, and the credibility of a pathological analysis result is improved.

A spore of a bacillus subtilis B.subtilis WB600 strain is used as an antigen delivery carrier, spore coat protein C (CotC) is used as anchoring protein, a key protein ATPase gene and a CotC gene of micropterus salmoides iridovirus are fused through a gene fusion technology, a recombinant spore surface display system is constructed, the ATPase antigen is stably displayed on the spore surface, and an oral vaccine is prepared. After being orally applied to fishes, the vaccine can tolerate the gastrointestinal tract environment and is accurately delivered to intestinal related lymphatic tissues to stimulate fish immunity, and finally prevention and control of the iridovirus of the micropterus salmoides are achieved.

The invention relates to the technical field of medical data management and analysis, in particular to a lymphedema treatment monitoring data management method and system. Comprising the following steps: synchronously acquiring bioelectrical impedance, tissue thermodynamic characteristics and subcutaneous tissue morphological data of a patient through multi-modal data acquisition equipment; transmitting the data to a cloud processing platform in a distributed manner, and generating a three-dimensional illness state assessment map containing edema quantitative indexes through a machine learning assessment model; generating a personalized treatment strategy adjustment scheme with a confidence score based on dynamic comparison between the current evaluation map and historical data; feeding back the evaluation map and the adjustment scheme to the medical staff through the interaction terminal, and receiving a clinical correction instruction; according to the method, on the premise of strictly protecting patient data privacy, cross-mechanism multi-modal knowledge sharing can be realized, and the contradiction between a data island and a model effect is solved.

A kit for detecting expression of AIRE and Treg in lymphatic tissue infected by EB virus comprises colloidal quantum well antibody conjugates, including a colloidal quantum well and protein AIRE and GITR conjugates and a colloidal quantum well and antibody CD25 and Foxp3 conjugates. The detection method comprises the following steps: (1) carrying out slicing treatment on a lymphatic tissue, and carrying out antigen repair by using an antigen repair liquid; (2) respectively adding colloidal quantum well proteins or antibodies coupled with different targets to dye the sections; (3) carrying out nucleus staining; and (4) collecting multi-channel fluorescence image information of the tissue slice, and judging expression levels and mutual relations of AIRE, Treg cells and dendritic cells in immune tolerance in combination with spatial positioning and intensity distribution of fluorescence signals of different channels. According to the invention, qualitative or quantitative multi-parameter and high-precision detection of the immune tolerance related cells in the lymph tissue is realized.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The invention discloses an intelligent classification and recognition method for ear-nose-throat lesion images, and relates to the technical field of image recognition, and the method comprises the steps: synchronously collecting a nasopharynx white light image and an i-Scan image, screening an image meeting a quality standard, carrying out the correlation of pathology and grading labeling, and constructing a data set containing a multi-center case; the white light image and the i-Scan image are subjected to denoising processing, key mark points are extracted, image registration is completed, a mucous membrane surface area, a submucous membrane blood vessel area and a lymphatic tissue enrichment area are divided through semantic segmentation, and feature enhancement is carried out on different areas; extracting morphological features and textural features from the enhanced image, calculating feature importance weights and fusing the feature importance weights into low-dimensional feature vectors; the benign and malignant dichotomy model and the pathological type multi-classification model are respectively constructed, and classification results are output in combination with a doctor diagnosis rule base and verification indexes, so that the accuracy and clinical practicability of ear-nose-throat lesion diagnosis are remarkably improved.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

This invention discloses a method for constructing a biological model of tertiary lymphoid structures, which can rapidly and efficiently induce the generation of in situ TLS, without relying on specific tissues or organs, and without the need for complex and expensive preparation processes such as cell editing and transgenic mice. It can generate stable, mature, and long-lasting TLS structures within 2 to 3 weeks, and has the characteristics of short cycle, low cost, simple operation, reproducibility, safety and effectiveness.

The invention discloses a head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation and control. The device comprises a nerve-lymph-blood vessel multi-mode imaging monitoring module, a multi-dimensional brain information quantitative analysis module, a closed-loop control module, a light / sound brain regulation and control module and a detachable head-mounted module. The method comprises the following steps: firstly, acquiring brain nerve, lymph and blood vessel information in real time by utilizing a multi-modal imaging monitoring module, then sending data to a multi-dimensional brain information quantitative analysis module, decoding and analyzing multi-dimensional data, extracting key features, performing multi-modal data feature fusion, and establishing an analysis method for quantitatively evaluating the brain microenvironment; therefore, the brain function state is accurately represented. The head-mounted device has the advantages that photoacoustic imaging, fluorescence imaging, optical regulation and control and ultrasonic regulation and control are added into the head-mounted device, closed-loop regulation and control parameters are achieved in a combined mode, and the functions of miniature, wearable and multi-parameter detection of the cerebral vessel-nerve-lymph microenvironment and closed-loop photoacoustic regulation and control are achieved.

The invention belongs to the technical field of organ chips, provides an in-vitro brain lymphatic system chip construction method and a brain lymphatic system chip, and makes up the blank of brain lymphatic system in-vitro model construction. The method comprises the following steps: firstly, carrying out flushing treatment, disinfection and sterilization treatment, rinsing treatment and cell culture on a micro-fluidic channel in the chip; then, in the treated micro-fluidic channel, blood vessel channel cell inoculation and brain parenchyma channel cell inoculation are carried out; and finally, in the blood vessel channel, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, basic formation of in-vitro cerebral vessels is achieved after continuous perfusion, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, and in-vitro cerebral vessels are formed. Intermittent liquid flow simulating arterial fluctuation is achieved.

The invention discloses a ganoderma lucidum peptide for enhancing immunity as well as a preparation method and application thereof, and belongs to the technical field of functional peptide preparation. The ganoderma lucidum peptide provided by the invention contains various active ingredients / nutritional ingredients, is high in utilization rate of ganoderma lucidum, can improve the health level of intestinal tracts, promotes absorption and utilization of nutrient substances by the intestinal tracts, and provides a fundamental material guarantee for improving the immunity of the organism; immune cells are activated, and related lymphatic tissues of intestinal tracts are stimulated, so that the effects of regulating cellular immunity and humoral immunity levels are achieved; the preparation method provided by the invention does not use high-temperature, high-pressure and toxic and harmful reagents, has mild conditions, and is simple, easy to operate and environment-friendly; no toxic and harmful substances are generated, and generated filter residues can be directly used as animal feed or plant fertilizer; the prepared ganoderma lucidum peptide is small in molecule, high in activity, rich in active substance variety, high in yield and easy to absorb and utilize by organisms.

The invention relates to the technical field of intelligent monitoring medical treatment of senile chronic diseases, and discloses a hypertensive brain injury early-stage monitoring and evaluation system and method based on multi-mode MRI data, and the system comprises a data collection module, a data preprocessing module, a virtual elastography analysis module, a microcirculation analysis module, a feature extraction and prediction model module, and a data visualization and report module. The method further comprises the steps of multi-modal MRI data collection, data processing, virtual elastic tensor calculation, lymphatic-like system function analysis, image feature extraction, prediction model construction, quantitative report generation and personalized suggestion providing. According to the method, virtual elastography analysis and microcirculation analysis technologies are combined, multi-dimensional data such as cerebrovascular elasticity modulus, blood flow velocity and lymphatic-like system function indexes are integrated, more comprehensive hypertension cerebrovascular injury assessment is provided, and in addition, the accuracy of hypertension cerebrovascular injury assessment is improved by combining a machine learning algorithm and radiomics characteristics. And a high-precision cerebrovascular injury prediction model is constructed.

The present invention provides therapies for the treatment of CCR9 positive cancers, such as T cell acute lymphoblastic leukemia. In particular, the present invention provides a CCR9 targeting moiety. The invention also relates to a CCR9 targeting moiety comprising another targeting moiety, preferably a CD1a targeting moiety, to a dual CAR comprising CCR9 and CD1a targeting moieties, to the use thereof in the treatment of CCR9 and / or CD1a positive cancers, and to the use of a CCR9 targeting moiety and a CD1a targeting moiety alone for such treatments.

Presented herein are systems and methods that provide automated analysis of 3D images to classify representations of lesions identified therein. In particular, in certain embodiments, approaches described herein allow hotspots representing lesions to be classified based on their spatial relationship with (e.g., whether they are in proximity to, overlap with, or are located within) one or more pelvic lymph node regions in detailed fashion.

The invention discloses a breast cancer postoperative upper limb function rehabilitation assisting method and system, and the method achieves the precise rehabilitation through multi-dimensional data collection and intelligent scheme generation: collecting the joint movement range, muscle strength index, lymphedema data, VAS pain score and Borg fatigue index of the upper limb of a patient, and carrying out the fusion to generate an upper limb function feature set; dividing the rehabilitation process into four stages, and generating a rehabilitation target corresponding to each stage by means of a preset mapping mechanism based on the feature set; generating a candidate rehabilitation scheme by applying a rehabilitation scheme generation model based on machine learning according to the staged rehabilitation target; through a prediction model based on multi-dimensional evaluation, rehabilitation prediction scores are generated in combination with the upper limb function feature set and the candidate rehabilitation schemes, and the candidate scheme with the highest score is selected as the optimal rehabilitation scheme. Personalized and dynamic management of upper limb rehabilitation after the breast cancer operation is achieved, and adaptability and effectiveness of a rehabilitation scheme are improved.

The invention discloses a noninvasive brain lymphatic network assessment method and system based on magnetic resonance imaging, and relates to the field of medical image processing, and the system comprises a data acquisition module which obtains a 3D-T1WI image, a 3D-T2WI image, a DWI image and a DTI image; the data preprocessing module preprocesses the image; the multi-dimensional function analysis module is used for determining multi-dimensional parameters of a gap around a blood vessel according to the preprocessed 3D-T1WI image and the preprocessed 3D-T2WI image; performing perfusion and dispersion component separation on the preprocessed DWI image to obtain incoherent motion imaging parameters in voxels, and calculating a free water fraction; calculating a diffusion tensor imaging index along the peripheral gap of the blood vessel based on the preprocessed DTI image; and the evaluation analysis module performs evaluation according to an output result of the multi-dimensional function analysis module, and can non-invasively, comprehensively and systematically evaluate the function state of the brain lymphatic system.

Provided herein are compositions of NK-92® cells that express a CD19 CAR, CD16 and IL2, and the method of using these cells to and treat cancer in a patient.

The present invention relates to anti-CD 103 antibodies, as well as use of these antibodies in diagnosis, prognosis, monitoring, and treatment of diseases. Also disclosed is an imaging agent comprising the anti-CD 103 antibody and a detectable label, wherein the antibody either does not block CD 103 binding to E-cadherin or at least partially blocks CD 103 binding to E-cadherin. The methods of treatment involve administering the anti CD 103 antibody which may be optionally coupled to a cytotoxic agent. Diseases to be treated include e.g. Hairy Cell leukemia, HCLv, intestinal and extraintestinal lymphomas, enteropathy-associated T-cell lymphoma (EATL), T-lymphoblastic leukemia / lymphoma (T-ALL), T-cell prolymphocytic leukemia (T-PLL), adult T cell leukemia / lymphoma (ATLL), mycosis fungoides (ME), anaplastic large cell lymphoma ALCL, cutaneous T-cell lymphoma (CTCL), Sezary Syndrome (SS), Alzheimer's disease, Parkinson's disease or multiple sclerosis.

The disclosure is directed to synthetic lymphoid organoids, methods of making a synthetic lymphoid organoid, and their uses.

Two plasmids are transformed in the bacterium, one plasmid is a gene editing plasmid which is used for expressing CRISPR / Cas9 gene editing tools in the bacterium, the sgRNA sequence is shown in SEQ ID NO.1, and the other plasmid is an X174E-CKS9 expression plasmid which is used for expressing targeting peptide shown in SEQ ID NO.2 and IPTG (isopropyl-beta-d-thiogalactoside) induced expression splitting gene X174E in the bacterium. The invention further discloses a cracking vesicle obtained after induction of the engineering bacterium and application of the cracking vesicle. CKS9-loaded lysing vesicles with M cell targeting are generated in situ, and a gene editing tool is transferred to antigen presenting cells by using the characteristic that the M cells can completely transfer antigens to lymphatic follicles. Compared with a strategy of mannose modification and other targeted antigen-presenting cells, the method has the advantages that the targeting property is more accurate, and a new choice is provided for the antigen-presenting cells of targeted intestinal tracts.

The invention discloses a culture method of in-vitro uniform monolayer cells of prawns, and belongs to the technical field of biology. The method comprises the following steps: (1) obtaining lymphatic tissues of a last-stage prawn at the early stage of shelling, completely stripping an outer membrane to obtain internal tissues, and cutting the internal tissues into small tissue blocks; (2) cleaning the small tissue blocks, inoculating the small tissue blocks to a culture plate coated with a gelatin solution, adding a complete culture solution into an inoculation system at intervals within 12 hours after inoculation for culture, replacing the complete culture solution 24-48 hours after inoculation, and inducing tissue cells to continuously migrate to form an in-vitro cell layer; (3) blowing and beating the cell culture to obtain a cell suspension, and centrifuging to obtain a cell monolayer; and (4) suspending the cell monolayer by adopting a complete culture solution, then inoculating the cell monolayer into a culture plate coated with a gelatin solution, and culturing to obtain the in-vitro uniform monolayer cells of the prawns. According to the method, the prawn monolayer cells which are long in in-vitro survival time, uniform and stable and are cultured in vitro can be obtained, and an important tool is provided for related virology research.

1. The name of the design product: breast lymphatic dredging instrument. 2. The use of the design product: for massaging the breast and dredging the breast lymph. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses a universal lymphedema measuring scale for upper and lower limbs, relates to the technical field of medical measuring instruments, and provides the following scheme: the universal lymphedema measuring scale comprises a pedal plate for a detector to step on and fix; the leg detection mechanism is arranged at the top of the pedal plate and used for detecting lymphedema of the lower limbs of a detector, and the leg detection mechanism comprises a height measuring rod; the balance plate is fixed at the top of the height measuring rod; and the arm detection mechanism is arranged on the balance plate and is used for performing upper limb lymphedema detection on the detected person. The device can accurately measure the lymphedema degree of the upper and lower limbs, has the advantages of simplicity and convenience in operation, reliable measurement result, high practicability and the like, can be widely applied to the medical field, and solves the problems of non-uniform measurement, high randomness, nonstandard operation and the like in an existing measurement mode; and a reliable measuring tool is provided for diagnosis and treatment effect evaluation of lymphedema.

The application discloses a kind of lymphedema wearable type baking therapy drainage devices, including pressure sleeve, pressure sleeve includes multiple independent control outer layer air bag and multiple independent control inner layer air bag, outer layer air bag and inner layer air bag staggered arrangement and along the axial distribution of limb;Each outer layer air bag and each inner layer air bag independent control, along the direction of far end to near end, in turn, air bag is inflated and deflated control, to complete a cycle air bag progressive drainage pressurization.The pressure sleeve of the application has double-layer air bag, each air bag is independently controlled, and can extrude tissue fluid from far end to near end, so that tissue fluid moves to near end, and pushes and extrudes tissue fluid from limb to trunk direction.Because inner layer air bag and outer layer air bag are staggered arrangement, can avoid effusion to remain in the gap of adjacent annular air bag;The pressure sleeve of the application is provided with inner support tube, and forms circumferential block.

The present disclosure is concerned with compounds and compositions for use in the prevention and treatment of cancer such as, for example, a primary or secondary tumor within a subject's brain, breast, kidney, pancreas, lung, colon, prostate, lymphatic system, liver, ovary, or cervix. Additional examples of cancers for which the disclosed compounds and compositions can be useful include, but are not limited to, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanomas, gliomas, leukemia, lymphoma, chronic myeloproliferative disorders, myelodysplastic syndrome, myeloproliferative neoplasm, non-small cell lung carcinomas, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Processing generated sensor data of a lymphedema device may include identifying use of the lymphedema device corresponding to a user. Sensor data associated with the user's identified use of the lymphedema device may be generated. At least some of the generated sensor data may comprise use data associated with a duration of use of the lymphedema device by the user. A protocol associated with use of the lymphedema device may be processed. The generated use data and the protocol associated with use of the lymphedema device may be correlated. Based on correlating the generated use data and the protocol, an alert associated with the generated use data and the protocol may be generated.

The present disclosure provides compositions and methods for the treatment and prevention of macrophage activation syndrome (MAS) or hemophagic lymphocyte hyperplasia (HLH). The methods involve administering to a patient in need thereof an antibody or fragment thereof that is specific for human GM-CSF protein.

Metastasis is a major cause of fatality and expense in cancer. Many metastatic patients express calcified, fibrotic, or deep-seated (lymph / Jung / brain) lesions that are not easily profiled. For such patients, decision-making regarding treatment selection is population-based and heavily reliant on standards of care and are not tailored to the individual's tumor. The present disclosure provides methods of identifying treatment protocols for cancer patients using released tumor cells (RTCs). Method described herein include isolating / enriching RTCs, profiling RTCs and comparing RTCs to reference RTC profile libraries.

This invention relates to a method for calculating and correcting the volume of a limb with lymphedema. The method involves acquiring the outer contour data of the limb with lymphedema under a first and second standard measurement position, and dividing the limb into segments along its length with equal intervals to obtain two sets of corresponding volume segments. The volume of each corresponding segment is calculated, and the volume difference for the same segment number is determined. The volume segment whose absolute value of the volume difference is greater than a preset threshold is identified as the target volume segment. Based on the correspondence of the local volume distribution of the target volume segment in the two sets of volume segments, the volume difference is determined to be either a solid increment or a positional drift increment. Using the volume of each volume segment under the first standard measurement position as a benchmark, the solid increment is retained in the target volume segment, and the positional drift increment is corrected. The volumes of each volume segment after correction are summed to obtain the corrected volume of the limb with lymphedema.