102 results about "Lymphatic/immune" patented technology

The invention relates to a lymphatic system regulation and control method and application. A lymphatic system modulator and / or a physical stimulus is provided to the subject to modulate the lymphatic system. The method provided by the invention is applied to organisms and can effectively improve the circulation function of a lymphatic-like system in a biological brain, so that an effective strategy is provided for treatment of brain function diseases.

The invention provides a response liposome for treating traumatic brain injury by targeting a blood-brain barrier loaded drug and a preparation method of the response liposome, and belongs to the field of traumatic brain injury treatment.The response liposome is prepared by preparing TfR-T12 target peptide firstly, then preparing nano-particles with hydrophobic molecular drugs wrapped inside, and finally preparing the TfR-T12 target peptide with the hydrophobic molecular drugs wrapped inside. And finally, preparing the response liposome for treating traumatic brain injury by the targeted blood-brain barrier loaded medicine. According to the application, the TfR-T12 target peptide which is highly expressed in cerebral cortex microvessels and can help a nano-drug to pass through a blood brain barrier through endocytosis is prepared as a target spot, meanwhile, the liposome is subjected to polypeptide modification, and the self-assembly driving force of the nano-particles is improved through process control; the outer surface of the response lipidosome is a target peptide, and the response lipidosome is internally coated with a nano-drug; the liposome can repair the blood brain barrier after injury, improve the blood flow of the brain, improve the drainage of the colloidal lymphatic system, improve the motor and cognitive functions of mice after injury, and reduce the dosage of drugs and various possible side effects caused by the drug dosage.

The invention discloses a brain feature extraction method, a brain feature extraction system, brain feature extraction equipment and a medium for an MRI (Magnetic Resonance Imaging) image, and relates to the technical field of intelligent biomedical signal processing. Deep features of a plurality of MRI sequence images are fully excavated, and the extracted imaging features related to brain lymphatic system functions and brain structure morphologies include diffusion degree values when bilateral brain tissues in the brain of a patient are converted into fiber bundles and fiber bundle reference values causing fiber bundle deviation when the brain of the patient discharges. The reference value of the fiber bundle can reflect which parameters are diffusion parameters when bilateral brain tissues are abnormal, and the diffusion degree value and the diffusion parameters reflected by the imaging characteristics are closely related to the epilepsy language barrier function of the patient and can be used as standards for predicting the language barrier of the epilepsy patient.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The invention relates to a gynecological pelvic and abdominal lymphatic cleaning prediction model training method and a lymph node model.The training method comprises the steps that preoperative image data and intraoperative instrument operation parameters of historical patients are subjected to modeling processing, and a dynamic mechanics-fluid coupling lymph node model based on bionic materials is constructed; mechanical deformation and fluid flow of a lymphatic system in various clinical scenes are simulated; performing data acquisition processing on the used lymph node model, and quantifying the dynamic influence of the surgical operation on the lymphatic system; the relevance between historical operation and injury risk is deeply learned, and the lymphatic vessel rupture probability is output; real-time feedback control processing is carried out based on the lymphatic vessel rupture probability, a training correction instruction and a risk thermodynamic diagram are generated, and medical workers are guided to optimize surgical skills. Through fusion analysis of the high-fidelity bionic model and multi-modal data, dynamic simulation of the mechanical-fluid coupling effect in the operation and real-time quantification of the operation risk are achieved, and the accuracy and clinical transformation value of operation training are improved.

Lymphedema is characterized by the accumulation of protein-rich interstitial fluid, lipids and a significant inflammatory cell infiltrate in the limb. It causes a significant morbidity and is a common disabling disease affecting more than 250 million people worldwide, however there is no curative treatment for lymphedema. Here, the inventors found that dermolipectomies from patient with lymphedema exhibit inflamed gene expression profile compared to normal arm on same patient. After lipidomic analysis, the inventors identified severe decrease in arachidonic acid-derived lipid mediators generated by the 15-lipoxygenase (15-LOX) in lymphedematous arms. Using a mouse model of lymphedema, they reproduced the etiology of the human pathology including the loss of specialized pro-resolving lipid mediators that play essential roles in resolution of inflammation. This was associated with a lack of regulatory T cells (Treg) recruitment in the injured limb adipose tissue. Importantly, the inventors identified the lymphatic endothelial 15-LOX was responsible for the chemoattraction and transendothelial migration of Tregs. These results were confirmed by an aggravation of lymphedema and deterioration of the lymphatic network in an original transgenic mouse model in which ALOX15 gene is selectively deleted in the lymphatic system. Importantly, this was reversed by the injection of 15-LOX expressing lentivectors. These results provide evidence that lymphatic lipoxygenase may represent a novel therapeutic target for lymphedema by serving as a mediator of Treg invasion into lymphedematous adipose tissue.

The invention belongs to the technical field of organ chips, provides an in-vitro brain lymphatic system chip construction method and a brain lymphatic system chip, and makes up the blank of brain lymphatic system in-vitro model construction. The method comprises the following steps: firstly, carrying out flushing treatment, disinfection and sterilization treatment, rinsing treatment and cell culture on a micro-fluidic channel in the chip; then, in the treated micro-fluidic channel, blood vessel channel cell inoculation and brain parenchyma channel cell inoculation are carried out; and finally, in the blood vessel channel, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, basic formation of in-vitro cerebral vessels is achieved after continuous perfusion, perfusion is carried out once at a preset flow speed every preset duration, shear force stimulation simulating pulse type blood flow is provided, and in-vitro cerebral vessels are formed. Intermittent liquid flow simulating arterial fluctuation is achieved.

The invention relates to the technical field of intelligent monitoring medical treatment of senile chronic diseases, and discloses a hypertensive brain injury early-stage monitoring and evaluation system and method based on multi-mode MRI data, and the system comprises a data collection module, a data preprocessing module, a virtual elastography analysis module, a microcirculation analysis module, a feature extraction and prediction model module, and a data visualization and report module. The method further comprises the steps of multi-modal MRI data collection, data processing, virtual elastic tensor calculation, lymphatic-like system function analysis, image feature extraction, prediction model construction, quantitative report generation and personalized suggestion providing. According to the method, virtual elastography analysis and microcirculation analysis technologies are combined, multi-dimensional data such as cerebrovascular elasticity modulus, blood flow velocity and lymphatic-like system function indexes are integrated, more comprehensive hypertension cerebrovascular injury assessment is provided, and in addition, the accuracy of hypertension cerebrovascular injury assessment is improved by combining a machine learning algorithm and radiomics characteristics. And a high-precision cerebrovascular injury prediction model is constructed.

Provided herein are composition, systems, kits, and methods for preventing and / or treating, reversing, and / or inhibiting progression of, a neurodegenerative and / or neurological conditions and / or eye conditions (e.g., retinitis pigmentosa) by administering a plurality of nanoparticles to a subject via subcutaneous, intramuscular, or intraperitoneal injection such that the plurality of nanoparticles are taken up by lymphatic capillaries and are transported to neurological and / or eye tissue of the subject via the subject's lymphatic system, wherein the plurality of nanoparticles encapsulate, or are attached or absorbed to, at least one drug agent.

The invention discloses a noninvasive brain lymphatic network assessment method and system based on magnetic resonance imaging, and relates to the field of medical image processing, and the system comprises a data acquisition module which obtains a 3D-T1WI image, a 3D-T2WI image, a DWI image and a DTI image; the data preprocessing module preprocesses the image; the multi-dimensional function analysis module is used for determining multi-dimensional parameters of a gap around a blood vessel according to the preprocessed 3D-T1WI image and the preprocessed 3D-T2WI image; performing perfusion and dispersion component separation on the preprocessed DWI image to obtain incoherent motion imaging parameters in voxels, and calculating a free water fraction; calculating a diffusion tensor imaging index along the peripheral gap of the blood vessel based on the preprocessed DTI image; and the evaluation analysis module performs evaluation according to an output result of the multi-dimensional function analysis module, and can non-invasively, comprehensively and systematically evaluate the function state of the brain lymphatic system.

A method for improving cerebrospinal fluid clearance through a glymphatic system, while a patient is sleeping, resting, or a combination thereof, the method comprising measuring ultrasound data with one or more ultrasound emitters and extracting B-wave oscillations from the ultrasound data.

The present disclosure is concerned with compounds and compositions for use in the prevention and treatment of cancer such as, for example, a primary or secondary tumor within a subject's brain, breast, kidney, pancreas, lung, colon, prostate, lymphatic system, liver, ovary, or cervix. Additional examples of cancers for which the disclosed compounds and compositions can be useful include, but are not limited to, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanomas, gliomas, leukemia, lymphoma, chronic myeloproliferative disorders, myelodysplastic syndrome, myeloproliferative neoplasm, non-small cell lung carcinomas, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

A simulation system for hands-on training for medical diagnostic and treatment techniques is provided. The simulation system is provided with a manikin of a human body having a first side and a second side. The second side has a transparent simulated skin, an internal organ simulated model, and a sensor module configured to collect and transmit data based on an input by a user. In addition, the system has a processor with an implemented computer program configured to receive and interpret the data from the sensor module and provide a feedback to the user based on the interpretation of the data.

The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

To develop novel lipid-pharmaceutical agent conjugates that facilitate stable transport of the pharmaceutical agent to the intestinal lymph.SOLUTION: The present invention relates to compounds and uses thereof and particularly to compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.SELECTED DRAWING: Figure 1

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The present invention discloses a method, system, device and medium for extracting brain features from MRI images, and relates to the technical field of intelligent biomedical signal processing. When extracting imaging brain features related to the function of the cerebral lymphatic system and the brain structure and morphology in T1WI sequence images, T2WI sequence images and DTI sequence images, the present invention fully exploits the deep features of multiple MRI sequence images. The extracted imaging features related to the function of the cerebral lymphatic system and the brain structure and morphology include the diffusion degree values ​​of the bilateral brain tissue in the patient's brain when converted into fiber bundles, and the fiber bundle reference values ​​that cause the fiber bundles to deviate when the patient's brain discharges. The fiber bundle reference values ​​can reflect which parameters are diffusion parameters when the bilateral brain tissue is abnormal. The diffusion degree values ​​and diffusion parameters reflected by these imaging features are closely related to the patient's epileptic language disorder function and can be used as standards for predicting language disorders in epileptic patients.

The present invention relates to a method for constructing a lymphedema pathological network based on graph neural networks. First, collect medical imaging data, clinical records, and biomarker data of the lymphatic system of patients, and use image processing techniques to extract key features and structure them into nodes and edges of a graph; then, based on the anatomical structure and physiological functions of the lymphatic system, define the topological structure of the graph, and introduce multi-modal data fusion technology to combine imaging data and biomarker data; then, design a multi-layer graph convolutional network model for learning the patterns of lymph nodes and their connections, and introduce an attention mechanism; then, use the graph convolutional network for deep learning to extract hidden features of nodes and edges, and apply graph embedding technology to transform high-dimensional graph data into a low-dimensional space; finally, develop a graph-based anomaly detection algorithm for identifying pathological changes that are significantly different from common patterns, and combine time series analysis to predict the pathological progression of lymphedema.

The invention belongs to the technical field of human body electroencephalogram signal processing and brain regulation and control. The invention provides an ultrasonic-electrical stimulation collaborative lymphatic system enhanced closed-loop regulation and control system, which integrates noradrenaline oscillation core driving signals to realize sleep staging and conversion detection, decides an ultrasonic-electrical stimulation collaborative mode based on a staging coupling index, completes parameter linear transition in a conversion period, and improves sleep quality. Stimulation parameters are dynamically optimized in combination with reinforcement learning and a PID fusion algorithm. According to the device, the defects of core signal deficiency, inaccurate stimulation coordination, one-sided coupling analysis and poor safety adaptability of an existing device are overcome, the lymphatic system metabolic waste removal efficiency is remarkably improved, the sleep interruption risk is reduced, regulation and control are accurate, safety and noninvasive are achieved, the device is suitable for prevention and adjuvant therapy of neurodegenerative diseases such as Alzheimer's disease, and the device has a wide application prospect. And the method can also be expanded to be used for lymphatic-like function mechanism research and early disease screening.

Disclosed herein, inter alia, are medical devices and methods for administering therapeutic agents to one or more positions comprising or proximal to one or more regions of the lymphatic system of a subject. Also disclosed herein are, inter alia, methods for treating a subject having, or suspected of having, an arthritic disease or associated condition, or a symptom of an arthritic disease of associated condition, by delivering a therapeutically effective amount of a therapeutic agent to the lymphatic system of the subject.

The invention discloses a method, equipment, medium and program product for evaluating the treatment effect of levosimendan on sepsis-related encephalopathy. According to the method, the treatment effect of the levosimendan on the sepsis-related encephalopathy is evaluated on the basis of cerebral blood flow data, clearance rate data of a colloidal lymphatic system and / or expression data of AQP4, and the treatment effect of the levosimendan on the sepsis-related encephalopathy can be effectively evaluated. Therefore, further guidance is provided for optimizing the treatment condition and research of the sepsis-related encephalopathy by the levosimendan, and a clinician can be guided to formulate an individualized treatment scheme for a patient.

The application discloses a non-invasive brain lymphoid network evaluation method and system based on magnetic resonance imaging, and relates to the field of medical image processing.The system comprises a data acquisition module which acquires 3D-T1WI images, 3D-T2WI images, DWI images and DTI images; a data preprocessing module which pre-processes the images; and a multi-dimensional function analysis module which is used for determining multi-dimensional parameters of perivascular spaces according to the pre-processed 3D-T1WI images and the pre-processed 3D-T2WI images; separating perfusion and diffusion components of the pre-processed DWI images to obtain intra-voxel incoherent motion imaging parameters, and calculating free water fractions; and calculating a perivascular space diffusion tensor imaging index based on the pre-processed DTI images; and an evaluation and analysis module which evaluates according to the output results of the multi-dimensional function analysis module, so that the functional state of the brain lymphoid system can be evaluated non-invasively, comprehensively and systematically.

The invention relates to the technical field of biology, in particular to a method for verifying influence of quercetin on HIE newborn rat lymphatic systems and neurological functions. The method comprises the following steps: a, acquiring a newborn rat for an experiment, and establishing an HIE model; b, preparing a quercetin working solution; c, after a rat in the HIE model is selected and injected with a quercetin working solution, nerve function evaluation is completed, then the brain of the rat is taken out to be sliced, TTC dyeing is completed, and the infarct area percentage is calculated; and performing brain water content detection on the rats to complete verification of influence of quercetin on lymphatic system functions in HIE. The method provided by the invention has the advantages that the steps are simple, and the influence of the quercetin on the lymphatic system and the neurological function of the HIE newborn rat can be more intuitively verified.

To provide a small, easy-to-handle portable biological information observation device. [Solution] A portable bio-information observation device according to one embodiment of the present invention is a portable bio-information observation system comprising at least an irradiation device for irradiating the lymphatic system and / or blood vessels as the part to be observed with photon energy, an imaging device for imaging the visualized part to be observed, a display device, and an operation unit, wherein the system comprises a main body having the irradiation device, the imaging device, and the display device, the main body having a photon energy emission unit and an imaging unit on one side of its opposing surface, a display unit on the other side of the opposing surface, and an illumination control unit for controlling the visualization light of the illumination device, the illumination control unit controlling the irradiation device for irradiating the photon energy to have a wavelength, brightness, and brightness distribution set according to the visualization conditions of the part to be observed, based on a command from the operation unit.

The present invention relates to the use of scyllo-inositol alone or in combination with other active ingredients, including the flavone apigenin, to support cognitive health in subjects taking the product or combination product. The present invention relates to compositions comprising scyllo-inositol alone or in combination with other agents, including, but not limited to, flavones or other substances that prevent the upregulation or downregulation of aquaporin 4 channels. The compositions, including oral dosage forms such as tablets or capsules, are provided to subjects, including humans or other mammals such as dogs or cats, or other animals, in need of cognitive improvement. The combination product(s) degrade amyloid-β aggregates and promote the clearance of amyloid-β fibrils from the glymphatic system.

A wearable radiation emitting device with integrated vibration element which operates to provide for the use of radiation treatment in conjunction with vibration treatment. The wearable radiation emitting device with integrated vibration element includes a plurality of LEDs, some of which emit blue visible light and others which emit red visible light and infrared light, and are arranged to direct these emissions to an injury site so as to reduce general pain as well as promote a wearer's recovery by way of increased blood flow and infection prevention. The wearable radiation emitting device with integrated vibration element also includes a plurality of integrated vibrating pads operative to generate vibration around an injury site that also promotes increased blood flow as well as stimulates the lymphatic system, all of which promotes systemic healing and aids in infection prevention and swelling reduction.

The present invention provides an oral formulation for activation of autologous stem cell, comprising a stem cell activator encapsulated into a water-in-oil-in-water (W / O / W) multiple emulsion; wherein the stem cell activator induces autologous CD34+CD45+ hematopoietic stem cells (HSCs), wherein the stem cell activator is selected from the group consisting of granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF) and combination thereof. The W / O / W multiple emulsion protects the stem cell activator from stomach acid digestion, preserving its bioactivity during transport to the bone marrow (BM) via the Peyer's patches of the intestinal lymphatic system.

The present disclosure relates to target sequencing of T and B cell receptor gene rearrangements at the DNA level and using this technology to detect and quantify lymphoid malignant T or B cells (minimal residual disease, MRD) during and after therapy.

A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistema magna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.