51 results about "Lymphatic/immune" patented technology

The invention relates to a gynecological pelvic and abdominal lymphatic cleaning prediction model training method and a lymph node model.The training method comprises the steps that preoperative image data and intraoperative instrument operation parameters of historical patients are subjected to modeling processing, and a dynamic mechanics-fluid coupling lymph node model based on bionic materials is constructed; mechanical deformation and fluid flow of a lymphatic system in various clinical scenes are simulated; performing data acquisition processing on the used lymph node model, and quantifying the dynamic influence of the surgical operation on the lymphatic system; the relevance between historical operation and injury risk is deeply learned, and the lymphatic vessel rupture probability is output; real-time feedback control processing is carried out based on the lymphatic vessel rupture probability, a training correction instruction and a risk thermodynamic diagram are generated, and medical workers are guided to optimize surgical skills. Through fusion analysis of the high-fidelity bionic model and multi-modal data, dynamic simulation of the mechanical-fluid coupling effect in the operation and real-time quantification of the operation risk are achieved, and the accuracy and clinical transformation value of operation training are improved.

A method for improving cerebrospinal fluid clearance through a glymphatic system, while a patient is sleeping, resting, or a combination thereof, the method comprising measuring ultrasound data with one or more ultrasound emitters and extracting B-wave oscillations from the ultrasound data.

A simulation system for hands-on training for medical diagnostic and treatment techniques is provided. The simulation system is provided with a manikin of a human body having a first side and a second side. The second side has a transparent simulated skin, an internal organ simulated model, and a sensor module configured to collect and transmit data based on an input by a user. In addition, the system has a processor with an implemented computer program configured to receive and interpret the data from the sensor module and provide a feedback to the user based on the interpretation of the data.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The invention belongs to the technical field of human body electroencephalogram signal processing and brain regulation and control. The invention provides an ultrasonic-electrical stimulation collaborative lymphatic system enhanced closed-loop regulation and control system, which integrates noradrenaline oscillation core driving signals to realize sleep staging and conversion detection, decides an ultrasonic-electrical stimulation collaborative mode based on a staging coupling index, completes parameter linear transition in a conversion period, and improves sleep quality. Stimulation parameters are dynamically optimized in combination with reinforcement learning and a PID fusion algorithm. According to the device, the defects of core signal deficiency, inaccurate stimulation coordination, one-sided coupling analysis and poor safety adaptability of an existing device are overcome, the lymphatic system metabolic waste removal efficiency is remarkably improved, the sleep interruption risk is reduced, regulation and control are accurate, safety and noninvasive are achieved, the device is suitable for prevention and adjuvant therapy of neurodegenerative diseases such as Alzheimer's disease, and the device has a wide application prospect. And the method can also be expanded to be used for lymphatic-like function mechanism research and early disease screening.

The invention discloses a method, equipment, medium and program product for evaluating the treatment effect of levosimendan on sepsis-related encephalopathy. According to the method, the treatment effect of the levosimendan on the sepsis-related encephalopathy is evaluated on the basis of cerebral blood flow data, clearance rate data of a colloidal lymphatic system and / or expression data of AQP4, and the treatment effect of the levosimendan on the sepsis-related encephalopathy can be effectively evaluated. Therefore, further guidance is provided for optimizing the treatment condition and research of the sepsis-related encephalopathy by the levosimendan, and a clinician can be guided to formulate an individualized treatment scheme for a patient.

The application discloses a non-invasive brain lymphoid network evaluation method and system based on magnetic resonance imaging, and relates to the field of medical image processing.The system comprises a data acquisition module which acquires 3D-T1WI images, 3D-T2WI images, DWI images and DTI images; a data preprocessing module which pre-processes the images; and a multi-dimensional function analysis module which is used for determining multi-dimensional parameters of perivascular spaces according to the pre-processed 3D-T1WI images and the pre-processed 3D-T2WI images; separating perfusion and diffusion components of the pre-processed DWI images to obtain intra-voxel incoherent motion imaging parameters, and calculating free water fractions; and calculating a perivascular space diffusion tensor imaging index based on the pre-processed DTI images; and an evaluation and analysis module which evaluates according to the output results of the multi-dimensional function analysis module, so that the functional state of the brain lymphoid system can be evaluated non-invasively, comprehensively and systematically.

To provide a small, easy-to-handle portable biological information observation device. [Solution] A portable bio-information observation device according to one embodiment of the present invention is a portable bio-information observation system comprising at least an irradiation device for irradiating the lymphatic system and / or blood vessels as the part to be observed with photon energy, an imaging device for imaging the visualized part to be observed, a display device, and an operation unit, wherein the system comprises a main body having the irradiation device, the imaging device, and the display device, the main body having a photon energy emission unit and an imaging unit on one side of its opposing surface, a display unit on the other side of the opposing surface, and an illumination control unit for controlling the visualization light of the illumination device, the illumination control unit controlling the irradiation device for irradiating the photon energy to have a wavelength, brightness, and brightness distribution set according to the visualization conditions of the part to be observed, based on a command from the operation unit.

A wearable radiation emitting device with integrated vibration element which operates to provide for the use of radiation treatment in conjunction with vibration treatment. The wearable radiation emitting device with integrated vibration element includes a plurality of LEDs, some of which emit blue visible light and others which emit red visible light and infrared light, and are arranged to direct these emissions to an injury site so as to reduce general pain as well as promote a wearer's recovery by way of increased blood flow and infection prevention. The wearable radiation emitting device with integrated vibration element also includes a plurality of integrated vibrating pads operative to generate vibration around an injury site that also promotes increased blood flow as well as stimulates the lymphatic system, all of which promotes systemic healing and aids in infection prevention and swelling reduction.

A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistema magna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.

An energizing garment comprising a compressive material configured to be worn by a user for therapeutic lymphatic drainage and tissue massage. The garment includes watershed fingers secured to watershed portions of the material that overlie lymphatic watershed regions of the user's body, and massage fingers secured to non-watershed portions that overlie non-watershed regions. The watershed fingers are arranged in a variable density pattern to encourage lymph flow through watershed areas, while massage fingers are arranged in a consistent density pattern to create fluid pathways directing flow from non-watershed regions toward watersheds. The compressive material applies targeted pressure to drive the fingers against the skin and underlying tissues, energizing the tissues to release fluid and smooth the skin. The garment can be formed as various clothing items including shirts, pants, shorts, jumpsuits, or leotards, providing a wearable therapeutic solution for lymphatic system stimulation and tissue treatment.

The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

This invention belongs to the field of organ-on-a-chip technology, proposing a method for constructing an in vitro brain lymphatic system chip and a brain lymphatic system chip, filling the gap in the construction of in vitro models of brain lymphatic systems. First, the microfluidic channels in the chip are rinsed, sterilized, washed, and cultured with cells. Then, vascular channel cells and brain parenchyma channel cells are seeded in the treated microfluidic channels. Finally, in the vascular channels, perfusion is performed at a preset flow rate and at preset intervals to provide shear force stimulation mimicking pulsed blood flow. Continuous perfusion achieves the basic formation of in vitro brain blood vessels. The intermittent fluid flow mimicking arterial pulsations is achieved through this preset flow rate and preset interval perfusion.

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

The invention discloses application of a mast cell inhibitor in prevention and treatment of brain injury after hair growth matrix bleeding, and relates to the technical field of biological medicines. The mast cell inhibitor is a mast cell stabilizer and plays a role by inhibiting degranulation of mast cells; the mast cell stabilizer is sodium cromoglycate or pharmaceutically acceptable salt, ester, solvate or prodrug thereof; the medicine is used for preventing and / or treating brain injury after newborn hair growth matrix bleeding, wherein the brain injury comprises one or more of neuroinflammation, lymphatic system dysfunction, intracerebral toxic metabolite accumulation, hematoma enlargement and neurobehavioral function impairment. Early activation of mast cells is used as a key intervention target spot for preventing and treating the brain injury after the newborn hair growth matrix bleeding; different from a traditional method for bleeding or wide later-stage inflammation, the method focuses on the extremely early hub link of the injury cascade reaction, and a novel prophylactic or ultra-early therapeutic thought is provided.

This invention relates to the interdisciplinary field of biomedicine and molecular imaging, specifically a novel magnetic resonance imaging contrast agent, its preparation method, and its application. The contrast agent uses thymosin α1 as the parent compound, linked with three identical substituents R, where R are metal chelate groups. These metal chelate groups are formed by coordination of a chelating agent and a metal ion; the chelating agent can be diethylenetriaminepentaacetic acid, etc., and the metal ion can be selected from gadolinium, manganese, and iron. The preparation method of the contrast agent includes: activating the chelating agent and grafting it onto thymosin α1 to form a chelate precursor; and coordinating the chelate precursor with a metal ion. The contrast agent prepared by this invention exhibits a significant T1 enhancement effect, lymphoselectivity, and reduced concomitant venous contamination; detection results show that it has excellent lymphatic system visualization capabilities in in vivo animal imaging, providing a prospective reference for replacing existing contrast agents.

Lidocaine for use in the treatment of a chronic, persistent or hyperinflammatory condition, where the lidocaine is administered in a format and a dose that targets the lymphatic system, resulting in p

A lymphatic system examination device includes a main body portion including a placement portion on which a subject in which a fluorescent dye is injected into a lymphatic system stands, and configured to position a lower body of the subject in an imaging region on the placement portion; an illumination unit configured to irradiate the lower body with excitation light; and an imaging unit configured to detect fluorescence emitted from the lower body in response to irradiation of the excitation light. The placement portion is provided with a positioning portion that indicates a standing position of the subject.

The invention discloses a lymphatic system early recognition device for cognitive impairment, and the device comprises a multi-modal image collection module which collects related image data and transmits the related image data to a lymphatic image recognition module, and the module extracts a lymphatic structure region through a corresponding model and then transmits the lymphatic structure region to a feature classification processing module; the feature classification processing module combines a classification model and an algorithm to process features and transmits the features to the function evaluation calculation module, and the function evaluation calculation module quantifies a lymphatic function based on an exclusive platform and then transmits the quantified lymphatic function to the parameter integration analysis module; and the parameter integration analysis module associates the evaluation result with the cognitive impairment parameters, generates association analysis data, transmits the association analysis data to the identification result output module, and outputs identification information after converting the data format. The device realizes integration of lymphatic-like system identification and cognitive disorder early warning, improves identification precision and efficiency, and provides a reliable basis for clinical early intervention.

The present disclosure provides an apparel for facilitating a lymphatic therapy in relation to a user body. Further, the apparel may include an apparel layer which may be configured to be positioned on the user body associated with a user. Further, the apparel layer includes a compression layer which may be configured for facilitating a compression of the apparel in relation to the user body. Further, the compression results in the lymphatic therapy in relation to a lymphatic system comprised in the user body. Further, the compression layer further includes a three dimensional pattern which may be configured for facilitating a nano-massage associated with the user body. Further, the nano-massage corresponds to a micro-level stimulation of the user body. Further, the lymphatic therapy may be further based on the nano massage.

The invention discloses a lymphatic system magnetic resonance imaging prediction postoperative brain injury evaluation method and system, and relates to the field of brain injury evaluation, and the method comprises the steps: obtaining multi-modal magnetic resonance imaging image data of a joint anatomy region of a target subject; extracting magnetic resonance imaging function parameters based on the multi-mode magnetic resonance imaging image data; fusing the magnetic resonance imaging function parameters, the brain region white matter fiber integrity parameters, the cerebral hemodynamic indexes and the clinical data of the operation process to construct a multi-dimensional feature vector; and inputting the feature vectors into a hybrid neural network model consisting of a graph convolutional network and a long-short-term memory network, and outputting risk prediction values of postoperative encephaledema, cognitive impairment and white matter injury. According to the method, the limitation that an existing evaluation means is highly dependent on a structural image, functional evaluation is lacked and prediction accuracy is insufficient is broken through, and accurate prediction and intervention of postoperative brain injury based on lymphatic-like function imaging are realized.

The invention discloses a room-temperature phosphorescent nanoprobe based on high-active oxygen phosphorescent molecules as well as a preparation method and application of the room-temperature phosphorescent nanoprobe. According to the probe, phosphorescent molecules with high active oxygen generation efficiency are encapsulated in polymer nano-microspheres through an emulsion polymerization method, and the compact structure of the nano-microspheres can effectively inhibit the quenching effect of water molecules on phosphorescence through a physical barrier; and macroscopic phosphorescence emission in an air environment is successfully realized. The probe has a high signal-to-noise ratio, excellent tissue penetrability and biocompatibility, is suitable for the fields of tumor imaging, intraoperative navigation, lymphatic system imaging and the like, and has a good clinical application prospect.

Examination of a test sample to determine the succination level of test sample is described. Examination can be via protein hydrolysis in total succination determination or via enzymatic digestion of isolated proteins and determination of the presence or quantity of modified peptides. The methods can be utilized for determination of excessive succination of lymph system proteins, which can be utilized in prevention or early detection of autoimmune disorders. Methods can be utilized for test samples of subjects under treatment with dimethyl fumarate suffering from an autoimmune disorder. Methods can be utilized as a determination that treatment of the subject with DMF should be slowed or stopped.

The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.

Provided herein is a method for determining cancer treatment using an immune-modulating therapy in a subject in need thereof. The method comprises assessing whether a lymphatic system in a subject is dysregulated. When the lymphatic system is dysregulated, a treatment for the lymphatic system is determined before a therapeutic amount of an immune-modulating therapy is administered to treat cancer in the subject. Alternatively, when the lymphatic system is dysregulated, an immune-modulating therapy is selected to treat cancer in the subject. The immune-modulating therapy is independent of immune-cell priming, antigen trafficking, antigen presentation, and any combination thereof. The subject may also be treated for cancer accordingly.

A composition is described comprising at least one folate which is useful in the treatment of a disorder linked to a deficiency of a micronutrient, in particular a folate, in a lymphatic and / or glymphatic system.

The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.