7 results about "Pain sensation" patented technology

A virtual reality (VR) system for generating pain sensations in VR environments using thermal grill illusion (TGI), comprising a VR device and a wearable thermos-haptic device with a thermoelectric stimulative module for inducing TGI-based pain sensations, a heat sink coupled to the module for temperature regulation and stabilization, and a thermocouple for monitoring and controlling temperature changes.

The application discloses a kind of based on pressure pain sensation's bionic flexible touch sensor and robot active protection method, it is related to bionic robot flexible sensing and safety protection field.The sensor adopts DIW integrated printing process, including flexible silica gel base, cross intersection row and column conductive grid and spherical cap micro convex pressure resistance sensing unit, no layering, full flexibility, can adapt to robot complex curved surface whole body.It is based on the critical pressure intensity of sensor material destruction as benchmark, constructs three-stage progressive quantization bionic pain sensation system, through pain sensation value driving robot executes graded protection action, core through expanding force area to eliminate structural risk from root;While constructing whole body partition density bionic skin system, fusion foot bottom pressure and gyroscope data realizes walking balance adjustment.The application gives consideration to sensing accuracy and engineering cost, greatly improves the bionic sensing ability of humanoid robot, operation safety and structure life.

This invention provides the application of berberine II derivatives in the preparation of drugs for treating diabetic foot, belonging to the field of biomedical technology. This invention is the first to discover that berberine II derivatives can significantly improve symptoms such as decreased motor / sensory nerve conduction velocity and loss of pain sensation in diabetic foot model rats, and promote wound healing in the affected foot. Berberine II derivatives hold promise for further development and research as a novel drug for treating diabetic foot.

The invention relates to the technical field of biological medicines, in particular to application of a CCR1 / 5 inhibitor Met-RANTES in inhibition of pathological pain of trigeminal nerves. According to the invention, CCR1 / 5 is taken as a therapeutic target of chronic pain, and a medicine which is remarkable in analgesic effect, small in side effect and capable of relieving chronic pain and improving pain mood is developed by combining the pharmacological function of an inhibitor Met-RANTES of CCR1 / 5. The Met-RANTES inhibits a central nervous system chemokine receptor CCRR1 / 5 in a targeted manner in a regular nasal administration manner, so that pathological mechanical pain-sensitive response and accompanying negative emotion caused by chronic compression of trigeminal nerves can be remarkably relieved, and pain feeling is relieved. In addition, the analgesic effect of the drug combination of the Met-RANTES and the carbamazepine is more obvious than that of the drug combination of the Met-RANTES and the carbamazepine which are independently used. The nasal delivery mode enables the medicine to directly reach the central nervous system, and reduces side effects of the whole body.

The invention relates to the technical field of traditional Chinese medicine plasters, in particular to a pain-relieving acupoint plaster and a preparation method thereof. The medicine component is prepared from the following raw materials: frankincense, myrrh, scorpion, centipede, corydalis tuber, clove, elecampane and cassia twig; according to the pain-relieving acupoint plaster disclosed by the invention, the traditional Chinese medicine components are scientifically screened and the ratio is optimized, and the components play specific functions in the pain-relieving process and form a synergistic effect. Boswellia carteri and myrrh are used as classic analgesic compatibility and have the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain, and effective components of frankincense and myrrh can permeate into local tissues to relieve qi and blood stasis of painful parts, so that pain is relieved from the source; the scorpio and the centipede have the effects of activating meridians to stop pain, and the active ingredients of the scorpio and the centipede can act on a pain sense conduction pathway to block the transmission of pain signals, so that the scorpio and the centipede have a remarkable inhibition effect on intractable pain.

The invention relates to a stretching-pain perception system based on a multi-gate synaptic transistor and a preparation method and application thereof, and belongs to the technical field of artificial sensory neuron and neuromorphic calculation. The system comprises a crack type strain sensor and a multi-gate synaptic transistor, the strain sensor adopts a metal / elastic composite material double-layer conductive structure, and has high sensitivity and a continuous conductive path; the multi-gate synaptic transistor takes an electrolyte material as a gate medium, takes a metal oxide as an electrode and a channel, and is provided with a bottom gate and a side gate. The strain sensor is connected with the bottom grid and the side grid through a voltage division circuit, and dynamic integration and processing of stretching signals are achieved by regulating and controlling different grid voltages. According to the invention, multi-stage mode conversion from conventional stretching perception to pain early warning is realized, the method is suitable for biological nerve simulation systems such as electronic skin, intelligent artificial limbs and bionic robots, and the bottleneck problem that an existing pain perception system is difficult to realize multi-signal fusion and dynamic regulation and control is solved.

The application discloses application of rapamycin in preparation of a reliever of opiate drug tolerance caused by an anti-angiogenic drug, the reliever and a medicine, and relates to the technical field of medicine application. It is found that a TSC1-mTOR-autophagy axis plays a role in opiate drug tolerance caused by an anti-angiogenic drug, and the specific embodiment is that the anti-angiogenic drug can cause a decrease in TSC1 content, an mTOR / RPS6 pathway is activated, thereby autophagy flow is blocked, and pain sensation is enhanced; therefore, the opiate tolerance condition can be relieved by adjusting the mTOR / RPS6 pathway through rapamycin.