807 results about "Thyroid" patented technology

This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg of bupropion hydrochloride, or a molar equivalent amount of a free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg of dextromethorphan hydrobromide, or a molar equivalent amount of a free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prolongation.

The invention relates to the technical field of image data processing, in particular to a thyroid ultrasound image intelligent analysis system. The system obtains an ultrasonic image of a thyroid gland, and obtains a calcification edge feature value according to the distribution position and gray level distribution of edge pixel points in a local area of pixel points in the ultrasonic image of the thyroid gland; according to the complexity and the discrete condition of the gray value of the pixel point in each preset direction in the local area of the pixel point, the confusion index of each preset direction is obtained, the organization boundary ambiguity is obtained in combination with the calcified edge feature value, and then the gain coefficient in the ACE algorithm is adjusted to obtain the improved gain coefficient, so that the accuracy and the robustness of the algorithm are improved. And carrying out image enhancement on the ultrasonic image of the thyroid gland by using the improved ACE algorithm. The gain coefficient in the ACE algorithm is improved based on the fuzzy degree of the tissue boundary of the ultrasonic image of the thyroid gland, and the contrast ratio and the image quality of the ultrasonic image are effectively improved.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention relates to the technical field of medical image processing, in particular to a thyroid calcification detection method and system based on image processing, and the method comprises the following steps: dividing a thyroid region ultrasonic image according to a fixed grid, calculating local contrast intensity and edge tendency based on a gray difference, screening a gray variation region, and recording an edge pixel group as a feature point set; according to the method, the detection precision of the calcification region in the thyroid ultrasound image is improved through gridding processing and gray difference analysis, artifact interference is effectively inhibited through gradient direction and angle change analysis of edge pixels, the accuracy of the calcification region boundary is ensured, boundary extraction is enhanced through recognition of a closed curve, and the accuracy of the calcification region is improved. The method avoids the problem of curve fuzziness, enables the recognition of the calcification structure to be more stable and reliable through the gray concentration and stability analysis, improves the detection accuracy, is suitable for different image qualities and disease types, and improves the clinical diagnosis support capability.

The invention discloses a transfer control method and device for an ultrasonic robot to autonomously scan thyroid gland, and the method comprises the steps: controlling an ultrasonic robot probe to move from an initial position to a target side by a first preset distance, collecting an ultrasonic image in real time, and recording a total movement distance and a distance to a trachea; obtaining a thyroid contour area based on the ultrasonic image, and determining the effectiveness of the ultrasonic image; if the continuous preset number of ultrasonic images are valid, determining that the probe completes two-side transfer; otherwise, contour features of the trachea and the carotid artery are obtained based on ultrasonic image fitting, and whether the probe completes two-side transfer or not is determined by combining the distance from the probe to the center of the neck; if not, whether the distance to the air pipe is larger than a second preset distance is judged; if not, whether the total moving distance is larger than a preset maximum distance or not is judged; if not, transferring is executed again; and if yes, determining that the probe completes two-side transfer. According to the method, the quality and efficiency of thyroid autonomous scanning are improved, and the safety and accuracy of operation are enhanced.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention discloses application and an extraction method of prinsepia utilis royle polysaccharide, which comprises the following steps: extracting prinsepia utilis royle residues with 95% ethanol at 85 DEG C, filtering, extracting the residues with deionized water at 85-95 DEG C for 2-3 times, merging extracts, performing alcohol precipitation with 90%-95% ethanol at 2-6 DEG C, removing protein through a Sevage method, centrifugally collecting supernate, and freeze-drying to obtain the prinsepia utilis royle polysaccharide. And finally determining the content of the prinsepia utilis royle polysaccharide by using an anthrone-sulfuric acid colorimetric method, wherein the obtained prinsepia utilis royle polysaccharide is used for treating and improving skin lesion of psoriasis. Tests prove that prinsepia utilis royle polysaccharide can significantly improve psoriasis skin lesion, reduce inflammatory factor expression, enhance skin barrier function and increase expression of epidermal related protein, and is helpful for relieving symptoms of psoriasis patients and improving skin conditions.

Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.

The invention provides a thyroid ablation intraoperative monitoring method and system, a storage medium and electronic equipment. The system comprises a data acquisition unit; the image segmentation unit is used for obtaining a thyroid organ segmentation region and a focus region, and generating an ablation safety region based on the spatial information of the focus region; the three-dimensional reconstruction unit is used for acquiring reconstructed organ volume data; and the dynamic monitoring unit is used for carrying out real-time registration on the preoperative image volume data and the ultrasonic image sequence obtained in the operation so as to observe the position of the focus, obtaining thyroid deformation and the ablation state of the focus, and dynamically monitoring the ablation process and the ablation completion condition of the focus area. According to the method, through one-time registration and multiple times of rapid secondary precise registration, the 3d reconstruction process of data collected in the operation is omitted, deformation of the thyroid gland in the ablation state is conveniently monitored, the problem that positioning is not clear enough in the ultrasonic focus operation is solved through registration in the operation and before the operation, and a better ablation result is obtained.

Described herein are methods of treating or reducing the severity of thyroid eye disease (TED), as well as antibodies that bind and inhibit signaling through the insulin-like growth factor receptor 1, useful in the methods.

The invention discloses a thyroid nodule segmentation method based on a large model and cooperative consistent training, relates to the technical field of ultrasonic image analysis, and organically embeds the general reasoning ability of the large model into a semi-supervised model to complement the advantages of the semi-supervised model and the large model. The insufficient knowledge migration capability of the semi-supervised model is relieved by utilizing the general prediction capability of the large model, and meanwhile, the high-confidence misprediction of the large model is relieved by utilizing the feature collaborative consistency of the semi-supervised model, so that the actual prediction performance of the model is improved; through large model fine tuning operation under a semi-supervised framework, the large model can be subjected to fine tuning synchronously based on an unsupervised image and a supervised image, and meanwhile, the fine tuning convergence speed and accuracy of the model are accelerated based on collaborative loss and a high-quality pseudo tag; and through collaborative consistency training operation, the advantages of a semi-supervised model and an SAM model are organically complemented, and a high-quality pseudo-label generation scheme and collaborative loss based on self-reliability and collaborative reliability are provided.

The invention relates to a nerve monitoring monopole electrocoagulation hook for thyroid surgery and a surgical instrument, and relates to the technical field of medical instruments.The electrocoagulation hook comprises a nerve detecting piece installed at the front end of a handle, an insulating pipe body is arranged in the nerve detecting piece, a smoke suction channel and a sliding hole are formed in the insulating pipe body, and a rod body is slidably inserted into the sliding hole and connected with an external power source; the far end of the rod body is provided with a hook body bent relative to the rod body, and the surface, deviating from the smoke suction channel, of the hook body forms an electrocoagulation face. The hook body is provided with a first-stage heat conduction assembly, avoids the electrocoagulation surface and is in heat conduction connection with the electrocoagulation surface; one end of the second-stage heat conduction assembly is in heat conduction connection with the first-stage heat conduction assembly, and the other end of the second-stage heat conduction assembly extends into the smoke suction channel. Through the combined design of two-stage heat conduction and heat dissipation, heat generated by the electrocoagulation surface during coagulation and cutting can be rapidly conducted through the heat conduction assembly and is dissipated and taken away through cooperation of the smoke suction channel, so that the diffusion risk of the heat in adjacent nerves and tissues is reduced to a certain extent, and the operation safety and stability in an operation are improved.

The invention relates to the technical field of computer medical detection, in particular to a thyroid nodule benign and malignant classification method based on clinical information, radiomics and gene detection. According to the method, pathological diagnosis of thyroid nodules is used as a dependent variable, detection data including radiomics characteristics and molecular omics are used as continuous variables, and the detection data of at least three genes CLDN10, HMGA2 and LANM3 are selected as the data of the molecular omics; meanwhile, in combination with part of clinical pathological characteristics including gender, age and BRAF V600E mutation condition factors, a thyroid nodule preoperative diagnosis prediction model based on radiomics and molecular omics is constructed through an SVM modeling method. Gene detection, radiomics and clinical basic information are combined, and a thyroid nodule diagnosis model based on the combination is established on the basis of Chinese population. The method is used for assisting clinicians in distinguishing benign and malignant thyroid nodules and guiding clinical decisions

Disclosed herein are thyroid receptor agonist compounds, polymorphic forms, pharmaceutical compositions, the method of use, and preparation thereof. Some embodiments relate to crystalline forms of Compound 1 and salts thereof.

Antibodies and compositions against Insulin-Like Growth Factor-1 Receptor (IGF-1R) and uses thereof for treating thyroid eye disease (TED) are provided herein. Anti-IGF-1R antibodies and compositions described herein can be used in methods of treating or reducing the severity of thyroid eye disease (TED) in subjects in need thereof, by inhibiting the activity of IGF-1R with such antibodies and compositions.

The invention discloses a thyroid postoperative bleeding monitoring method and system, and relates to the technical field of medical monitoring. According to the method, the YOLO-Seg network model is adopted, and the SRCNN layer and the Blind Dconv layer are combined, so that the drainage tube area and the dressing area can be identified with high precision, the accuracy of area identification is improved, and the definition and the deblurring effect of the image are improved; the color, the category and the proportion information of the drainage liquid are accurately detected, so that powerful support is provided for judging whether the patient bleeding or not; by comprehensively analyzing the physiological index data, the overall health condition of the patient is more comprehensively evaluated, the health condition of the patient is accurately reflected through the physiological index score, the potential bleeding risk is found in time, a comprehensive, accurate and timely solution is provided for monitoring the thyroid postoperative patient, and safety and rehabilitation of the patient are effectively guaranteed.

A pharmaceutical composition comprising sitagliptin or a pharmaceutically acceptable salt thereof, wherein the composition comprises less than 5 ppm of 7-Nitroso-3-(trifluoromethyl)- 5,6,7,8-tetrahydr

The invention provides a feature enhancement system and method for a thyroid and breast surgery CT image, and the method comprises the steps: segmenting a target enhancement region of a target thyroid and breast surgery patient through a tissue recognition model, and extracting a target region CT image; a thermal imaging image of the target patient in the thyroid and breast surgery department is collected, and a soft tissue recognition boundary and a focus communication area of a target enhancement area of the target patient in the thyroid and breast surgery department are extracted based on the thermal imaging image; performing soft tissue boundary enhancement on the CT image of the target area according to the soft tissue identification boundary to obtain a CT enhanced image, and extracting image texture features of the CT enhanced image; and performing consistency enhancement on the image texture features of the CT enhanced image according to the focus connected region to obtain a CT visual image of the target patient in the thyroid and breast surgery, and performing image enhancement on the CT image in the thyroid and breast surgery according to the soft tissue identification boundary and the focus connected region of the thermal imaging image of the target patient. And the texture coherence of the CT image in the focus area is improved.

The present disclosure relates to methods of treatment of thyroid eye disease (TED) by administering a fusion protein, such as a fusion protein as defined herein, to subjects in need thereof. The disclosure provides treatment of pathophysiological parameters of TED, including both systemic and local pathophysiological parameters, whereby the disease is efficiently treated.

The invention discloses a surface coating material for a thyroid retractor and a preparation method of the surface coating material. In order to improve the corrosion resistance of the stainless steel thyroid retractor, the DLC-HfO2 composite coating is prepared on the surface of the stainless steel substrate. Researches show that along with the increase of the HfO2 content, the corrosion resistance of the DLC-HfO2 composite coating is in a trend of firstly increasing and then stabilizing. However, when the content of HfO2 is too high, the high hemolysis rate determines that the composite coating is not suitable for being used as a medical material, and therefore in actual use, the content of HfO2 in the composite coating needs to be controlled to be 5.2 wt%-19 wt%.

The invention provides a thyroid postoperative rehabilitation training neck support which comprises a fixator, a neck support body connected through an elastic band is arranged on the fixator, a sliding rail is arranged on the neck support body, connecting blocks are arranged at the two ends of the sliding rail in a sliding mode, a sliding block is arranged in the middle area of the sliding rail in a sliding mode, and two resistance assemblies are arranged on the neck support body. The fixing device is provided with an adjusting mechanism, the fixing device further comprises a connecting cylinder connected with the fixing device through a spherical joint assembly, the connecting cylinder is sleeved with the sliding block in a sliding mode, and the connecting cylinder is provided with a locking mechanism. By means of the rehabilitation training neck support, movement of the neck in multiple directions can be adjusted, after training is completed, the relative positions of the neck support body, the sliding block and the fixator can be rapidly fixed through the locking mechanism so that the neck of a patient can be supported, and compared with a traditional rehabilitation training neck support, the rehabilitation training neck support is wider in application range, more comprehensive in training and higher in practicability. The postoperative rehabilitation efficiency is effectively improved.

The present invention relates to methods for treating or reducing the severity of thyroid eye disease. In particular, the present invention provides methods for treating or reducing the severity of thyroid eye disease in patients in need thereof comprising administering an IGF-1R antagonist antibody according to specific dosage regimens. Pharmaceutical compositions comprising the IGF-1R antagonist antibody for use in the methods are also described.

The utility model relates to the technical field of medical instruments, and discloses a pair of separating forceps for endoscopic thyroid surgery, which comprises a connecting tube, one end of the connecting tube is communicated with a mounting cylinder, a draw bar penetrates through the connecting tube in a sliding manner, two groups of forceps heads are rotatably mounted at one end of the draw bar, and the other end of the draw bar penetrates through the mounting cylinder and is provided with two groups of limiting blocks. A spring is connected between the top of the mounting cylinder and the closer set of limiting blocks, a rotating plate is rotationally mounted at the top of one side wall of the mounting cylinder, a bending frame is arranged on the side, away from the connecting pipe, of the rotating plate, and the side wall, away from the rotating plate, of the bending frame is located between the two sets of limiting blocks and internally provided with a sliding way matched with the traction rod to slidably penetrate through. Compared with the prior art, the separating forceps have the advantages that the rotating plate is pressed towards the direction of the mounting cylinder through the thumb, opening and closing of the two sets of forceps heads are achieved, fingers cannot be pressed in the operation process, and the separating forceps are convenient to take up in the operation process.

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

The invention relates to the technical field of image analysis, in particular to a thyroid nodule grading identification method and system.The thyroid nodule grading identification method comprises the following steps that Gaussian filtering processing is conducted on the basis of an ultrasonic image, a two-dimensional Gaussian kernel with the same size as the image is constructed, and the weight of each element in the kernel is calculated; the weighted value is subjected to weighted operation according to the relative position of each pixel and the neighborhood pixel and the pixel value, each pixel value in the original image is updated through weighted average, and a noise reduction image is obtained. According to the method, the local brightness is optimized by dynamically adjusting the histogram, the contrast is enhanced, and the detail expression is obviously improved; the edge definition of a rapid change area is enhanced through second-order gradient sharpening processing, artifacts are reduced, edge detection utilizes a composite gradient and double-threshold strategy, the accuracy of edge recognition is improved, texture feature extraction is comprehensively analyzed through a gray-level co-occurrence matrix, the stability and discrimination of feature vectors are enhanced, and the accuracy of edge recognition is improved. And a more reliable basis is provided for medical diagnosis.

Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THRβ) agonist and methods comprising administering to a subject in need thereof such combinations.

The invention discloses a composition for detecting benign and malignant thyroid nodules and a detection method thereof, and relates to the technical field of medical detection, the composition comprises the following components: a DNA / RNA extraction reagent and a fluorescent quantitative PCR reagent; by combining the DNA / RNA extraction reagent and the fluorescent quantitative PCR reagent, nucleic acid can be efficiently and accurately extracted from the thyroid nodule fine needle puncture sample, specific gene mutation and gene fusion are detected through the fluorescent quantitative PCR technology, the accuracy and sensitivity of benign and malignant judgment of the thyroid nodule are remarkably improved, and the method is suitable for clinical application. And a doctor can formulate a treatment scheme earlier and more accurately, and the prognosis of a patient is improved.

The invention discloses nursing flow guiding equipment for thyroid surgery, and belongs to the technical field of medical instruments.The nursing flow guiding equipment for thyroid surgery comprises a wound contact block, the bottom of the wound contact block is fixedly connected with a connecting pipe, and the other end of the connecting pipe is fixedly connected with a one-way valve; a mounting box is mounted at the bottom of the one-way valve, a flow guide bag is placed in the mounting box, and a fixing mechanism is arranged on the outer wall of the mounting box. By designing the flow dividing and filtering mechanism, ultrasonic waves are continuously emitted through two miniature ultrasonic vibration assemblies, and if blood clots exist in seepage, the blood clots can be effectively separated under the action of the ultrasonic waves, so that the blood clots can be effectively prevented from flowing out; when the drainage tube is used, the blood clots are decomposed into small fragments, the situation that the drainage tube is blocked due to the fact that the blood clots are too large is avoided, fat substances in the seepage are intercepted by the filter holes and stored in the filter storage tube, the filter storage tube is taken out for centralized treatment, and the good drainage effect is guaranteed.