443 results about "Thyroid" patented technology

The invention relates to a nerve monitoring monopole electrocoagulation hook for thyroid surgery and a surgical instrument, and relates to the technical field of medical instruments.The electrocoagulation hook comprises a nerve detecting piece installed at the front end of a handle, an insulating pipe body is arranged in the nerve detecting piece, a smoke suction channel and a sliding hole are formed in the insulating pipe body, and a rod body is slidably inserted into the sliding hole and connected with an external power source; the far end of the rod body is provided with a hook body bent relative to the rod body, and the surface, deviating from the smoke suction channel, of the hook body forms an electrocoagulation face. The hook body is provided with a first-stage heat conduction assembly, avoids the electrocoagulation surface and is in heat conduction connection with the electrocoagulation surface; one end of the second-stage heat conduction assembly is in heat conduction connection with the first-stage heat conduction assembly, and the other end of the second-stage heat conduction assembly extends into the smoke suction channel. Through the combined design of two-stage heat conduction and heat dissipation, heat generated by the electrocoagulation surface during coagulation and cutting can be rapidly conducted through the heat conduction assembly and is dissipated and taken away through cooperation of the smoke suction channel, so that the diffusion risk of the heat in adjacent nerves and tissues is reduced to a certain extent, and the operation safety and stability in an operation are improved.

The invention provides a feature enhancement system and method for a thyroid and breast surgery CT image, and the method comprises the steps: segmenting a target enhancement region of a target thyroid and breast surgery patient through a tissue recognition model, and extracting a target region CT image; a thermal imaging image of the target patient in the thyroid and breast surgery department is collected, and a soft tissue recognition boundary and a focus communication area of a target enhancement area of the target patient in the thyroid and breast surgery department are extracted based on the thermal imaging image; performing soft tissue boundary enhancement on the CT image of the target area according to the soft tissue identification boundary to obtain a CT enhanced image, and extracting image texture features of the CT enhanced image; and performing consistency enhancement on the image texture features of the CT enhanced image according to the focus connected region to obtain a CT visual image of the target patient in the thyroid and breast surgery, and performing image enhancement on the CT image in the thyroid and breast surgery according to the soft tissue identification boundary and the focus connected region of the thermal imaging image of the target patient. And the texture coherence of the CT image in the focus area is improved.

The present invention relates to methods for treating or reducing the severity of thyroid eye disease. In particular, the present invention provides methods for treating or reducing the severity of thyroid eye disease in patients in need thereof comprising administering an IGF-1R antagonist antibody according to specific dosage regimens. Pharmaceutical compositions comprising the IGF-1R antagonist antibody for use in the methods are also described.

The utility model relates to the technical field of medical instruments, and discloses a pair of separating forceps for endoscopic thyroid surgery, which comprises a connecting tube, one end of the connecting tube is communicated with a mounting cylinder, a draw bar penetrates through the connecting tube in a sliding manner, two groups of forceps heads are rotatably mounted at one end of the draw bar, and the other end of the draw bar penetrates through the mounting cylinder and is provided with two groups of limiting blocks. A spring is connected between the top of the mounting cylinder and the closer set of limiting blocks, a rotating plate is rotationally mounted at the top of one side wall of the mounting cylinder, a bending frame is arranged on the side, away from the connecting pipe, of the rotating plate, and the side wall, away from the rotating plate, of the bending frame is located between the two sets of limiting blocks and internally provided with a sliding way matched with the traction rod to slidably penetrate through. Compared with the prior art, the separating forceps have the advantages that the rotating plate is pressed towards the direction of the mounting cylinder through the thumb, opening and closing of the two sets of forceps heads are achieved, fingers cannot be pressed in the operation process, and the separating forceps are convenient to take up in the operation process.

Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THRβ) agonist and methods comprising administering to a subject in need thereof such combinations.

The invention discloses a composition for detecting benign and malignant thyroid nodules and a detection method thereof, and relates to the technical field of medical detection, the composition comprises the following components: a DNA / RNA extraction reagent and a fluorescent quantitative PCR reagent; by combining the DNA / RNA extraction reagent and the fluorescent quantitative PCR reagent, nucleic acid can be efficiently and accurately extracted from the thyroid nodule fine needle puncture sample, specific gene mutation and gene fusion are detected through the fluorescent quantitative PCR technology, the accuracy and sensitivity of benign and malignant judgment of the thyroid nodule are remarkably improved, and the method is suitable for clinical application. And a doctor can formulate a treatment scheme earlier and more accurately, and the prognosis of a patient is improved.

The invention discloses a preparation method of granules for treating breast and thyroid nodules and canceration, which comprises the following steps: S1, raw material preparation: preparing 199g of codonopsis pilosula, 332g of astragalus membranaceus, 149g of glossy privet fruit, 100g of herba epimedii, 166g of selfheal, 100g of uniflower swisscentaury root, 100g of rhizoma pinellinae praeparata, 100g of curcuma zedoary, 199g of salvia chinensis, 332g of selaginella doederleinii hieron, 100g of curcuma aromatica and 149g of cortex albiziae according to a mass ratio; s2, adding water to decoct the twelve medicines twice, adding 8 times by mass of water for the first time, extracting for 2.0 hours, and filtering; s3, adding 6 times by mass of water for the second time, extracting for 1.5 hours, filtering, and combining filtrates; s4, concentrating under reduced pressure to obtain clear paste with the relative density of about 1.05-1.10 (60 DEG C); and S5, performing vacuum drying, crushing into fine powder, adding dextrin and 10g of stevioside, uniformly mixing, granulating with 75% by volume of ethanol, drying, preparing into 1000g, and packaging, thereby obtaining the product.

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

The invention discloses a negative ion metabolism marker for thyroid-associated ophthalmopathy, a product and application of the negative ion metabolism marker. The metabolic marker is prepared from any one or more of 7alpha, 17alpha-dimethyl-5beta-androstane-3 alpha, 17beta-diol, N, N-dimethyl phosphatidyl ethanolamine, 15 (S)-hydroxy eicosatrienoic acid and 1-myristoyl-2-[(9Z)-octadecenoyl]-sn-glycerol-3-phosphatidylcholine, and the metabolic marker is prepared from any one or more of the following raw materials: 1-myristoyl-2-[(9Z)-octadecenoyl]-sn-glycerol-3-phosphatidylcholine. The invention provides a kit which comprises a detection reagent for detecting the negative ion metabolism marker. The invention provides a computer program product for thyroid-related eye diseases. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of thyroid-related eye diseases, and provides a new tool for clinical diagnosis.

The invention provides a three-dimensional medical image segmentation method and system for thyroid-related eye diseases, and is applied to the technical field of data processing. Multi-modal medical image data, a coarse-grained segmentation result and a fine-grained segmentation result are obtained, the multi-modal medical image data comprise a CT image and an MRI image, the multi-modal medical image data are preprocessed, a fused image body is generated, and the fused image body is formed by registration and feature fusion of the CT image and the MRI image; processing the fused image body and the coarse-grained segmentation result to generate a fine segmentation result; processing the fine segmentation result to generate a preliminary segmentation mask; processing the preliminary segmentation mask and the multi-modal medical image data to generate a mixed loss function; and processing the preliminary segmentation mask, the mixed loss function and the extraocular muscle attachment point position based on a dynamic post-processing strategy to generate a final segmentation result.

Provided herein are methods of treating or reducing the severity of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention discloses a medical record diagnosis auxiliary system for thyroid puncture pathology and clinical data association analysis, and relates to the technical field of medical diagnosis intelligent analysis. Comprising a regional risk sensing module, a self-adaptive partition compression module, a transmission priority scheduling module, a detail integrity verification module, a cross-domain feature fusion and detail enhancement module and a diagnosis result return and model optimization module, in the digital scanning process, a regional risk perception model based on a pathological diagnosis task is established, a high-sensitivity region is calibrated according to cell nucleus density distribution, cell nucleus morphological anomaly degree and chromatin particle change, and corresponding lossless fidelity demand data is generated. Pathology key detail fidelity transmission and multi-dimensional feature fusion are achieved under the condition that resources are limited, the early-stage tiny focus recognition rate is increased, misdiagnosis and missed diagnosis are reduced, and diagnosis accuracy and efficiency are continuously improved through closed-loop optimization.

The application discloses a kind of thyroid boundary smoothness detection system and method, it is related to medical image processing and medical auxiliary diagnosis technical field, including the following steps: the image after ultrasonic imaging is analyzed, the imaging feature data in it are extracted, and feature data set is constructed after pre-processing;Using feature engineering technology, from the data set after pre-processing, the key feature index reflecting the potential overlap situation of high-intensity edge region in image is extracted, and the key index extracted is comprehensively analyzed, and the degree of edge overlap in image is quantified.The application intelligently identifies high-intensity overlapping edge region and dynamically adjusts feature contribution, effectively suppresses the interference of ultrasonic artifact on boundary extraction, avoids boundary overlap, self-intersection and deformation, ensures that the extracted boundary has good continuity and smoothness, and provides reliable boundary basis for smoothness quantification analysis and lesion diagnosis.

The invention relates to the technical field of biological medicine, in particular to a medicine for improving thyroid-related eye diseases and application of the medicine. The single-chain antibody provided by the invention has small molecular weight and good physiological activity, and can effectively inhibit the activity and function of IGF1R mediated by IGF1, thereby inhibiting cell proliferation. According to the medicine prepared from the recombinant adeno-associated virus, the treatment cost can be remarkably reduced, side effects caused by repeated injection of antibody medicines are avoided, the safety is very high, and a new clinical treatment method and strategy are provided for inhibiting pathological phenotypes of thyroid-associated ophthalmopathy.

The present disclosure is generally directed to pharmaceutical compositions comprising lonigutamab and methods of making and using such compositions for the treatment of thyroid eye disease (TED).

The utility model relates to the technical field of medical instruments, in particular to a thyroid puncture positioning frame which comprises two sets of arc-shaped rods, supporting frames are connected between the ends of the two sets of arc-shaped rods respectively, positioning blocks are sleeved on the outer sides of the arc-shaped rods in a sliding mode, and puncture needle catheters penetrate through the middle portions of the positioning blocks. Two sets of arc-shaped guide holes matched with the arc-shaped rods to penetrate through are formed in the positioning block, and clamping and positioning mechanisms matched with the arc-shaped rods are arranged at the two ends of the arc-shaped guide holes correspondingly. Compared with the prior art, the thyroid sampling device has the advantages that the positioning block slides on the outer sides of the two sets of arc-shaped rods, the inclination angle of the puncture needle catheter is adjusted, the positioning block is fixed to the outer sides of the two sets of arc-shaped rods through the clamping and positioning mechanism, the puncture needle penetrates through the puncture needle catheter, and a needle head is inserted into a thyroid affected part of a patient for sampling. The angle of the puncture needle is limited through the puncture needle catheter.

The utility model relates to the technical field of medical instruments, in particular to a thyroid post-operation neck collar which comprises a base, a bracket assembly, an installation assembly and a protection assembly. The bracket assembly comprises two sliding shafts, two fixing discs, a sleeve seat and a fixing block, the two sliding shafts are slidably connected with the base and penetrate through the base, the two fixing discs are fixedly connected with the sliding shafts and located on the inner side of the base, a plurality of ratchet grooves are formed in the inner side of each fixing disc, and the ratchet grooves are located in the sleeve seat. The sleeve seat is rotationally connected with the sliding shaft and located on the outer side of the sliding shaft, the multiple fixing blocks are fixedly connected with the sleeve seat and located in the ratchet groove, and the installation assembly and the protection assembly are connected with the base. Therefore, the problem of inconvenience in coping with various neck collar use scenes is solved.

The application relates to the field of medical image assisted ablation technology, and provides a thyroid nodule ablation control system based on ultrasound contrast parameters. The system comprises an ultrasound data acquisition module, a contrast parameter analysis module, a blood supply identification module, an ablation strategy generation module, an ablation execution module, a feedback evaluation module, a closed-loop control module and an energy optimization module. By acquiring an ultrasound contrast image of target tissue, perfusion time, perfusion intensity and perfusion sequence parameters are extracted, blood supply arteries or blood supply areas are identified, and a phased ablation strategy is generated, the blood supply area is preferentially ablated, and then main ablation is carried out on the target tissue; at the same time, residual active areas are detected based on contrast feedback, and supplementary ablation is carried out through a closed-loop control mechanism; and ablation parameters are dynamically optimized in combination with a unit volume energy model. The system can improve ablation integrity, reduce the heat sink effect and the risk of intraoperative bleeding, reduce the recurrence rate, and improve energy utilization efficiency.

The invention relates to the field of medical informatics, and provides a biomarker-based thyroid nodule benign and malignant identification method and system. The method comprises the following steps: collecting a serum sample; performing quantitative detection on the multiple markers in the serum sample to obtain concentration data of the multiple markers; inputting the multi-marker concentration data into a pre-constructed probability calculation model to obtain a prediction probability value; and according to a preset diagnosis threshold value and the prediction probability value, judging whether the thyroid nodule is benign or malignant to obtain a thyroid nodule benign or malignant identification result. By integrating multi-marker information, the biological difference between benign and malignant nodules is effectively captured, and the overall efficiency of differential diagnosis is improved.

The application discloses a trachea conforming hook, an ear-behind neck side conforming hook and a thyroid surgery kit. The trachea conforming hook comprises a first handle, a first hook head arranged at the distal end of the first handle, the first hook head comprises a first clamping arm, a first connecting section, a second clamping arm and an extension section connected in sequence, the first clamping arm and the second clamping arm are perpendicular to the forward direction of the first handle and are used for pushing and pulling the trachea, the first clamping arm extends from the distal end of the first handle in a first direction, the first connecting section extends from the distal end of the first clamping arm in a second direction, the second clamping arm extends from the distal end of the first connecting section in the opposite direction of the first direction, and the extension section extends from the distal end of the second clamping arm in the opposite direction of the second direction, and the bending curvature of the first connecting section is the same as that of the extension section to form parallel arc sections, and the bending direction of the second clamping arm is perpendicular to the bending direction of the first connecting section. The thyroid surgery kit can form a large enough surgical cavity for thyroid surgery and improve the surgical quality.

This invention provides a traditional Chinese medicine composition and its application in the preparation of a topical herbal eye patch for treating thyroid eye diseases, belonging to the field of biomedical technology. The herbal composition consists of *Gynostemma pentaphyllum*, peppermint, *Platycladus orientalis* leaves, borneol, cicada slough, *Astragalus membranaceus*, *Selaginella tamariscina*, *Pteris vittata*, *Scutellaria baicalensis*, apricot leaf, and *Ipomoea aquatica*. Using this herbal composition as raw material, a topical herbal eye patch is prepared. This patch acts directly on acupoints and skin around the eyes, allowing the medicinal properties to penetrate the skin and reach the eye system, achieving the effects of promoting blood circulation, clearing heat and detoxifying, invigorating qi and unblocking meridians, reducing swelling and improving vision. It is suitable for the treatment of thyroid-related eye diseases. This invention's topical herbal eye patch can effectively improve clinical symptoms such as exophthalmos and eye inflammation in patients with thyroid eye diseases, positively impacting their quality of life and effectively improving the clinical treatment efficacy of this disease. The topical herbal eye patch provided by this invention can be further promoted and applied in the clinical treatment of thyroid eye diseases.

The utility model relates to the technical field of medical instruments, in particular to an incision protection sleeve for thyroid surgery. The notch protection sleeve is made of an elastic strip-shaped material with a circular-arc-shaped section, a connecting structure (10) and a matching structure (20) are arranged at the two ends of the notch protection sleeve respectively, the two ends of the notch protection sleeve are connected to form a circular cylinder, the connecting structure (10) is two through holes formed side by side, and the matching structure (20) is two axial through grooves formed side by side; when the two ends of the protective sleeve coincide and are aligned, the two through holes are located in the inner sides of the two axial through grooves. According to the utility model, a simple structure is adopted, an operation silk thread and scissors are matched, an annular cylinder body which strictly corresponds to an incision in size can be formed, the ring diameter is continuously adjustable, the production cost is low, the use is convenient, the flaring function is realized, and the improvement of the operation adaptability is facilitated.

The utility model discloses a kind of thyroid breast drainage equipment, comprising: threaded insertion in the upper end of fixed storage component for the drainage connection component of body fluid circulation, the upper end of the drainage connection component is fixedly connected with the drainage fixed component for drainage.The beneficial effects of the utility model are as follows: by being provided with fixed storage component, drainage bag is conveniently replaced, and at the same time, the device can be firmly fixed on the patient, by being provided with drainage connection component, let drainage connecting pipe be firmly fixed in the upper end of fixed storage component by threaded sleeve joint structure, it is convenient to disassemble and replace, by being provided with drainage fixed component, let drainage cover block cover drainage port, greatly reduce the liquid exudation of wound, increase the protective property of device use.

The utility model discloses a novel material thyroid open operation disposable trachea drag hook relates to the field of medical devices, this novel material thyroid open operation disposable trachea drag hook, including drag hook head and with the drag hook handle of drag hook head connection, the appearance of drag hook head is arc structure, the top surface of drag hook is concave arc surface, the head of drag hook head is obtuse circle of arc shape, the both sides of drag hook head all are formed protection side wing to the up cocking, two protection side wing and drag hook head smooth transition form arc surface. The obtuse circle and protection side wing of the utility model can reduce or avoid the cutting injury of drag hook head head and edge to the pulled tissue as far as possible, protect the tissue such as trachea of being pulled.

The utility model discloses a special pillow for a thyroid postoperative patient, and aims to solve the problems that in the prior art, in the ice compress process, family members or the patient need to be lifted by two hands to fix the ice compress position all the time, and use is inconvenient. The pillow special for the thyroid postoperative patient comprises a pillow body, the two ends of one side face of the pillow body are each fixedly connected with a first hook-and-loop fastener loop face, a fixing band is pasted to each first hook-and-loop fastener loop face, and the ends, away from the first hook-and-loop fastener loop faces, of the fixing bands are fixedly connected with pockets for containing articles. The two pockets are connected through an adjusting component. Through cooperation of the first connecting band, the second connecting band, the pocket and the fixing band, the position of the ice bag can be fixed, a patient and family members of the patient are liberated, and use is convenient.

The application belongs to the technical field of molecular biology and medicine, and discloses a methylation marker for detecting the benignity and malignancy of thyroid nodules and an application. 780 new methylation sites are identified, 273 tumor occurrence and development related genes are associated, and the Fc gamma R-mediated phagocytosis signal pathway is involved. The methylation marker for detecting the benignity and malignancy of thyroid nodules comprises multiple genes and multiple methylation sites. The methylation level of multiple genes and multiple sites is detected, the problem of low and unstable methylation signal of single gene or single site is overcome, and thus the sensitivity and specificity of detection are improved.

The invention discloses an electric thyroid puncture suction device which comprises a needle cylinder, a piston, a piston rod, a shell and a driving device. The shell and the driving device are detachably connected, the driving device is installed in the shell in an embedded mode, the tail of the piston rod is connected with an execution part of the driving device, and a switch connected with the driving device is arranged on the outer side of the shell; the appearance of the shell is a cylinder, the shell and the needle cylinder are coaxially connected, and the outer diameter of the shell meets the following use conditions that an operator can use a thumb, an index finger and a middle finger to hold the shell to execute a puncture operation. A doctor can directly operate the electric thyroid puncture and suction device by using the habitual gestures of the doctor, and the doctor can successfully puncture without changing the holding posture and only needs to operate the switch by using a thumb or a little finger, so that the suction operation is easily carried out, and the large hand action and physical output of the doctor are reduced.

The present disclosure provides methods for treating thyroid eye disease, comprising subcutaneously administering a therapeutically effective dose of an anti-interleukin-6 (anti-IL-6) antibody or antibody fragment to a patient in need of treatment. Also provided herein are pharmacologically active agents, compositions, methods, and / or administration schedules for the treatment of thyroid eye disease.

The present invention relates to novel heterocyclic compounds useful in the preparation of medicaments for the treatment of diseases associated with various functions of the histamine 4 receptor.In particular, said drugs are useful for treating inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itching, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritis pain, autoimmune disease, thyroid, immune-mediated (also known as type I) diabetes, lupus, post-surgical adhesions, vestibular disorders and cancer.