614 results about "Thyroid" patented technology

The invention relates to the technical field of medical image processing, in particular to a thyroid calcification detection method and system based on image processing, and the method comprises the following steps: dividing a thyroid region ultrasonic image according to a fixed grid, calculating local contrast intensity and edge tendency based on a gray difference, screening a gray variation region, and recording an edge pixel group as a feature point set; according to the method, the detection precision of the calcification region in the thyroid ultrasound image is improved through gridding processing and gray difference analysis, artifact interference is effectively inhibited through gradient direction and angle change analysis of edge pixels, the accuracy of the calcification region boundary is ensured, boundary extraction is enhanced through recognition of a closed curve, and the accuracy of the calcification region is improved. The method avoids the problem of curve fuzziness, enables the recognition of the calcification structure to be more stable and reliable through the gray concentration and stability analysis, improves the detection accuracy, is suitable for different image qualities and disease types, and improves the clinical diagnosis support capability.

Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.

Described herein are methods of treating or reducing the severity of thyroid eye disease (TED), as well as antibodies that bind and inhibit signaling through the insulin-like growth factor receptor 1, useful in the methods.

The invention discloses a thyroid nodule segmentation method based on a large model and cooperative consistent training, relates to the technical field of ultrasonic image analysis, and organically embeds the general reasoning ability of the large model into a semi-supervised model to complement the advantages of the semi-supervised model and the large model. The insufficient knowledge migration capability of the semi-supervised model is relieved by utilizing the general prediction capability of the large model, and meanwhile, the high-confidence misprediction of the large model is relieved by utilizing the feature collaborative consistency of the semi-supervised model, so that the actual prediction performance of the model is improved; through large model fine tuning operation under a semi-supervised framework, the large model can be subjected to fine tuning synchronously based on an unsupervised image and a supervised image, and meanwhile, the fine tuning convergence speed and accuracy of the model are accelerated based on collaborative loss and a high-quality pseudo tag; and through collaborative consistency training operation, the advantages of a semi-supervised model and an SAM model are organically complemented, and a high-quality pseudo-label generation scheme and collaborative loss based on self-reliability and collaborative reliability are provided.

The invention relates to a nerve monitoring monopole electrocoagulation hook for thyroid surgery and a surgical instrument, and relates to the technical field of medical instruments.The electrocoagulation hook comprises a nerve detecting piece installed at the front end of a handle, an insulating pipe body is arranged in the nerve detecting piece, a smoke suction channel and a sliding hole are formed in the insulating pipe body, and a rod body is slidably inserted into the sliding hole and connected with an external power source; the far end of the rod body is provided with a hook body bent relative to the rod body, and the surface, deviating from the smoke suction channel, of the hook body forms an electrocoagulation face. The hook body is provided with a first-stage heat conduction assembly, avoids the electrocoagulation surface and is in heat conduction connection with the electrocoagulation surface; one end of the second-stage heat conduction assembly is in heat conduction connection with the first-stage heat conduction assembly, and the other end of the second-stage heat conduction assembly extends into the smoke suction channel. Through the combined design of two-stage heat conduction and heat dissipation, heat generated by the electrocoagulation surface during coagulation and cutting can be rapidly conducted through the heat conduction assembly and is dissipated and taken away through cooperation of the smoke suction channel, so that the diffusion risk of the heat in adjacent nerves and tissues is reduced to a certain extent, and the operation safety and stability in an operation are improved.

The invention relates to the technical field of computer medical detection, in particular to a thyroid nodule benign and malignant classification method based on clinical information, radiomics and gene detection. According to the method, pathological diagnosis of thyroid nodules is used as a dependent variable, detection data including radiomics characteristics and molecular omics are used as continuous variables, and the detection data of at least three genes CLDN10, HMGA2 and LANM3 are selected as the data of the molecular omics; meanwhile, in combination with part of clinical pathological characteristics including gender, age and BRAF V600E mutation condition factors, a thyroid nodule preoperative diagnosis prediction model based on radiomics and molecular omics is constructed through an SVM modeling method. Gene detection, radiomics and clinical basic information are combined, and a thyroid nodule diagnosis model based on the combination is established on the basis of Chinese population. The method is used for assisting clinicians in distinguishing benign and malignant thyroid nodules and guiding clinical decisions

Antibodies and compositions against Insulin-Like Growth Factor-1 Receptor (IGF-1R) and uses thereof for treating thyroid eye disease (TED) are provided herein. Anti-IGF-1R antibodies and compositions described herein can be used in methods of treating or reducing the severity of thyroid eye disease (TED) in subjects in need thereof, by inhibiting the activity of IGF-1R with such antibodies and compositions.

The invention provides a feature enhancement system and method for a thyroid and breast surgery CT image, and the method comprises the steps: segmenting a target enhancement region of a target thyroid and breast surgery patient through a tissue recognition model, and extracting a target region CT image; a thermal imaging image of the target patient in the thyroid and breast surgery department is collected, and a soft tissue recognition boundary and a focus communication area of a target enhancement area of the target patient in the thyroid and breast surgery department are extracted based on the thermal imaging image; performing soft tissue boundary enhancement on the CT image of the target area according to the soft tissue identification boundary to obtain a CT enhanced image, and extracting image texture features of the CT enhanced image; and performing consistency enhancement on the image texture features of the CT enhanced image according to the focus connected region to obtain a CT visual image of the target patient in the thyroid and breast surgery, and performing image enhancement on the CT image in the thyroid and breast surgery according to the soft tissue identification boundary and the focus connected region of the thermal imaging image of the target patient. And the texture coherence of the CT image in the focus area is improved.

The present disclosure relates to methods of treatment of thyroid eye disease (TED) by administering a fusion protein, such as a fusion protein as defined herein, to subjects in need thereof. The disclosure provides treatment of pathophysiological parameters of TED, including both systemic and local pathophysiological parameters, whereby the disease is efficiently treated.

The present invention relates to methods for treating or reducing the severity of thyroid eye disease. In particular, the present invention provides methods for treating or reducing the severity of thyroid eye disease in patients in need thereof comprising administering an IGF-1R antagonist antibody according to specific dosage regimens. Pharmaceutical compositions comprising the IGF-1R antagonist antibody for use in the methods are also described.

The utility model relates to the technical field of medical instruments, and discloses a pair of separating forceps for endoscopic thyroid surgery, which comprises a connecting tube, one end of the connecting tube is communicated with a mounting cylinder, a draw bar penetrates through the connecting tube in a sliding manner, two groups of forceps heads are rotatably mounted at one end of the draw bar, and the other end of the draw bar penetrates through the mounting cylinder and is provided with two groups of limiting blocks. A spring is connected between the top of the mounting cylinder and the closer set of limiting blocks, a rotating plate is rotationally mounted at the top of one side wall of the mounting cylinder, a bending frame is arranged on the side, away from the connecting pipe, of the rotating plate, and the side wall, away from the rotating plate, of the bending frame is located between the two sets of limiting blocks and internally provided with a sliding way matched with the traction rod to slidably penetrate through. Compared with the prior art, the separating forceps have the advantages that the rotating plate is pressed towards the direction of the mounting cylinder through the thumb, opening and closing of the two sets of forceps heads are achieved, fingers cannot be pressed in the operation process, and the separating forceps are convenient to take up in the operation process.

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

The invention relates to the technical field of image analysis, in particular to a thyroid nodule grading identification method and system.The thyroid nodule grading identification method comprises the following steps that Gaussian filtering processing is conducted on the basis of an ultrasonic image, a two-dimensional Gaussian kernel with the same size as the image is constructed, and the weight of each element in the kernel is calculated; the weighted value is subjected to weighted operation according to the relative position of each pixel and the neighborhood pixel and the pixel value, each pixel value in the original image is updated through weighted average, and a noise reduction image is obtained. According to the method, the local brightness is optimized by dynamically adjusting the histogram, the contrast is enhanced, and the detail expression is obviously improved; the edge definition of a rapid change area is enhanced through second-order gradient sharpening processing, artifacts are reduced, edge detection utilizes a composite gradient and double-threshold strategy, the accuracy of edge recognition is improved, texture feature extraction is comprehensively analyzed through a gray-level co-occurrence matrix, the stability and discrimination of feature vectors are enhanced, and the accuracy of edge recognition is improved. And a more reliable basis is provided for medical diagnosis.

Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THRβ) agonist and methods comprising administering to a subject in need thereof such combinations.

The invention discloses a composition for detecting benign and malignant thyroid nodules and a detection method thereof, and relates to the technical field of medical detection, the composition comprises the following components: a DNA / RNA extraction reagent and a fluorescent quantitative PCR reagent; by combining the DNA / RNA extraction reagent and the fluorescent quantitative PCR reagent, nucleic acid can be efficiently and accurately extracted from the thyroid nodule fine needle puncture sample, specific gene mutation and gene fusion are detected through the fluorescent quantitative PCR technology, the accuracy and sensitivity of benign and malignant judgment of the thyroid nodule are remarkably improved, and the method is suitable for clinical application. And a doctor can formulate a treatment scheme earlier and more accurately, and the prognosis of a patient is improved.

The present disclosure provides a one-piece garment for protection of a wearer from radiation. The garment comprises an upper body section, a collar section and a front flap section to shield a region of thyroid, a region of torso and a region of gonad of the wearer.

The invention discloses a preparation method of granules for treating breast and thyroid nodules and canceration, which comprises the following steps: S1, raw material preparation: preparing 199g of codonopsis pilosula, 332g of astragalus membranaceus, 149g of glossy privet fruit, 100g of herba epimedii, 166g of selfheal, 100g of uniflower swisscentaury root, 100g of rhizoma pinellinae praeparata, 100g of curcuma zedoary, 199g of salvia chinensis, 332g of selaginella doederleinii hieron, 100g of curcuma aromatica and 149g of cortex albiziae according to a mass ratio; s2, adding water to decoct the twelve medicines twice, adding 8 times by mass of water for the first time, extracting for 2.0 hours, and filtering; s3, adding 6 times by mass of water for the second time, extracting for 1.5 hours, filtering, and combining filtrates; s4, concentrating under reduced pressure to obtain clear paste with the relative density of about 1.05-1.10 (60 DEG C); and S5, performing vacuum drying, crushing into fine powder, adding dextrin and 10g of stevioside, uniformly mixing, granulating with 75% by volume of ethanol, drying, preparing into 1000g, and packaging, thereby obtaining the product.

The invention relates to an endoscopic thyroid surgery training result discrimination method and a resection training model. The method comprises the following steps: S1, sending a data acquisition instruction to a sensor; the data acquisition instruction is used for indicating the sensor to acquire operation data in the operation process and transmitting the operation data and the judgment instruction to the server; s2, in response to the judgment instruction, analyzing and judging the operation data according to a preset judgment rule to obtain a judgment result, and obtaining an operation optimization suggestion according to the judgment result; s3, the judgment result, the operation optimization suggestion and the display instruction are transmitted to a display module; the display instruction is used for indicating the display equipment to display the judgment result and the operation optimization suggestion in a visual mode. According to the method, the endoscopic thyroid surgery training result can be effectively distinguished, the distinguishing result and optimization suggestions can be visually presented for trainees, and the technical effects of assisting in improving the training effect are achieved.

The invention discloses a thyroid gland positioning and puncturing device which comprises a fixing frame, a movable positioning mechanism is arranged above the fixing frame and comprises a moving mechanism, a lifting rod and an adjusting rod, and a puncturing sampling mechanism is arranged on the moving mechanism and comprises a telescopic rod and a sampling needle. The sampling needle is mounted at the telescopic end of the telescopic rod through a mounting assembly, and a micro sampling assembly is arranged in the sampling needle; the moving mechanism is used for adjusting the left-right position, angle and orientation of the sampling needle, and the lifting rod is fixedly mounted at the top of the moving mechanism. According to the thyroid gland positioning and puncturing device, the position and orientation of the sampling needle are adjusted through the movable positioning mechanism, the first driving motor drives the first lead screw to rotate so as to adjust the left-right position of the sampling needle, and the angle of the sampling needle is adjusted through cooperation of the second driving motor, the driving gear and the annular inner gear.

A method of monitoring an overall thyroid ophthalmopathy treatment includes requesting a user device to take a facial image and enter a questionnaire survey content according to treatment monitoring cycle; obtaining the facial image and the questionnaire survey content from the user device; obtaining, using the facial image and the questionnaire survey content obtained from the user device, a personalized estimate of the user corresponding to exophthalmos information, CAS (Clinical Activity Score) information, and diplopia information among an indicator proven at an approval stage of the medicine; and displaying, which comprises visualizing the personalized estimate of the user in a time-series order from the time the user started administering the medicine on the user device.

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

The invention discloses a negative ion metabolism marker for thyroid-associated ophthalmopathy, a product and application of the negative ion metabolism marker. The metabolic marker is prepared from any one or more of 7alpha, 17alpha-dimethyl-5beta-androstane-3 alpha, 17beta-diol, N, N-dimethyl phosphatidyl ethanolamine, 15 (S)-hydroxy eicosatrienoic acid and 1-myristoyl-2-[(9Z)-octadecenoyl]-sn-glycerol-3-phosphatidylcholine, and the metabolic marker is prepared from any one or more of the following raw materials: 1-myristoyl-2-[(9Z)-octadecenoyl]-sn-glycerol-3-phosphatidylcholine. The invention provides a kit which comprises a detection reagent for detecting the negative ion metabolism marker. The invention provides a computer program product for thyroid-related eye diseases. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of thyroid-related eye diseases, and provides a new tool for clinical diagnosis.

The utility model discloses a thyroid postoperative ice compress device, relates to the technical field of medical instruments, and solves the technical problems that the ice compress position of an existing device is fixed, so that the ice compress position cannot be adjusted according to the actual condition of a patient, and a good ice compress effect cannot be achieved. The multifunctional shoulder belt comprises a neck sleeve ring, a first shoulder bandage, a second shoulder bandage and a vest, a containing groove is formed in the upper surface of the neck sleeve ring, at least one adjusting plate is connected into the containing groove in a sliding mode, a connecting ring is detachably connected to the lower end of the neck sleeve ring, and the vest is rotationally connected to the lower end of the connecting ring. The bottom of the connecting ring is further rotationally connected with the first shoulder bandage and the second shoulder bandage, and the first shoulder bandage and the second shoulder bandage are located on the two sides of the upper end of the vest. The ice compress vest has the advantages that the ice compress part can be adjusted, the ice compress vest is more suitable for wounds and operation paths, and covering is more complete.

The invention provides a multi-mode fluorescence imaging method and system applied to thyroid surgery, and the method comprises the steps: collecting image data through a multi-wavelength endoscope system, and generating an image set; performing Fourier transform on the image set, and performing refined enhancement processing on the target area based on an enhancement technology of local contrast adjustment to obtain an enhanced image; monitoring the blood flow state of the parathyroid gland in real time, and constructing a parathyroid gland function protection and blood flow change evaluation model to evaluate the parathyroid gland function risk in real time; real-time blood flow changes and electrical impedance changes in an operation are compared with an existing standard model, when monitoring data exceed a set threshold value, an alarm is triggered, an operation team is reminded of the possible damage risk of the parathyroid gland area, and meanwhile protection measures are automatically activated according to a parathyroid gland function risk assessment model. Through spectral navigation, tumor positioning and protection of surrounding important tissues in the operation process are powerfully guaranteed, and the problems of missed cutting and accidental injury are avoided.

The invention provides a three-dimensional medical image segmentation method and system for thyroid-related eye diseases, and is applied to the technical field of data processing. Multi-modal medical image data, a coarse-grained segmentation result and a fine-grained segmentation result are obtained, the multi-modal medical image data comprise a CT image and an MRI image, the multi-modal medical image data are preprocessed, a fused image body is generated, and the fused image body is formed by registration and feature fusion of the CT image and the MRI image; processing the fused image body and the coarse-grained segmentation result to generate a fine segmentation result; processing the fine segmentation result to generate a preliminary segmentation mask; processing the preliminary segmentation mask and the multi-modal medical image data to generate a mixed loss function; and processing the preliminary segmentation mask, the mixed loss function and the extraocular muscle attachment point position based on a dynamic post-processing strategy to generate a final segmentation result.

Provided herein are methods of treating or reducing the severity of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention relates to the technical field of defect detection, in particular to a thyroid ultrasonic auxiliary scanning method and system, and the method comprises the following steps: obtaining a pixel gray value, local contrast and edge sharpness of a thyroid ultrasonic image, calculating a pixel gradient change rate, and screening a thyroid gland boundary region according to the gradient amplitude change rate. According to the method, the pixel gradient change rate is calculated, the boundary region is screened, the gland recognition accuracy is enhanced, noise interference is reduced, the boundary segmentation is optimized in combination with the multi-scale gradient change rate and the edge strength, the error recognition probability is reduced, the gradient difference weight matrix is constructed, and the boundary is adjusted based on the gray level uniformity, so that the segmentation is more in line with the tissue form; the low-contrast lesion detection capability is improved in combination with gray shift, gradient direction distribution and morphological parameters, the classification accuracy is improved through matching of the morphological change rate and global features, diagnosis support is optimized in combination with the gland volume, the hormone level and the lesion morphological ratio, and the credibility of personalized diagnosis is improved.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention discloses a medical record diagnosis auxiliary system for thyroid puncture pathology and clinical data association analysis, and relates to the technical field of medical diagnosis intelligent analysis. Comprising a regional risk sensing module, a self-adaptive partition compression module, a transmission priority scheduling module, a detail integrity verification module, a cross-domain feature fusion and detail enhancement module and a diagnosis result return and model optimization module, in the digital scanning process, a regional risk perception model based on a pathological diagnosis task is established, a high-sensitivity region is calibrated according to cell nucleus density distribution, cell nucleus morphological anomaly degree and chromatin particle change, and corresponding lossless fidelity demand data is generated. Pathology key detail fidelity transmission and multi-dimensional feature fusion are achieved under the condition that resources are limited, the early-stage tiny focus recognition rate is increased, misdiagnosis and missed diagnosis are reduced, and diagnosis accuracy and efficiency are continuously improved through closed-loop optimization.