275 results about "Thyroid" patented technology

The invention relates to a nerve monitoring monopole electrocoagulation hook for thyroid surgery and a surgical instrument, and relates to the technical field of medical instruments.The electrocoagulation hook comprises a nerve detecting piece installed at the front end of a handle, an insulating pipe body is arranged in the nerve detecting piece, a smoke suction channel and a sliding hole are formed in the insulating pipe body, and a rod body is slidably inserted into the sliding hole and connected with an external power source; the far end of the rod body is provided with a hook body bent relative to the rod body, and the surface, deviating from the smoke suction channel, of the hook body forms an electrocoagulation face. The hook body is provided with a first-stage heat conduction assembly, avoids the electrocoagulation surface and is in heat conduction connection with the electrocoagulation surface; one end of the second-stage heat conduction assembly is in heat conduction connection with the first-stage heat conduction assembly, and the other end of the second-stage heat conduction assembly extends into the smoke suction channel. Through the combined design of two-stage heat conduction and heat dissipation, heat generated by the electrocoagulation surface during coagulation and cutting can be rapidly conducted through the heat conduction assembly and is dissipated and taken away through cooperation of the smoke suction channel, so that the diffusion risk of the heat in adjacent nerves and tissues is reduced to a certain extent, and the operation safety and stability in an operation are improved.

The present invention relates to methods for treating or reducing the severity of thyroid eye disease. In particular, the present invention provides methods for treating or reducing the severity of thyroid eye disease in patients in need thereof comprising administering an IGF-1R antagonist antibody according to specific dosage regimens. Pharmaceutical compositions comprising the IGF-1R antagonist antibody for use in the methods are also described.

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

The invention provides a three-dimensional medical image segmentation method and system for thyroid-related eye diseases, and is applied to the technical field of data processing. Multi-modal medical image data, a coarse-grained segmentation result and a fine-grained segmentation result are obtained, the multi-modal medical image data comprise a CT image and an MRI image, the multi-modal medical image data are preprocessed, a fused image body is generated, and the fused image body is formed by registration and feature fusion of the CT image and the MRI image; processing the fused image body and the coarse-grained segmentation result to generate a fine segmentation result; processing the fine segmentation result to generate a preliminary segmentation mask; processing the preliminary segmentation mask and the multi-modal medical image data to generate a mixed loss function; and processing the preliminary segmentation mask, the mixed loss function and the extraocular muscle attachment point position based on a dynamic post-processing strategy to generate a final segmentation result.

Provided herein are methods of treating or reducing the severity of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention discloses a medical record diagnosis auxiliary system for thyroid puncture pathology and clinical data association analysis, and relates to the technical field of medical diagnosis intelligent analysis. Comprising a regional risk sensing module, a self-adaptive partition compression module, a transmission priority scheduling module, a detail integrity verification module, a cross-domain feature fusion and detail enhancement module and a diagnosis result return and model optimization module, in the digital scanning process, a regional risk perception model based on a pathological diagnosis task is established, a high-sensitivity region is calibrated according to cell nucleus density distribution, cell nucleus morphological anomaly degree and chromatin particle change, and corresponding lossless fidelity demand data is generated. Pathology key detail fidelity transmission and multi-dimensional feature fusion are achieved under the condition that resources are limited, the early-stage tiny focus recognition rate is increased, misdiagnosis and missed diagnosis are reduced, and diagnosis accuracy and efficiency are continuously improved through closed-loop optimization.

The application discloses a kind of thyroid boundary smoothness detection system and method, it is related to medical image processing and medical auxiliary diagnosis technical field, including the following steps: the image after ultrasonic imaging is analyzed, the imaging feature data in it are extracted, and feature data set is constructed after pre-processing;Using feature engineering technology, from the data set after pre-processing, the key feature index reflecting the potential overlap situation of high-intensity edge region in image is extracted, and the key index extracted is comprehensively analyzed, and the degree of edge overlap in image is quantified.The application intelligently identifies high-intensity overlapping edge region and dynamically adjusts feature contribution, effectively suppresses the interference of ultrasonic artifact on boundary extraction, avoids boundary overlap, self-intersection and deformation, ensures that the extracted boundary has good continuity and smoothness, and provides reliable boundary basis for smoothness quantification analysis and lesion diagnosis.

The application relates to the field of medical image assisted ablation technology, and provides a thyroid nodule ablation control system based on ultrasound contrast parameters. The system comprises an ultrasound data acquisition module, a contrast parameter analysis module, a blood supply identification module, an ablation strategy generation module, an ablation execution module, a feedback evaluation module, a closed-loop control module and an energy optimization module. By acquiring an ultrasound contrast image of target tissue, perfusion time, perfusion intensity and perfusion sequence parameters are extracted, blood supply arteries or blood supply areas are identified, and a phased ablation strategy is generated, the blood supply area is preferentially ablated, and then main ablation is carried out on the target tissue; at the same time, residual active areas are detected based on contrast feedback, and supplementary ablation is carried out through a closed-loop control mechanism; and ablation parameters are dynamically optimized in combination with a unit volume energy model. The system can improve ablation integrity, reduce the heat sink effect and the risk of intraoperative bleeding, reduce the recurrence rate, and improve energy utilization efficiency.

The application discloses a trachea conforming hook, an ear-behind neck side conforming hook and a thyroid surgery kit. The trachea conforming hook comprises a first handle, a first hook head arranged at the distal end of the first handle, the first hook head comprises a first clamping arm, a first connecting section, a second clamping arm and an extension section connected in sequence, the first clamping arm and the second clamping arm are perpendicular to the forward direction of the first handle and are used for pushing and pulling the trachea, the first clamping arm extends from the distal end of the first handle in a first direction, the first connecting section extends from the distal end of the first clamping arm in a second direction, the second clamping arm extends from the distal end of the first connecting section in the opposite direction of the first direction, and the extension section extends from the distal end of the second clamping arm in the opposite direction of the second direction, and the bending curvature of the first connecting section is the same as that of the extension section to form parallel arc sections, and the bending direction of the second clamping arm is perpendicular to the bending direction of the first connecting section. The thyroid surgery kit can form a large enough surgical cavity for thyroid surgery and improve the surgical quality.

This invention provides a traditional Chinese medicine composition and its application in the preparation of a topical herbal eye patch for treating thyroid eye diseases, belonging to the field of biomedical technology. The herbal composition consists of *Gynostemma pentaphyllum*, peppermint, *Platycladus orientalis* leaves, borneol, cicada slough, *Astragalus membranaceus*, *Selaginella tamariscina*, *Pteris vittata*, *Scutellaria baicalensis*, apricot leaf, and *Ipomoea aquatica*. Using this herbal composition as raw material, a topical herbal eye patch is prepared. This patch acts directly on acupoints and skin around the eyes, allowing the medicinal properties to penetrate the skin and reach the eye system, achieving the effects of promoting blood circulation, clearing heat and detoxifying, invigorating qi and unblocking meridians, reducing swelling and improving vision. It is suitable for the treatment of thyroid-related eye diseases. This invention's topical herbal eye patch can effectively improve clinical symptoms such as exophthalmos and eye inflammation in patients with thyroid eye diseases, positively impacting their quality of life and effectively improving the clinical treatment efficacy of this disease. The topical herbal eye patch provided by this invention can be further promoted and applied in the clinical treatment of thyroid eye diseases.

The utility model discloses a kind of thyroid breast drainage equipment, comprising: threaded insertion in the upper end of fixed storage component for the drainage connection component of body fluid circulation, the upper end of the drainage connection component is fixedly connected with the drainage fixed component for drainage.The beneficial effects of the utility model are as follows: by being provided with fixed storage component, drainage bag is conveniently replaced, and at the same time, the device can be firmly fixed on the patient, by being provided with drainage connection component, let drainage connecting pipe be firmly fixed in the upper end of fixed storage component by threaded sleeve joint structure, it is convenient to disassemble and replace, by being provided with drainage fixed component, let drainage cover block cover drainage port, greatly reduce the liquid exudation of wound, increase the protective property of device use.

The utility model discloses a novel material thyroid open operation disposable trachea drag hook relates to the field of medical devices, this novel material thyroid open operation disposable trachea drag hook, including drag hook head and with the drag hook handle of drag hook head connection, the appearance of drag hook head is arc structure, the top surface of drag hook is concave arc surface, the head of drag hook head is obtuse circle of arc shape, the both sides of drag hook head all are formed protection side wing to the up cocking, two protection side wing and drag hook head smooth transition form arc surface. The obtuse circle and protection side wing of the utility model can reduce or avoid the cutting injury of drag hook head head and edge to the pulled tissue as far as possible, protect the tissue such as trachea of being pulled.

The application belongs to the technical field of molecular biology and medicine, and discloses a methylation marker for detecting the benignity and malignancy of thyroid nodules and an application. 780 new methylation sites are identified, 273 tumor occurrence and development related genes are associated, and the Fc gamma R-mediated phagocytosis signal pathway is involved. The methylation marker for detecting the benignity and malignancy of thyroid nodules comprises multiple genes and multiple methylation sites. The methylation level of multiple genes and multiple sites is detected, the problem of low and unstable methylation signal of single gene or single site is overcome, and thus the sensitivity and specificity of detection are improved.

The invention discloses an electric thyroid puncture suction device which comprises a needle cylinder, a piston, a piston rod, a shell and a driving device. The shell and the driving device are detachably connected, the driving device is installed in the shell in an embedded mode, the tail of the piston rod is connected with an execution part of the driving device, and a switch connected with the driving device is arranged on the outer side of the shell; the appearance of the shell is a cylinder, the shell and the needle cylinder are coaxially connected, and the outer diameter of the shell meets the following use conditions that an operator can use a thumb, an index finger and a middle finger to hold the shell to execute a puncture operation. A doctor can directly operate the electric thyroid puncture and suction device by using the habitual gestures of the doctor, and the doctor can successfully puncture without changing the holding posture and only needs to operate the switch by using a thumb or a little finger, so that the suction operation is easily carried out, and the large hand action and physical output of the doctor are reduced.

The invention relates to the field of biological medicine, in particular to an aryloxy indole formic acid compound as well as a preparation method and application thereof. The general formula (I) of the aryloxy indole carboxylic acid compound is shown in the specification, wherein R1 is a Cl atom or a Br atom; r2 and R3 are two methylene groups connected to the same oxygen atom, or R2 is any one of a methyl group, a methoxy group, an isopropyl group, a methylthio group and a hydrogen atom, and R3 is any one of a halogen atom, a methyl group, a methoxy group, an isopropyl group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group, a cyclopropyl methoxy group, a benzyl group, a benzyloxy group and a hydrogen atom. As a thyroid hormone receptor agonist, the aryloxy indole formic acid compound has good THRbeta selectivity and THRbeta agonist activity, has the advantages of low toxicity and good biological safety, and has high practical value.

The invention discloses an adjustable fixator for a subclavian approach thyroid surgery endoscope lens, and relates to the technical field of endoscope lens fixation. The device comprises a mounting seat, a bent connecting rod and an elastic clamping jaw, a mounting groove is formed in one side of the mounting seat, a fixing seat is fixedly connected to the other side of the mounting seat, and an inserting hole is formed in the fixing seat; the bent connecting rod is located in the inserting hole, the end of the bent connecting rod is fixedly connected with a connecting block, and a groove is formed in one side of the connecting block. The bent connecting rod is arranged, has good plasticity and supporting strength and can be manually bent into any angle and keep the shape according to the operation requirement, so that the spatial position of the endoscope lens is flexibly adjusted to adapt to different observation view angle requirements in the subclavian approach thyroid operation.

The invention discloses an RGB-D image-based thyroid body surface key point detection method and system, and the method comprises the steps: carrying out the image collection through an RGB-D camera, and carrying out the preprocessing of a collected RGB image and a depth image; constructing a key point detection model based on a convolutional neural network; training a key point detection model by using the marked thyroid image data set, and optimizing the model by adjusting parameters; extracting features from the preprocessed RGB image and depth image by using the optimized key point detection model, carrying out feature learning, and fusing the extracted RGB features and depth features; carrying out thyroid body surface key point detection on the fused feature map; according to the method, based on the RGB-D image, through deep learning and feature fusion technologies, high thyroid body surface key point detection is carried out, and the limitation of the prior art in the aspects of illumination interference, skin color similarity and the like is overcome; and the detection accuracy and stability are improved.

The invention relates to the technical field of thermal ablation, in particular to a thyroid nodule ultramicro-invasive ablation precise puncture positioning method, which comprises the following steps of: acquiring continuous gray frames and extracting tissue gray to complete normalization and phase demodulation to generate phase time data; detecting a brightness peak value according to phase time data to obtain a tip echo, calculating a phase gradient in a neighborhood by using a fixed window to generate a stable domain data set, calculating a spatial range according to a stable domain, extracting a phase change signal along with time, and completing frequency domain dominant frequency extraction and period analysis to generate a period consistent region; according to the method, the continuous image phases are extracted, the time sequence is combined, the needle point recognition stability is enhanced, the echo region is restrained through the brightness peak value and the phase gradient, and the accuracy of positioning is improved. Position judgment is enhanced through spatial range and period analysis, and the guiding precision is improved by combining a three-dimensional distance and a symbol sequence.

The invention belongs to the technical field of medical auxiliary equipment, and discloses an adjustable negative pressure drainage device for mammary gland and thyroid surgery, which comprises a base plate, and the base plate is connected with a transfer wheel set, a transfer handle and a box body, the box body is connected with a box door, an alarm device, a conductive groove, a first spring, a first groove body, a negative pressure suction device, a sliding adjusting assembly, a diversion groove body and a second groove body, the first spring is connected with a placement plate, the placement plate is connected with a liquid storage cylinder and a conductive column, the negative pressure suction device is provided with a liquid inlet end and a liquid outlet end, and the second groove body is slidably connected with a sliding block. The guide groove body is connected with a connecting rod and a second spring. The negative pressure of the negative pressure suction equipment is automatically adjusted by utilizing the linkage assembly according to the flow of the drainage residual liquid, so that the drainage effect and efficiency are ensured, and the probability of secondary injury to the wound surface of a patient can be reduced.

Methods of treating patients with thyroid eye disease are provided for herein, such as by administering subcutaneously antibodies and compositions that bind to and / or antagonize IGF-1R. 

The invention belongs to the technical field of medical auxiliary instruments, and discloses a thyroid postoperative drainage auxiliary device which comprises a fixing plate and an adjusting plate, the fixing plate is connected with an adjusting seat, the adjusting seat is connected with a locking bolt, the adjusting seat is provided with an adjusting groove, and the adjusting plate is provided with an adjusting part; the fixing plate is connected with a clamping assembly, the clamping assembly comprises a second clamping seat, the second clamping seat is connected with a flexible pad, a heating piece and a temperature detector, the heating piece is used for heating the tube wall of the drainage tube, and the temperature detector is used for detecting the temperature of the tube wall of the drainage tube; the adjusting plate is connected with a rectifying assembly, the rectifying assembly comprises a first clamping seat, and the first clamping seat is connected with a flexible pad. The circular ring formed by the fixing plate and the adjusting plate is connected to the neck in a sleeving mode, skin discomfort caused by adhesive tape fixation is avoided, fixation is firm and comfortable, the non-contact flow speed sensing module is used for detecting the speed of drainage liquid in the drainage tube, the flow speed can be safely and accurately monitored, and key data are provided for negative pressure adjustment.

The embodiment of the utility model provides a compression type hemostasis neck sleeve for thyroid postoperative nursing, which comprises a compression belt positioned on the inner side of the neck sleeve and used for applying uniform pressure to realize a hemostasis effect; the two ends of the fixing band are connected with the compression bands and used for surrounding and fixing the neck of the patient and preventing the neck sleeve from shifting when the neck moves; the adjusting buckle is arranged at one end of the fixing belt, and the length of the fixing belt is adjusted through the adjusting buckle; one end of the support frame is connected with the fixing band and the other end is connected with the compression band; the non-slip mat is arranged on one side, in contact with the skin of the patient, of the compression belt; wherein the support frame consists of a plurality of slender spring steel wires which are distributed in a net shape; one end of the support frame is connected with the fixing band through a rotary joint, so that the support frame can slightly rotate along with the movement of the neck; and a damping gasket is arranged in the rotary joint. Through the scheme of the embodiment of the invention, the problem that the hemostatic effect is poor due to the fact that the position of the neck sleeve deviates when the neck moves can be solved.

The utility model discloses a kind of parathyroid gland detection devices, belong to medical instrument technical field, including limiting component, installation shell, light guide beam, signal conversion component, light transmission component and connecting lens, installation shell upper end is installed with light guide beam, light guide beam other end is connected with light source, limiting component is installed in installation shell one end, signal transmission cable is installed in limiting component, connecting lens is installed in installation shell other end, light transmission component is installed in installation shell inside, light transmission component one end is opposite connecting lens, light transmission component other end is connected with signal conversion component. Solve the problem that it is easy to be miscut due to the position of parathyroid gland cannot be detected clearly in the prior art. Improve the accuracy of thyroid surgery, prevent the occurrence of complications.

Disclosed herein are methods of modulating the activity of a thyroid hormone receptor beta and methods of treating disease using a pyridazinone compound.

The invention discloses a fixing device for postoperative care of the thyroid and mammary gland department, and belongs to the technical field of postoperative care. The shoulder adjusting and limiting mechanism comprises a fixing ring I which is fixedly connected and arranged on one side of the fixing belt and is used for limiting the adjusted fixing belt; the neck adjusting and limiting structure comprises a limiting block which is arranged above the fixing belt and is used for limiting the movement of the neck; the shoulder adjusting and limiting mechanism and the neck adjusting and limiting mechanism are connected into a whole through the connecting assembly, neck-shoulder synchronous linkage limiting is achieved, meanwhile, the shoulder can adjust the tightness degree through cooperation of the first hook and the first fixing rings, the neck can increase or decrease the number of limiting blocks, and the neck can adjust the enclosing degree through cooperation of the second hook and the second fixing rings. The device can accurately restrain excessive movement of the neck, the shoulders and the upper limbs, reduces wound surface traction from the source, adapts to neck and shoulder sizes of patients with different body types, is high in universality, and provides a stable body position environment for postoperative wound surface healing.

The utility model discloses a thyroid surgery traction device, and relates to the field of medical instruments. The thyroid surgery traction device comprises a traction device and a traction device fixing device. The traction device comprises an annular guide rail, a traction structure and a drag hook; the number of the traction structures is at least two, the traction structures are arranged on the annular guide rail in a sleeving mode and can move along the annular guide rail, and each traction structure comprises a traction rod capable of moving inwards and outwards in the radial direction of the annular guide rail; the drag hooks and the traction structures are arranged in a one-to-one correspondence manner and are detachably connected with the traction rods; the number of the retractor fixing devices is two, the two retractor fixing devices are arranged on the two sides of the retractor respectively and connected with the annular guide rail, and the outer ends of the retractor fixing devices can be detachably connected with the operating bed. According to the utility model, the function of pulling an operative incision open can be realized, the device only needs to be adjusted when the device is arranged and needs to be adjusted in the operation process, and the traction of the operative incision does not need manual participation in other time.

A peptide-based vaccine for use in the treatment or prevention of amyloid-to-thyroid amyloidosis (ATTR) is provided.

Antibodies and compositions against Insulin-Like Growth Factor-1 Receptor (IGF-1R) and uses thereof are provided herein and antibodies and pharmaceutical compositions that can be used in methods of treating or reducing the severity of thyroid eye disease (TED) in subjects in need thereof, including reducing proptosis and Clinical Activity Score (CAS), by inhibiting the activity of IGF-1R with such antibodies and compositions.

The utility model relates to the technical field of medical auxiliary instruments, in particular to a drainage tube for drainage after head and neck thyroid surgery and an auxiliary structure, which comprises an application pressing sheet, neck bandages are connected to the left side and the right side of the application pressing sheet, one end, far away from the application pressing sheet, of each neck bandage is connected with an adhesive tape, and the adhesive tape is connected with a drainage tube for drainage after head and neck thyroid surgery. A pipe inserting base is arranged in the middle of the top of the application pressing piece, fixing vertical plates are arranged on the portions, located on the left side and the right side of the pipe inserting base, of the top of the application pressing piece, and extrusion springs are connected to the tops of the inner sides of the fixing vertical plates in a longitudinal symmetry mode. The auxiliary structure of the drainage tube can be used for carrying out auxiliary supporting and fixing on the connecting end of the drainage tube body and the neck, the supporting force can prevent the connecting end from being folded and shrunken due to the action amplitude, and therefore the drainage effect is improved.