135 results about "Bone disease" patented technology

The invention provides a compound with a structure as shown in a formula (I). The compound can be used as a polyphenol organic ligand to be self-assembled with metal ions to form metal polyphenol nanoparticles. The nano-particles have a bone targeting effect, are safe, effective, stable and uniform, can realize whole-body transfer, can be degraded in a bone pathology microenvironment, have regulation and control effects on bone resorption and bone formation, can cooperatively regulate and control bone balance, and have a great application prospect in the field of bone diseases such as osteoporosis. # imgabs0 #

The invention discloses a bone organ chip loaded with a microelectrode array and a use method, and relates to the technical field of organ chips, the bone organ chip is made of a polydimethylsiloxane material, and the bone organ chip comprises a three-layer structure: a top layer, a middle layer and a bottom layer; the middle layer comprises two blood vessel micro-channels, two osteoblast micro-channels and a neuron micro-channel, the channels are separated through columns and micro-columns, and cell interaction in a bone micro-environment is simulated; a microelectrode array is arranged on the top layer and is used for monitoring electrical activity of neurons in real time; the bottom layer is provided with a pneumatic valve which can control opening and closing of the micro-channel. According to the invention, nerve and blood vessel channels are introduced, a nerve-blood vessel-immunoregulation bone microenvironment is constructed, physiological processes such as osteogenesis-blood vessel formation coupling and the like are embodied, intervals of different sizes can enhance intercellular crosstalk and allow blood vessels and neuron axons to selectively pass through, so that the chip can simulate a complex microenvironment of bone tissues, and the microenvironment of the bone tissues can be simulated; and an efficient and accurate in-vitro model is provided for bone disease mechanism research and drug development.

The invention belongs to the field of biological products, and particularly relates to a bone glue product for preventing and treating osteoporosis and application, the bone glue comprises sheep bone glue (small molecules), pig bone glue (small molecules) and black pig bone glue (small molecules); five animals are beneficial, sheep and pigs are food beneficial to body health, bones are made into bone glue (small molecules) through modern production processes such as an enzyme preparation method and the like, the bone glue (small molecules) is easily dissolved in water and easily absorbed by a human body, can supplement colloid in the bones, is non-toxic and can be eaten for a long time; due to different yin and yang attributes, different types of osteoporosis patients can be prevented and treated; the traditional Chinese medicine also has good prevention and treatment effects on complications, fracture, hairline fracture, arthralgia and other bone diseases caused by osteoporosis; the compound can be applied to preparation of medicines, foods and health-care foods for preventing and treating osteoporosis.

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The present invention provides anti-Siglec-15 antibodies and antigen-binding fragments thereof as well as isolated nucleic acids, vectors, engineered cells, formulations thereof, and methods of use thereof for treating diseases including cancer and bone disease in a human subject. The invention is further directed to bispecific and multispecific antibodies, antibody-drug conjugates and chimeric antigen receptors derived from the anti-Siglec-15 antibodies and fragments thereof.

Compositions comprising an isolated population of nanovesicles from a plant, mushroom or algae are provided. Methods of treating muscle and bone diseases, treating neurological diseases, treating age-related disease, inducing muscle differentiation, inducing neuronal differentiation, treating malnutrition, reducing inflammation and reducing oxidative stress by administering a composition comprising an isolated population of nanovesicles from a plant, mushroom or algae are also provided. Methods of delivering a compound to a cell comprising loading the compound into nanovesicles from a plant, mushroom or algae and contacting the cell with the loaded nanovesicles are also provided.

The present invention relates to a composition comprising 4-hexylresorcinol (4-HR) as an active ingredient for prevention or treatment of a bone disease, and a formulation thereof. The composition comprising 4-hexylresorcinol (4-HR) as an active ingredient, or an ointment thereof was found to improve bone thickness, density, and strength and control bone remodeling by promoting the differentiation of osteoblasts and suppressing the proliferation and differentiation of osteoclasts in osteoporosis-induced animal models. Thus, the composition or ointment comprising 4-hexylresorcinol (4-HR) as an active ingredient can be provided as a therapeutic agent for bone diseases including bone fracture, osteoarthritis, rheumatoid arthritis, and osteoporosis.

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The invention provides a traditional Chinese medicine composition for relieving or treating qi stagnation and blood stasis type bone diseases including osteoarthritis, fracture delayed healing and osteoporosis and a preparation method and application of the traditional Chinese medicine composition, and the traditional Chinese medicine composition comprises, by weight, 6-12 parts of radix paeoniae rubra, 10-20 parts of angelica sinensis, 10-20 parts of ligusticum wallichii, 10-15 parts of carthamus tinctorius and 15-25 parts of vinegar frankincense. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of vinegar myrrh, 3-8 parts of borax, 6-12 parts of wine-treated rhubarb, 3-8 parts of dragon's blood, 10-20 parts of pseudo-ginseng, 3-7 parts of fried semen persicae, 3-7 parts of radix aucklandiae, 3-8 parts of vinegar-treated rhizoma cyperi, 20-30 parts of scalded rhizoma drynariae, 8-15 parts of radix achyranthis bidentatae, 6-10 parts of cortex lycii radicis, 6-10 parts of cortex acanthopanacis, 20-30 parts of crabs and 5-10 parts of radix dipsaci slices. The traditional Chinese medicine composition can promote qi to activate blood, relieve swelling and pain, reunion bones and reunion and promote healing, and has no toxic or side effect.

The invention belongs to the technical field of traditional Chinese medicine compositions, and provides a powder decoction plaster for treatment and health care of rheumatism bone diseases and a preparation method thereof, the powder decoction plaster comprises the following raw materials by mass: 20-25 parts of ox horn slices, 10-25 parts of light wheat, 20-25 parts of yellow ginger, 20-25 parts of dried ginger, 2-10 parts of notopterygium root, 3-10 parts of sichuanese peppercorn, 0.1-0.5 part of safflower, 0.1-2 parts of cortex acanthopanacis, 0.1-0.5 part of licorice, 1-5 parts of rhizoma cibotii, and 1-5 parts of cortex dictamni. The traditional Chinese medicine disclosed by the invention is decocted into ointment to be applied to an affected part, has the effects of promoting rehabilitation and health, and is used for treatment and health care of lumbar disc herniation, cervical spondylosis, fracture, arthritis, synovitis, hyperostosis, scapulohumeral periarthritis, lumbar disc herniation, sprain and contusion and soft tissue contusion.

The utility model relates to the technical field of medical instruments, in particular to a physical therapy device for knee rheumatism bone diseases, which comprises a kneecap body, the kneecap body comprises a kneecap shell, fixing components are fixedly mounted on two sides of the inner wall of the kneecap shell, each fixing component comprises a fixing block, and the fixing blocks are fixedly connected with the inner walls of two sides of the kneecap shell. A cross-shaped sliding groove is formed in the middle of the kneecap shell, a supporting plate is movably installed in a cavity of the cross-shaped sliding groove, protruding strips are arranged on the upper surface and the lower surface of the supporting plate in a cross-shaped mode, the protruding strips are matched with the cross-shaped sliding groove in size, a replacement assembly is detachably installed at the bottom of the supporting plate and comprises a rubber plate, and the rubber plate and the supporting plate are detachably installed. A massage head is movably mounted at the bottom of the rubber plate. The protruding strips on the upper surface and the lower surface of the supporting plate are matched with the cross-shaped sliding grooves in size, stability and accuracy of the supporting plate in the moving process are guaranteed, and the massage heads can be designed into various shapes so as to meet massage requirements of different users.

The invention relates to the technical field of traditional Chinese medicines, in particular to anti-osteoporosis processed isinglass as well as preparation and application thereof. According to the prepared isinglass provided by the invention, the component M is less than or equal to 5kDa, and the proportion is 63.71%, so that the intestinal absorption efficiency and the bioavailability can be remarkably improved. The invention also provides an application of the processed isinglass in preparation of medicines. The medicines can be used for treating and / or preventing osteoporosis caused by estrogen deficiency, intestinal flora imbalance caused by estrogen deficiency or bone diseases caused by estrogen deficiency. Compared with traditional donkey-hide gelatin, the prepared isinglass is better in molecular weight distribution and richer in Maillard reaction products; compared with swim bladder collagen which is not processed by the preparation method disclosed by the invention, the processed swim bladder collagen disclosed by the invention generates active ingredients such as melanoidins through a Maillard reaction, and the active ingredients are cooperated with amino acids, so that the limitation of traditional glues in anti-osteoporosis application is broken through, and a scientific basis is provided for development of functional bone health products.

The present disclosure relates to a composite material for application to a bone defect site to promote new bone growth at the site comprising: a combination of freeze-dried mineralized bone allograft particles; and a monophasic gel comprising cross-linked hyaluronic acid; wherein the hyaluronic acid is cross-linked by a cross-linking agent, the cross-linking agent being a diglycidyl ether. The present disclosure also relates to a method to obtain a composite material for application to a bone defect site to promote new bone growth at the site comprising mixing freeze-dried mineralized bone allograft particles with a monophasic gel comprising hyaluronic acid; and to a bone regenerative material comprising the composite material as defined herein for use in a method of treating a patient suffering from a degenerative bone condition, bone loss, bone deficiency or bone atrophy.

The present disclosure relates generally to processes for providing compounds that can be used as inhibitors of ectonucleotide pyrophosphatase / phosphodiesterase 1 (ENPP1), which inhibitors can be useful in treating or preventing soft bone diseases, such as hypophosphatasia (HPP).

The present invention provides usage of boric acid in a method of brittle bone disease treatment. In the present invention, moreover, there is a new brittle bone disease (osteogenesis imperfecta) in-vitro model for observing the effect of boric acid on brittle bone disease.

To provide a novel Lactobacillus paracasei strain with bone regeneration effects, and pharmaceutical and food compositions containing the same. [Solution] The present invention relates to a novel Lactobacillus paracasei L-30 and its uses, and more particularly to Lactobacillus paracasei L-30 (KCTC16035BP) which has the ability to promote the differentiation or formation of osteoblasts, the ability to suppress the differentiation or formation of osteoclasts, and the ability to promote immune activity, and which can regenerate bone, and to a pharmaceutical composition for the treatment or prevention of bone diseases containing the same.

The invention provides a traditional Chinese medicine formula for treating rheumatism bone diseases. The traditional Chinese medicine formula comprises the following raw material medicines in parts by weight: 10g or 40g of pangolin, 10g or 15g of pseudo-ginseng, 10g or 15g of dragon's blood, 15g or 20g of angelica sinensis, 15g of rhizoma drynariae and 10g or 15g of teasel root. According to the principle of monarch, minister, assistant and guide, the formula is scientific, the compatibility is reasonable, all the components are synergistic, and the traditional Chinese medicine composition has the effects of treating wind-cold-dampness arthralgia, arthralgia, sore and ulcer pyogenic infections, soreness and weakness of waist and knees, falling injury and osteoarticular soreness, can safely, quickly and efficiently remove wind, cold, dampness, heat, toxicity and stasis in the body, and achieves the effects of treating and preventing diseases, and has no toxic or side effects. The effects of supporting healthy energy, promoting metabolism and enhancing the immunity of the organism are achieved.

This invention discloses a traditional Chinese medicine composition for treating degenerative bone diseases, its preparation method, and its application. It is made from the following raw materials in parts by weight: 30-50 parts Rehmannia glutinosa (processed), 15-30 parts deer antler glue, 20-80 parts Cistanche deserticola, 15-50 parts Morinda officinalis, 15-50 parts tortoise shell glue, 30-80 parts Lycium barbarum, 10-50 parts Curculigo orchioides, 15-50 parts Eucommia ulmoides, 20-80 parts Cuscuta chinensis, and 30-50 parts Dioscorea opposita. 0 parts, Drynaria fortunei 15-50 parts, Achyranthes bidentata 10-50 parts, Taxillus chinensis 20-50 parts, Broussonetia papyrifera 15-30 parts, Clematis chinensis 15-50 parts, Acanthopanax senticosus 15-50 parts; Through the formulation strategy of "regulating the liver and kidneys, nourishing essence and blood, and combining tonification and purging", combined with a specific extraction process, it systematically regulates the balance of bone metabolism, achieves dual prevention and treatment of osteoporosis and bone hyperplasia, and treats both the symptoms and the root cause, and has high safety for long-term use.

This invention relates to a method of treating a joint and / or bone disease, slowing progression of a reduction in bone mass, increasing osteoblast formation, decreasing osteoclast formation, and / or reducing osteocyte death, slowing progression of a reduction in joint mobility and / or function, slowing progression of a reduction in cartilage, and / or reducing chondrocyte senescence and / or death by administering a therapeutically effective amount of a SIRT6 activator, optionally with nicotinamide adenine dinucleotide (NAD+) and / or an NAD+ precursor.

The application provides a kind of medicine composition for treating muscle and bone disease and its application, belong to medical technology field.The medicine composition includes the following weight parts components: compound angelica injection 5-10 parts, kadsura injection 5-10 parts, wild medlar injection 5-10 parts, methylcobalamin injection 5-10 parts;It can also be selectively added vitamin B1 injection, vitamin B12 injection, yellow Chinese wax injection or bone peptide injection.The composition of the application is administered by acupoint injection or intramuscular injection, utilizes the synergistic effect of multiple traditional Chinese medicine injection and western medicine injection, reaches the comprehensive treatment effect of promoting blood circulation to remove blood stasis, dispelling wind to stop pain, nerve nutrition.Clinical experiments show that the application has significant effect on lumbar disc herniation, cervical spondylosis, shoulder periarthritis, knee osteoarthritis, femoral head necrosis, osteoporosis and the like, and the total effective rate is more than 95%, with fast effect, low recurrence rate, and no hormone-related side effects, suitable for patients of all ages.

The invention discloses an antioxidant mesoporous organic silicon self-assembled nano material as well as a preparation method and application thereof, and belongs to the technical field of nano materials and biomedicine. The method comprises the following steps: S1, preparing an ROS removal micromolecule precursor TK-NH2 through a mercaptan condensation reaction; s2, preparing antioxidant mesoporous organic silicon spheres (PMOs) by taking TK-NH2 as a raw material through a sol-gel method; and S3, preparing the antioxidant mesoporous organic silicon self-assembled nano material (PMOs (at) Cur (at) Ca) by taking the PMOs as a raw material through an anti-solvent method. The method is simple in steps, normal in temperature and pressure, low in cost and capable of achieving large-scale production; the prepared antioxidant mesoporous organosilicon self-assembled nano material can be applied to preparation of drugs for treating inflammations, especially inflammatory bone diseases, by removing ROS (reactive oxygen species), especially drugs for treating rheumatoid arthritis.

Described herein are compositions for maintaining and / or improving bone health in a subject (e.g., an aging subject) comprising N 1 - dihydrocaffeoyl-N 10 - caffeoyl spermidine and an additive. Further, described herein are methods for maintaining and / or improving bone health in a subject (e.g., an aging subject). Further, described herein are methods for preventing and / or treating bone disease in a subject (e.g., an aging subject).

The present invention provides anti-Siglec-9 antibodies and antigen-binding fragments thereof as well as isolated nucleic acids, vectors, engineered cells, formulations thereof, and methods of use thereof for treating diseases including cancer and bone disease in a human subject. The invention is further directed to bispecific and multispecific antibodies, antibody-drug conjugates and chimeric antigen receptors derived from the anti-Siglec-9 antibodies and fragments thereof.

The invention discloses a functional composition capable of improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component, the first active component is prepared from elastin peptide, haematococcus pluvialis and ergothioneine; the second active component is prepared from one or more of herba houttuyniae and non-denatured type II collagen. Through scientific compatibility of all the components, the levels of glycosaminoglycan in chondrocytes and osteocalcin in osteoblasts are synergistically improved, and the protection effect on joint, cartilage and skeleton health is achieved. Meanwhile, a plurality of components in the functional composition capable of improving the health of the bones and the joints are natural in source, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of the bone diseases.

The present invention relates to a recombinant stabilized galectin 9 protein and the use thereof, and more specifically, relates to a pharmaceutical composition comprising the recombinant stabilized galectin 9 protein for prevention or treatment of rheumatoid arthritis and a bone disease. The recombinant stabilized galectin 9 protein differs from the wild-type galectin 9 protein in that the amino acids in the link region connecting two carbohydrates recognition domains (CRDs) are deleted, and the amino acids in the C-terminal CRD (CCRD) are deleted and substituted.

The invention discloses a pharmaceutical composition for bone diseases and bone fractures. The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of calcined native copper, 10-20 parts of vinegar myrrh, 10-20 parts of vinegar frankincense, 3-10 parts of cornu cervi degelatinatum, 3-10 parts of white dipsacus, 3-10 parts of safflower carthamus, 15-25 parts of ground beetles, 3-10 parts of white mulberry root-bark and 3-10 parts of dragon's blood. The fine powder of the pharmaceutical composition and pharmaceutically acceptable auxiliary materials or auxiliary components are prepared into an external preparation. The patch has good biocompatibility with skin, and the hydrophilic polymer matrix has air permeability, perspiration resistance, no sensitization and no irritation; the drug release performance is good, the affinity with the skin is strong, the hydration effect of the cuticle can be improved, and the transdermal absorption of the drug is facilitated; a transdermal absorption controlled release technology is applied, so that the blood concentration is stable, and the drug effect is lasting.

The present invention provides anti-Siglec-9 antibodies and antigen-binding fragments thereof as well as isolated nucleic acids, vectors, engineered cells, formulations thereof, and methods of use thereof for treating diseases including cancer and bone disease in a human subject. The invention is further directed to bispecific and multispecific antibodies, antibody-drug conjugates and chimeric antigen receptors derived from the anti-Siglec-9 antibodies and fragments thereof.

Provided herein are compounds that are useful for or methods of inhibiting β-catenin or disrupting the interaction between β-catenin and T-cell factor 4, which are useful in the treatment of diseases or health conditions, such as cancer, neurodegenerative, a metabolic disease, a cardiovascular disease, fibrosis, and a bone disease. In one aspect, the compounds have Formula 1 wherein R1 is —(CR42)mXR5; R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, aralkyl, heteroaralkyl, or heteroaryl; and R3 is —(CR62)nR7.

The invention belongs to the technical field of important compositions, and particularly relates to a traditional Chinese medicine composition for treating muscle and bone diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: radix angelicae pubescentis, ligusticum wallichii, rhizoma sparganii, rhizoma atractylodis macrocephalae, peach kernels, radix angelicae sinensis, flos daturae, radix paeoniae rubra, radix angelicae, unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, unprocessed rhizoma pinelliae, unprocessed rhizoma arisaematis, flos carthami, unprocessed radix rehmanniae, radix et rhizoma rhei, fructus forsythiae, trogopterus dung, unprocessed radix astragali, unprocessed semen strychni, rhizoma et radix notopterygii, unprocessed radix glycyrrhizae, drynaria baronii, frankincense, myrrh and storax. Aiming at the technical problems of single effect and limited curative effect of the existing plaster, the plaster disclosed by the invention combines the functions of eliminating evil and strengthening the body resistance through scientific formula compatibility, and realizes the synergistic effect of multiple effects of clearing heat, tonifying qi, activating blood, dredging collaterals and the like, so that the treatment of the plaster is more comprehensive and deep, and the plaster has a remarkable curative effect on chronic and intractable muscle and bone diseases.

The invention provides application of wogonoside in preparation of a medicine for preventing and treating inflammatory osteolysis, and belongs to the technical field of bone disease treatment, wogonoside has an inhibiting effect on RANKL-induced osteoclast generation and bone resorption, and MAPK and NF-kB signal channels related to osteoclast differentiation are detected through WB and PCR experiments. The wogonoside has an inhibiting effect on osteoclast differentiation, bone resorption function and bone loss of LPS-induced inflammatory osteolysis mice, and the effect is possibly related to inhibition of RANKL-mediated ROS level and a downstream MAPK signal channel. Therefore, the invention possibly provides a new treatment thought for preventing inflammatory osteolysis diseases.