69 results about "Bone formation" patented technology

The invention discloses a glucose responsive composite material as well as a preparation method and application thereof. The composite material sequentially comprises porous metal, a polydopamine layer and a mesoporous silicon dioxide coating from inside to outside, the porous metal is coated with the polydopamine layer, the polydopamine layer is coated with the mesoporous silicon dioxide coating, and preparation raw materials of the mesoporous silicon dioxide coating comprise aminated mesoporous silicon dioxide, aspirin, 4-carboxyphenylboronic acid and sodium alginate. The composite material disclosed by the invention has blood sugar concentration dual-mode response capability, aspirin is suddenly released in a hyperglycemia environment, up-regulation expression of anti-inflammatory factors is remarkably promoted, and an anti-inflammatory effect is dominated; in a normal blood glucose environment, aspirin is slowly released, and the expression of osteogenic factors is remarkably up-regulated, so that osteogenic differentiation is promoted as a leading effect; the dual-mode response realizes accurate regulation and control of ASP dosage, organically combines bone formation promotion and anti-inflammatory functions, and provides a brand new solution for patients with bone defects, especially patients with bone defects caused by diabetes mellitus.

The invention provides a milk protein peptide which takes milk protein as a raw material and has the effects of promoting calcium absorption and improving bone health and application of the milk protein peptide. Specifically, milk protein peptide sequences, including YGGVSL and SQRY, are screened by adopting enzymolysis, sequence identification and molecular docking methods. The milk protein peptide is proved to have high calcium transport promoting capacity in the in-vitro intervention of Caco-2 cells, and the milk protein peptide is proved to have the capacity of promoting osteogenesis and inhibiting bone resorption in the in-vitro intervention of MC3T3-E1 mouse embryo osteoblasts. In animal experiments, by increasing the content of blood calcium and bone calcium, reducing the content of excrement calcium, improving mRNA expression of calcium ion channel protein, calcium binding protein and peptide transporter in intestinal tracts, enhancing the efficiency of calcium entering blood, promoting osteogenesis and inhibiting bone resorption, the milk protein peptide is comprehensively proved to have the capabilities of improving calcium resorption of organisms and improving bone health. The milk protein peptide has both functionality and nutrition, and has a wide application prospect in the aspect of bone health.

The invention relates to the technical field of biomedical materials, in particular to a degradable zinc-based composite GBR film with the surface loaded with a nanometer electrostatic spinning fiber coating and preparation and application of the degradable zinc-based composite GBR film. According to the degradable zinc-based composite GBR membrane with the surface loaded with the nano electrostatic spinning fiber coating, the nano fiber coating is implanted into the surface of a zinc-based material such as zinc alloy by adopting an electrostatic spinning technology, and the degradable zinc-based composite GBR membrane with the surface loaded with the nano electrostatic spinning fiber coating can inhibit excessive release of zinc ions, improve biocompatibility of the zinc alloy and the like, promote osteoblast differentiation and promote angiogenesis. The electrostatic spinning coating on the surface of the zinc-based composite GBR membrane serves as a physical barrier to block invasion of epithelial cells and fibrocytes, and angiogenesis is promoted along with degradation of fibers and slow release of drugs; the porous zinc alloy and the like in the middle layer not only provide mechanical support, but also release zinc ions in the degradation process to achieve multiple functions of resisting bacteria and promoting osteogenesis.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The invention provides a bone targeting nano composite carrier, a bone targeting nano composite drug and a preparation method and application of the bone targeting nano composite carrier and the bone targeting nano composite drug, and belongs to the technical field of biological medicine, the bone targeting nano composite carrier comprises epigallocatechin gallate and E7 targeting peptide, and the mass ratio of the epigallocatechin gallate to the E7 targeting peptide is 1: (1.5-2.5); the epigallocatechin gallate and the E7 targeting peptide are connected through a condensation reaction. According to the invention, the bone-targeted nano composite carrier is used for entrapping an osteogenic induction component, and a bone-targeted nano composite drug is obtained through self-assembly. According to the invention, triple functions of osteogenesis promoting drugs, anti-inflammatory / anti-oxidation components and active targeting are integrated, and the bone-targeting nano composite drug not only can directly stimulate bone formation, but also can fundamentally improve the crucial pathological microenvironment in diabetic osteoporosis.

A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

The application belongs to the technical field of biomedical engineering, and relates to a selenium-containing high polymer compound modified zinc alloy material and a preparation method and application thereof. The selenium-containing high polymer compound modified zinc alloy material is obtained by coordination and compounding of a selenium-containing high polymer compound and a zinc alloy, and the selenium-containing high polymer compound is prepared from raw materials including H2N-(CH2)3-Se-(CH2)3-NH2, 1,4-bis(2-hydroxyethyl)piperazine, diisocyanate and polyethylene glycol monomethyl ether through a reaction. The selenium-containing high polymer compound modified zinc alloy material prepared by the preparation method can be used as an oral implant or an orthopedic implant, and can reduce inflammation caused by implantation after being implanted into a body, and realize the synergistic effect of anti-inflammation and bone formation promotion.

The invention discloses a traditional Chinese medicine ingredient modified bone graft material and a preparation method thereof, and relates to the technical field of bone graft materials. The feed additive is prepared from the following raw materials: calcined bone meal and a traditional Chinese medicine extract, the traditional Chinese medicine extract comprises a radix salviae miltiorrhizae extract and / or a radix scutellariae extract. The preparation method comprises the following steps: preparing calcined bone meal, preparing simulated body fluid and preparing the modified bone graft material. The product material can be applied to a dental bone grafting material. The traditional Chinese medicine extract is loaded on the bone material, and the bone material is modified, so that the bone graft material with good biocompatibility, osteogenesis promoting capability and better osteogenesis induction potential can be obtained.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

FIELD: otorhinolaryngology.SUBSTANCE: under endotracheal anesthesia, an endoscope equipped with optics and an instrument for removing pathological contents of the maxillary sinus are inserted into the nasal passage. The inferior nasal concha is displaced medially using a raspatory. Then, stepping back from the edge of the piriform opening by 1.5–2.0 cm in the caudal direction, a mucoperiosteal flap of the lateral wall is separated in the lower nasal passage. The mucoperiosteal flap is displaced posteriorly, exposing the bone skeleton in the projection of the inferomedial angle of the maxillary sinus. Next, using a cold plasma coblator, in ablation mode, the mucous surface of the bone skeleton is evaporated for 2–3 seconds, followed by coagulation of small vessels. Then, a bone valve measuring 10–15 mm is formed from the exposed bone skeleton. The bony valve is retracted in the caudal direction, forming an antrostomy. A 70-degree endoscope is inserted through the formed antrostomy and the pathological contents of the sinus are visualized. In this case, if the cyst is visualized with a coblator in ablation mode, the cyst is evaporated along with its contents, and the remaining cyst is captured and removed. If a polyp is visualized, the polyp stalk is first evaporated, and then the remaining part of the polyp is removed. If a foreign body is visualized, it is removed with forceps. In this case, if the foreign body is encapsulated or located in the thickness of the mucosa, a coblator in ablation mode evaporates part of the mucosa until the foreign body is exposed, and then removed. Next, the sinus cavity is washed with saline solution. The antrostomy is closed with a bone flap. The formed mucoperiosteal flap is placed back in its original place.EFFECT: method allows for endoscopic endonasal removal of pathological contents from the maxillary sinuses with a minimal risk of cyst / polyp recurrence and postoperative complications, reduced blood loss during surgery, shortened surgical time, postoperative rehabilitation periods, and temporary disability.3 cl, 3 ex

This invention provides a strain of *Lactobacillus plantarum*, and discloses the fermentation product of *Eucommia ulmoides* leaves, *Rehmannia glutinosa*, dried ginger, and *Dendrobium officinale* obtained by fermenting these herbs, along with its preparation method and applications. This fermentation product can directionally activate the phenylpropane biosynthetic pathway, inducing the generation of characteristic small molecule metabolites of polyphenols, particularly sanguranyl sulfadiazine (SSA). Moreover, compared to the raw materials, the fermentation product contains more active small molecule metabolites. Finally, experiments on zebrafish modeled with prednisone demonstrated that the fermentation product can significantly promote bone formation. The fermentation product mainly restores the expression levels of related genes to normal zebrafish gene expression levels by regulating these genes. Therefore, the fermentation product can be used to prepare foods or medicines that improve bone health.

The application provides a screening method of human amniotic membrane mesenchymal stem cells (hAMSCs) with bone regeneration promoting potential, and uses the protein level of transmembrane protein 119 (TMEM119) as a functional index of the bone regeneration promoting ability of the hAMSCs, and uses an enzyme-linked immunosorbent assay (ELISA) to detect the TMEM119 protein concentration in a lysis solution prepared from 1×10 7 The application uses the TMEM119 protein concentration not lower than 15000 pg / mL as a screening standard of the hAMSCs with bone regeneration promoting potential, and screens the hAMSCs with significant bone regeneration promoting potential from different batches of hAMSCs, so that the hAMSCs meeting the screening standard of the application have obvious bone formation promoting potential, and the technical problem that the hAMSCs with bone regeneration promoting potential are difficult to be accurately identified and screened in clinical transformation is solved.

The utility model discloses a 3D (three-dimensional) printing implant for oral implantation in the technical field of medical equipment, which comprises an implant structure, the implant structure comprises an implant body, the implant body is of a gradient pore net structure, a bioactive layer is arranged on the outer side of the implant body, and the bioactive layer is made of a transparent material. A bone meal attaching and guiding structure is arranged on the inner wall of a mesh hole of the implant body, a surface fixing structure is arranged on the surface of the implant body, and a bottom fixing structure is arranged at the bottom of the implant body. According to the utility model, the implant body is arranged into the net-shaped structure, and the bone meal attachment and guide structure is matched, so that the bone meal can be guided to directionally grow along the net-shaped pores, the traditional osteogenesis waiting stage is skipped, the implant implantation and bone increment are synchronously completed, and the damage to soft tissues caused by repeated bone meal filling and pressing operation is avoided.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

This invention provides a calcium phosphate-polycaprolactone composite scaffold, its preparation method, and its applications. The raw materials for preparing the calcium phosphate-polycaprolactone composite include polycaprolactone, β-tricalcium phosphate, and hydroxyapatite. The resulting composite scaffold possesses functions of promoting immunity and regulating bone regeneration. The preparation method of this invention involves first forming a hydroxyapatite / polycaprolactone composite film, which is then broken down and recombined with β-tricalcium phosphate to form a composite solution. The resulting 3D-printed composite scaffold not only possesses good mechanical strength and biocompatibility but also induces stem cell proliferation and osteogenic differentiation, and induces macrophage regeneration and polarization. It can be used to regulate immune cell responses, induce a bone immune microenvironment conducive to bone formation, thereby enhancing bone regeneration, and can be used for the repair and regeneration of tissue defects.

The present invention relates to a customized device made of inert and rigid ceramics for rebuilding bone, bridge bone defects or reshaping bone, and more particularly, to the combination of material properties and design to protect fractured portions or volumes to form new bone from movements and external forces that may interfere with bone formation and bone healing. This contributes to the best situation for natural bone healing, thereby improving clinical outcomes. The design of the implant member (1) is based on the initial bone structure (2) and the intended treatment, in which at least a portion of the bone-oriented inner surface (9) of the implant member (1) follows irregularities of the initial bone structure (2) to mechanically support the area around the fixation screws (6) for connecting the implant member to the initial bone structure (2).

To provide bone fortifier dietary supplements with a high osteogenesis promoting effect.SOLUTION: A bone fortifier dietary supplement is characterized by containing as an active ingredient isoflavone, and specific components of plant materials, such as Hordeum vulgare, Ipomoea batatas, Peucedanum japonicum, Pinus, Terminalia, Cocos nucifera, Aristotelia Chilensis, and Brassica oleracea.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of bionic bone scaffolds, and particularly relates to a TPMS structure bionic bone scaffold with an immune regulation function and a preparation method of the TPMS structure bionic bone scaffold. Comprising the following steps: preparing a three-period extremely-small curved surface bionic scaffold and micro-tissues, loading micro-tissue spheres in a methacryloyl gelatin solution, then pouring the micro-tissue spheres into the three-period extremely-small curved surface bionic scaffold, and carrying out photo-crosslinking gel forming to obtain the three-period extremely-small curved surface structure bionic bone scaffold with the immune regulation and control function. The bionic bone scaffold disclosed by the invention can be used for accurately simulating components and structures of natural bones, has good immunoregulation and osteogenesis promoting capabilities, and is expected to cooperate with functionalized micro-tissues to construct an immune microenvironment and promote bone tissue regeneration.

The invention discloses a bone-blood vessel coupling regeneration material based on S1P modified decellularized fish scale bone meal as well as a preparation method and application thereof, and belongs to the technical field of biology. After the fish scales are treated by a decellularization method, sphingosine-1-phosphoric acid (S1P) is efficiently anchored on the surfaces of the fish scales by utilizing a cationic gelatin middle layer, and a novel bone-blood vessel coupling regeneration material is developed. The bone-blood vessel coupling regeneration material retains natural components and topological structures of fish scales, and can guide ordered deposition of calcium and phosphorus to improve bone matrix density and compression strength; the endogenous bone marrow mesenchymal stem cells and vascular endothelial cells are actively collected to migrate to the center of a defect cavity by loading the S1P to simulate the homing principle of natural stem cells in an organism, osteogenesis and angiogenesis signal channels are synchronously activated, and endogenous bone-blood vessel coupling regeneration is rapidly started. The invention provides an effective strategy for regulating and controlling osteogenesis-angiogenesis coupling for the field of bone injury repair.

The application relates to the technical field of biomaterials, in particular to an antibacterial and bone growth promoting composite material and a preparation method and application thereof. An antibacterial and bone growth promoting composite material is provided, which comprises 80-99.5% of metal materials and 0.5-20% of auxiliary materials in terms of weight percentage, wherein the auxiliary materials are at least one selected from strontium-containing compounds, fluorine-containing compounds and zinc-containing compounds. The obtained composite material has strong antibacterial property and bone formation promoting effect, and has the advantages of good biocompatibility, corrosion resistance, metal luster and the like, and can be stably and long-term used as a medical metal material in the orthopedic and dental fields.

The invention discloses a bone scrap retention prevention operation drill bit, and belongs to the technical field of medical instruments, the bone scrap retention prevention operation drill bit comprises a hollow drill bit, a plurality of bone scrap collecting ports are formed in the bottom end of the drill bit in the circumferential direction at equal intervals, a micro spiral conveying shaft is arranged in the drill bit, and a follow-up driving mechanism is assembled between the bottom end of the micro spiral conveying shaft and the drill bit; a plurality of bone chip collecting openings are formed in the bottom end of a drill bit in the circumferential direction at equal intervals, a miniature spiral conveying shaft is arranged in the drill bit, a follow-up driving mechanism is assembled between the miniature spiral conveying shaft and the drill bit, a connecting rod is arranged at the top end of the miniature spiral conveying shaft, and a bone chip collecting box is rotationally arranged on the outer side wall of the miniature spiral conveying shaft; the miniature spiral conveying shaft and the drill bit are driven to rotate, the rotating drill bit cuts bones to form bone holes, bone scraps generated in the cutting process enter the drill bit through the multiple bone scrap collecting openings and are conveyed into the bone scrap collecting box through the rotating miniature spiral conveying shaft, and bone scrap retention can be prevented.

In one aspect, the present application provides compounds of Formula I, and salts, hydrates, and isomers thereof. In another aspect, the present application provides a method of promoting bone formation in a subject by administering to the subject in need thereof a therapeutically effective amount of a compound of Formula I. The present application also provides orthopedic and periodontal devices using compounds of Formula I, and methods for treating kidney disease, diabetes, bone loss, and cancer.

In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine / threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine / threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and / or cells of hematopoietic lineages, including red blood cells. In certain aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cellular networks, and endocrine systems.

The invention provides naloxone-loaded adhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of adhesive hydrogel. The naloxone-carrying adhesive hydrogel is obtained by cross-linking boric acid oxidized chondroitin sulfate and methacrylated gelatin; and naloxone and hectorite nano particles are loaded in the naloxone carrying adhesive hydrogel. The naloxone-loaded hydrogel constructed by the invention is used for repairing damage of bone and nervous tissues, naloxone is used as a small molecule drug, has more stable physical and chemical properties, is easier to store, and also has the functions of promoting osteogenesis and neurogenesis, so that the combined use of various bioactive factors is reduced; and the naloxone-carrying adhesive hydrogel has adhesive performance, can effectively fill a bone defect area and form a stable repair microenvironment, and accelerates the bone and nervous tissue regeneration efficiency.

The application discloses a colostrum powder digestion-released bone formation active peptide and application thereof, the amino acid sequence of the bone formation active peptide is HLVDEPQ, and the bone formation active peptide is derived from bovine colostrum within 24 hours after a cow gives birth to a calf. It is found through a simulation digestion experiment that after the bovine colostrum enters the human gastrointestinal tract, the specific active polypeptide with high target affinity for preventing osteoporosis can be accurately released only by virtue of the natural digestion pathway of the human body without additional in-vitro enzymolysis, the material basis for improving bone metabolism of the bovine colostrum is determined from a molecular level, it is fully proved that the natural bovine colostrum itself can serve as a safe and efficient bone formation functional food, and definite material basis and solid theoretical basis are provided for development of a high-target bone health auxiliary preparation.

The invention relates to a liquid pharmaceutical composition comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. Furthermore, it relates to a method of reducing the precipitation of an antibody or antigen-binding fragment thereof in a liquid pharmaceutical composition by adding methionine and cyclodextrin. Specifically. the liquid pharmaceutical composition comprises an anti-sclerostin antibody, hydroxypropyl-γ-cyclodextrin and methionine and can be used in the treatment of a bone disorder associated with at least one of the following: low bone formation, low bone density, low bone mineral content, low bone mass. low bone quality and low bone strength, and especially in the treatment of osteoporosis.Furthermore, the invention relates to a method of reducing injection site inflammation in a mammalian subject comprising administering a therapeutically effective amount of a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine.

The application belongs to the technical field of medical materials, and discloses a novel titanium-based implant material with oxygen release, antibacterial and bone formation promoting properties and a preparation method thereof. The titanium-based implant material comprises a titanium base material and calcium peroxide on the surface of the titanium base material. The application proposes that the dense or porous titanium-based implant material is modified by calcium peroxide. The characteristics of calcium peroxide itself, i.e., the reaction with water to release oxygen, hydrogen peroxide and calcium ions, and the biological activity of calcium ions in bone repair make the titanium-based implant material have application potential in preventing / relieving / treating bacterial infection of implants, oxygen deficiency of large-size bone defects and poor bone integration.

The present application belongs to the technical field of hydrogel, and particularly relates to a periodontal bone defect repair hydrogel and a preparation method thereof; wherein the periodontal bone defect repair hydrogel comprises the following raw materials in parts by weight: 5-20 parts of gelatin, 1-10 parts of sodium alginate, 2.5-15 parts of bioactive filler, and 1-10 parts of hydroxyapatite; the gelatin and the sodium alginate are compounded and synergized to provide a stable carrier basis for uniform dispersion and long-acting effect of functional components. The bioactive filler prepared by the present application is surface core-shell coated and modified by PCL on zinc silicate, a PCL hydrophobic thin layer effectively blocks the burst release of zinc ions in the early stage, with slow degradation of PCL, gradient slow release of zinc and silicon ions, so that the antibacterial and anti-inflammatory functions and the bone formation function time of the material are accurately matched with the alveolar bone regeneration cycle. Meanwhile, sodium magnesium lithium silicate is further introduced and uniformly inserted into the hydrogel network, which significantly improves the compactness of the hydrogel network.

The application discloses a kind of biomimetic biological mineralization osteogenesis hydrophilic bioactive ceramic coating material, which includes HA / BaTiO3 composite layer in the material.The application also discloses its preparation method, which is prepared by using wideband laser cladding method.The application introduces BaTiO3 into traditional bioactive ceramic coating material to form HA / BaTiO3 composite layer, in-situ constructs bioelectric microenvironment to make hydrophilic bioactive ceramic coating, realizes the effective combination of electric stimulation and artificial joint coating, uses the electrostatic interaction between piezoelectric charge and inorganic salt ions in body fluid to adsorb calcium and phosphorus inorganic salt to coating surface, creates osteogenesis environment for life body osteogenesis, improves the hydrophilic performance of coating surface, promotes the inorganic salt and water molecules in body fluid environment to infiltrate on material surface, enhances bioactivity and accelerates bone integration, so as to be beneficial to promote the rapid establishment of joint prosthesis and host bone interface bone integration.

The invention belongs to the field of biomedical materials, and discloses a magnetoelectric hydrogel microneedle, the magnetoelectric hydrogel microneedle comprises a backing and a microneedle array, the backing comprises hydrogel containing magnetic ionic liquid Fe-IL and thiolated chitosan, and the microneedle array comprises magnetoelectric nanoparticles and hydrogel; the magnetoelectric nano-particles are CB core-shell structure nano-particles of which the surface of magnetic nano cobalt ferrite (CFO) is coated with a piezoelectric responsive barium titanate (BTO) shell layer. The invention further discloses a preparation method of the magnetoelectric hydrogel microneedle and application of the magnetoelectric hydrogel microneedle in preparation of products for treating bone tissue repair. During preparation, CB gradient distribution is regulated and controlled through an external magnetic field, the magnetoelectric response efficiency is enhanced, when the magnetoelectric hydrogel is applied to preparation of products for treating bone tissue repair, the osteogenesis efficiency can be improved, the adaptability of the magnetoelectric hydrogel to the bone tissue can be enhanced, and efficient electrical stimulation repair of the bone tissue is achieved.