17 results about "Bone formation" patented technology

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

FIELD: otorhinolaryngology.SUBSTANCE: under endotracheal anesthesia, an endoscope equipped with optics and an instrument for removing pathological contents of the maxillary sinus are inserted into the nasal passage. The inferior nasal concha is displaced medially using a raspatory. Then, stepping back from the edge of the piriform opening by 1.5–2.0 cm in the caudal direction, a mucoperiosteal flap of the lateral wall is separated in the lower nasal passage. The mucoperiosteal flap is displaced posteriorly, exposing the bone skeleton in the projection of the inferomedial angle of the maxillary sinus. Next, using a cold plasma coblator, in ablation mode, the mucous surface of the bone skeleton is evaporated for 2–3 seconds, followed by coagulation of small vessels. Then, a bone valve measuring 10–15 mm is formed from the exposed bone skeleton. The bony valve is retracted in the caudal direction, forming an antrostomy. A 70-degree endoscope is inserted through the formed antrostomy and the pathological contents of the sinus are visualized. In this case, if the cyst is visualized with a coblator in ablation mode, the cyst is evaporated along with its contents, and the remaining cyst is captured and removed. If a polyp is visualized, the polyp stalk is first evaporated, and then the remaining part of the polyp is removed. If a foreign body is visualized, it is removed with forceps. In this case, if the foreign body is encapsulated or located in the thickness of the mucosa, a coblator in ablation mode evaporates part of the mucosa until the foreign body is exposed, and then removed. Next, the sinus cavity is washed with saline solution. The antrostomy is closed with a bone flap. The formed mucoperiosteal flap is placed back in its original place.EFFECT: method allows for endoscopic endonasal removal of pathological contents from the maxillary sinuses with a minimal risk of cyst / polyp recurrence and postoperative complications, reduced blood loss during surgery, shortened surgical time, postoperative rehabilitation periods, and temporary disability.3 cl, 3 ex

This invention provides a strain of *Lactobacillus plantarum*, and discloses the fermentation product of *Eucommia ulmoides* leaves, *Rehmannia glutinosa*, dried ginger, and *Dendrobium officinale* obtained by fermenting these herbs, along with its preparation method and applications. This fermentation product can directionally activate the phenylpropane biosynthetic pathway, inducing the generation of characteristic small molecule metabolites of polyphenols, particularly sanguranyl sulfadiazine (SSA). Moreover, compared to the raw materials, the fermentation product contains more active small molecule metabolites. Finally, experiments on zebrafish modeled with prednisone demonstrated that the fermentation product can significantly promote bone formation. The fermentation product mainly restores the expression levels of related genes to normal zebrafish gene expression levels by regulating these genes. Therefore, the fermentation product can be used to prepare foods or medicines that improve bone health.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

This invention provides a calcium phosphate-polycaprolactone composite scaffold, its preparation method, and its applications. The raw materials for preparing the calcium phosphate-polycaprolactone composite include polycaprolactone, β-tricalcium phosphate, and hydroxyapatite. The resulting composite scaffold possesses functions of promoting immunity and regulating bone regeneration. The preparation method of this invention involves first forming a hydroxyapatite / polycaprolactone composite film, which is then broken down and recombined with β-tricalcium phosphate to form a composite solution. The resulting 3D-printed composite scaffold not only possesses good mechanical strength and biocompatibility but also induces stem cell proliferation and osteogenic differentiation, and induces macrophage regeneration and polarization. It can be used to regulate immune cell responses, induce a bone immune microenvironment conducive to bone formation, thereby enhancing bone regeneration, and can be used for the repair and regeneration of tissue defects.

In one aspect, the present application provides compounds of Formula I, and salts, hydrates, and isomers thereof. In another aspect, the present application provides a method of promoting bone formation in a subject by administering to the subject in need thereof a therapeutically effective amount of a compound of Formula I. The present application also provides orthopedic and periodontal devices using compounds of Formula I, and methods for treating kidney disease, diabetes, bone loss, and cancer.

The application discloses a colostrum powder digestion-released bone formation active peptide and application thereof, the amino acid sequence of the bone formation active peptide is HLVDEPQ, and the bone formation active peptide is derived from bovine colostrum within 24 hours after a cow gives birth to a calf. It is found through a simulation digestion experiment that after the bovine colostrum enters the human gastrointestinal tract, the specific active polypeptide with high target affinity for preventing osteoporosis can be accurately released only by virtue of the natural digestion pathway of the human body without additional in-vitro enzymolysis, the material basis for improving bone metabolism of the bovine colostrum is determined from a molecular level, it is fully proved that the natural bovine colostrum itself can serve as a safe and efficient bone formation functional food, and definite material basis and solid theoretical basis are provided for development of a high-target bone health auxiliary preparation.

The application discloses a preparation method of a bone formation inducing biological additive based on red blood cell-derived apoptotic vesicles and application thereof, and the preparation method comprises the following steps: a, red blood cell apoptosis induction treatment; b, collection and purification of red blood cell-derived apoptotic vesicles RBC-ApoEVs through series differential ultracentrifugation; c, characterization and quality control of the apoptotic vesicles; d, acquisition, culture and basic identification of SHED; and e, determination of 0.5 mu g / mL as the optimal bone formation inducing synergistic concentration of the red blood cell-derived apoptotic vesicles RBC-ApoEVs. The bone formation inducing biological additive prepared by the preparation method can be used as a safe and efficient bone formation inducing synergistic agent, and can solve the problem that "proliferation promotion" and "differentiation promotion" are difficult to be coordinated, and can also avoid the dependence on exogenous growth factors and related risks. The bone formation inducing biological additive can be applied to in-vitro induction of SHED bone differentiation, bone regeneration cell suspension and bone tissue engineering compound.

The application provides a developmental growth plate layered scaffold and a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered scaffold provided by the application is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is a bone formation layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite scaffold structure is stable and is not easy to break; and the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are cell-free. Under the in-vitro chondrogenic induction culture condition, the BMSCs in the upper layer can pass through the middle layer and colonize in the lower layer, and in the process, part of the BMSCs can differentiate into cartilage cells. The middle layer containing thrombospondin 1 (TSP1) has specific intervention effect on cell migration, which is manifested as inhibition of the migration of vascular endothelial cells, but has no effect on the migration of BMSCs.

The application provides a supramolecular complex and a preparation method and application thereof, and belongs to the field of biological medicines. The supramolecular complex is prepared from raw materials in the following mass ratio: the mass ratio of puerarin to collagen or a complex thereof is 1:(0.5-20), or the mass ratio of an antibacterial peptide, puerarin and collagen or a complex thereof is 1:5:(2.5-100); the supramolecular complex can form a hydrogel. The supramolecular complex and the hydrogel thereof have significantly improved permeability, can effectively penetrate deep tissue and cells of gingival epithelium, deliver drugs into inner layers of tissue and cells, realize efficient clearance of intracellular pathogens, and break through the problem of insufficient clearance of intracellular bacteria in the existing periodontal drug delivery system. Meanwhile, the supramolecular complex has excellent antibacterial and anti-inflammatory properties and bone formation promoting ability, can effectively treat periodontitis, and provides a new integrated solution for periodontitis treatment.

The application provides a ZP@GGA / OCMC composite hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogels.The preparation method comprises the following steps: performing a gelation reaction on a gallic acid grafted gelatin solution, an oxidized carboxymethyl cellulose solution and ZIF-8 / 67@PDA nanoparticles to obtain the ZP@GGA / OCMC composite hydrogel.In the application, the Schiff base reaction between GGA and OCMC endows the hydrogel with a rapid in-situ gelation capability and a dynamic reversible network structure, the PDA coating layer significantly improves the hydrophilicity and dispersibility of the ZIF-8 / 67 nanoparticles, and the Zn 2+ and Co 2+ The time-sequential release of two functional ions is realized; the composite hydrogel not only has the properties of injectability, tissue adhesion and degradation behavior matching the bone healing period, but also has multiple functions such as time-sequential ion release, oxidation resistance and bone formation promotion.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

The application provides application of animal Bifidobacterium lactis BGI-L99 in prevention and treatment of hormone imbalance and aging related diseases, and belongs to the technical field of biotechnology. The aforementioned animal Bifidobacterium lactis BGI-L99 is preserved in Guangdong Microbial Culture Collection Center (GDMCC) on March 31, 2026, and the preservation number is GDMCC No. 68017. Products prepared from the animal Bifidobacterium lactis BGI-L99 in the examples of the application can effectively prevent and treat sex hormone imbalance related diseases and delay aging related degenerative diseases, including relieving polycystic ovary syndrome and osteoporosis, specifically including improving ovarian function, endocrine disorder, depression, metabolic disorder, inflammatory reaction, abnormal intestinal metabolic product, bone microstructure degradation, imbalance between bone formation and bone resorption and the like.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.

The application provides a double-layer guided bone regeneration membrane and a preparation method thereof, relates to the technical field of bone regeneration, and is composed of a compact layer and a porous layer which are arranged in a top-bottom stack, wherein the compact layer is prepared by cross-linking and modifying soluble eggshell membrane protein (SEP), epigallocatechin gallate (EGCG) and carboxymethyl chitosan (CMC) through genipin, has a compact non-porous structure and is used for blocking the migration of soft tissue cells; the porous layer is obtained by cross-linking hydroxyapatite modified by 3-aminopropyl triethoxysilane (APTES) and carboxymethyl chitosan (CMC) through genipin, has a three-dimensional porous structure and is used for promoting the growth of bone cells and bone regeneration. The double-layer guided bone regeneration membrane has good tensile strength, physical barrier function, antibacterial performance and controllable degradation, and can realize safe and effective bone formation effect under the irradiation of 808nm near-infrared light and 1W power.

The application discloses a kind of bovine collagen peptide for increasing bone density and a preparation method thereof, and relates to the technical field of enzyme processing preparation of protein peptide.The application relates to the application of bovine collagen peptide in the field of composition.The composition containing bovine collagen peptide is prepared from the following components in mass fraction:bovine collagen peptide 25-45 parts, calcium citrate 12-28 parts, vitamin D 0.0002-0.0004 parts, extract of rhizoma drynariae 6-14 parts, extract of astragalus 4-9 parts, auxiliary materials 12-38 parts, and zoledronate derivative 0.01-0.05 parts.The application breaks through the limitation of single component and poor synergistic effect in the prior art, and forms a multi-dimensional action system of "inhibiting bone resorption, promoting bone formation and supplementing matrix" by matching bovine collagen peptide, calcium citrate, traditional Chinese medicine extract and modified zoledronate derivative, so that the effect of improving bone density is improved.