7 results about "Acute hepatitis" patented technology

The present invention relates to the technical field of liver-protecting formula compositions, and in particular, to a liver-protecting milk thistle formula composition, and a preparation method thereof. Technical problems: the liver-protecting milk thistle formula composition, and a preparation method thereof are intended to solve the technical problems that most of existing liver-protecting compositions in the prior art are designed for the general liver protection needs of the general population and cannot specifically treat liver damage caused by excessive alcohol intake and liver diseases such as cirrhosis, acute hepatitis, hepatitis, fatty liver, cholangitis, cholelithiasis, psoriasis, and hypercholesterolemia. Technical solution: a liver-protecting milk thistle formula composition, including the following components: silymarin, puerarin, artichoke extract, glutathione, dandelion extract, and GABA. The liver-protecting formula composition has a good therapeutic effect on liver damage caused by excessive alcohol intake, and liver diseases such as cirrhosis, acute hepatitis, hepatitis, fatty liver, cholangitis, cholelithiasis, psoriasis, and hypercholesterolemia.

The present disclosure provides compounds of Formula I and pharmaceutically acceptable salts, solvates, and / or derivatives thereof. In addition, the disclosure also provides methods of treating a disease, disorder or condition mediated by SHIP1 or treatable by SHIP1 activation comprising administering a compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof. The compounds of Formula I, or pharmaceutically acceptable salts, solvates, or derivatives thereof, are useful for the treatment of SHIP1 mediated diseases, disorders, or conditions, including inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, multiple myeloma, liver injury, acute hepatitis, and severe sepsis.

The invention belongs to the field of antiviral compounds, and discloses an application of a benzoylaniline compound in preparation of broad-spectrum antiviral drugs. The benzoylaniline compound has a general formula as shown in a formula I, wherein R1, R2, R3, R4 and R5 are at least one of H, C1-4 alkyl, C1-4 alkoxy, halogen, hydroxyl and nitryl; wherein H on the C1-4 alkyl group and H on the C1-4 alkoxy group are optionally substituted by halogen atoms, and the condition is that at least two of R1, R2, R3, R4 and R5 are halogens, but not more than 4; at least one of R1, R2, R3, R4 and R5 is F, but not more than 2. The compound disclosed by the invention has a relatively good in-vitro antiviral effect, and the compound BAB162 is wide in antiviral spectrum and has a remarkable inhibition effect on various viruses at low concentration. The BAB162 shows an obvious treatment effect in a piglet viral diarrhea infection model and a mouse acute hepatitis virus infection model.

Virus-Like Particles derived from the subfamilies, Parahepevirinae, which infect trout and salmon, and the Orthohepevirinae, which infect mammals and birds, particularly those of the species Paslahepevirus balayani, which can cause acute hepatitis in humans and several mammalian species, and chronic conditions in immunocompromised patients are also disclosed. Major aspects of the invention relate to compositions of Virus-Like Particles comprising viral capsid proteins capable of assembly in cultured cells that may be purified, disassembled, and reassembled in the presence of other molecules suitable for use as therapeutic drug products to facilitate the targeting and delivery of cargo molecules to specific cells or tissues, or as antigenic agents designed to stimulate responses to heterologous epitopes exposed on the surfaces of Virus-Like Particles. Preferred aspects relate to functional capsids comprising polypeptide sequences comprising one or more amino acid substitutions, insertions, or deletions of amino acid encoded by a consensus of ORF2 genes, wherein said variant polypeptides are functionally-similar or have enhanced properties compared to capsid polypeptides encoded by naturally-occurring viruses obtained from clinical samples or prototype Hepatitis E Viruses (HEV). Other aspects include the design and assembly of modified vectors to facilitate the basic and applied studies leading to the development and commercialization of novel drug products, and as tools advancing the interests of institutions involved in animal and human healthcare.

Virus-Like Particles derived from the subfamilies, Parahepevirinae and Orthohepevirinae, particularly those of the species Paslahepevirus balayani, which can cause acute hepatitis in humans and several mammalian species, and chronic conditions in immunocompromised patients are disclosed. Compositions of VirusLike Particles comprising viral capsid proteins capable of assembly in cultured cells that may be purified, disassembled, and reassembled in the presence of other molecules suitable for use as therapeutic drug products to facilitate the targeting and delivery of cargo molecules to specific cells or tissues, or as antigenic agents designed to stimulate responses to heterologous epitopes exposed on the surfaces of Virus- Like Particles are provided. Functional capsids comprising polypeptide sequences comprising amino acid substitutions, insertions, or deletions of amino acid encoded by a consensus of ORF2 genes, that are functionally-similar or have enhanced properties compared to capsid polypeptides encoded by naturally-occurring viruses obtained from clinical samples or prototype Hepatitis E Viruses (HEV) are provided.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a preparation method of Qingkailing injection and a product thereof. The preparation method comprises the following steps: firstly, extracting, filtering, and obtaining an extract liquid by adding water to isatis root, gardenia and honeysuckle; secondly, adding water buffalo horn powder and nacre into 8 times of water, adding keratinase and aminopeptidase for enzymolysis, filtering, and obtaining an enzymolysis liquid 1; thirdly, mixing the extract liquid and the enzymolysis liquid 1, adding tannase for enzymolysis, filtering, and obtaining an enzymolysis liquid 2; and finally, adding baicalin into water, mixing the baicalin and the enzymolysis liquid 2, adding into an ethanol solution of cholic acid and hyodeoxycholic acid, mixing, filtering, recovering ethanol from the filtrate, adding water for injection to 1000 ml, treating by activated carbon, filtering, and performing ultrafiltration to obtain the Qingkailing injection. The Qingkailing injection prepared by the preparation method has good stability after being accelerated for 6 months; and pharmacodynamic results show that the Qingkailing injection has certain advantages in treating acute hepatitis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of a Qingkailing injection and a product thereof. The preparation method comprises the following steps: adding water into the radix isatidis, the fructus gardeniae and the honeysuckle flower, extracting, and filtering to obtain an extracting solution; adding buffalo horn powder and nacre mother powder into 8 times amount of water, mixing, adding keratinase and aminopeptidase for enzymolysis, and filtering to obtain enzymatic hydrolysate 1; mixing the extracting solution with the enzymatic hydrolysate 1, adding tannase for enzymolysis, and filtering to obtain enzymatic hydrolysate 2; and finally, adding water into baicalin, mixing with the enzymatic hydrolysate 2, adding into an ethanol solution of cholic acid and hyodeoxycholic acid, uniformly mixing, filtering, recovering ethanol from filtrate, adding water for injection to 1000ml, treating with activated carbon, filtering, and carrying out ultrafiltration. The Qingkailing injection prepared by the preparation method provided by the invention is accelerated for 6 months and has good stability; pharmacodynamic results show that the traditional Chinese medicine composition has certain advantages in the aspect of treating acute hepatitis.